{"id":6402,"date":"2025-12-02T13:23:23","date_gmt":"2025-12-02T13:23:23","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/prediction-ternaire-des-proteines\/"},"modified":"2026-02-05T14:25:54","modified_gmt":"2026-02-05T14:25:54","slug":"prediction-ternaire-des-proteines","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-ternaire-des-proteines\/","title":{"rendered":"pr\u00e9diction ternaire des prot\u00e9ines"},"content":{"rendered":"\n<div x-data='subNav({&quot;anchor_map&quot;:{&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/&quot;:&quot;Conception de m\\u00e9dicaments assist\\u00e9e par ordinateur&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/science-des-proteines-et-biologie-structurale\\\/&quot;:&quot;Prot\\u00e9ines et structure&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/bioscience\\\/&quot;:&quot;Bioscience&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/chemistry\\\/&quot;:&quot;Chimie&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\\\/&quot;:&quot;DMPK&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/in-vivo-pharmacology\\\/&quot;:&quot;Pharmacologie in vivo&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/&quot;:&quot;Forme et formulation&quot;}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" @click.away=\"mobileSubMenuOpen = false\" x-cloak style=\"\">\n    <div x-ref=\"fixedNav\"\n        class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/\" \n                                                                class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Solutions scientifiques<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            Conception de m\u00e9dicaments assist\u00e9e par ordinateur\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            Prot\u00e9ines et structure\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/bioscience\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/bioscience\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/bioscience\/' === window.location.href ? 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'-active' : ''\"\n                                        >\n                                            Pharmacologie in vivo\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/' === window.location.href ? 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prot\u00e9ines<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-868be1d0a67448fbfe70c6a19597a39c\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">Nous vous aidons \u00e0 concevoir et \u00e0 optimiser avec pr\u00e9cision des complexes ternaires, en combinant mod\u00e9lisation avanc\u00e9e et expertise collaborative, rendant ainsi accessibles des cibles auparavant \u00ab impossibles \u00e0 traiter \u00bb.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-90bb52c3aac24bb379a087a134687390\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" 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srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Visualisation de la structure mol\u00e9culaire 3D utilis\u00e9e dans la conception de m\u00e9dicaments assist\u00e9e par ordinateur, repr\u00e9sentant les approches bas\u00e9es sur la structure et sur les ligands pour la mod\u00e9lisation pr\u00e9dictive dans la d\u00e9couverte de m\u00e9dicaments.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\"><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-8f86441d1d55a740c2fcc2498107c4a9\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">soutenir vos recherches<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">Chez Sygnature, nous int\u00e9grons la mod\u00e9lisation informatique avanc\u00e9e \u00e0 une vaste expertise en d\u00e9couverte de m\u00e9dicaments pour pr\u00e9dire avec pr\u00e9cision les structures ternaires et \u00e9valuer leur stabilit\u00e9, transformant ainsi des donn\u00e9es structurales complexes en d\u00e9cisions de conception concr\u00e8tes. En tirant parti de la biologie structurale, des simulations mol\u00e9culaires et des analyses bas\u00e9es sur l&rsquo;IA, nous \u00e9valuons la faisabilit\u00e9 des cibles, analysons et pr\u00e9disons les structures ternaires.