{"id":5772,"date":"2025-12-02T11:41:02","date_gmt":"2025-12-02T11:41:02","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/prediction-de-la-structure-des-proteines\/"},"modified":"2026-02-05T14:20:51","modified_gmt":"2026-02-05T14:20:51","slug":"prediction-de-la-structure-des-proteines","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/","title":{"rendered":"Pr\u00e9diction de la structure des prot\u00e9ines"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/bioinformatique\\\/\":\"Bioinformatique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/analyse-de-la-cible\\\/\":\"Analyse des cibles\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/depistage-virtuel\\\/\":\"d\\u00e9pistage virtuel\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/conception-de-medicaments-basee-sur-la-structure\\\/\":\"Conception de m\\u00e9dicaments bas\\u00e9e sur la structure  \",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/ia-generative-et-apprentissage-automatique\\\/\":\"Intelligence artificielle g\\u00e9n\\u00e9rative et apprentissage automatique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/conception-de-medicaments-basee-sur-des-ligands\\\/\":\"Conception de m\\u00e9dicaments bas\\u00e9e sur les ligands\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/conception-de-la-bibliotheque\\\/\":\"Conception de biblioth\\u00e8que\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/predictions-admet\\\/\":\"Pr\\u00e9diction ADMET\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/informatique\\\/\":\"Informatique\"}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" false x-cloak style=\"\">\n    <div x-ref=\"fixedNav\" class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/\" class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Conception de m\u00e9dicaments assist\u00e9e par ordinateur<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' === window.location.href ? '-active' : ''\">\n                                            Bioinformatique\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/analyse-de-la-cible\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/analyse-de-la-cible\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/analyse-de-la-cible\/' === window.location.href ? '-active' : ''\">\n                                            Analyse des cibles\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/depistage-virtuel\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/depistage-virtuel\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/depistage-virtuel\/' === window.location.href ? '-active' : ''\">\n                                            d\u00e9pistage virtuel\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/' === window.location.href ? '-active' : ''\">\n                                            Conception de m\u00e9dicaments bas\u00e9e sur la structure  \n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/ia-generative-et-apprentissage-automatique\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/ia-generative-et-apprentissage-automatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/ia-generative-et-apprentissage-automatique\/' === window.location.href ? '-active' : ''\">\n                                            Intelligence artificielle g\u00e9n\u00e9rative et apprentissage automatique\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/' === window.location.href ? '-active' : ''\">\n                                            Conception de m\u00e9dicaments bas\u00e9e sur les ligands\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-la-bibliotheque\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-la-bibliotheque\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-la-bibliotheque\/' === window.location.href ? '-active' : ''\">\n                                            Conception de biblioth\u00e8que\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' === window.location.href ? '-active' : ''\">\n                                            Pr\u00e9diction ADMET\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' === window.location.href ? '-active' : ''\">\n                                            Informatique\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                    <\/ul>\n                        \n                        <div x-ref=\"scrollIndicator\" class=\"scroll-indicator\" x-show=\"showScrollIndicator\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0 transform translate-x-full\" x-transition:enter-end=\"opacity-100 transform translate-x-0\">\n                            <svg class=\"chevron-icon w-4 h-4\" viewbox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\">\n                                <path d=\"M5.65306 3.53025L10.6531 8.53025C10.7227 8.60018 10.7775 8.68297 10.8154 8.77414C10.8533 8.8653 10.8735 8.96304 10.8735 9.06175C10.8735 9.16046 10.8533 9.2582 10.8154 9.34936C10.7775 9.44053 10.7227 9.52332 10.6531 9.59325L5.65306 14.5932C5.51217 14.7341 5.32107 14.8133 5.12181 14.8133C4.92255 14.8133 4.73145 14.7341 4.59056 14.5932C4.44966 14.4523 4.37051 14.2612 4.37051 14.062C4.37051 13.8627 4.44966 13.6716 4.59056 13.5307L9.06294 9.06175L4.59056 4.59325C4.44966 4.45236 4.37051 4.26126 4.37051 4.062C4.37051 3.86274 4.44966 3.67164 4.59056 3.53075C4.73145 3.38985 4.92255 3.3107 5.12181 3.3107C5.32107 3.3107 5.51217 3.38985 5.65306 3.53075V3.53025Z\" fill=\"currentColor\"><\/path>\n                            <\/svg>\n                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n\n            <!-- Mobile menu button -->\n            <button x-ref=\"navMenuButton\" type=\"button\" class=\"flex justify-center items-center py-2 whitespace-nowrap pl-5 pr-2.5 ml-auto md:hidden\" aria-label=\"Show more navigation items\" :aria-expanded=\"mobileSubMenuOpen\">\n                <span class=\"sr-only pr-2 inline-block\">More<\/span>\n\n                <svg class=\"transition duration-500 ease-in-out\" :class=\"mobileSubMenuOpen ? 'rotate-180' : ''\" width=\"16\" height=\"16\" viewbox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\">\n                <path d=\"M13.5306 6.53025L8.5306 11.5302C8.46092 11.6002 8.37813 11.6556 8.28696 11.6935C8.1958 11.7314 8.09806 11.7508 7.99935 11.7508C7.90064 11.7508 7.8029 11.7314 7.71173 11.6935C7.62057 11.6556 7.53778 11.6002 7.4681 11.5302L2.4681 6.53025C2.3272 6.38935 2.24805 6.19825 2.24805 5.999C2.24805 5.79974 2.3272 5.60864 2.4681 5.46775C2.60899 5.32685 2.80009 5.2477 2.99935 5.2477C3.19861 5.2477 3.3897 5.32685 3.5306 5.46775L7.99997 9.93712L12.4693 5.46712C12.6102 5.32623 12.8013 5.24707 13.0006 5.24707C13.1999 5.24707 13.391 5.32623 13.5318 5.46712C13.6727 5.60802 13.7519 5.79911 13.7519 5.99837C13.7519 6.19763 13.6727 6.38873 13.5318 6.52962L13.5306 6.53025Z\" fill=\"currentColor\"><\/path>\n                <\/svg>\n            <\/button>\n        \n        <!