{"id":17458,"date":"2026-06-08T14:49:45","date_gmt":"2026-06-08T14:49:45","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=poster&#038;p=17458"},"modified":"2026-06-13T11:11:20","modified_gmt":"2026-06-13T11:11:20","slug":"photocatalyzed-ring-opening-of-bicyclobutane","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/photocatalyzed-ring-opening-of-bicyclobutane\/","title":{"rendered":"Photocatalyzed Ring-Opening of Bicyclobutane"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\">Access to 1,2,3-Trisubstituted Bicyclo[1.1.1]pentanes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Bicyclo[1.1.1]pentanes (BCPs) have emerged as valuable bioisosteres for aromatic rings in drug discovery, offering improved solubility, reduced lipophilicity and enhanced metabolic stability. Their rigid, three-dimensional structure enables more effective modulation of biological interactions, supporting improved potency, selectivity and pharmacokinetic performance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Despite rapid advances in synthetic methodologies, access to <strong>1,2,3-trisubstituted BCPs<\/strong> remains limited due to the lack of efficient and versatile approaches.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-2-xl-font-size\">Poster Overview <\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This poster presents a <strong>novel single-step photocatalyzed ring-opening approach<\/strong> using bicyclo[1.1.0]butane (BCB) and diazo compounds to provide efficient access to 1,2,3-trisubstituted BCPs.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Single-step synthesis<\/strong> of complex BCP scaffolds<\/li>\n\n\n\n<li>Demonstrated across <strong>31 trisubstituted examples<\/strong> <\/li>\n\n\n\n<li><strong>Broad substrate scope<\/strong> and functional group tolerance<\/li>\n\n\n\n<li>Use of <strong>diazo compounds as versatile carbene precursors<\/strong><\/li>\n\n\n\n<li>Improved efficiency vs traditional multistep approaches<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This methodology expands accessible chemical space and supports medicinal chemistry programmes targeting next-generation therapeutics. <\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":17459,"template":"","category":[682],"class_list":["post-17458","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-chemistry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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