{"id":16656,"date":"2026-04-21T20:00:00","date_gmt":"2026-04-21T20:00:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=poster&#038;p=16656"},"modified":"2026-06-15T13:38:46","modified_gmt":"2026-06-15T13:38:46","slug":"direct-to-discovery-extending-direct-to-biology-paradigms","status":"publish","type":"poster","link":"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/direct-to-discovery-extending-direct-to-biology-paradigms\/","title":{"rendered":"Direct-to-Discovery: Extending Direct-to-Biology Paradigms to Accelerate Drug Discovery\u00a0"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"#poster-download\">Download the poster here.<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\">Direct-to-Discovery: <\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Drug discovery timelines are often extended by bottlenecks between chemistry, biology and downstream decision-making. Traditional workflows rely on purified compounds and sequential data generation, slowing progression from hit identification to candidate nomination. Our <strong>direct-to-discovery<\/strong> approach removes these barriers by extending <a href=\"https:\/\/www.sygnaturediscovery.com\/chemistry\/direct-to-biology\/\">direct-to-biology<\/a> paradigms beyond biophysics, enabling rapid, data-rich decision-making earlier in discovery.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-xl-font-size\">Extending established discovery workflows<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Direct-to methodologies are typically associated with early biophysical screening such as SPR, where crude reaction mixtures can be assessed without full purification. While effective for assessing target binding, these methods alone do not capture functional activity or developability risk. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By expanding this paradigm to include function biology, structure validation and DMPK insight, we enable teams to generate richer datasets directly from unpurified compounds and move forward with greater confidence. <\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-xl-font-size\">A joined-up direct-to platform<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Our platform enables:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Functional biochemical and cellular readouts<\/strong> directly from crude reaction mixtures <\/li>\n\n\n\n<li><strong>Rapid structural validation<\/strong> through direct-to-crystallography from HTS and design libraries <\/li>\n\n\n\n<li><strong>Early physicochemical and DMPK insight<\/strong>, supporting smarter triage decisions<\/li>\n\n\n\n<li><strong>Seamless integration with high-throughput chemistry and AI-driven design<\/strong> <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Together, these capabilities shorten DMTA cycles, reduce resynthesis burden and compress timelines from hit discovery to lead optimization. <\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-xl-font-size\">Impact on oncology drug discovery<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Applied within oncology programs, this approach has demonstrated the ability to significantly accelerate progression from hit finding to pre-candidate nomination. By generating holistic datasets earlier, teams can focus resources on the most promising compounds sooner. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The result is <strong>faster timelines, better-informed decision and reduced program risk<\/strong>. <\/p>\n\n\n\n<p class=\"has-text-2-xl-font-size wp-block-paragraph\" style=\"padding-top:var(--wp--preset--spacing--40)\"><strong>Download the poster<\/strong> to explore how our direct-to-discovery approach extends direct-to-biology methods to accelerate early drug discovery, supported by real data and case study examples.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"poster-download\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":17494,"template":"","category":[1402,751,688],"class_list":["post-16656","poster","type-poster","status-publish","has-post-thumbnail","hentry","category-direct-to-biology","category-oncology","category-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Direct-to-Discovery: Extending Direct-to-Biology | Poster<\/title>\n<meta name=\"description\" content=\"Functional assays, structural validation and DMPK insight generated directly from crude, unpurified reaction mixtures to shorten DMTA cycles. 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