<br\/> formation complexe et optimisation des d\u00e9gradeurs guid\u00e9s, aidant nos partenaires \u00e0 d\u00e9bloquer de nouvelles opportunit\u00e9s th\u00e9rapeutiques dans divers domaines pathologiques. <\/h2>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">Cette capacit\u00e9 permet de relever l&rsquo;un des d\u00e9fis les plus complexes de la d\u00e9couverte de m\u00e9dicaments\u00a0: la modulation de prot\u00e9ines impliqu\u00e9es dans la maladie et d\u00e9pourvues de sites de liaison conventionnels ou d&rsquo;activit\u00e9 enzymatique. Gr\u00e2ce aux strat\u00e9gies de d\u00e9gradation cibl\u00e9e des prot\u00e9ines (DCP), nous pouvons rendre accessibles des cibles auparavant consid\u00e9r\u00e9es comme \u00ab\u00a0inaccessibles\u00a0\u00bb. Nos capacit\u00e9s de DCP couvrent \u00e0 la fois les PROTAC et les d\u00e9gradeurs de type colle mol\u00e9culaire.  <br\/><\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">Forte de plus de 14 ans d&rsquo;exp\u00e9rience en conception de m\u00e9dicaments par mod\u00e9lisation informatique, Sygnature est un chef de file dans la mod\u00e9lisation et la simulation de d\u00e9gradeurs bifonctionnels. Nos scientifiques s&rsquo;engagent \u00e0 perfectionner les flux de travail informatiques permettant la construction, la simulation et l&rsquo;\u00e9valuation pr\u00e9cises d&rsquo;assemblages multicomposants, qu&rsquo;ils soient connus ou nouveaux. Nos flux de travail couvrent l&rsquo;ensemble du processus, de la g\u00e9n\u00e9ration de concepts et la mod\u00e9lisation de complexes ternaires \u00e0 l&rsquo;affinement structural, l&rsquo;\u00e9valuation \u00e9nerg\u00e9tique et le classement des d\u00e9gradeurs, en s&rsquo;appuyant sur une connaissance approfondie des \u00e9pitopes de liaison et des interfaces d&rsquo;interaction.  <\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\"><\/p>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\"\n         style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-640x360.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1441\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"Diagram illustrating goals and scenarios for ternary complex prediction in targeted protein degradation (TPD) strategies, including fast follower and hit-based approaches for recruiter proteins and glue molecules.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ternary-complex-prediction-tpd-strategy-drug-discovery-640x360.webp 640w\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-light mobile-stacking-standard   stacking-content -sticky-heading -two-columns is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100); \" id=\"sticky-scroll-progress\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-dark-blue-700-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-cbe57604 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-global-padding is-layout-constrained wp-block-column-is-layout-constrained\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--80);margin-bottom:var(--wp--preset--spacing--80);padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div\n    class=\"Progress Progress--left Progress--scroll absolute z-[1000]\"\n    style=\"--progress-thickness: 1px; --progress-color: var(--wp--preset--color--ivory-300); --progress-background: rgba(249, 242, 232, 0.2);\"            x-data=\"progress()\"\n        x-init=\"init({&quot;position&quot;:&quot;left&quot;,&quot;eventType&quot;:&quot;scroll&quot;,&quot;scrollOptions&quot;:{&quot;scroll_target&quot;:&quot;m\\u00e8re&quot;,&quot;container_selector&quot;:&quot;&quot;},&quot;tickerOptions&quot;:[],&quot;formOptions&quot;:[],&quot;anchorPoints&quot;:{&quot;align_points&quot;:true,&quot;points&quot;:[{&quot;element_id&quot;:&quot;\\u00e9l\\u00e9ment-collant-1&quot;,&quot;label&quot;:&quot;&quot;},{&quot;element_id&quot;:&quot;\\u00e9l\\u00e9ment-collant-2&quot;,&quot;label&quot;:&quot;&quot;},{&quot;element_id&quot;:&quot;\\u00e9l\\u00e9ment-collant-3&quot;,&quot;label&quot;:&quot;&quot;}]},&quot;showEndDot&quot;:true,&quot;containerScrollOffset&quot;:0.2,&quot;progressThreshold&quot;:0.005})\"\n        x-cloak\n        data-position=\"left\"\n    