-- CTA Button (desktop only) -->\n                    <div class=\"hidden md:block flex-shrink-0 \" x-show=\"showCtaButton\" x-transition:enter=\"transition ease-out duration-500 delay-500\" x-transition:enter-start=\"opacity-0 transform translate-x-8\" x-transition:enter-end=\"opacity-100 transform translate-x-0\">\n                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n            <\/div>\n        \n        <!-- Mobile Dropdown Menu -->\n                    <div class=\"absolute top-full z-20 w-full left-0 block md:hidden\" x-show=\"mobileSubMenuOpen\" x-collapse>\n                <div class=\"rounded-b-xl max-h-[calc(100dvh-80px)] overflow-y-auto bg-white shadow-lg\">\n                    <div class=\"py-10 px-5\">\n                        <ul x-ref=\"hiddenLinks\" class=\"hidden-links !m-0 !p-0 !list-none\">\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Bioinformatique\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/analyse-de-la-cible\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/analyse-de-la-cible\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/analyse-de-la-cible\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Analyse des cibles\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/depistage-virtuel\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/depistage-virtuel\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/depistage-virtuel\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        d\u00e9pistage virtuel\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Conception de m\u00e9dicaments bas\u00e9e sur la structure  \n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/ia-generative-et-apprentissage-automatique\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/ia-generative-et-apprentissage-automatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/ia-generative-et-apprentissage-automatique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Intelligence artificielle g\u00e9n\u00e9rative et apprentissage automatique\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Conception de m\u00e9dicaments bas\u00e9e sur les ligands\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-la-bibliotheque\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-la-bibliotheque\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-la-bibliotheque\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Conception de biblioth\u00e8que\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Pr\u00e9diction ADMET\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Informatique\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-add252dc9550731db58090869d7c2474\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">Solutions scientifiques | Conception de m\u00e9dicaments assist\u00e9e par ordinateur<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-a2121e61f68f4c2d63c97b1c91812230\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Pr\u00e9diction de la structure des prot\u00e9ines<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-e5244e4cd67e863f27abf9d06956ec7e\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">L\u2019utilisation d\u2019une IA avanc\u00e9e et de techniques de mod\u00e9lisation \u00e9prouv\u00e9es permet de pr\u00e9dire avec confiance les structures prot\u00e9iques, acc\u00e9l\u00e9rant ainsi la conception de m\u00e9dicaments bas\u00e9e sur la structure et d\u00e9couvrant de nouvelles possibilit\u00e9s th\u00e9rapeutiques.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-90bb52c3aac24bb379a087a134687390\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" style=\"padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d6b9ab57 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Visualisation de la structure mol\u00e9culaire 3D utilis\u00e9e dans la conception de m\u00e9dicaments assist\u00e9e par ordinateur, repr\u00e9sentant les approches bas\u00e9es sur la structure et sur les ligands pour la mod\u00e9lisation pr\u00e9dictive dans la d\u00e9couverte de m\u00e9dicaments.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-8f86441d1d55a740c2fcc2498107c4a9\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">soutenir vos recherches<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">La pr\u00e9diction de la structure des prot\u00e9ines est devenue un outil puissant pour comprendre les interactions entre petites mol\u00e9cules et orienter les strat\u00e9gies de projet.  <\/h2>\n\n\n\n<p style=\"padding-bottom:var(--wp--preset--spacing--20)\">Les avanc\u00e9es bas\u00e9es sur l\u2019IA, telles qu\u2019AlphaFold, permettent d\u00e9sormais de g\u00e9n\u00e9rer des mod\u00e8les 3D tr\u00e8s pr\u00e9cis directement \u00e0 partir de donn\u00e9es de s\u00e9quences, offrant ainsi aux chercheurs de nouvelles perspectives hypoth\u00e9tiques pour de nouvelles cibles.<\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">Chez Sygnature Discovery, nous exploitons une suite d\u2019outils compl\u00e9mentaires, dont AlphaFold Multimer et OmegaFold, et nous \u00e9valuons actuellement Boltz-2 sur notre cluster interne, afin de g\u00e9n\u00e9rer des pr\u00e9dictions structurales de haute fiabilit\u00e9. Ces mod\u00e8les accompagnent chaque \u00e9tape de la d\u00e9couverte de m\u00e9dicaments, depuis la conception de ligands jusqu\u2019\u00e0 la fourniture de mod\u00e8les pour le remplacement mol\u00e9culaire en cristallographie des prot\u00e9ines lors de la r\u00e9solution de nouveaux probl\u00e8mes.<br> structures. <\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">En combinant des algorithmes avanc\u00e9s \u00e0 une vaste expertise en mati\u00e8re de d\u00e9couverte de m\u00e9dicaments, nous traduisons ces pr\u00e9dictions en strat\u00e9gies concr\u00e8tes qui acc\u00e9l\u00e8rent les progr\u00e8s et r\u00e9duisent les risques.<\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\"><\/p>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-640x360.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1441\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"Graphic showing protein structure prediction applications in drug discovery, including molecular interactions, virtual screening, ligand desolvation, electrostatics, protein dynamics, novel pockets, and drug repurposing.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-tools-640x360.