{"id":6555,"date":"2025-12-04T13:38:47","date_gmt":"2025-12-04T13:38:47","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/profilage-physicochimique\/"},"modified":"2026-02-05T14:17:52","modified_gmt":"2026-02-05T14:17:52","slug":"profilage-physicochimique","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/profilage-physicochimique\/","title":{"rendered":"Profilage physico-chimique"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/profilage-physicochimique\\\/\":\"Profilage physico-chimique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/stabilite-chimique-et-metabolique\\\/\":\"Stabilit\\u00e9 chimique et m\\u00e9tabolique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/permeabilite\\\/\":\"Perm\\u00e9abilit\\u00e9\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/liaison-tissulaire\\\/\":\"Liaison tissulaire\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/interactions-medicamenteuses-medicaments\\\/\":\"Interactions m\\u00e9dicamenteuses\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/biotransformation\\\/\":\"Biotransformation\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/developpement-de-methodes-analytiques-et-bioanalyse\\\/\":\"D\\u00e9veloppement de m\\u00e9thodes analytiques et bioanalyse\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\\\/\":\"\\u00c9tudes pharmacocin\\u00e9tiques et pharmacodynamiques in vivo\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/modelisation-et-simulation-pk-et-pk-pd\\\/\":\"Mod\\u00e9lisation et simulation PK et PK\\\/PD\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/dmpk-consultancy\\\/\":\"DMPK Consultancy\"}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" false x-cloak style=\"\">\n    <div x-ref=\"fixedNav\" class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/\" 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'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Liaison tissulaire\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/interactions-medicamenteuses-medicaments\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/interactions-medicamenteuses-medicaments\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/interactions-medicamenteuses-medicaments\/' === window.location.href ? 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'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Biotransformation\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/developpement-de-methodes-analytiques-et-bioanalyse\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/developpement-de-methodes-analytiques-et-bioanalyse\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/developpement-de-methodes-analytiques-et-bioanalyse\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        D\u00e9veloppement de m\u00e9thodes analytiques et bioanalyse\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/etudes-pharmacocinetiques-et-pharmacodynamiques-in-vivo\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        \u00c9tudes pharmacocin\u00e9tiques et pharmacodynamiques in vivo\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/modelisation-et-simulation-pk-et-pk-pd\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/modelisation-et-simulation-pk-et-pk-pd\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/modelisation-et-simulation-pk-et-pk-pd\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Mod\u00e9lisation et simulation PK et PK\/PD\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/dmpk-consultancy\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/dmpk-consultancy\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/dmpk-consultancy\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        DMPK Consultancy\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-07efcdf192d42655a11e154609f5d387\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">Solutions scientifiques | DMPK<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-1197c7e95f6a5756b23cd446385093d3\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Profilage physico-chimique<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-0e707c7da36f728aa02f57aad52c18d0\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">La lipophilie et la solubilit\u00e9 sont bien plus que de simples chiffres\u00a0: ce sont des indicateurs cl\u00e9s de succ\u00e8s. En combinant des m\u00e9thodologies de pointe \u00e0 une interpr\u00e9tation experte, Sygnature Discovery vous aide \u00e0 optimiser vos strat\u00e9gies de conception de m\u00e9dicaments, \u00e0 r\u00e9duire les risques et \u00e0 progresser sereinement vers les \u00e9tapes cliniques essentielles. <\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-90bb52c3aac24bb379a087a134687390\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" style=\"padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d6b9ab57 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Environnement de laboratoire dot\u00e9 d'instruments analytiques avanc\u00e9s repr\u00e9sentant les \u00e9tudes de m\u00e9tabolisme et de pharmacocin\u00e9tique des m\u00e9dicaments (DMPK) pour une conception rationnelle et une prise de d\u00e9cision.