data-event-type=\"scroll\"\n>\n    <div\n        class=\"Progress__track bg-[var(--progress-background,rgba(0,124,186,0.2))] relative overflow-visible\" x-ref=\"track\">\n        <div\n            class=\"Progress__fill transition-all duration-100 ease-out bg-[var(--progress-color,#0053CC)]\"  x-ref=\"fill\"        ><\/div>\n            <\/div>\n<\/div>\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-57067efd wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div id=\"sticky-item-1\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Notre approche<\/h2>\n\n\n\n<p>Nous exploitons un ensemble de technologies de pointe et de plateformes propri\u00e9taires pour stimuler la d\u00e9couverte et l&rsquo;optimisation des colles mol\u00e9culaires\u00a0:<\/p>\n\n\n\n<p>\u2022 Simulations de dynamique mol\u00e9culaire (DM)<\/p>\n\n\n\n<p>\u2022 Amarrage prot\u00e9ine-prot\u00e9ine<\/p>\n\n\n\n<p>\u2022 Criblage virtuel bas\u00e9 sur les ligands<\/p>\n\n\n\n<p>\u2022 Outils de pointe du secteur\u00a0: Orion, MolSoft ICM, MOE, Gamess<\/p>\n\n\n\n<p>\u2022 Plateforme propri\u00e9taire FMO prot\u00e9ine-prot\u00e9ine Sygnature FMO-PPI<\/p>\n\n\n\n<p>\u2022 Conception g\u00e9n\u00e9rative guid\u00e9e par l&rsquo;IA et mod\u00e9lisation QSPR multiparam\u00e9trique pour affiner la mati\u00e8re chimique et pr\u00e9dire l&rsquo;efficacit\u00e9 de d\u00e9gradation.<\/p>\n\n\n\n<p>Ces outils permettent une mod\u00e9lisation pr\u00e9cise des complexes ternaires, la pr\u00e9diction de la coop\u00e9rativit\u00e9 de liaison, des interactions au niveau des r\u00e9sidus et la cartographie de la compl\u00e9mentarit\u00e9 \u00e9lectrostatique.<\/p>\n\n\n\n<p>En combinant la biologie structurale, la chimioinformatique et l&rsquo;apprentissage automatique, nous aidons nos clients \u00e0 surmonter les d\u00e9fis li\u00e9s \u00e0 la s\u00e9lectivit\u00e9, \u00e0 la puissance et \u00e0 la validation m\u00e9canistique, en faisant le lien entre la conception <em>in silico<\/em> et le succ\u00e8s <em>in vitro<\/em> .<\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-2\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">D\u00e9bloquer l\u2019\u00ab intraitable \u00bb gr\u00e2ce aux PROTAC et aux colles mol\u00e9culaires<\/h2>\n\n\n\n<p>Pour permettre la conception pr\u00e9cise de d\u00e9gradeurs bifonctionnels et monovalents, nos capacit\u00e9s comprennent\u00a0:<\/p>\n\n\n\n<p>\u2022 Optimisation rapide du linker et du colleur suiveur<\/p>\n\n\n\n<p>\u2022 Criblage virtuel pour la r\u00e9duction des risques et la diversification des ch\u00e9motypes de colles connues<\/p>\n\n\n\n<p>\u2022 Mod\u00e9lisation et post-traitement avanc\u00e9s des complexes ternaires<\/p>\n\n\n\n<p>\u2022 Conception de colle pilot\u00e9e par l&rsquo;IA<\/p>\n\n\n\n<p>\u2022 Profilage pr\u00e9dictif de la d\u00e9gradation \u00e0 l&rsquo;aide de la plateforme FMO-PPI (Fragmented Molecular Orbital at Protein-Protein Interface) de Sygnature et de la dynamique mol\u00e9culaire (MD)<\/p>\n\n\n\n<p>Alors que les PROTAC et les colles mol\u00e9culaires (MG) introduisent des d\u00e9fis complexes en mati\u00e8re de conception et d&rsquo;interpr\u00e9tation des donn\u00e9es, l&rsquo;approche int\u00e9gr\u00e9e de Sygnature combine la mod\u00e9lisation bas\u00e9e sur la structure, l&rsquo;analyse des interactions au niveau de la m\u00e9canique quantique (QM) et l&rsquo;optimisation guid\u00e9e par l&rsquo;IA pour fournir des informations pr\u00e9dictives et des strat\u00e9gies valid\u00e9es qui acc\u00e9l\u00e8rent la d\u00e9couverte et r\u00e9duisent les risques.<\/p>\n\n\n\n<p>Notre plateforme propri\u00e9taire CHARMED et nos flux de travail de mod\u00e9lisation avanc\u00e9s permettent la conception rationnelle de PROTAC et de colles mol\u00e9culaires (MG), r\u00e9pondant ainsi \u00e0 des d\u00e9fis tels que la s\u00e9lectivit\u00e9, la coop\u00e9rativit\u00e9 et l&rsquo;efficacit\u00e9 de d\u00e9gradation. Ces approches \u00e9tendent le champ d&rsquo;application du d\u00e9veloppement th\u00e9rapeutique \u00e0 des classes de cibles auparavant inaccessibles aux m\u00e9dicaments, repr\u00e9sentant une avanc\u00e9e majeure en m\u00e9decine de pr\u00e9cision. <\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-3\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Pourquoi choisir Sygnature ?