{"id":5187,"date":"2025-11-20T13:43:23","date_gmt":"2025-11-20T13:43:23","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cristallographie-aux-rayons-x\/"},"modified":"2026-04-23T12:46:59","modified_gmt":"2026-04-23T12:46:59","slug":"cristallographie-aux-rayons-x","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cristallographie-aux-rayons-x\/","title":{"rendered":"Cristallographie aux rayons X"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/science-des-proteines-et-biologie-structurale\\\/cristallographie-aux-rayons-x\\\/\":\"Cristallographie aux rayons X\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/science-des-proteines-et-biologie-structurale\\\/cryo-em-a-particule-unique\\\/\":\"cryo-EM\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/science-des-proteines-et-biologie-structurale\\\/proteines-rmn\\\/\":\"RMN macromol\\u00e9culaire\"}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" false x-cloak style=\"\">\n    <div x-ref=\"fixedNav\" class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/biologie-structurale\/\" class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Biologie structurale<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cristallographie-aux-rayons-x\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cristallographie-aux-rayons-x\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cristallographie-aux-rayons-x\/' === window.location.href ? '-active' : ''\">\n                                            Cristallographie aux rayons X\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/' === window.location.href ? '-active' : ''\">\n                                            cryo-EM\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/proteines-rmn\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/proteines-rmn\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/proteines-rmn\/' === window.location.href ? '-active' : ''\">\n                                            RMN macromol\u00e9culaire\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                    <\/ul>\n                        \n                        <div x-ref=\"scrollIndicator\" class=\"scroll-indicator\" x-show=\"showScrollIndicator\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0 transform translate-x-full\" x-transition:enter-end=\"opacity-100 transform translate-x-0\">\n                            <svg class=\"chevron-icon w-4 h-4\" viewbox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\">\n                                <path d=\"M5.65306 3.53025L10.6531 8.53025C10.7227 8.60018 10.7775 8.68297 10.8154 8.77414C10.8533 8.8653 10.8735 8.96304 10.8735 9.06175C10.8735 9.16046 10.8533 9.2582 10.8154 9.34936C10.7775 9.44053 10.7227 9.52332 10.6531 9.59325L5.65306 14.5932C5.51217 14.7341 5.32107 14.8133 5.12181 14.8133C4.92255 14.8133 4.73145 14.7341 4.59056 14.5932C4.44966 14.4523 4.37051 14.2612 4.37051 14.062C4.37051 13.8627 4.44966 13.6716 4.59056 13.5307L9.06294 9.06175L4.59056 4.59325C4.44966 4.45236 4.37051 4.26126 4.37051 4.062C4.37051 3.86274 4.44966 3.67164 4.59056 3.53075C4.73145 3.38985 4.92255 3.3107 5.12181 3.3107C5.32107 3.3107 5.51217 3.38985 5.65306 3.53075V3.53025Z\" fill=\"currentColor\"><\/path>\n                            <\/svg>\n                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n\n            <!-- Mobile menu button -->\n            <button x-ref=\"navMenuButton\" type=\"button\" class=\"flex justify-center items-center py-2 whitespace-nowrap pl-5 pr-2.5 ml-auto md:hidden\" aria-label=\"Show more navigation items\" :aria-expanded=\"mobileSubMenuOpen\">\n                <span class=\"sr-only pr-2 inline-block\">More<\/span>\n\n                <svg class=\"transition duration-500 ease-in-out\" :class=\"mobileSubMenuOpen ? 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'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Cristallographie aux rayons X\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        cryo-EM\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/proteines-rmn\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/proteines-rmn\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/proteines-rmn\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        RMN macromol\u00e9culaire\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-542701842e2e9e9a72ea6715b50fcfb3\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">Solutions scientifiques | Science des