{"id":17548,"date":"2026-06-26T15:01:09","date_gmt":"2026-06-26T15:01:09","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=poster&#038;p=17548"},"modified":"2026-06-30T11:49:30","modified_gmt":"2026-06-30T11:49:30","slug":"hte-csp2-csp3-cross-electrophile-coupling","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/hte-csp2-csp3-cross-electrophile-coupling\/","title":{"rendered":"High-Throughput Experimentation for C(sp2)-C(sp3) Cross-Electrophile Coupling"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Cross-electrophile coupling (XEC) has become an important tool for introducing sp<sup>3<\/sup>-rich functionality into drug candidates, helping medicinal chemists access compounds with improved physicochemical and ADME properties. However, reaction performance is highly dependent on multiple variables including catalysts, reductants, solvents and additives. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this poster, Sygnature Discovery presents the development and validation of a high-throughput cross-electrophile coupling workflow, enabling rapid screening and optimisation of reaction conditions using minimal material. The study demonstrates successful translation from microscale screening to preparative-scale synthesis, while exploring a broad range of medicinally relevant substrates and coupling partners. <\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-2-xl-font-size\">Key Highights<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>High-throughput screening of C(sp<sup>2<\/sup>)-C(sp<sup>3<\/sup>) cross-electrophile coupling reactions <\/li>\n\n\n\n<li>Evaluation of catalysts, ligands, additives and reductants to optimise reaction performance<\/li>\n\n\n\n<li>Broad substrate scope with strong functional group tolerance<\/li>\n\n\n\n<li>Successful scale-up of optimised reactions from screening plates to larger-scale synthesis <\/li>\n\n\n\n<li>Future application of machine learning and Bayesian optimisation to accelerate compound library generation <\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":17559,"template":"","category":[682,714],"class_list":["post-17548","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-chemistry","category-synthetic-chemistry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HTE for C(sp2)-C(sp3) Cross-Electrophile Coupling<\/title>\n<meta name=\"description\" content=\"Download a poster on high-throughput experimentation for C(sp2)-C(sp3) cross-electrophile coupling in drug discovery.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/hte-csp2-csp3-cross-electrophile-coupling\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" 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