<\/h2>\n\n\n\n<p>Nous combinons une expertise scientifique pointue \u00e0 des technologies de pointe pour acc\u00e9l\u00e9rer la d\u00e9couverte de vos m\u00e9dicaments. Notre force r\u00e9side dans une collaboration interfonctionnelle, gr\u00e2ce \u00e0 un soutien int\u00e9gr\u00e9 et centralis\u00e9 en chimie m\u00e9dicinale, biosciences, DMPK et mod\u00e9lisation informatique. En nous appuyant sur des donn\u00e9es pertinentes, nous accompagnons chaque \u00e9tape de la d\u00e9couverte et collaborons \u00e9troitement avec nos partenaires pour concevoir des solutions sur mesure, adapt\u00e9es \u00e0 leurs cibles sp\u00e9cifiques.  <br\/><\/p>\n\n\n\n<p>Gr\u00e2ce \u00e0 notre plateforme propri\u00e9taire CHARMED, nous optimisons les programmes TPD en phase pr\u00e9coce par la synth\u00e8se et le criblage \u00e0 haut d\u00e9bit. Cette approche est \u00e9troitement li\u00e9e \u00e0 des flux de travail informatiques avanc\u00e9s afin de rationaliser la conception et la validation des d\u00e9gradeurs. <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><section class=\"Pegasus__Container w-full hidden sm:block  sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"  padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Reveal \" x-data=\"reveal({&quot;initiallyVisible&quot;:true,&quot;element&quot;:&quot;autre&quot;,&quot;elementId&quot;:&quot;\\u00e9l\\u00e9ment-collant-1&quot;,&quot;action&quot;:&quot;vue&quot;})\" styles=\";\">\n\t        \n    \t\t<div x-show=\"show\"\n\t\t\tx-transition:enter=\"transition ease-out duration-500\"\n\t\t\tx-transition:enter-start=\"opacity-0\"\n\t\t\tx-transition:enter-end=\"opacity-100\"\n\t\t\tx-transition:leave=\"transition ease-in duration-500 absolute inset-0\"\n\t\t\tx-transition:leave-start=\"opacity-100\"\n\t\t\tx-transition:leave-end=\"opacity-0\"\n\t\t\tx-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section class=\"Pegasus__Container w-full   relative h-fit overflow-hidden text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-left:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); border-top-left-radius:24px;border-top-right-radius:24px;border-bottom-left-radius:24px;border-bottom-right-radius:24px;border-style:none;border-width:0px;\" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-000-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media original shrink-0\"\n         style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-ternary-prediction-structure-modeling-complex.webp 144w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"144\" height=\"215\" class=\"image-original \" alt=\"Visualisation mol\u00e9culaire 3D d'un complexe prot\u00e9ique ternaire en jaune, rose et cyan, illustrant une mod\u00e9lisation avanc\u00e9e pour la pr\u00e9diction ternaire afin de permettre des cibles m\u00e9dicamenteuses exploitables.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-ternary-prediction-structure-modeling-complex.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-ternary-prediction-structure-modeling-complex.webp 144w\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        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width=\"1400\" height=\"1401\" class=\"image-original \" alt=\"Diagram showing Sygnature\u2019s CHARMED platform workflow for targeted protein degradation (TPD), including hit identification, exit vector analysis, plate-based synthesis of degraders, rapid ADME assessment, and optimization of degrader properties.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design-300x300.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design-768x769.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design-1024x1024.