{"id":22483,"date":"2026-10-14T08:00:00","date_gmt":"2026-10-14T08:00:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/poster\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\/"},"modified":"2026-11-12T13:47:58","modified_gmt":"2026-11-12T13:47:58","slug":"modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\/","title":{"rendered":"Mod\u00e8les Th1\/17 in vitro pour le criblage de petites mol\u00e9cules et le profilage de la s\u00e9lectivit\u00e9"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Les cellules Th17 humaines jouent un r\u00f4le central dans les maladies auto-immunes et inflammatoires, ce qui en fait une cible importante pour la d\u00e9couverte de m\u00e9dicaments. Cependant, l&rsquo;identification de compos\u00e9s capables de moduler s\u00e9lectivement les voies Th17 n\u00e9cessite des mod\u00e8les de criblage robustes et physiologiquement pertinents.<\/p>\n\n<p class=\"wp-block-paragraph\">Ce poster d\u00e9crit le d\u00e9veloppement et la validation de <strong>mod\u00e8les humains de polarisation Th17 et Th1<\/strong> con\u00e7us pour faciliter le criblage de compos\u00e9s, le profilage de s\u00e9lectivit\u00e9 et les \u00e9tudes de m\u00e9canisme d&rsquo;action. Utilisant des lymphocytes T CD4+ issus de donneurs sains, ces mod\u00e8les ont \u00e9t\u00e9 caract\u00e9ris\u00e9s par l&rsquo;analyse de la s\u00e9cr\u00e9tion de cytokines et par cytom\u00e9trie en flux, puis \u00e9valu\u00e9s avec un panel d&rsquo;inhibiteurs ciblant des voies de signalisation cl\u00e9s impliqu\u00e9es dans la diff\u00e9renciation des lymphocytes T auxiliaires.<\/p>\n\n<p class=\"has-text-lg-font-size wp-block-paragraph\"><strong>T\u00e9l\u00e9chargez cette affiche pour en savoir plus\u00a0:<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Comment les mod\u00e8les de polarisation Th17 et Th1 humains ont \u00e9t\u00e9 \u00e9tablis et valid\u00e9s.<\/li>\n\n\n\n<li>Les tests utilis\u00e9s pour caract\u00e9riser la diff\u00e9renciation des cellules T auxiliaires.<\/li>\n\n\n\n<li>Impact de l&rsquo;inhibition de JAK, TYK2, STAT3 et ROR\u03b3t sur les r\u00e9ponses des lymphocytes T\u00a0;<\/li>\n\n\n\n<li>utilisation des mod\u00e8les pour \u00e9valuer la puissance et la s\u00e9lectivit\u00e9 des compos\u00e9s\u00a0;<\/li>\n\n\n\n<li>applications en immunologie et en d\u00e9couverte de m\u00e9dicaments anti-inflammatoires<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22485,"template":"","category":[29],"class_list":["post-22483","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-non-categorise"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mod\u00e8les de polarisation Th17 et Th1 pour le criblage de compos\u00e9s<\/title>\n<meta name=\"description\" content=\"Mod\u00e8les valid\u00e9s de polarisation Th17 et Th1 chez l&#039;humain pour le criblage de compos\u00e9s et le profilage de s\u00e9lectivit\u00e9. Caract\u00e9risation par dosage de l&#039;IL-17 et de l&#039;IFN\u03b3 et cytom\u00e9trie en flux.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mod\u00e8les Th1\/17 in vitro pour le criblage de petites mol\u00e9cules et le profilage de la s\u00e9lectivit\u00e9\" \/>\n<meta property=\"og:description\" content=\"Mod\u00e8les valid\u00e9s de polarisation Th17 et Th1 chez l&#039;humain pour le criblage de compos\u00e9s et le profilage de s\u00e9lectivit\u00e9. Caract\u00e9risation par dosage de l&#039;IL-17 et de l&#039;IFN\u03b3 et cytom\u00e9trie en flux.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-12T13:47:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/human-th17-th1-polarisation-models-compound-screening.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"360\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\\\/\",\"name\":\"Mod\u00e8les de polarisation Th17 et Th1 pour le criblage de compos\u00e9s\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/modeles-th1-17-in-vitro-pour-le-criblage-de-petites-molecules-et-le-profilage-de-la-selectivite\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/human-th17-th1-polarisation-models-compound-screening.webp\",\"datePublished\":\"2026-10-14T08:00:00+00:00\",\"dateModified\":\"2026-11-12T13:47:58+00:00\",\"description\":\"Mod\u00e8les valid\u00e9s de polarisation Th17 et Th1 chez l'humain pour le criblage de compos\u00e9s et le profilage de s\u00e9lectivit\u00e9. 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