{"id":21107,"date":"2026-11-15T11:00:00","date_gmt":"2026-11-15T11:00:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=poster&#038;p=21107"},"modified":"2026-11-13T10:22:44","modified_gmt":"2026-11-13T10:22:44","slug":"eaat2-functional-characterization-multi-platform-drug-discovery","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/eaat2-functional-characterization-multi-platform-drug-discovery\/","title":{"rendered":"A Multi-Platform Strategy for Comprehensive Functional Characterization of EAAT2 (SLC1A2)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">EAAT2 (SLC1A2) is the primary glutamate transporter in the central nervous system and plays a critical role in maintaining glutamate homeostasis. As an emerging therapeutic target in neurological disorders, robust functional assays are essential for screening and characterizing novel modulators. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This poster highlights Sygnature Discovery&rsquo;s integrated approach to EAAT2 drug discovery, combining electrophysiology, radioligand uptake and high-throughput screening technologies to enable comprehensive transporter profiling. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\">Poster Highlights <\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Functional characterization of EAAT2 across multiple assay platforms <\/li>\n\n\n\n<li>SURFE2R and two-electrode voltage clamp (TEVC) electrophysiology assays <\/li>\n\n\n\n<li>Radiolabelled glutamate uptake for direct transport measurements <\/li>\n\n\n\n<li>FLIPR-based assays in 96- and 384-well screening formats <\/li>\n\n\n\n<li>Cross-platform validation using reference substrates and inhibitors <\/li>\n\n\n\n<li>Screening-ready workflows for transporter-focused drug discovery <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":21948,"template":"","category":[1],"class_list":["post-21107","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>EAAT2 Functional Characterisation &amp; Transporter Assays<\/title>\n<meta name=\"description\" content=\"EAAT2 functional characterization using SURFE\u00b2R, TEVC, radiolabelled uptake and FLIPR assays. A multi-platform approach for transporter pharmacology and HTS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/eaat2-functional-characterization-multi-platform-drug-discovery\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Multi-Platform Strategy for Comprehensive Functional Characterization of EAAT2 (SLC1A2)\" \/>\n<meta property=\"og:description\" content=\"EAAT2 functional characterization using SURFE\u00b2R, TEVC, radiolabelled uptake and FLIPR assays. A multi-platform approach for transporter pharmacology and HTS.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/eaat2-functional-characterization-multi-platform-drug-discovery\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/eaat2-functional-characterization-platform-poster.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"724\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/eaat2-functional-characterization-multi-platform-drug-discovery\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/eaat2-functional-characterization-multi-platform-drug-discovery\\\/\",\"name\":\"EAAT2 Functional Characterisation & Transporter Assays\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/eaat2-functional-characterization-multi-platform-drug-discovery\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/poster\\\/eaat2-functional-characterization-multi-platform-drug-discovery\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/eaat2-functional-characterization-platform-poster.webp\",\"datePublished\":\"2026-11-15T11:00:00+00:00\",\"description\":\"EAAT2 functional characterization using SURFE\u00b2R, TEVC, radiolabelled uptake and FLIPR assays. 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