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design.webp 1400w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design-1079x1080.webp 1079w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design-360x360.webp 360w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/charmed-platform-tpd-workflow-degrader-design-640x640.webp 640w\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full block sm:hidden md:hidden  sticky top-0 lg:relative lg:h-fixed md:relative md:h-fit relative  text-content-dark 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data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--60); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-e84fdc4b wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2c75125d wp-block-group-is-layout-constrained\" style=\"margin-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style wp-elements-d54eb4eaa9e4db5e0d820cff3ba28df9\" style=\"color:#001024b3;padding-right:0;padding-left:0;font-style:normal;font-weight:600;letter-spacing:0.96px;--paragraph-dot-color:#005de5\">Centre de ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-292e3aecac1f775e2ab135efc50ecaec wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Recherches et ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data=\"postGrid({&quot;respondToFiltering&quot;:true,&quot;singleFilterMode&quot;:true,&quot;initialFilterSlug&quot;:&quot;&quot;})\"  class=\"Post__Grid relative\" style=\"--post-grid-grid-cols: 3; --post-grid-row-gap: 1.5rem;\" data-single-filter-mode=\"false\" 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                         dur=\"1s\"\n                                                  repeatCount=\"indefinite\"\/>\n                            <\/g>\n                            <g fill=\"currentColor\" opacity=\"1\">\n                                <path>\n                                    <animate attributeName=\"opacity\" values=\"1;0.4;1\" dur=\"1.2s\" begin=\"0s\" repeatCount=\"indefinite\"\/>\n                                <\/path>\n                            <\/g>\n                        <\/svg>\n                    <\/div>\n                    \n                                            <p class=\"text-center\">No posts found.<\/p>\n                                    <\/div>\n                    \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-5 is-position-sticky\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Capacit\u00e9s connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-c54fcc7cffe74703160b5151ccfd9bbc\" style=\"color:#001024b3\">Nous vous aidons \u00e0 concevoir des compos\u00e9s plus intelligents et \u00e0 prendre des d\u00e9cisions plus rapidement en combinant la mod\u00e9lisation bas\u00e9e sur l&rsquo;IA, une vaste expertise scientifique et un acc\u00e8s s\u00e9curis\u00e9 et collaboratif aux donn\u00e9es pour r\u00e9soudre des probl\u00e8mes complexes et acc\u00e9l\u00e9rer votre processus de d\u00e9couverte de m\u00e9dicaments.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein Structure Prediction\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-a8d3376898730941dacee6d3174ef9ff\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\" type=\"page\" id=\"4821\">Pr\u00e9diction de la structure des prot\u00e9ines<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-65a8460d368c8c8bb6d0cf5c14469527\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">L&rsquo;utilisation d&rsquo;une IA avanc\u00e9e et de techniques de mod\u00e9lisation \u00e9prouv\u00e9es permet de pr\u00e9dire avec pr\u00e9cision les structures prot\u00e9iques, acc\u00e9l\u00e9rant ainsi la conception de m\u00e9dicaments bas\u00e9e sur la structure et la d\u00e9couverte de nouvelles th\u00e9rapies.<br\/> possibilit\u00e9s.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Free Energy Methods\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-b74d5a24506c4be2f04af56c52f5cb95\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/free-energy-methods\/\" type=\"page\" id=\"4911\">M\u00e9thodes d&rsquo;\u00e9nergie libre<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-dd529cd9743ac96f6c685c129f30b65e\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Calcul de l&rsquo;\u00e9nergie libre de liaison relative par commutation hors \u00e9quilibre (NES) gr\u00e2ce \u00e0 la plateforme Orion\u00ae d&rsquo;OpenEye. Fournit des pr\u00e9dictions pr\u00e9cises d&rsquo;affinit\u00e9 de liaison pour vous aider \u00e0 classer les compos\u00e9s avec confiance et \u00e0 prioriser les d\u00e9cisions de synth\u00e8se pour les candidats les plus prometteurs d\u00e8s les premi\u00e8res \u00e9tapes de la d\u00e9couverte. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/free-energy-methods\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Molecular Dynamic Simulations\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-d0afa7ade39bbf5f1d29363f5a74ba36\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/molecular-dynamic-simulations\/\" type=\"page\" id=\"4926\">Simulations de dynamique mol\u00e9culaire<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-4bffe5a25caea969e56e57dec1021b1f\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Utilisation de technologies de pointe et de logiciels propri\u00e9taires pour d\u00e9couvrir des interactions cach\u00e9es, pr\u00e9dire la stabilit\u00e9 des ligands et faire des choix de conception \u00e9clair\u00e9s qui acc\u00e9l\u00e8rent votre programme de d\u00e9couverte de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/molecular-dynamic-simulations\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group wp-container-content-69bc4bdf is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Generative AI and Machine Learning\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-1ffcc47d20b06b8b70c544b58e486108\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/generative-ai-and-machine-learning\/\" type=\"page\" id=\"1595\">Intelligence artificielle g\u00e9n\u00e9rative et apprentissage automatique<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-27699cdce9eb9a1cf05ad7a37c03d4a7\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">En combinant la conception pilot\u00e9e par l&rsquo;IA, des mod\u00e8les d&rsquo;apprentissage automatique sur mesure et la bioinformatique bas\u00e9e sur le LLM avec une collaboration pratique, nous vous aidons \u00e0 d\u00e9couvrir plus rapidement des candidats m\u00e9dicaments optimis\u00e9s.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/generative-ai-and-machine-learning\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Virtual Screening\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-69ded10ca0c1c907c6588f1dd7d4e4be\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/virtual-screening\/\" data-type=\"page\" data-id=\"1632\">d\u00e9pistage virtuel<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e94f62ffd0345c3b225c03461225d211\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Identifier rapidement des compos\u00e9s prometteurs gr\u00e2ce au criblage virtuel \u00e0 grande \u00e9chelle, \u00e0 des biblioth\u00e8ques s\u00e9lectionn\u00e9es et \u00e0 un tri par des experts afin d&rsquo;acc\u00e9l\u00e9rer les programmes de d\u00e9couverte de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/virtual-screening\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Target Analysis\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-7467028471d027402febeda209ef7bc4\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/target-analysis\/\" type=\"page\" id=\"1070\">Analyse des cibles<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-4195d6781b9bc548558787dfd80c1ec3\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Des sites de liaison \u00e0 la pharmacologie, nos \u00e9quipes de chimie computationnelle et de science des prot\u00e9ines vous aident \u00e0 trouver plus rapidement les bons points de d\u00e9part, en combinant une connaissance approfondie des structures avec des outils de pointe pour concevoir des compos\u00e9s qui font progresser votre projet en toute confiance.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/target-analysis\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Ligand Based Drug Discovery\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-5306d3520b5b3c8aa6708aab286d04a8\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/\" type=\"page\" id=\"1519\">Conception de m\u00e9dicaments bas\u00e9e sur les ligands<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e7276f6cdc6b4d50290c46b2e50330ac\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Exploiter les propri\u00e9t\u00e9s de mol\u00e9cules actives connues pour g\u00e9n\u00e9rer et optimiser rapidement de nouveaux compos\u00e9s gr\u00e2ce \u00e0 des connaissances bas\u00e9es sur les ligands, des outils aliment\u00e9s par l&rsquo;IA et une expertise collaborative afin de d\u00e9couvrir de nouveaux espaces chimiques et d&rsquo;acc\u00e9l\u00e9rer les d\u00e9couvertes.