{"id":22463,"date":"2026-11-14T11:00:00","date_gmt":"2026-11-14T11:00:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=poster&#038;p=22463"},"modified":"2026-11-13T10:29:37","modified_gmt":"2026-11-13T10:29:37","slug":"plateforme-de-criblage-a-haut-debit-et-tests-orthogonaux-pour-la-decouverte-du-recepteur-de-lapeline","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/plateforme-de-criblage-a-haut-debit-et-tests-orthogonaux-pour-la-decouverte-du-recepteur-de-lapeline\/","title":{"rendered":"Plateforme de criblage \u00e0 haut d\u00e9bit et tests orthogonaux pour la d\u00e9couverte du r\u00e9cepteur de l&rsquo;apeline"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Le r\u00e9cepteur de l&rsquo;apeline (APLNR) est une cible th\u00e9rapeutique \u00e9mergente pr\u00e9sentant un potentiel d&rsquo;application dans les maladies cardiovasculaires, m\u00e9taboliques et neurologiques. L&rsquo;identification de compos\u00e9s poss\u00e9dant le profil de signalisation souhait\u00e9 n\u00e9cessite des approches robustes de criblage et de caract\u00e9risation fonctionnelle. <\/p>\n\n<p class=\"wp-block-paragraph\">Cette affiche met en lumi\u00e8re la plateforme int\u00e9gr\u00e9e de criblage des r\u00e9cepteurs d&rsquo;apeline de Sygnature Discovery, combinant un criblage FLIPR \u00e0 haut d\u00e9bit avec des tests orthogonaux cAMP, CRE et \u03b2-arrestine pour identifier et profiler les agonistes biais\u00e9s.<\/p>\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\">Points saillants de l&rsquo;affiche<\/h2>\n\n<ul class=\"wp-block-list\">\n<li>Criblage \u00e0 haut d\u00e9bit d&rsquo;agonistes d&rsquo;APLNR au format 1536 puits\u00a0;<\/li>\n\n\n\n<li>d\u00e9veloppement et optimisation d&rsquo;un test de mobilisation du calcium FLIPR<\/li>\n\n\n\n<li>Analyses orthogonales de la signalisation Gi et du recrutement de la \u03b2-arrestine\u00a0;<\/li>\n\n\n\n<li>profilage de la puissance sur plusieurs plateformes d\u2019analyse\u00a0;<\/li>\n\n\n\n<li>strat\u00e9gies d\u2019identification d\u2019agonistes biais\u00e9s s\u00e9lectifs de voie.<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":22464,"template":"","category":[790,973,843,1431,1319],"class_list":["post-22463","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-bioscience","category-classes-cibles","category-essais-cellulaires","category-generation-de-lignees-cellulaires","category-rcpg"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Criblage des r\u00e9cepteurs de l&#039;apeline pour identifier les agonistes des RCPG biais\u00e9s<\/title>\n<meta name=\"description\" content=\"Criblage des r\u00e9cepteurs d&#039;apeline \u00e0 l&#039;aide de tests de flux de calcium, d&#039;AMPc et d&#039;arr\u00eat \u03b2 pour identifier les agonistes GPCR biais\u00e9s avec un profilage fonctionnel orthogonal.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/plateforme-de-criblage-a-haut-debit-et-tests-orthogonaux-pour-la-decouverte-du-recepteur-de-lapeline\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plateforme de criblage \u00e0 haut d\u00e9bit et tests orthogonaux pour la d\u00e9couverte du r\u00e9cepteur de l&#039;apeline\" \/>\n<meta property=\"og:description\" content=\"Criblage des r\u00e9cepteurs d&#039;apeline \u00e0 l&#039;aide de tests de flux de calcium, d&#039;AMPc et d&#039;arr\u00eat \u03b2 pour identifier les 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