{"id":6616,"date":"2025-12-04T14:21:19","date_gmt":"2025-12-04T14:21:19","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/stabilite-chimique-et-metabolique\/"},"modified":"2026-02-06T15:24:43","modified_gmt":"2026-02-06T15:24:43","slug":"stabilite-chimique-et-metabolique","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/stabilite-chimique-et-metabolique\/","title":{"rendered":"Stabilit\u00e9 chimique et m\u00e9tabolique"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/profilage-physicochimique\\\/\":\"Profilage 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'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Interactions m\u00e9dicamenteuses\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/biotransformation\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/biotransformation\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/biotransformation\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Biotransformation\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/developpement-de-methodes-analytiques-et-bioanalyse\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/developpement-de-methodes-analytiques-et-bioanalyse\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/developpement-de-methodes-analytiques-et-bioanalyse\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        D\u00e9veloppement de m\u00e9thodes analytiques et bioanalyse\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        \u00c9tudes pharmacocin\u00e9tiques et pharmacodynamiques in vivo\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/modelisation-et-simulation-pk-et-pk-pd\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/modelisation-et-simulation-pk-et-pk-pd\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/modelisation-et-simulation-pk-et-pk-pd\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Mod\u00e9lisation et simulation PK et PK\/PD\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/dmpk-consultancy\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/dmpk-consultancy\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/dmpk-consultancy\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        DMPK Consultancy\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-07efcdf192d42655a11e154609f5d387\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">Solutions scientifiques | DMPK<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-bd67b54fee3f6a7f6335663fd1ccc392\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Stabilit\u00e9 chimique et m\u00e9tabolique<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-17563767d3549688c362f5e3bd8199d8\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">Chez Sygnature Discovery, nous vous aidons \u00e0 comprendre le comportement de votre compos\u00e9 dans l\u2019organisme en \u00e9valuant sa stabilit\u00e9 chimique et m\u00e9tabolique d\u00e8s les premi\u00e8res \u00e9tapes de son d\u00e9veloppement. Notre expertise acc\u00e9l\u00e8re l\u2019optimisation, am\u00e9liore les pr\u00e9dictions pharmacocin\u00e9tiques et renforce la pr\u00e9cision de la recherche translationnelle. <\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-90bb52c3aac24bb379a087a134687390\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" style=\"padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d6b9ab57 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Environnement de laboratoire dot\u00e9 d'instruments analytiques avanc\u00e9s repr\u00e9sentant les \u00e9tudes de m\u00e9tabolisme et de pharmacocin\u00e9tique des m\u00e9dicaments (DMPK) pour une conception rationnelle et une prise de d\u00e9cision.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-266ccfb97f47b588d1144b0f03bbaa0e\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">SOUTENIR VOS RECHERCHES<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">Le profil chimique et m\u00e9tabolique d\u2019un compos\u00e9 influence directement son exposition syst\u00e9mique, son efficacit\u00e9 th\u00e9rapeutique et sa s\u00e9curit\u00e9. L\u2019instabilit\u00e9 peut entra\u00eener une \u00e9limination rapide, une demi-vie r\u00e9duite et une alt\u00e9ration de son efficacit\u00e9 <em>in vivo<\/em> . <\/h2>\n\n\n\n<p>Chez Sygnature Discovery, nous proposons des \u00e9valuations compl\u00e8tes de la stabilit\u00e9 chimique et m\u00e9tabolique <em>in vitro<\/em> afin d\u2019optimiser les compos\u00e9s et de pr\u00e9dire leur pharmacocin\u00e9tique <em>in vivo<\/em> . Nos analyses \u00e9valuent la cin\u00e9tique d\u2019\u00e9limination du compos\u00e9 parent et la clairance intrins\u00e8que (CLint) chez diff\u00e9rentes esp\u00e8ces, permettant une mod\u00e9lisation IVIVE pr\u00e9cise et guidant l\u2019affinement de la structure. Surtout, nos donn\u00e9es de CLint pr\u00e9sentent une forte corr\u00e9lation avec la CLint <em>in vivo<\/em> des compos\u00e9s commercialis\u00e9s, favorisant ainsi une transposition r\u00e9ussie et renfor\u00e7ant la confiance dans leur validation translationnelle.  <\/p>\n\n\n\n<p><br>Nous proposons des \u00e9valuations cibl\u00e9es de\u00a0:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Stabilit\u00e9 chimique :<\/strong> Identification de la d\u00e9gradation d\u00e9pendante du pH dans les milieux bior\u00e9actifs<\/li>\n\n\n\n<li><strong>Stabilit\u00e9 plasmatique et sanguine\u00a0:<\/strong> \u00c9valuation de la sensibilit\u00e9 \u00e0 l\u2019hydrolyse et des risques de d\u00e9gradation <em>ex vivo<\/em><\/li>\n\n\n\n<li><strong>Stabilit\u00e9 microsomale et h\u00e9patocytaire :<\/strong> D\u00e9termination de la clairance m\u00e9tabolique<\/li>\n\n\n\n<li><strong>Absorption h\u00e9patique\u00a0:<\/strong> quantification de la clairance m\u00e9di\u00e9e par les transporteurs pour r\u00e9soudre les incoh\u00e9rences IVIVE et am\u00e9liorer la pr\u00e9cision des pr\u00e9dictions.<\/li>\n<\/ul>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1707\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"Installation de laboratoire avec des syst\u00e8mes automatis\u00e9s et des instruments analytiques utilis\u00e9s pour les essais de stabilit\u00e9 chimique et m\u00e9tabolique, permettant des analyses pharmacocin\u00e9tiques pr\u00e9dictives.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/chemical-metabolic-stability-assay-high-throughput-lab-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-light mobile-stacking-standard   carousel-gap-1xs is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-dark-blue-700-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section x-data='newcarousel({\"transition\":\"slide\",\"overflow\":false,\"autoplay\":0,\"infinite\":false,\"preview\":false,\"slidesInView\":3,\"slidesInViewTablet\":2,\"slidesInViewMobile\":1.15,\"slideGap\":0,\"align\":\"left\",\"swipeScroll\":false,\"snapToSlides\":false})' x-intersect.once=\"initAutoplay()\" class=\"Content__Carousel carousel-gap-1xs wp-elements-a39af1efe54f9f954b57fd22f746205a relative h-full\" style=\"--slides-to-show-desktop: 3; --slides-to-show-tablet: 2; --slides-to-show-mobile: 1.15; --slide-gap: 0px; --carousel-arrow-spacing: 1%; --carousel-arrow-inset: 0rem;\">\n            \n    <div class=\"Carousel__WrapperOuter relative z-10\" data-carousel-anchor style=\"--carousel-arrow-spacing: 1%; --carousel-arrow-inset: 0rem\">\n\n                    <div class=\"pb-10 intro-text-wrapper\">\n                <div class=\"flex flex-col md:flex-row relative\">\n                    <div class=\"Carousel__introText mb-16 md:mb-0 w-full md:w-[45%] text-left md:max-w-[708px]\">\n                        <p class=\"has-text-4-xl-font-size has-text-3-xl-font-size\">Expertise en stabilit\u00e9 chimique et m\u00e9tabolique<\/p>\n<p>Notre approche fond\u00e9e sur les donn\u00e9es favorise la pertinence translationnelle et \u00e9claire les d\u00e9cisions strat\u00e9giques dans l\u2019ensemble des programmes de recherche.<\/p>\n\n                    <\/div>\n                                            <div class=\"Navigation__Arrows container md:absolute alignment vertical-top horizontal-right \" style=\"--carousel-arrow-spacing: 1%; --carousel-arrow-inset: 0rem\">\n                                                    <button x-on:click=\"previousSlide()\" class=\"Navigation__Arrows--prev flex items-center justify-center w-10 h-10 rounded-full p-2 transition-opacity duration-500\" :class=\"firstSlide ? 'opacity-50 pointer-events-none' : 'opacity-100'\" style=\"background-color:var(--wp--preset--color--blue-300);\">\n                                <span class=\"sr-only\">Previous Slide<\/span>\n                                <svg width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path d=\"M22.8047 14.6992L6.60438 14.6992\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                    <path d=\"M14.7031 22.8008L6.60297 14.7006L14.7031 6.60048\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                <\/svg>\n                            <\/button>\n                        \n                                                    <button x-on:click=\"nextSlide()\" class=\"Navigation__Arrows--next flex items-center justify-center w-10 h-10 rounded-full p-2 transition-opacity duration-500\" :class=\"lastSlide ? 