{"id":22501,"date":"2026-09-15T13:49:49","date_gmt":"2026-09-15T13:49:49","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/de-la-conception-de-structures-aux-informations-structurelles-une-approche-de-plateforme-pour-les-cibles-gpcr-complexes\/"},"modified":"2026-11-12T13:48:14","modified_gmt":"2026-11-12T13:48:14","slug":"de-la-conception-de-structures-aux-informations-structurelles-une-approche-de-plateforme-pour-les-cibles-gpcr-complexes","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/de-la-conception-de-structures-aux-informations-structurelles-une-approche-de-plateforme-pour-les-cibles-gpcr-complexes\/","title":{"rendered":"De la conception de structures aux informations structurelles : une approche de plateforme pour les cibles GPCR complexes"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Les r\u00e9cepteurs coupl\u00e9s aux prot\u00e9ines G (RCPG) demeurent parmi les cibles th\u00e9rapeutiques les plus importantes. Cependant, leur instabilit\u00e9 intrins\u00e8que, leur flexibilit\u00e9 conformationnelle et leur d\u00e9pendance membranaire continuent de poser des d\u00e9fis consid\u00e9rables pour leur caract\u00e9risation biochimique et structurale. La d\u00e9couverte de m\u00e9dicaments ciblant les RCPG repose donc sur des approches int\u00e9gr\u00e9es permettant la production d&rsquo;\u00e9chantillons de r\u00e9cepteurs de haute qualit\u00e9, adapt\u00e9s \u00e0 une large gamme d&rsquo;applications en aval.<\/p>\n\n<p class=\"wp-block-paragraph\">En 2025, nous avons rendu possibles l&rsquo;analyse de plus de 20 cibles prot\u00e9iques membranaires et fourni plus de 200 \u00e9chantillons pr\u00eats pour la cryo-microscopie \u00e9lectronique.<\/p>\n\n<p class=\"wp-block-paragraph\">Notre approche permet de surmonter efficacement des obstacles techniques persistants et d&rsquo;acc\u00e9l\u00e9rer les flux de travail en biologie structurale.<\/p>\n\n<p class=\"wp-block-paragraph\">Sur notre affiche, nous d\u00e9crivons\u00a0:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Notre strat\u00e9gie de production pour les RCPG<\/strong>\n<ul class=\"wp-block-list\">\n<li>des flux de travail pilot\u00e9e par les applications<\/li>\n\n\n\n<li>Strat\u00e9gie d&rsquo;optimisation<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Utilisation de la FSEC pour le criblage de constructions de prot\u00e9ines membranaires.<\/strong><\/li>\n\n\n\n<li><strong>Nos outils pour am\u00e9liorer la stabilit\u00e9 d&rsquo;un RCPG par ing\u00e9nierie.<\/strong><\/li>\n\n\n\n<li><strong>Techniques utilis\u00e9es pour la caract\u00e9risation biophysique des prot\u00e9ines membranaires<\/strong><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\">\u00c0 titre de preuve de principe, nous d\u00e9crivons une \u00e9tude de cas de cryo-EM avec liaison de la s\u00e9rotonine et cartographie des \u00e9pitopes d&rsquo;anticorps du r\u00e9cepteur 5-HT <sub>2A.<\/sub><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22503,"template":"","category":[1408,1416,1414,1474,1407,815,1415,1319],"class_list":["post-22501","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-biologie-structurale","category-cristallographie-aux-rayons-x","category-cryo-em","category-expression-des-proteines","category-expression-et-purification-des-proteines","category-proteines-et-structure","category-proteines-membranaires","category-rcpg"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>De la conception de structures aux informations structurelles : une approche de plateforme pour les cibles GPCR complexes - Sygnature<\/title>\n<meta name=\"description\" content=\"Sygnature a optimis\u00e9 le processus de g\u00e8ne \u00e0 la cryo-microscopie \u00e9lectronique 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