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-light mobile-stacking-standard   stacking-content -sticky-heading -two-columns is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100); \" id=\"sticky-scroll-progress\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-dark-blue-700-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-cbe57604 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-global-padding is-layout-constrained wp-block-column-is-layout-constrained\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--80);margin-bottom:var(--wp--preset--spacing--80);padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Progress Progress--left Progress--scroll absolute z-[1000]\" style=\"--progress-thickness: 1px; --progress-color: var(--wp--preset--color--ivory-300); --progress-background: rgba(249, 242, 232, 0.2);\" x-data=\"progress()\" x-init='init({\"position\":\"left\",\"eventType\":\"scroll\",\"scrollOptions\":{\"scroll_target\":\"m\\u00e8re\",\"container_selector\":\"\"},\"tickerOptions\":[],\"formOptions\":[],\"anchorPoints\":{\"align_points\":true,\"points\":[{\"element_id\":\"\\u00e9l\\u00e9ment-collant-1\",\"label\":\"\"},{\"element_id\":\"\\u00e9l\\u00e9ment-collant-2\",\"label\":\"\"},{\"element_id\":\"\\u00e9l\\u00e9ment-collant-3\",\"label\":\"\"}]},\"showEndDot\":true,\"containerScrollOffset\":0.2,\"progressThreshold\":0.005})' x-cloak data-position=\"left\" data-event-type=\"scroll\">\n    <div class=\"Progress__track bg-[var(--progress-background,rgba(0,124,186,0.2))] relative overflow-visible\" x-ref=\"track\">\n        <div class=\"Progress__fill transition-all duration-100 ease-out bg-[var(--progress-color,#0053CC)]\" x-ref=\"fill\"><\/div>\n            <\/div>\n<\/div>\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-57067efd wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div id=\"sticky-item-1\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Pr\u00e9diction de structure pilot\u00e9e par l\u2019IA<\/h2>\n\n\n\n<p>AlphaFold permet une mod\u00e9lisation 3D pr\u00e9cise \u00e0 partir de donn\u00e9es de s\u00e9quences. AlphaFold 2.0 a marqu\u00e9 une avanc\u00e9e majeure pour la mod\u00e9lisation des prot\u00e9ines non membranaires et des domaines prot\u00e9iques uniques, tandis qu\u2019AlphaFold Multimer a \u00e9tendu ses capacit\u00e9s aux interactions prot\u00e9ine-prot\u00e9ine. Les scores de confiance attribu\u00e9s aux diff\u00e9rentes r\u00e9gions rendent ces mod\u00e8les extr\u00eamement informatifs pour la d\u00e9couverte de m\u00e9dicaments. Des outils open source tels que Boltz-2 ont encore \u00e9largi les possibilit\u00e9s, en prenant \u00e9galement en charge la pr\u00e9diction de l\u2019affinit\u00e9 des petites mol\u00e9cules et en fournissant un apport compl\u00e9mentaire \u00e0 nos processus de conception bas\u00e9s sur la structure.   <\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-2\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">L\u2019importance persistante de la mod\u00e9lisation par homologie<\/h2>\n\n\n\n<p>Parall\u00e8lement aux nouveaux outils de pr\u00e9diction de la structure des prot\u00e9ines, la mod\u00e9lisation par homologie demeure un outil important et polyvalent. Elle est particuli\u00e8rement importante lorsqu\u2019on recherche un \u00e9tat fonctionnel ou une conformation prot\u00e9ique sp\u00e9cifique, comme un mod\u00e8le de RCPG li\u00e9 \u00e0 un agoniste ou une kinase sous sa forme DFG-out, avec un positionnement particulier de l\u2019h\u00e9lice \u03b1C ou de la boucle d\u2019activation. <\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-3\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Flexibilit\u00e9 des prot\u00e9ines et \u00e9tats conformationnels<\/h2>\n\n\n\n<p>La pr\u00e9diction de la structure des prot\u00e9ines soutient \u00e9galement la cristallographie des prot\u00e9ines en fournissant des mod\u00e8les pour le remplacement mol\u00e9culaire lors de la r\u00e9solution de nouvelles structures.<\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-4\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">\u00c9valuation de la qualit\u00e9 et de l\u2019utilit\u00e9 structurelle du mod\u00e8le<\/h2>\n\n\n\n<p>La ma\u00eetrise des donn\u00e9es structurales et l\u2019\u00e9valuation de leur utilit\u00e9 sont cruciales. L\u2019importance de cette ma\u00eetrise peut \u00eatre illustr\u00e9e par un mod\u00e8le de LSD1 g\u00e9n\u00e9r\u00e9 \u00e0 l\u2019aide d\u2019AlphaFold Multimer. Bien que le mod\u00e8le du site de liaison soit excellent, ce dernier est auto-inhib\u00e9 par une autre r\u00e9gion de la prot\u00e9ine. Rien ne prouve que cet effet soit physiquement significatif, et la structure doit \u00eatre modifi\u00e9e pour l\u2019\u00e9liminer avant toute utilisation dans la conception de m\u00e9dicaments.   <\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-4\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Pourquoi choisir Sygnature ?<\/h2>\n\n\n\n<p>Forte d\u2019une longue exp\u00e9rience r\u00e9ussie en pr\u00e9diction de structures prot\u00e9iques pour diverses cibles, Sygnature allie mod\u00e9lisation de pointe et expertise approfondie en d\u00e9couverte de m\u00e9dicaments. Nous proposons une gamme compl\u00e8te d\u2019outils pour la pr\u00e9diction de structures prot\u00e9iques, la mod\u00e9lisation des complexes prot\u00e9ine-ligand et prot\u00e9ine-prot\u00e9ine, ainsi que la conception de m\u00e9dicaments guid\u00e9e par la structure. <br><\/p>\n\n\n\n<p>L\u2019expertise de Sygnature r\u00e9side dans l\u2019\u00e9valuation rigoureuse de la qualit\u00e9 des mod\u00e8les et l\u2019application efficace des connaissances structurales pour soutenir la d\u00e9couverte de m\u00e9dicaments. Qu\u2019il s\u2019agisse de mod\u00e8les d\u2019homologie ou de pr\u00e9dictions de type AlphaFold, nous \u00e9valuons les mod\u00e8les dans leur contexte, en tenant compte des homologues fonctionnels, de la coh\u00e9rence des relations structure-activit\u00e9 et des conditions physiologiques. Nos \u00e9quipes affinent et \u00e9valuent les structures dans leur contexte biologique et chimique global afin de garantir leur pertinence pour la prise de d\u00e9cision.  <br><\/p>\n\n\n\n<p>Cette capacit\u00e9 est renforc\u00e9e par notre vaste \u00e9quipe d\u2019experts en chimie computationnelle et en biosciences, travaillant en \u00e9troite collaboration avec des \u00e9quipes de projet multidisciplinaires afin d\u2019exploiter efficacement les donn\u00e9es structurales pr\u00e9dites et exp\u00e9rimentales. Sans aucun programme de d\u00e9veloppement de m\u00e9dicaments en interne, nous nous consacrons enti\u00e8rement \u00e0 votre r\u00e9ussite, en vous fournissant une expertise d\u00e9di\u00e9e, des analyses ax\u00e9es sur les r\u00e9sultats et une mod\u00e9lisation structurale qui acc\u00e9l\u00e8re le d\u00e9veloppement de vos projets de d\u00e9couverte de m\u00e9dicaments. <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><section class=\"Pegasus__Container w-full hidden sm:block  sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"  padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":true,\"element\":\"autre\",\"elementId\":\"\\u00e9l\\u00e9ment-collant-1\",\"action\":\"vue\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-57x40 shrink-0\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-300x192.