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Structure-Based Drug Design\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-935cbd7616b9aa7bec1f6068f0efc491\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/structure-based-drug-design\/\">Conception de m\u00e9dicaments bas\u00e9e sur la structure<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e3c3fd7ce9b129aa16f8cb5cff3d29bc\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous vous aidons \u00e0 concevoir de meilleurs compos\u00e9s avec une plus grande confiance. Gr\u00e2ce \u00e0 des connaissances \u00e0 l&rsquo;\u00e9chelle quantique et \u00e0 des simulations dynamiques, nous pr\u00e9disons l&rsquo;affinit\u00e9, guidons l&rsquo;optimisation et vous aidons \u00e0 identifier plus rapidement les candidats les plus prometteurs. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/structure-based-drug-design\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group is-vertical is-content-justification-stretch is-layout-flex wp-container-core-group-is-layout-353c4f5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-eb5039d6 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-c9ee0c5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">FAQ<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a7849e3a wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Accordion relative w-full mx-auto \"\n         style=\"\">\n            \n        <div>\n        <div class=\"acf-innerblocks-container\">\n<div x-data=\"accordionPanel(1, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-f90d81bf7953a79e82de358995501f41\"\n     :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quels types de classes cibles pouvez-vous mod\u00e9liser avec PROTACs et Molecular Glues ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-5f70df24cc1271542cc455d73a15421d\" style=\"color:#475467\">Nous appliquons la mod\u00e9lisation informatique avanc\u00e9e \u00e0 un large \u00e9ventail de cibles, notamment les kinases, les facteurs de transcription, les prot\u00e9ines d&rsquo;\u00e9chafaudage, les r\u00e9gulateurs \u00e9pig\u00e9n\u00e9tiques, les r\u00e9cepteurs nucl\u00e9aires, les cibles des maladies neurod\u00e9g\u00e9n\u00e9ratives et les ligases E3. Notre expertise couvre aussi bien les prot\u00e9ines bien caract\u00e9ris\u00e9es que les prot\u00e9ines traditionnellement consid\u00e9r\u00e9es comme \u00ab\u00a0inaccessibles aux m\u00e9dicaments\u00a0\u00bb. <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-f7e2a3fe544d02b9ec044a9301cbbf60\"\n     :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">\u00c0 quelles modalit\u00e9s les PROTAC et la mod\u00e9lisation de colle mol\u00e9culaire peuvent-ils \u00eatre appliqu\u00e9s&nbsp;?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-60b1d82dbb0720b1e45b1941b193c94c\" style=\"color:#475467\">Notre mod\u00e9lisation prend en charge les PROTAC, les colles mol\u00e9culaires, les d\u00e9gradeurs peptidiques et d&rsquo;autres d\u00e9gradeurs h\u00e9t\u00e9robifonctionnels. Ces approches permettent la d\u00e9gradation s\u00e9lective de prot\u00e9ines impliqu\u00e9es dans des maladies, gr\u00e2ce \u00e0 divers m\u00e9canismes. Nos flux de travail de mod\u00e9lisation sont con\u00e7us pour accompagner chaque modalit\u00e9 en pr\u00e9disant la formation de complexes ternaires avec des \u00e9pitopes de liaison connus, en guidant la conception des connecteurs et des colles, et en \u00e9valuant le potentiel de d\u00e9gradation.  <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-d5cffb601e33d9c2893f3ef1139f9030\"\n     :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quels types de flux de travail de mod\u00e9lisation PROTAC et Molecular Glue proposez-vous ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-10a69512df420f134ac78e6f0fb4a262\" style=\"color:#475467\">Nous proposons des flux de travail personnalis\u00e9s comprenant le criblage virtuel bas\u00e9 sur la structure, l&rsquo;analyse conformationnelle avec regroupement, le post-traitement des assemblages ternaires et le classement \u00e9nerg\u00e9tique au niveau des r\u00e9sidus gr\u00e2ce \u00e0 la plateforme FMO-PPI de Sygnature et aux pipelines de dynamique mol\u00e9culaire, afin de prioriser les candidats d\u00e9gradeurs. Ces flux de travail sont int\u00e9gr\u00e9s aux plateformes exp\u00e9rimentales, notamment CHARMED, pour une it\u00e9ration rapide et des d\u00e9cisions fond\u00e9es sur les donn\u00e9es. <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-aeabdb3c8f4707564edc9a4fb9b2b1af\"\n     :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quels types de r\u00e9sultats de mod\u00e9lisation PROTAC et Molecular Glue partagez-vous avec vos clients&nbsp;?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-6539fb3a43d0a95c1d12ff28f0ff928b\" style=\"color:#475467\">Nous fournissons des rapports scientifiques complets incluant des mod\u00e8les de structures de complexes ternaires dans les formats souhait\u00e9s, un classement des poses de d\u00e9gradation avec analyse de regroupement, et des cartes d&rsquo;interaction d\u00e9taill\u00e9es avec des informations au niveau des r\u00e9sidus, telles que FMO-PPI-SP. Ces rapports sont g\u00e9n\u00e9ralement livr\u00e9s au format CSV ou dans d&rsquo;autres formats accessibles et comprennent des recommandations de conception d&rsquo;experts, des m\u00e9triques de validation et une justification compl\u00e8te des calculs. <br\/><\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-2ee44c81b745e21a5ecfc83b0f3579bd\" style=\"color:#475467\">Sont \u00e9galement inclus des r\u00e9sum\u00e9s visuels clairs tels que des diagrammes d&rsquo;interaction et des repr\u00e9sentations de surfaces limites afin de garantir la transparence, la tra\u00e7abilit\u00e9 et des informations exploitables tout au long du processus de d\u00e9veloppement du d\u00e9gradeur.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-b34f27adc4099e103fec4c9086790dd5\"\n     :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quelles sont les donn\u00e9es d&rsquo;entr\u00e9e typiques requises pour un projet de mod\u00e9lisation PROTACs et Molecular Glue&nbsp;?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-bff887eca3156306799b8e03afc2f1aa\" style=\"color:#475467\">Pour mod\u00e9liser avec pr\u00e9cision les complexes ternaires des nouveaux PROTAC et colles mol\u00e9culaires, nous avons besoin d&rsquo;un ensemble bien d\u00e9fini de donn\u00e9es d&rsquo;entr\u00e9e permettant une analyse computationnelle pr\u00e9cise. Celles-ci comprennent g\u00e9n\u00e9ralement des informations structurales et m\u00e9canistiques sur la prot\u00e9ine d&rsquo;int\u00e9r\u00eat (POI) et la prot\u00e9ine recruteuse ou la ligase E3, les \u00e9pitopes de liaison connus ou hypoth\u00e9tiques et les r\u00e9sidus d&rsquo;interface cl\u00e9s. <br\/><\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-bd00ca119f3e2696e3920fd569f12fb2\" style=\"color:#475467\">Les donn\u00e9es pr\u00e9liminaires d&rsquo;essais de d\u00e9gradation ou les r\u00e9sultats exp\u00e9rimentaux, lorsqu&rsquo;ils sont disponibles, sont extr\u00eamement pr\u00e9cieux pour valider les r\u00e9sultats de la mod\u00e9lisation. Nous demandons \u00e9galement des informations d\u00e9taill\u00e9es sur la chimie des lieurs, les motifs de liaison et toute mutation connue susceptible d&rsquo;influencer la formation et la stabilit\u00e9 du complexe. Les donn\u00e9es structurales telles que les mod\u00e8les cristallographiques, les cartes de cryo-microscopie \u00e9lectronique ou les mod\u00e8les d&rsquo;homologie sont essentielles pour affiner les simulations et adapter nos flux de travail informatiques au syst\u00e8me biologique sp\u00e9cifique \u00e9tudi\u00e9.  <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n    \n            <\/section><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":9817,"parent":16400,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6402","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pr\u00e9dictions 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