{"id":22576,"date":"2026-04-08T15:00:14","date_gmt":"2026-04-08T15:00:14","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/decouverte-de-degradeurs-de-lrrk2-une-plateforme-de-criblage-direct-a-haut-debit-pour-la-biologie\/"},"modified":"2026-11-12T14:20:40","modified_gmt":"2026-11-12T14:20:40","slug":"decouverte-de-degradeurs-de-lrrk2-une-plateforme-de-criblage-direct-a-haut-debit-pour-la-biologie","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/decouverte-de-degradeurs-de-lrrk2-une-plateforme-de-criblage-direct-a-haut-debit-pour-la-biologie\/","title":{"rendered":"D\u00e9couverte de d\u00e9gradeurs de LRRK2&nbsp;: une plateforme de criblage direct \u00e0 haut d\u00e9bit pour la biologie"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\">Acc\u00e9l\u00e9ration <a href=\"https:\/\/www.sygnaturediscovery.com\/therapeutic-areas\/neuroscience\/\">de la d\u00e9couverte de m\u00e9dicaments pour le SNC<\/a> gr\u00e2ce \u00e0 une plateforme d&rsquo;acc\u00e8s direct \u00e0 la biologie\u00a0:<\/h2>\n\n<p class=\"wp-block-paragraph\"><span style=\"font-family: arial, helvetica, sans-serif;\">La maladie de Parkinson (MP) repr\u00e9sente un probl\u00e8me de sant\u00e9 publique mondial croissant, et la kinase LRRK2 appara\u00eet comme une cible th\u00e9rapeutique majeure. Dans cette \u00e9tude, nous pr\u00e9sentons une nouvelle plateforme d&rsquo;acc\u00e8s direct \u00e0 la biologie \u00e0 haut d\u00e9bit permettant de d\u00e9couvrir des d\u00e9gradeurs puissants de la kinase LRRK2, offrant ainsi une alternative int\u00e9ressante \u00e0 l&rsquo;inhibition classique des kinases.<\/span><\/p>\n\n<p class=\"wp-block-paragraph\"><span style=\"font-family: arial, helvetica, sans-serif;\">Notre approche flexible et \u00e9volutive a permis la synth\u00e8se et l&rsquo;\u00e9valuation rapides de d\u00e9gradeurs bifonctionnels de LRRK2, identifiant plusieurs compos\u00e9s \u00e0 activit\u00e9 nanomolaire, pr\u00eats pour la validation dans des syst\u00e8mes neurologiques pertinents.<\/span><\/p>\n\n<p class=\"has-text-lg-font-size wp-block-paragraph\"><span style=\"font-family: arial, helvetica, sans-serif;\">T\u00e9l\u00e9chargez l&rsquo;affiche gratuite pour d\u00e9couvrir comment notre plateforme Direct-to-Biology peut \u00eatre appliqu\u00e9e \u00e0 la d\u00e9couverte de m\u00e9dicaments contre les maladies neurod\u00e9g\u00e9n\u00e9ratives, au-del\u00e0 de LRRK2.<\/span><\/p>\n\n<p class=\"has-text-sm-font-size wp-block-paragraph\">R\u00e9f\u00e9rences\u00a0:<\/p>\n\n<ol class=\"wp-block-list\">\n<li class=\"has-text-sm-font-size\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c05499\" type=\"link\" id=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c05499\">Liu, X., <em>et al.<\/em> , D\u00e9couverte du XL01126\u00a0: un d\u00e9gradeur PROTAC puissant, rapide, coop\u00e9ratif, s\u00e9lectif, biodisponible par voie orale et capable de franchir la barri\u00e8re h\u00e9mato-enc\u00e9phalique de la kinase 2 \u00e0 r\u00e9p\u00e9titions riches en leucine. J. Am. Chem. Soc. 2022, 144, 16930\u201316952.<\/a><\/li>\n\n\n\n<li class=\"has-text-sm-font-size\"><a href=\"https:\/\/patents.google.com\/patent\/WO2022198112A1\/en\">Araujo, E., <em>et al.<\/em> , Compos\u00e9s \u00e0 base d\u2019indazole et m\u00e9thodes d\u2019utilisation associ\u00e9es. Brevet am\u00e9ricain n\u00b0 WO2022198112A1, 22 septembre 2022.<\/a><\/li>\n\n\n\n<li class=\"has-text-sm-font-size\"><a href=\"https:\/\/patents.google.com\/patent\/US11858940B2\/en\">Araujo, E., <em>et al.<\/em> , Modulateurs s\u00e9lectifs de la prot\u00e9olyse de la LRRK2 mutante et m\u00e9thodes d\u2019utilisation associ\u00e9es. Brevet am\u00e9ricain n\u00b0 US11858940B2, 2 janvier 2024.<\/a><\/li>\n<\/ol>\n\n<h3 class=\"wp-block-heading\"><span style=\"font-family: arial, helvetica, sans-serif;\" data-teams=\"true\"> <\/span><\/h3>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22580,"template":"","category":[790,973,814,1471,1413,817,813,820,818],"class_list":["post-22576","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-classes-cibles","category-criblage-a-haut-debit","category-degradation-ciblee-des-proteines","category-direct-to-biology","category-domaines-therapeutiques","category-identification-des-hit","category-modalites","category-neuroscience"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>D\u00e9couverte d&#039;un d\u00e9gradeur de LRRK2\u00a0: une approche directe en biologie | Sygnature<\/title>\n<meta name=\"description\" content=\"Plateforme de criblage direct \u00e0 haut d\u00e9bit pour la maladie de Parkinson\u00a0: synth\u00e8se rapide de compos\u00e9s d\u00e9gradeurs de LRRK2 \u00e0 puissance nanomolaire. 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