'opacity-50 pointer-events-none' : 'opacity-100'\" style=\"background-color:var(--wp--preset--color--blue-300);\">\n                                <span class=\"sr-only\">Next Slide<\/span>\n                                <svg width=\"28\" height=\"28\" viewbox=\"0 0 28 28\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path d=\"M5.92188 14.0264H22.1222\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                    <path d=\"M14.0234 5.92871L22.1236 14.0289L14.0234 22.129\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                <\/svg>\n                            <\/button>\n                        \n                        <\/div>\n                                    <\/div>\n            <\/div>\n            \n        <div x-ref=\"sliderContainer\" class=\"Carousel__Container h-full \">\n        <div class=\"Carousel__Wrapper overflow-hidden  Carousel--snap-scroll Carousel--snap-left \" style=\"\">\n            <div class=\"Carousel\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-601c3b46 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-4d5a9acc911df53b90085162eb35f025\" style=\"font-style:normal;font-weight:400\">Stabilit\u00e9 chimique<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fa8f8eb1 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-4bf3fec52f1372832a67e07498010a79\">\u2022 \u00c9value l\u2019int\u00e9grit\u00e9 des compos\u00e9s dans des tampons et des milieux bior\u00e9actifs.<br> \u2022 Identifie la d\u00e9gradation d\u00e9pendante du pH<br> risque.<br> \u2022 Permet de distinguer l\u2019instabilit\u00e9 chimique de la v\u00e9ritable \u00e9limination m\u00e9tabolique.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/chemical-stability-2\/\">Apprendre encore plus  <\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-601c3b46 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-1578dc45d7f8b9c2af0d72528b2a657b\" style=\"font-style:normal;font-weight:400\">Stabilit\u00e9 du plasma<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fa8f8eb1 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-14d9eb0b0be4c3d924cc05d6e71eaf7e\">\u2022 D\u00e9tecte les instabilit\u00e9s susceptibles de raccourcir la demi-vie et de r\u00e9duire l\u2019efficacit\u00e9.<br> \u2022 Pr\u00e9vient les interf\u00e9rences pharmacocin\u00e9tiques<br> donn\u00e9es dues \u00e0 une d\u00e9gradation <em>ex vivo<\/em> .<br> \u2022 Permet d\u2019optimiser la structure pour de meilleures performances.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/plasma-stability-2\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-601c3b46 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-ae912c3543849c6d41e7c5fbcc02a8fc\" style=\"font-style:normal;font-weight:400\">Liaison tissulaire<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fa8f8eb1 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-e9379b48adc937efc7a2ecef440505a7\">\u2022 \u00c9value la sensibilit\u00e9 hydrolytique et enzymatique<br> effets du plasma et des globules rouges.<br> \u2022 Permet de g\u00e9rer les risques li\u00e9s aux est\u00e9rases et<br> amidases qui influencent la cin\u00e9tique de d\u00e9gradation.<br> \u2022 Garantit une pharmacocin\u00e9tique fiable<br> mesures.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/liaison-tissulaire\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-601c3b46 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-411473233953835c6be56aca3d3ea4ff\" style=\"font-style:normal;font-weight:400\">Stabilit\u00e9 m\u00e9tabolique microsomale<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fa8f8eb1 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-bb8201b3c7fd0670362f6d8b499bf3a4\">\u2022 Mesure la clairance intrins\u00e8que et la stabilit\u00e9 m\u00e9tabolique \u00e0 l\u2019aide de microsomes h\u00e9patiques.<br>\u2022 Identifie les voies m\u00e9taboliques et les m\u00e9tabolites potentiels.<br>\u2022 \u00c9value le potentiel d\u2019interactions m\u00e9dicamenteuses.<br>\u2022 Permet des comparaisons intersp\u00e9cifiques pour une pertinence translationnelle.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/microsomal-stability\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-601c3b46 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-8a97ff9049aacb3209a654af9b7c9435\" style=\"font-style:normal;font-weight:400\">Stabilit\u00e9 m\u00e9tabolique des h\u00e9patocytes<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fa8f8eb1 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-ed70249a1a19f9784a5f641a21fb961f\">\u2022 Capture le m\u00e9tabolisme de phase I et de phase II dans les cellules h\u00e9patiques intactes.