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-metabolism-pharmacokinetics-dmpk-laboratory-analysis-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-8f86441d1d55a740c2fcc2498107c4a9\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">soutenir vos recherches<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group children-fill-width is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">Sygnature Discovery propose des \u00e9valuations physico-chimiques compl\u00e8tes qui guident la conception pr\u00e9coce des m\u00e9dicaments et le d\u00e9veloppement pr\u00e9clinique.  <\/h2>\n\n\n\n<p>Nos outils de profilage se concentrent sur deux param\u00e8tres essentiels \u2013 la lipophilie et la solubilit\u00e9 \u2013 qui influencent directement l\u2019absorption, la distribution et le comportement pharmacocin\u00e9tique global. Ces informations vous aident \u00e0 prendre des d\u00e9cisions \u00e9clair\u00e9es qui r\u00e9duisent les risques et acc\u00e9l\u00e8rent le d\u00e9veloppement de vos produits. <\/p>\n\n\n\n<div style=\"margin-top:var(--wp--preset--spacing--60)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-aspect-ratio aspect-59x35 has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-1024x682.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Flacons en verre contenant des solutions pour le profilage physico-chimique, illustrant les tests de solubilit\u00e9 et de lipophilie essentiels pour l'absorption des m\u00e9dicaments et la conception de la formulation.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-1024x682.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/physicochemical-profiling-solubility-lipophilicity-drug-discovery-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section x-data='newcarousel({\"transition\":\"slide\",\"overflow\":false,\"autoplay\":0,\"infinite\":false,\"preview\":false,\"slidesInView\":3,\"slidesInViewTablet\":2,\"slidesInViewMobile\":1.15,\"slideGap\":0,\"align\":\"left\",\"swipeScroll\":false,\"snapToSlides\":false})' x-intersect.once=\"initAutoplay()\" class=\"Content__Carousel wp-elements-83332794f9109bb541134637fb3c80ac relative h-full\" style=\"--slides-to-show-desktop: 3; --slides-to-show-tablet: 2; --slides-to-show-mobile: 1.15; --slide-gap: 0px; --carousel-arrow-spacing: 50%; --carousel-arrow-inset: 0rem; padding-bottom:var(--wp--preset--spacing--50);;\">\n            \n    <div class=\"Carousel__WrapperOuter relative z-10\" data-carousel-anchor style=\"--carousel-arrow-spacing: %; --carousel-arrow-inset: rem\">\n\n                    <div class=\"pb-10 intro-text-wrapper\">\n                <div class=\"flex flex-col md:flex-row relative\">\n                    <div class=\"Carousel__introText mb-16 md:mb-0 w-full md:w-[45%] text-left md:max-w-[708px]\">\n                        <p class=\"has-text-4-xl-font-size\">Profilage de la lipophilie<\/p>\n<p>La lipophilie joue un r\u00f4le crucial dans la pharmacocin\u00e9tique d\u2019un m\u00e9dicament, influen\u00e7ant son absorption, sa distribution tissulaire, sa liaison aux prot\u00e9ines et sa solubilit\u00e9. Si une lipophilie \u00e9lev\u00e9e peut am\u00e9liorer la perm\u00e9abilit\u00e9 membranaire et la biodisponibilit\u00e9, une lipophilie excessive peut r\u00e9duire la solubilit\u00e9 et accro\u00eetre les risques de toxicit\u00e9. <\/p>\n\n                    <\/div>\n                                    <\/div>\n            <\/div>\n            \n        <div x-ref=\"sliderContainer\" class=\"Carousel__Container h-full \">\n        <div class=\"Carousel__Wrapper overflow-hidden  Carousel--snap-scroll Carousel--snap-left \" style=\"padding-bottom:var(--wp--preset--spacing--50);;\">\n            <div class=\"Carousel\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"min-height:100%;padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:100%;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-c2f24623 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:400\">LogD<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-74cfab58 wp-block-group-is-layout-constrained\" style=\"padding-top:0;padding-bottom:0\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-69e844c0898dba50e4a89131d970a7d6\">M\u00e9thode miniaturis\u00e9e en flacon agit\u00e9, quantification du partage octanol\/tampon \u00e0 pH 7,4<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/logd7-4-assay-validation-shake-flask\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"min-height:100%;padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:100%;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-c2f24623 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:400\">ChromLogD<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7e9a086d wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-17cc35d2d3e6a0b6a72f81b3cf55164c\">Lipophilie estim\u00e9e en corr\u00e9lant le temps de r\u00e9tention dans un syst\u00e8me de chromatographie liquide en phase inverse avec les valeurs de r\u00e9f\u00e9rence LogD.