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-768x492.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-1024x656.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-1536x984.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-562x360.webp 562w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-640x410.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"2560\" height=\"1641\" class=\"image-original \" alt=\"Illustration de la pr\u00e9diction de la structure des prot\u00e9ines et de la mod\u00e9lisation par homologie, repr\u00e9sentant des approches permettant de g\u00e9n\u00e9rer des informations structurelles fiables dans la d\u00e9couverte de m\u00e9dicaments.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-300x192.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-768x492.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-1024x656.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-1536x984.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-562x360.webp 562w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-640x410.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n\n\n<p class=\"has-ivory-000-color has-text-color has-link-color has-text-sm-font-size wp-elements-7d4b1319672d260b9fbebd827ea10661\" style=\"margin-top:var(--wp--preset--spacing--20)\"><strong>Mod\u00e8le multim\u00e8re AlphaFold du complexe IL3:IL3RA compar\u00e9 \u00e0 la structure cristalline.<\/strong><\/p>\n\n\n\n<p class=\"has-ivory-000-color has-text-color has-link-color wp-elements-a40a463b935e9ad13bb6c98a1eb8dd40\">L\u2019accord est excellent au niveau de l\u2019interface prot\u00e9ine-prot\u00e9ine et le mod\u00e8le est d\u2019une qualit\u00e9 suffisamment \u00e9lev\u00e9e pour servir de base \u00e0 un projet de conception de m\u00e9dicaments bas\u00e9 sur la structure. La structure PDB du complexe (code\u00a0: 5UWC8) est repr\u00e9sent\u00e9e avec la portion IL3R en orange et IL3 en magenta. La r\u00e9gion correspondante mod\u00e9lis\u00e9e par AlphaFold Multimer est repr\u00e9sent\u00e9e en jaune et cyan. En dehors des domaines centraux, les pr\u00e9dictions sont plus variables, mais cette r\u00e9gion n\u2019est pas \u00e9tay\u00e9e par les donn\u00e9es cristallographiques disponibles et ne constitue pas la zone la plus pertinente pour la d\u00e9couverte de m\u00e9dicaments.   <\/p>\n\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n\n\n<div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":false,\"element\":\"autre\",\"elementId\":\"\\u00e9l\\u00e9ment-collant-2\",\"action\":\"vue\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-57x40 shrink-0\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-300x130.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-768x334.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-1024x445.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-1536x667.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-640x278.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"2560\" height=\"1112\" class=\"image-original \" alt=\"3D molecular visualization comparing ligand-induced conformations in MEK1, showing crystal structure (3WH9) in blue and alternative structure (5HZE10) in orange, illustrating conformational plasticity and allosteric pocket differences.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-300x130.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-768x334.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-1024x445.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-1536x667.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-flexibility-conformational-states-640x278.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n\n\n<p class=\"has-ivory-000-color has-text-color has-link-color wp-elements-b95dd9c97edb576f48d228faa8c4686b\" style=\"padding-top:var(--wp--preset--spacing--10)\"><strong>Plasticit\u00e9 conformationnelle, par exemple dans MEK1.  <\/strong><\/p>\n\n\n\n<p class=\"has-ivory-000-color has-text-color has-link-color wp-elements-0b42c8f52433880910fb89db7c4c6f6d\">L\u2019image compare les conformations induites par un ligand dans MEK1. L\u2019analogue d\u2019ATP est repr\u00e9sent\u00e9 \u00e0 titre indicatif, mais les autres ligands sont omis. La structure cristalline 3VVH9 est en bleu et la structure 5HZE10 en orange. MEK1 peut adopter une poche allost\u00e9rique absente chez la plupart des autres kinases.   <\/p>\n\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n\n\n<div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":false,\"element\":\"autre\",\"elementId\":\"\\u00e9l\\u00e9ment-collant-3\",\"action\":\"vue\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-aspect-ratio aspect-57x40 has-border-radius w-full\" style=\"border-top-left-radius:24px;border-top-right-radius:24px;border-bottom-left-radius:24px;border-bottom-right-radius:24px;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/model-quality-structural-utility-lsd1-300x176.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/model-quality-structural-utility-lsd1.webp 316w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"3D molecular visualization of LSD1 protein model showing spurious auto-inhibition with cyan peptide sequence, illustrating structural assessment for model quality and drug design utility.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMzE2IiBoZWlnaHQ9IjE4NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/model-quality-structural-utility-lsd1.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/model-quality-structural-utility-lsd1-300x176.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/model-quality-structural-utility-lsd1.webp 316w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n\n\n<p class=\"has-ivory-000-color has-text-color has-link-color wp-elements-ebf9d0bbd961539c1e16ceb8b1cdbaa3\" style=\"padding-top:var(--wp--preset--spacing--10)\"><strong>Mod\u00e8le de LSD1.<\/strong><\/p>\n\n\n\n<p class=\"has-ivory-000-color has-text-color has-link-color wp-elements-98f4c55149109a2e69d5326df840684a\">LSD1 avec auto-inhibition erron\u00e9e mise en \u00e9vidence par la s\u00e9quence peptidique en cyan.<\/p>\n\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n\n\n<div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":false,\"element\":\"autre\",\"elementId\":\"\\u00e9l\\u00e9ment-collant-4\",\"action\":\"vue\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-300x300.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-768x768.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-1024x1024.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery.webp 1401w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-1080x1080.webp 1080w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-360x360.webp 360w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-640x640.