<br>\u2022 Fournit des donn\u00e9es sp\u00e9cifiques \u00e0 chaque esp\u00e8ce pour des pr\u00e9dictions pr\u00e9cises.<br>\u2022 Permet de mod\u00e9liser l\u2019exposition syst\u00e9mique, la demi-vie et les strat\u00e9gies de dosage.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/hepatocyte-stability\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-601c3b46 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-4ac7aa93e2f3b308546c674dea7384e2\" style=\"font-style:normal;font-weight:400\">Absorption h\u00e9patique<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fa8f8eb1 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-18f0b64b0feac57923df71c019578691\">\u2022 Quantifie la clairance m\u00e9di\u00e9e par le transporteur pour r\u00e9soudre les d\u00e9connexions IVIVE.<br>\u2022 Am\u00e9liore la pr\u00e9cision des pr\u00e9dictions pour les compos\u00e9s poss\u00e9dant des composants de transport actif.<br>\u2022 Valid\u00e9 sur des h\u00e9patocytes humains et de rat pour une confiance translationnelle.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    \n\t\t\t\t\t            \t\n\t\t\t\t\n                <\/div>\n    <\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-e84fdc4b wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2c75125d wp-block-group-is-layout-constrained\" style=\"margin-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style wp-elements-74f2bbf7c2f1dbcb134229150002b271\" style=\"color:#001024b3;padding-right:0;padding-left:0;font-style:normal;font-weight:600;letter-spacing:0.96px;--paragraph-dot-color:#005de5\">Ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-b8085af24bff4b40b0d89dbacd6ac6a2 wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data='postGrid({\"respondToFiltering\":true,\"singleFilterMode\":true,\"initialFilterSlug\":\"\"})' class=\"Post__Grid relative\" style=\"--post-grid-grid-cols: 3; --post-grid-row-gap: 1.5rem;\" data-single-filter-mode=\"false\" data-show-all-button=\"false\" data-initial-filter=\"\">\n                            \n\n        \n        \n            <div class=\"Post__Grid-grid   flex-col relative\" data-pegasus-filterable=\"block_05762d9fa8f123aa345070ddeb1a675d\">\n                <div x-cloak x-show=\"isLoading\" class=\"absolute -top-3 -left-3 -right-3 -bottom-3 flex items-start justify-center pt-8 md:items-center md:pt-0 z-10 rounded-2xl overflow-visible transition duration-200 pointer-events-none bg-white\/80 backdrop-blur-sm\" style=\"background-color: rgb(255 255 255 \/ 80%);\">\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"50\" height=\"50\" viewbox=\"0 0 40 48\" role=\"img\" aria-label=\"Loading\" style=\"color:#005DE5\">\n                        <title>Loading\u2026<\/title>\n                        <g id=\"spinner\" fill=\"currentColor\">\n                            <path d=\"M19.6241 6.30823C21.3654 6.30823 22.7735 4.89753 22.7735 3.15412C22.7735 1.4107 21.3654 0 19.6241 0C17.8828 0 16.4746 1.4107 16.4746 3.15412C16.4746 4.89753 17.8872 6.30823 19.6241 6.30823Z\"><\/path>\n                            <path d=\"M19.629 47.5563C21.3703 47.5563 22.7784 46.1456 22.7784 44.4022C22.7784 42.6587 21.3703 41.248 19.629 41.248C17.8876 41.248 16.4795 42.6587 16.4795 44.4022C16.4795 46.1456 17.8876 47.5563 19.629 47.5563Z\"><\/path>\n                            <path d=\"M36.1016 14.5602C37.8385 14.5602 39.2511 13.1495 39.2511 11.4061C39.2511 9.66266 37.8385 8.25195 36.1016 8.25195C34.3647 8.25195 32.9521 9.66266 32.9521 11.4061C32.9521 13.1495 34.3603 14.5602 36.1016 14.5602Z\"><\/path>\n                            <path d=\"M3.14946 39.3043C4.88633 39.3043 6.29894 37.8936 6.29894 36.1502C6.29894 34.4068 4.88633 32.9961 3.14946 32.9961C1.41259 32.9961 0 34.4068 0 36.1502C0 37.8936 1.41259 39.3043 3.14946 39.3043Z\"><\/path>\n                            <path d=\"M19.6318 8.25195C20.3868 8.25197 21.1374 8.3047 21.8701 8.41113H21.8682C29.3743 9.49892 35.1348 15.967 35.1348 23.7783C35.1346 31.5902 29.3687 38.0576 21.8662 39.1445C21.7983 39.1346 21.7308 39.1211 21.6631 39.1104C21.7321 39.1213 21.8008 39.1354 21.8701 39.1455C21.1418 39.2519 20.3957 39.3047 19.6318 39.3047C11.0674 39.3047 4.12402 32.3534 4.12402 23.7783C4.12405 15.2032 11.0674 8.25195 19.6318 8.25195ZM19.623 12.6162C14.5414 12.6162 10.254 16.0262 8.91406 20.6855C8.91072 20.7021 8.90661 20.7188 8.90332 