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/chromlogd-assay-validation\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"min-height:100%;padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:100%;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-c2f24623 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:400\">EPSA<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7e9a086d wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-992f101c9e423dc3ee039a425ae4aa86\">Une approche bas\u00e9e sur la SFC qui mesure la surface polaire expos\u00e9e et les liaisons hydrog\u00e8ne internes. Elle permet de pr\u00e9dire la perm\u00e9abilit\u00e9 membranaire, particuli\u00e8rement utile pour les mol\u00e9cules ne respectant pas la r\u00e8gle des 5. <\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/epsa-assay-validation\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    \n\t\t\t\t\n\t\t\t\t\n                <\/div>\n    <\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-bottom:var(--wp--preset--spacing--80); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section x-data='newcarousel({\"transition\":\"slide\",\"overflow\":false,\"autoplay\":0,\"infinite\":false,\"preview\":false,\"slidesInView\":3,\"slidesInViewTablet\":2,\"slidesInViewMobile\":1.15,\"slideGap\":0,\"align\":\"left\",\"swipeScroll\":false,\"snapToSlides\":false})' x-intersect.once=\"initAutoplay()\" class=\"Content__Carousel wp-elements-dbad83a80c964f36679c41a3ffaddc7f relative h-full\" style=\"--slides-to-show-desktop: 3; --slides-to-show-tablet: 2; --slides-to-show-mobile: 1.15; --slide-gap: 0px; --carousel-arrow-spacing: 50%; --carousel-arrow-inset: 0rem; padding-bottom:var(--wp--preset--spacing--50);;\">\n            \n    <div class=\"Carousel__WrapperOuter relative z-10\" data-carousel-anchor style=\"--carousel-arrow-spacing: %; --carousel-arrow-inset: rem\">\n\n                    <div class=\"pb-10 intro-text-wrapper\">\n                <div class=\"flex flex-col md:flex-row relative\">\n                    <div class=\"Carousel__introText mb-16 md:mb-0 w-full md:w-[45%] text-left md:max-w-[708px]\">\n                        <p class=\"has-text-4-xl-font-size\">Criblage de solubilit\u00e9<\/p>\n<p>La solubilit\u00e9 d\u00e9termine la performance d\u2019un compos\u00e9.  <em>in vitro<\/em>  et  <em>in vivo<\/em>. Une faible solubilit\u00e9 peut compromettre la fiabilit\u00e9 des analyses et limiter l\u2019absorption et la biodisponibilit\u00e9, affectant en fin de compte l\u2019exposition th\u00e9rapeutique.<\/p>\n\n                    <\/div>\n                                    <\/div>\n            <\/div>\n            \n        <div x-ref=\"sliderContainer\" class=\"Carousel__Container h-full \">\n        <div class=\"Carousel__Wrapper overflow-hidden  Carousel--snap-scroll Carousel--snap-left \" style=\"padding-bottom:var(--wp--preset--spacing--50);;\">\n            <div class=\"Carousel\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"min-height:100%;padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:100%;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-c2f24623 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:400\">Solubilit\u00e9 cin\u00e9tique<br> (Turbidm\u00e9trique)<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7e9a086d wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-04734d62154e534a2a859ab94443bc6b\">Fournit des estimations pr\u00e9liminaires pour orienter la conception des \u00e9tudes et interpr\u00e9ter les donn\u00e9es <em>in vitro<\/em> .<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/turbidimetric-kinetic-solubility-assay-validation\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-72e8cf26 wp-block-group-is-layout-constrained\" style=\"min-height:100%;padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-61721bd9 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:100%;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-c2f24623 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:400\">Solubilit\u00e9 thermodynamique<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7e9a086d wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-d8925ab60cd5805b771e349e2b83c8be\">La r\u00e9f\u00e9rence absolue en mati\u00e8re de mesures de solubilit\u00e9 d\u00e9finitives, \u00e9valuant la solubilit\u00e9 \u00e0 l\u2019\u00e9quilibre dans diff\u00e9rents syst\u00e8mes tampons.