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"1401\" height=\"1401\" class=\"image-original \" alt=\"Diagram showing evaluation of initial protein structure models for drug discovery, including checks for conformational flexibility, SAR consistency, mutagenesis data alignment, and protein family conservation.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTQwMSIgaGVpZ2h0PSIxNDAxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-300x300.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-768x768.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-1024x1024.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery.webp 1401w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-1080x1080.webp 1080w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-360x360.webp 360w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-model-evaluation-drug-discovery-640x640.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full block sm:hidden md:hidden  sticky top-0 lg:relative lg:h-fixed md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-4 is-position-sticky\" style=\" --height-lg-fixed: 630px;  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"561\" height=\"588\" class=\"image-original \" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTYxIiBoZWlnaHQ9IjU4OCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-e84fdc4b wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2c75125d wp-block-group-is-layout-constrained\" style=\"margin-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style wp-elements-d54eb4eaa9e4db5e0d820cff3ba28df9\" style=\"color:#001024b3;padding-right:0;padding-left:0;font-style:normal;font-weight:600;letter-spacing:0.96px;--paragraph-dot-color:#005de5\">Centre de ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-292e3aecac1f775e2ab135efc50ecaec wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Recherches et ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data='postGrid({\"respondToFiltering\":true,\"singleFilterMode\":true,\"initialFilterSlug\":\"\"})' class=\"Post__Grid relative\" style=\"--post-grid-grid-cols: 3; --post-grid-row-gap: 1.5rem;\" data-single-filter-mode=\"false\" data-show-all-button=\"false\" data-initial-filter=\"\">\n                            \n\n        \n        \n            <div class=\"Post__Grid-grid   flex-col relative\" data-pegasus-filterable=\"block_3f2dc379b518b7d1bc6cd458b6404ec0\">\n                <div x-cloak x-show=\"isLoading\" class=\"absolute -top-3 -left-3 -right-3 -bottom-3 flex items-start justify-center pt-8 md:items-center md:pt-0 z-10 rounded-2xl overflow-visible transition duration-200 pointer-events-none bg-white\/80 backdrop-blur-sm\" style=\"background-color: rgb(255 255 255 \/ 80%);\">\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"50\" height=\"50\" viewbox=\"0 0 40 48\" role=\"img\" aria-label=\"Loading\" style=\"color:#005DE5\">\n                        <title>Loading\u2026<\/title>\n                        <g id=\"spinner\" fill=\"currentColor\">\n                            <path d=\"M19.6241 6.30823C21.3654 6.30823 22.7735 4.89753 22.7735 3.15412C22.7735 1.4107 21.3654 0 19.6241 0C17.8828 0 16.4746 1.4107 16.4746 3.15412C16.4746 4.89753 17.8872 6.30823 19.6241 6.30823Z\"><\/path>\n                            <path d=\"M19.629 47.5563C21.3703 47.5563 22.7784 46.1456 22.7784 44.4022C22.7784 42.6587 21.3703 41.248 19.629 41.248C17.8876 41.248 16.4795 42.6587 16.4795 44.4022C16.4795 46.1456 17.8876 47.5563 19.629 47.5563Z\"><\/path>\n                            <path d=\"M36.1016 14.5602C37.8385 14.5602 39.2511 13.1495 39.2511 11.4061C39.2511 9.66266 37.8385 8.25195 36.1016 8.25195C34.3647 8.25195 32.9521 9.66266 32.9521 11.4061C32.9521 13.1495 34.3603 14.5602 36.1016 14.5602Z\"><\/path>\n                            <path d=\"M3.14946 39.3043C4.88633 39.3043 6.29894 37.8936 6.29894 36.1502C6.29894 34.4068 4.88633 32.9961 3.14946 32.9961C1.41259 32.9961 0 34.4068 0 36.1502C0 37.8936 1.41259 39.3043 3.14946 39.3043Z\"><\/path>\n                            <path d=\"M19.6318 8.25195C20.3868 8.25197 21.1374 8.3047 21.8701 8.41113H21.8682C29.3743 9.49892 35.1348 15.967 35.1348 23.7783C35.1346 31.5902 29.3687 38.0576 21.8662 39.1445C21.7983 39.1346 21.7308 39.1211 21.6631 39.1104C21.7321 39.1213 21.8008 39.1354 21.8701 39.1455C21.1418 39.2519 20.3957 39.3047 19.6318 39.3047C11.0674 39.3047 4.12402 32.3534 4.12402 23.7783C4.12405 15.2032 11.0674 8.25195 19.6318 8.25195ZM19.623 12.6162C14.5414 12.6162 10.254 16.0262 8.91406 20.6855C8.91072 20.7021 8.90661 20.7188 8.90332 20.7354C8.62796 21.7023 8.48145 22.7182 8.48145 23.7783C8.48145 24.8386 8.63235 25.8591 8.90332 26.8262C8.9061 26.8402 8.90929 26.8541 8.91211 26.8682C10.2498 31.5309 14.539 34.9395 19.623 34.9395C25.7751 34.9393 30.7674 29.9399 30.7676 23.7783C30.7676 17.6166 25.7797 12.6164 19.623 12.6162Z\"><\/path>\n                            <animatetransform attributename=\"transform\" type=\"rotate\" from=\"0 19.6318 23.7783\" to=\"360 19.6318 23.7783\" dur=\"1s\" repeatcount=\"indefinite\"><\/animatetransform>\n                        <\/g>\n                        <g fill=\"currentColor\" opacity=\"1\">\n                            <path>\n                                <animate attributename=\"opacity\" values=\"1;0.4;1\" dur=\"1.2s\" begin=\"0s\" repeatcount=\"indefinite\"><\/animate>\n                            <\/path>\n                        <\/g>\n                    <\/svg>\n                <\/div>\n\n                                                \n                                                                                        <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-a-choisi-elsevier-comme-nouveau-partenaire-privilegie-pour-renforcer-son-equipe-mondiale-de-chimistes\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Sygnature Discovery a choisi Elsevier comme nouveau partenaire privil\u00e9gi\u00e9 pour renforcer son \u00e9quipe mondiale de chimistes.<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-300x225.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-480x360.png 480w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/png\"><img decoding=\"async\" loading=\"lazy\" width=\"480\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxOTIwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-scaled.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-300x225.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-480x360.png 480w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-a-choisi-elsevier-comme-nouveau-partenaire-privilegie-pour-renforcer-son-equipe-mondiale-de-chimistes\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Sygnature Discovery a choisi Elsevier comme nouveau partenaire privil\u00e9gi\u00e9 pour renforcer son \u00e9quipe mondiale de chimistes.