20.7354C8.62796 21.7023 8.48145 22.7182 8.48145 23.7783C8.48145 24.8386 8.63235 25.8591 8.90332 26.8262C8.9061 26.8402 8.90929 26.8541 8.91211 26.8682C10.2498 31.5309 14.539 34.9395 19.623 34.9395C25.7751 34.9393 30.7674 29.9399 30.7676 23.7783C30.7676 17.6166 25.7797 12.6164 19.623 12.6162Z\"><\/path>\n                            <animatetransform attributename=\"transform\" type=\"rotate\" from=\"0 19.6318 23.7783\" to=\"360 19.6318 23.7783\" dur=\"1s\" repeatcount=\"indefinite\"><\/animatetransform>\n                        <\/g>\n                        <g fill=\"currentColor\" opacity=\"1\">\n                            <path>\n                                <animate attributename=\"opacity\" values=\"1;0.4;1\" dur=\"1.2s\" begin=\"0s\" repeatcount=\"indefinite\"><\/animate>\n                            <\/path>\n                        <\/g>\n                    <\/svg>\n                <\/div>\n\n                                                \n                                                                                        <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/bifunctional-degrader-drug-discovery-the-power-of-measuring-epsa\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Bifunctional Degrader Drug Discovery: The Power of measuring EPSA<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-300x138.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-640x293.png 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/png\"><img decoding=\"async\" width=\"640\" height=\"293\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"Bifunctional Degrader Drug Discovery - Sygnature Discovery|\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-300x138.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-640x293.png 640w\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/bifunctional-degrader-drug-discovery-the-power-of-measuring-epsa\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Bifunctional Degrader Drug Discovery: The Power of measuring EPSA<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tLearn from Dr Phillip MacFaul, Sygnature Discovery\u2019s Principal Scientist in DMPK about measuring EPSA in bifunctional degraders.\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-7c4158aaf8a22a35edef55f5030853b1\" style=\"color:#001024b3\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d\u2019experts chevronn\u00e9s de l\u2019industrie pharmaceutique du monde entier, garantissant l\u2019excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation.webp 517w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Form &amp; Formulation\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation.webp 517w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-62ada6e0951e3179aebea64551a38124\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/\">Forme et formulation<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-ef3202aa48e1102dd72a675eb4167c94\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les strat\u00e9gies int\u00e9gr\u00e9es de formulation et de forme solide r\u00e9duisent les risques, am\u00e9liorent la stabilit\u00e9 et la solubilit\u00e9 et acc\u00e9l\u00e8rent le passage de la s\u00e9lection des candidats \u00e0 la clinique.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"in vivo Pharmacology\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-95cb6840b5cc45da381f55b6b4c9fa98\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/pharmacologie-in-vivo\/\">Pharmacologie <em>in vivo<\/em><\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e7ea388b7a5e7a088a42b5217fefa086\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les mod\u00e8les <em>in vivo<\/em> valid\u00e9s fournissent des donn\u00e9es cliniquement pertinentes dans tous les domaines th\u00e9rapeutiques, acc\u00e9l\u00e9rant la prise de d\u00e9cisions \u00e9clair\u00e9es et r\u00e9duisant les risques li\u00e9s au d\u00e9veloppement de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/pharmacologie-in-vivo\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":9450,"parent":6627,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6616","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sygnature<\/title>\n<meta name=\"description\" content=\"\u00c9valuations de la stabilit\u00e9 chimique et m\u00e9tabolique in vitro pour pr\u00e9dire la pharmacocin\u00e9tique, optimiser les compos\u00e9s et am\u00e9liorer la pr\u00e9cision translationnelle.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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