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/technical-note\/thermodynamic-solubility-assay-validation\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    \n\t\t\t\t\n\t\t\t\t\n                <\/div>\n    <\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-e84fdc4b wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2c75125d wp-block-group-is-layout-constrained\" style=\"margin-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style wp-elements-d54eb4eaa9e4db5e0d820cff3ba28df9\" style=\"color:#001024b3;padding-right:0;padding-left:0;font-style:normal;font-weight:600;letter-spacing:0.96px;--paragraph-dot-color:#005de5\">Centre de ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-b8085af24bff4b40b0d89dbacd6ac6a2 wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        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                           <animatetransform attributename=\"transform\" type=\"rotate\" from=\"0 19.6318 23.7783\" to=\"360 19.6318 23.7783\" dur=\"1s\" repeatcount=\"indefinite\"><\/animatetransform>\n                        <\/g>\n                        <g fill=\"currentColor\" opacity=\"1\">\n                            <path>\n                                <animate attributename=\"opacity\" values=\"1;0.4;1\" dur=\"1.2s\" begin=\"0s\" repeatcount=\"indefinite\"><\/animate>\n                            <\/path>\n                        <\/g>\n                    <\/svg>\n                <\/div>\n\n                                                \n                                                                                        <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/bifunctional-degrader-drug-discovery-the-power-of-measuring-epsa\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Bifunctional Degrader Drug Discovery: The Power of measuring EPSA<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-300x138.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-640x293.png 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/png\"><img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"293\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"Bifunctional Degrader Drug Discovery - Sygnature Discovery|\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-300x138.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/EPSA-640x293.png 640w\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/bifunctional-degrader-drug-discovery-the-power-of-measuring-epsa\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Bifunctional Degrader Drug Discovery: The Power of measuring EPSA<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tLearn from Dr Phillip MacFaul, Sygnature Discovery\u2019s Principal Scientist in DMPK about measuring EPSA in bifunctional degraders.\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-7c4158aaf8a22a35edef55f5030853b1\" style=\"color:#001024b3\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d\u2019experts chevronn\u00e9s de l\u2019industrie pharmaceutique du monde entier, garantissant l\u2019excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation.webp 517w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Form &amp; Formulation\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Form-and-Formulation.webp 517w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-62ada6e0951e3179aebea64551a38124\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/\">Forme et formulation<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-ef3202aa48e1102dd72a675eb4167c94\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les strat\u00e9gies int\u00e9gr\u00e9es de formulation et de forme solide r\u00e9duisent les risques, am\u00e9liorent la stabilit\u00e9 et la solubilit\u00e9 et acc\u00e9l\u00e8rent le passage de la s\u00e9lection des candidats \u00e0 la clinique.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"in vivo Pharmacology\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-95cb6840b5cc45da381f55b6b4c9fa98\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/pharmacologie-in-vivo\/\">Pharmacologie <em>in vivo<\/em><\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e7ea388b7a5e7a088a42b5217fefa086\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les mod\u00e8les <em>in vivo<\/em> valid\u00e9s fournissent des donn\u00e9es cliniquement pertinentes dans tous les domaines th\u00e9rapeutiques, acc\u00e9l\u00e9rant la prise de d\u00e9cisions \u00e9clair\u00e9es et r\u00e9duisant les risques li\u00e9s au d\u00e9veloppement de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/pharmacologie-in-vivo\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":9435,"parent":6627,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6555","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Profilage physico-chimique<\/title>\n<meta name=\"description\" content=\"Explorez les solutions de profilage physico-chimique de Sygnature Discovery pour optimiser la solubilit\u00e9, la perm\u00e9abilit\u00e9 et la stabilit\u00e9 des m\u00e9dicaments.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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