<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSygnature Discovery a le plaisir d\u2019annoncer son nouveau partenariat avec Elsevier, soci\u00e9t\u00e9 mondiale d\u2019information et\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/synnature-discovery-et-daewoong-pharma-annoncent-une-collaboration-de-recherche\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Synnature Discovery et Daewoong Pharma annoncent une collaboration de recherche<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-300x183.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-592x360.jpg 592w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"592\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjAwIiBoZWlnaHQ9IjM2NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-300x183.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-592x360.jpg 592w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/synnature-discovery-et-daewoong-pharma-annoncent-une-collaboration-de-recherche\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Synnature Discovery et Daewoong Pharma annoncent une collaboration de recherche<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSygnature Discovery est heureuse d\u2019avoir conclu un accord de collaboration de recherche avec le groupe\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-deploie-la-technologie-dia-diktos-makya\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Sygnature Discovery d\u00e9ploie la technologie d\u2019IA d\u2019Iktos, \u00ab Makya\u2122 \u00bb.<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"540\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAwMCIgaGVpZ2h0PSI2NjciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-deploie-la-technologie-dia-diktos-makya\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Sygnature Discovery d\u00e9ploie la technologie d\u2019IA d\u2019Iktos, \u00ab Makya\u2122 \u00bb.<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tNous sommes ravis d\u2019annoncer que nous avons entam\u00e9 un accord de collaboration de 3 ans\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-se-renforce-grace-a-la-solution-logicielle-de-medchemica\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Sygnature se renforce gr\u00e2ce \u00e0 la solution logicielle de MedChemica.<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"540\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTIwMCIgaGVpZ2h0PSI4MDAiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-se-renforce-grace-a-la-solution-logicielle-de-medchemica\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Sygnature se renforce gr\u00e2ce \u00e0 la solution logicielle de MedChemica.<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tNous avons encore renforc\u00e9 notre offre en mati\u00e8re de d\u00e9couverte de m\u00e9dicaments \u2013 en acqu\u00e9rant\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/amelioration-des-services-de-conception-moleculaire-sygnature-discovery-adopte-la-plateforme-orion-dopeneye\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Am\u00e9lioration des services de conception mol\u00e9culaire\u00a0: Sygnature Discovery adopte la plateforme Orion\u2122 d\u2019OpenEye<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-300x167.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-640x356.png 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/png\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"356\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNDIzIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-scaled.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-300x167.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-640x356.png 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/amelioration-des-services-de-conception-moleculaire-sygnature-discovery-adopte-la-plateforme-orion-dopeneye\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Am\u00e9lioration des services de conception mol\u00e9culaire\u00a0: Sygnature Discovery adopte la plateforme Orion\u2122 d\u2019OpenEye<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSygnature acc\u00e9l\u00e8re le processus de d\u00e9couverte de m\u00e9dicaments de ses clients gr\u00e2ce \u00e0 une meilleure\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/pathios-therapeutics-et-sygnature-discovery-signent-un-partenariat-strategique\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Pathios Therapeutics et Sygnature Discovery signent un partenariat strat\u00e9gique<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP2883-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP2883-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"540\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTMzNiIgaGVpZ2h0PSI4OTEiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP2883.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP2883-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP2883-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/pathios-therapeutics-et-sygnature-discovery-signent-un-partenariat-strategique\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Pathios Therapeutics et Sygnature Discovery signent un partenariat strat\u00e9gique<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tPathios Therapeutics et Sygnature Discovery signent un partenariat strat\u00e9gique pour d\u00e9couvrir de nouveaux modulateurs du\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-5 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Capacit\u00e9s connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-c54fcc7cffe74703160b5151ccfd9bbc\" style=\"color:#001024b3\">Nous vous aidons \u00e0 concevoir des compos\u00e9s plus intelligents et \u00e0 prendre des d\u00e9cisions plus rapidement en combinant la mod\u00e9lisation bas\u00e9e sur l\u2019IA, une vaste expertise scientifique et un acc\u00e8s s\u00e9curis\u00e9 et collaboratif aux donn\u00e9es pour r\u00e9soudre des probl\u00e8mes complexes et acc\u00e9l\u00e9rer votre processus de d\u00e9couverte de m\u00e9dicaments.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein Structure Prediction\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-a8d3376898730941dacee6d3174ef9ff\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\" type=\"page\" id=\"4821\">Pr\u00e9diction de la structure des prot\u00e9ines<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-65a8460d368c8c8bb6d0cf5c14469527\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">L\u2019utilisation d\u2019une IA avanc\u00e9e et de techniques de mod\u00e9lisation \u00e9prouv\u00e9es permet de pr\u00e9dire avec pr\u00e9cision les structures prot\u00e9iques, acc\u00e9l\u00e9rant ainsi la conception de m\u00e9dicaments bas\u00e9e sur la structure et la d\u00e9couverte de nouvelles th\u00e9rapies.<br> possibilit\u00e9s.