{"id":22537,"date":"2026-08-18T16:05:26","date_gmt":"2026-08-18T16:05:26","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/une-strategie-evolutive-pour-la-diversification-des-peptides-utilisant-des-acides-amines-n-betyles\/"},"modified":"2026-11-12T13:55:14","modified_gmt":"2026-11-12T13:55:14","slug":"une-strategie-evolutive-pour-la-diversification-des-peptides-utilisant-des-acides-amines-n-betyles","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/une-strategie-evolutive-pour-la-diversification-des-peptides-utilisant-des-acides-amines-n-betyles\/","title":{"rendered":"Une strat\u00e9gie \u00e9volutive pour la diversification des peptides utilisant des acides amin\u00e9s N-b\u00e9tyl\u00e9s"},"content":{"rendered":"\n<p class=\"has-text-2-xl-font-size wp-block-paragraph\">L&rsquo;acc\u00e8s aux acides amin\u00e9s non canoniques est essentiel pour \u00e9largir l&rsquo;espace chimique des peptides, mais les approches traditionnelles peuvent limiter les possibilit\u00e9s de modification et de diversification en fin de synth\u00e8se. Ce poster pr\u00e9sente une voie pratique et adaptable \u00e0 grande \u00e9chelle d&rsquo;acc\u00e8s aux acides amin\u00e9s <em>N-<\/em> b\u00eata-syl\u00e9s, permettant la fonctionnalisation, la macrocyclisation et la diversification des peptides, tout en restant compatible avec les flux de travail SPPS standard. <\/p>\n\n<p class=\"wp-block-paragraph\">D\u00e9couvrez comment Sygnature Discovery a mis au point une m\u00e9thode de synth\u00e8se d&rsquo;acides amin\u00e9s <em>N-<\/em> b\u00e9syl\u00e9s par sulfinate-hypochlorite \u00e0 partir de r\u00e9actifs peu co\u00fbteux et facilement disponibles. Le poster met en lumi\u00e8re\u00a0: <\/p>\n\n<ul class=\"wp-block-list\">\n<li>Synth\u00e8se \u00e0 grande \u00e9chelle d&rsquo;acides amin\u00e9s <em>N-<\/em> b\u00eata-syl\u00e9s.<\/li>\n\n\n\n<li>Large compatibilit\u00e9 avec les acides amin\u00e9s canoniques.<\/li>\n\n\n\n<li>Strat\u00e9gies de modification peptidique compatibles avec la synth\u00e8se peptidique en phase solide (SPPS)\u00a0:<\/li>\n\n\n\n<li>applications en macrocyclisation peptidique,<\/li>\n\n\n\n<li><em>N-<\/em> fonctionnalisation sur r\u00e9sine et en phase liquide,<\/li>\n\n\n\n<li>nouvelles perspectives pour la diversification peptidique en fin de synth\u00e8se.<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading has-text-xl-font-size\" style=\"padding-top:var(--wp--preset--spacing--30)\">Faire progresser la d\u00e9couverte des peptides<\/h2>\n\n<p class=\"wp-block-paragraph\">Le groupe Bts offre une approche orthogonale polyvalente pour la modification des peptides, permettant des transformations difficiles \u00e0 r\u00e9aliser par les m\u00e9thodes de synth\u00e8se peptidique classiques. Ces travaux enrichissent la bo\u00eete \u00e0 outils peptidiques de Sygnature Discovery et favorisent la g\u00e9n\u00e9ration rapide de peptides th\u00e9rapeutiques structurellement diversifi\u00e9s pour les programmes de d\u00e9couverte de m\u00e9dicaments. <\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22538,"template":"","category":[797,796,820,1442],"class_list":["post-22537","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-chimie","category-chimie-synthetique","category-modalites","category-peptides-et-macrocycles"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Acides amin\u00e9s N-b\u00e9tyl\u00e9s pour la diversification des peptides<\/title>\n<meta name=\"description\" content=\"Une voie \u00e9volutive vers les acides amin\u00e9s N-b\u00e9syl\u00e9s pour la 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