{"id":22525,"date":"2026-06-15T10:53:52","date_gmt":"2026-06-15T10:53:52","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/combiner-intelligence-artificielle-et-expertise-humaine-dans-la-recherche-de-nouveaux-inhibiteurs-de-polq\/"},"modified":"2026-11-12T13:55:07","modified_gmt":"2026-11-12T13:55:07","slug":"combiner-intelligence-artificielle-et-expertise-humaine-dans-la-recherche-de-nouveaux-inhibiteurs-de-polq","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/combiner-intelligence-artificielle-et-expertise-humaine-dans-la-recherche-de-nouveaux-inhibiteurs-de-polq\/","title":{"rendered":"Combiner intelligence artificielle et expertise humaine dans la recherche de nouveaux inhibiteurs de PolQ"},"content":{"rendered":"<p><span style=\"font-family: arial, helvetica, sans-serif;\">Sygnature Discovery, en collaboration avec Iktos, pr\u00e9sente une affiche d\u00e9crivant l&rsquo;utilisation de l&rsquo;IA dans la d\u00e9couverte de m\u00e9dicaments pour concevoir et optimiser une nouvelle structure d&rsquo;inhibiteurs de PolQ. Gr\u00e2ce \u00e0 une conception g\u00e9n\u00e9rative it\u00e9rative, au perfectionnement de la chimie m\u00e9dicinale et \u00e0 une \u00e9valuation ADME pr\u00e9coce, le projet illustre comment l&rsquo;IA et la conception pilot\u00e9e par des experts peuvent collaborer pour acc\u00e9l\u00e9rer la d\u00e9couverte de th\u00e9rapies oncologiques de pr\u00e9cision.<\/span><\/p>\n<h3><span style=\"font-family: arial, helvetica, sans-serif;\">Points saillants de l&rsquo;\u00e9tude&nbsp;:<\/span><\/h3>\n<ul>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">IA g\u00e9n\u00e9rative pour l&rsquo;identification des \u00e9chafaudages<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Am\u00e9lioration de l&rsquo;efficacit\u00e9 par la chimie m\u00e9dicinale<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Profils ADME pr\u00e9coces favorables<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Approche d&rsquo;oncologie de pr\u00e9cision ciblant les DDR<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-family: arial, helvetica, sans-serif;\">Am\u00e9lioration de la conception des inhibiteurs de PolQ gr\u00e2ce \u00e0 la d\u00e9couverte de m\u00e9dicaments par l&rsquo;IA<\/span><\/h3>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Cette \u00e9tude d\u00e9montre comment les inhibiteurs de PolQ peuvent \u00eatre con\u00e7us et optimis\u00e9s rapidement gr\u00e2ce \u00e0 des m\u00e9thodes de d\u00e9couverte de m\u00e9dicaments bas\u00e9es sur l&rsquo;IA, combin\u00e9es \u00e0 une expertise en chimie m\u00e9dicinale. Les compos\u00e9s obtenus sont prometteurs pour la poursuite du profilage pr\u00e9clinique dans le cadre de strat\u00e9gies oncologiques ciblant la r\u00e9ponse aux dommages \u00e0 l&rsquo;ADN.<\/span><\/p>\n<h2><span style=\"font-family: arial, helvetica, sans-serif;\">Explorez notre expertise en chimie de d\u00e9couverte int\u00e9gr\u00e9e \u00e0 l&rsquo;IA<\/span><\/h2>\n<p> <span style=\"font-family: arial, helvetica, sans-serif;\">Sygnature Discovery accompagne la d\u00e9couverte de petites mol\u00e9cules guid\u00e9e par l&rsquo;IA gr\u00e2ce \u00e0 une approche int\u00e9gr\u00e9e <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/chemistry\/\">de chimie m\u00e9dicinale<\/a> , <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/integrated-drug-discovery\/targeted-protein-degradation\/\">de d\u00e9gradation cibl\u00e9e des prot\u00e9ines et de biologie de la r\u00e9paration des dommages \u00e0 l&rsquo;ADN (DDR)<\/a> , ainsi que <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/dmpk-and-physical-sciences\/\">de profilage ADME<\/a> . Qu&rsquo;il s&rsquo;agisse d&rsquo;outils d&rsquo;IA g\u00e9n\u00e9rative, de mod\u00e9lisation structurale ou de criblage traditionnel, nos \u00e9quipes acc\u00e9l\u00e8rent l&rsquo;optimisation des compos\u00e9s candidats et leur profilage.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22528,"template":"","category":[1430,811,992,821,933,1421],"class_list":["post-22525","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-analyses-biochimiques","category-conception-de-medicaments-assistee-par-ordinateur","category-metabolisme-des-medicaments-et-pharmacocinetique-dmpk","category-hit-pour-devenir-leader","category-intelligence-artificielle-generative-et-apprentissage-automatique","category-profilage-physico-chimique"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Inhibiteurs de PolQ con\u00e7us par IA pour l&#039;oncologie DDR | Sygnature<\/title>\n<meta name=\"description\" content=\"Comment Sygnature et Iktos ont combin\u00e9 l&#039;IA g\u00e9n\u00e9rative et la chimie m\u00e9dicinale pour concevoir une nouvelle structure inhibitrice de PolQ pr\u00e9sentant un profil ADME pr\u00e9coce favorable. 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