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Free Energy Methods\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-b74d5a24506c4be2f04af56c52f5cb95\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/free-energy-methods\/\" type=\"page\" id=\"4911\">M\u00e9thodes d\u2019\u00e9nergie libre<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-dd529cd9743ac96f6c685c129f30b65e\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Calcul de l\u2019\u00e9nergie libre de liaison relative par commutation hors \u00e9quilibre (NES) gr\u00e2ce \u00e0 la plateforme Orion\u00ae d\u2019OpenEye. Fournit des pr\u00e9dictions pr\u00e9cises d\u2019affinit\u00e9 de liaison pour vous aider \u00e0 classer les compos\u00e9s avec confiance et \u00e0 prioriser les d\u00e9cisions de synth\u00e8se pour les candidats les plus prometteurs d\u00e8s les premi\u00e8res \u00e9tapes de la d\u00e9couverte. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/free-energy-methods\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Molecular Dynamic Simulations\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Molecular-Dynamic-Simulations.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-d0afa7ade39bbf5f1d29363f5a74ba36\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/molecular-dynamic-simulations\/\" type=\"page\" id=\"4926\">Simulations de dynamique mol\u00e9culaire<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-4bffe5a25caea969e56e57dec1021b1f\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Utilisation de technologies de pointe et de logiciels propri\u00e9taires pour d\u00e9couvrir des interactions cach\u00e9es, pr\u00e9dire la stabilit\u00e9 des ligands et faire des choix de conception \u00e9clair\u00e9s qui acc\u00e9l\u00e8rent votre programme de d\u00e9couverte de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/molecular-dynamic-simulations\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group wp-container-content-69bc4bdf is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Generative AI and Machine Learning\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Generative-AI-and-Machine-Learning.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-1ffcc47d20b06b8b70c544b58e486108\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/generative-ai-and-machine-learning\/\" type=\"page\" id=\"1595\">Intelligence artificielle g\u00e9n\u00e9rative et apprentissage automatique<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-27699cdce9eb9a1cf05ad7a37c03d4a7\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">En combinant la conception pilot\u00e9e par l\u2019IA, des mod\u00e8les d\u2019apprentissage automatique sur mesure et la bioinformatique bas\u00e9e sur le LLM avec une collaboration pratique, nous vous aidons \u00e0 d\u00e9couvrir plus rapidement des candidats m\u00e9dicaments optimis\u00e9s.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/generative-ai-and-machine-learning\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Virtual Screening\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/virtual-screening.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-69ded10ca0c1c907c6588f1dd7d4e4be\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/virtual-screening\/\" data-type=\"page\" data-id=\"1632\">d\u00e9pistage virtuel<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e94f62ffd0345c3b225c03461225d211\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Identifier rapidement des compos\u00e9s prometteurs gr\u00e2ce au criblage virtuel \u00e0 grande \u00e9chelle, \u00e0 des biblioth\u00e8ques s\u00e9lectionn\u00e9es et \u00e0 un tri par des experts afin d\u2019acc\u00e9l\u00e9rer les programmes de d\u00e9couverte de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/virtual-screening\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Target Analysis\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Target-Analysis.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-7467028471d027402febeda209ef7bc4\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/target-analysis\/\" type=\"page\" id=\"1070\">Analyse des cibles<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-4195d6781b9bc548558787dfd80c1ec3\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Des sites de liaison \u00e0 la pharmacologie, nos \u00e9quipes de chimie computationnelle et de science des prot\u00e9ines vous aident \u00e0 trouver plus rapidement les bons points de d\u00e9part, en combinant une connaissance approfondie des structures avec des outils de pointe pour concevoir des compos\u00e9s qui font progresser votre projet en toute confiance.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/target-analysis\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Ligand Based Drug Discovery\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Ligand-Based-Drug-Discovery.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-5306d3520b5b3c8aa6708aab286d04a8\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/\" type=\"page\" id=\"1519\">Conception de m\u00e9dicaments bas\u00e9e sur les ligands<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e7276f6cdc6b4d50290c46b2e50330ac\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Exploiter les propri\u00e9t\u00e9s de mol\u00e9cules actives connues pour g\u00e9n\u00e9rer et optimiser rapidement de nouveaux compos\u00e9s gr\u00e2ce \u00e0 des connaissances bas\u00e9es sur les ligands, des outils aliment\u00e9s par l\u2019IA et une expertise collaborative afin de d\u00e9couvrir de nouveaux espaces chimiques et d\u2019acc\u00e9l\u00e9rer les d\u00e9couvertes.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/conception-de-medicaments-basee-sur-des-ligands\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Structure-Based Drug Design\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Structure-Based-Drug-Design.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-935cbd7616b9aa7bec1f6068f0efc491\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/structure-based-drug-design\/\">Conception de m\u00e9dicaments bas\u00e9e sur la structure<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e3c3fd7ce9b129aa16f8cb5cff3d29bc\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous vous aidons \u00e0 concevoir de meilleurs compos\u00e9s avec une plus grande confiance. Gr\u00e2ce \u00e0 des connaissances \u00e0 l\u2019\u00e9chelle quantique et \u00e0 des simulations dynamiques, nous pr\u00e9disons l\u2019affinit\u00e9, guidons l\u2019optimisation et vous aidons \u00e0 identifier plus rapidement les candidats les plus prometteurs. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/structure-based-drug-design\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group is-vertical is-content-justification-stretch is-layout-flex wp-container-core-group-is-layout-353c4f5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-eb5039d6 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-c9ee0c5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">FAQ<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a7849e3a wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Accordion relative w-full mx-auto \" style=\"\">\n            \n        <div>\n        <div class=\"acf-innerblocks-container\">\n<div x-data=\"accordionPanel(1, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-8c3e06fa3d36d380525b20f7ffc90655\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Pour quels types de classes cibles pouvez-vous pr\u00e9dire les structures ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-21f35d9c2d5955e0e2a77897f3fe6a5f\" style=\"color:#475467\">Nous appliquons la pr\u00e9diction et la conception de structures \u00e0 de multiples familles de prot\u00e9ines et domaines th\u00e9rapeutiques.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-21543afe02547fb184a57f790c150f85\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Comment d\u00e9termine-t-on qu\u2019un mod\u00e8le de prot\u00e9ine pr\u00e9dit est de qualit\u00e9 suffisante pour \u00eatre utile\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-2c7d86a8a7535455eff086382d3253ec\" style=\"color:#475467\">Nous \u00e9valuons les mod\u00e8les par rapport \u00e0 des homologues structurels et fonctionnels, \u00e0 leur coh\u00e9rence avec les donn\u00e9es SAR connues et au contexte physiologique, notamment le pH du compartiment cellulaire ou tissulaire, ainsi qu\u2019au r\u00f4le des cofacteurs et des ions m\u00e9talliques.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-54abf36da748918a9e9364abefad60c9\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">La pr\u00e9diction de la structure des prot\u00e9ines remplace-t-elle le besoin de m\u00e9thodes exp\u00e9rimentales d\u2019identification de la structure\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-effcdae3db64d4f322e96e7df4f200b4\" style=\"color:#475467\">Non. Les structures exp\u00e9rimentales demeurent essentielles pour la fiabilit\u00e9 et la pr\u00e9cision des r\u00e9sultats. Lorsque cela est possible, les donn\u00e9es \u00e0 haute r\u00e9solution associ\u00e9es aux compos\u00e9s candidats am\u00e9liorent consid\u00e9rablement l\u2019efficacit\u00e9 et les chances de succ\u00e8s des projets de d\u00e9couverte de m\u00e9dicaments.  <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n    \n            <\/section><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":9801,"parent":16400,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-5772","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sygnature<\/title>\n<meta name=\"description\" content=\"Pr\u00e9diction de la structure des prot\u00e9ines par l&#039;IA \u00e0 l&#039;aide d&#039;AlphaFold, d&#039;OmegaFold et de mod\u00e9lisation avanc\u00e9e pour acc\u00e9l\u00e9rer la conception de m\u00e9dicaments bas\u00e9e sur la structure.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:description\" content=\"Pr\u00e9diction de la structure des prot\u00e9ines par l&#039;IA \u00e0 l&#039;aide d&#039;AlphaFold, d&#039;OmegaFold et de mod\u00e9lisation avanc\u00e9e pour acc\u00e9l\u00e9rer la conception de m\u00e9dicaments bas\u00e9e sur la structure.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-05T14:20:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1641\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/\",\"name\":\"\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp\",\"datePublished\":\"2025-12-02T11:41:02+00:00\",\"dateModified\":\"2026-02-05T14:20:51+00:00\",\"description\":\"Pr\u00e9diction de la structure des prot\u00e9ines par l'IA \u00e0 l'aide d'AlphaFold, d'OmegaFold et de mod\u00e9lisation avanc\u00e9e pour acc\u00e9l\u00e9rer la conception de m\u00e9dicaments bas\u00e9e sur la structure.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp\",\"width\":2560,\"height\":1641,\"caption\":\"Illustration de la pr\u00e9diction de la structure des prot\u00e9ines et de la mod\u00e9lisation par homologie, repr\u00e9sentant des approches permettant de g\u00e9n\u00e9rer des informations structurelles fiables dans la d\u00e9couverte de m\u00e9dicaments.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/computer-aided-drug-design\\\/prediction-de-la-structure-des-proteines\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pr\u00e9diction de la structure des prot\u00e9ines\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Sygnature","description":"Pr\u00e9diction de la structure des prot\u00e9ines par l'IA \u00e0 l'aide d'AlphaFold, d'OmegaFold et de mod\u00e9lisation avanc\u00e9e pour acc\u00e9l\u00e9rer la conception de m\u00e9dicaments bas\u00e9e sur la structure.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/","og_locale":"fr_CA","og_type":"article","og_description":"Pr\u00e9diction de la structure des prot\u00e9ines par l'IA \u00e0 l'aide d'AlphaFold, d'OmegaFold et de mod\u00e9lisation avanc\u00e9e pour acc\u00e9l\u00e9rer la conception de m\u00e9dicaments bas\u00e9e sur la structure.","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/","og_site_name":"Sygnature","article_modified_time":"2026-02-05T14:20:51+00:00","og_image":[{"width":2560,"height":1641,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/","name":"","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp","datePublished":"2025-12-02T11:41:02+00:00","dateModified":"2026-02-05T14:20:51+00:00","description":"Pr\u00e9diction de la structure des prot\u00e9ines par l'IA \u00e0 l'aide d'AlphaFold, d'OmegaFold et de mod\u00e9lisation avanc\u00e9e pour acc\u00e9l\u00e9rer la conception de m\u00e9dicaments bas\u00e9e sur la structure.","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/sygnature-protein-structure-prediction-homology-modeling-scaled.webp","width":2560,"height":1641,"caption":"Illustration de la pr\u00e9diction de la structure des prot\u00e9ines et de la mod\u00e9lisation par homologie, repr\u00e9sentant des approches permettant de g\u00e9n\u00e9rer des informations structurelles fiables dans la d\u00e9couverte de m\u00e9dicaments."},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/prediction-de-la-structure-des-proteines\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"Pr\u00e9diction de la structure des prot\u00e9ines"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/pages\/5772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/comments?post=5772"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/pages\/5772\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/pages\/16400"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/9801"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=5772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}