prot\u00e9ines et biologie structurale<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-b89d910cdb0ccb4b34f2a855c48b7dcf\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Cristallographie aux rayons X<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-8b1503c95aa4084d6f627a41153ddc29\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">Chez Sygnature Discovery, nous vous aidons \u00e0 acc\u00e9der \u00e0 des informations structurales essentielles pour faire progresser la d\u00e9couverte de m\u00e9dicaments. Nos services de cristallographie aux rayons X fournissent des structures prot\u00e9iques et des complexes prot\u00e9ine-ligand pr\u00e9cis, couvrant toutes les \u00e9tapes, de la recherche fondamentale \u00e0 la g\u00e9n\u00e9ration de compos\u00e9s candidats \u00e0 partir de fragments (FBLG). Chaque projet est con\u00e7u sur mesure pour r\u00e9pondre \u00e0 vos objectifs, alliant technologies de pointe et expertise acquise au fil des d\u00e9cennies.  <\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" style=\"padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d6b9ab57 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Mod\u00e8les structuraux D de biomol\u00e9cules, repr\u00e9sentant les techniques de biologie structurale pour la conception de m\u00e9dicaments, la cartographie des \u00e9pitopes et le criblage de fragments\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-aa44ba95d7be2dff44c637536503b178\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">soutenir vos recherches<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group children-fill-width is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">La cristallographie est rarement lin\u00e9aire\u00a0; c\u2019est un processus it\u00e9ratif. Chaque \u00e9tape peut r\u00e9v\u00e9ler de nouvelles donn\u00e9es qui orientent la suivante. Par exemple, un test d\u2019expression peut mettre en \u00e9vidence un produit de d\u00e9gradation, nous incitant \u00e0 rechercher une r\u00e9gion plus stable et cristallisable de la prot\u00e9ine cible.  <\/h2>\n\n\n\n<p>Dans ce cas, nous confirmons les limites du domaine et r\u00e9organisons le g\u00e8ne afin d\u2019optimiser les r\u00e9sultats. Pour garantir l\u2019efficacit\u00e9 et la transparence des projets, nous les d\u00e9composons en \u00e9tapes claires, assorties de points de d\u00e9cision d\u2019arr\u00eat ou de poursuite. <\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\"><\/p>\n\n\n\n<div style=\"margin-top:var(--wp--preset--spacing--60)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-aspect-ratio aspect-59x35 has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-640x360.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Graphic illustrating the iterative process of protein crystallography with Stop\/Go decision points, showing sequential stages from expression testing to crystallization and structural optimization.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallography-iterative-process-640x360.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard   stacking-content -sticky-heading -two-columns is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" id=\"sticky-scroll-progress\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-cbe57604 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-global-padding is-layout-constrained wp-block-column-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--100)\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--80)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Progress Progress--left Progress--scroll absolute z-[1000]\" style=\"--progress-thickness: 1px; --progress-color: var(--wp--preset--color--dark-blue-600); --progress-background: rgba(0, 50, 82, 0.2);\" x-data=\"progress()\" x-init='init({\"position\":\"left\",\"eventType\":\"scroll\",\"scrollOptions\":{\"scroll_target\":\"m\\u00e8re\",\"container_selector\":\"\"},\"tickerOptions\":[],\"formOptions\":[],\"anchorPoints\":{\"align_points\":true,\"points\":[{\"element_id\":\"\\u00e9l\\u00e9ment-collant-1\",\"label\":\"\"},{\"element_id\":\"\\u00e9l\\u00e9ment-collant-2\",\"label\":\"\"},{\"element_id\":\"\\u00e9l\\u00e9ment-collant-3\",\"label\":\"\"}]},\"showEndDot\":true,\"containerScrollOffset\":0.2,\"progressThreshold\":0.005})' x-cloak data-position=\"left\" data-event-type=\"scroll\">\n    <div class=\"Progress__track bg-[var(--progress-background,rgba(0,124,186,0.2))] relative overflow-visible\" x-ref=\"track\">\n        <div class=\"Progress__fill transition-all duration-100 ease-out bg-[var(--progress-color,#0053CC)]\" x-ref=\"fill\"><\/div>\n            <\/div>\n<\/div>\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d2c5c54a wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div id=\"sticky-item-1\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Conception de constructions prot\u00e9iques<\/h2>\n\n\n\n<p>Nous choisissons des s\u00e9quences de g\u00e8nes optimale pour donner \u00e0 votre prot\u00e9ine les meilleures chances de succ\u00e8s d\u00e8s le d\u00e9part :<\/p>\n\n\n\n<p>\u2022 La bioinformatique et la mod\u00e9lisation guident chaque d\u00e9cision<\/p>\n\n\n\n<p>\u2022 Les ajouts de s\u00e9quence d\u2019affinit\u00e9 simplifient l\u2019expression et la purification tout en respectant aux besoins des applications en aval.<\/p>\n\n\n\n<p>\u2022 Chim\u00e8res, mutations, troncations, d\u00e9l\u00e9tions selectionn\u00e9s selon les besoins de votre projet.<\/p>\n\n\n\n<p>\u2022 Le logiciel IMPROvER am\u00e9liore la stabilit\u00e9 des prot\u00e9ines membranaires.<br><\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-2\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-3ae50e87 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--70);padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Cristallisation<\/h2>\n\n\n\n<p>Nous combinons pr\u00e9cision et automatisation pour offrir un processus efficace et maximiser le succ\u00e8s de la cristallisation\u00a0:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>D\u00e9pistage initial avec des criblages multi factoriels commerciaux et internes<\/li>\n\n\n\n<li>Exploration par thermostabilit\u00e9 des tampons, du pH, des additifs, des substrats, des cofacteurs et des ions.<\/li>\n\n\n\n<li>Co-cristallisation avec des compos\u00e9s-outils si n\u00e9cessaire<\/li>\n\n\n\n<li>Options de criblage de fragments disponibles<\/li>\n\n\n\n<li>Cristallisation et imagerie automatis\u00e9es utilisant\u00a0:\n<ul class=\"wp-block-list\">\n<li>Robot de pipetage pour l\u2019optimisation des conditions initiales<\/li>\n\n\n\n<li>Pipetage \u00e0 tr\u00e8s faible volume par Mosquito pour minimiser l\u2019utilisation de prot\u00e9ines<\/li>\n\n\n\n<li>H\u00f4tel Formulatrix Rock Imager 1000 plaques<\/li>\n\n\n\n<li>Analyse des donn\u00e9es de Rockmaker<\/li>\n\n\n\n<li>CrystalShifter pour une r\u00e9colte de cristaux efficace<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div id=\"sticky-item-3\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-3ae50e87 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--70);padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Collecte de donn\u00e9es par rayons X<\/h2>\n\n\n\n<p>Nous g\u00e9n\u00e9rons des donn\u00e9es de haute qualit\u00e9 dans des installations synchrotron de pointe.<\/p>\n\n\n\n<p>\u2022 Acc\u00e8s \u00e0 des sources lumineuses de troisi\u00e8me g\u00e9n\u00e9ration telles que Diamond, ESRF, Soleil, ALS, CLS et SLS.<\/p>\n\n\n\n<p>\u2022 Des cr\u00e9neaux horaires r\u00e9serv\u00e9s pour la collecte de donn\u00e9es, selon des \u00e9ch\u00e9anciers pr\u00e9visibles.<\/p>\n\n\n\n<p>\u2022 Acc\u00e8s aux lignes de synchrotron avec horaires flexibles pour un traitement acc\u00e9l\u00e9r\u00e9 en cas de besoin.<\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-4\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-3ae50e87 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--70);padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">D\u00e9termination de la structure<\/h2>\n\n\n\n<p>Notre \u00e9quipe applique des m\u00e9thodes \u00e9prouv\u00e9es pour fournir des structures informatives pr\u00e9cises:<\/p>\n\n\n\n<p>\u2022 Remplacement mol\u00e9culaire ou phasage de novo utilisant Se-Met ou SAD\/MAD<\/p>\n\n\n\n<p>\u2022 Plusieurs cycles de d\u2019affinement pour une pr\u00e9cision et une fiabilit\u00e9 accrues<\/p>\n<\/div>\n\n\n<section class=\"Pegasus__Container w-full hidden sm:block  relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100)\"><section class=\"Pegasus__Container w-full hidden sm:block  sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"  padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":true,\"element\":\"other\",\"elementId\":\"sticky-item-1\",\"action\":\"inview\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1707\" class=\"image-original \" alt=\"Dispositif de laboratoire illustrant le processus de cristallographie aux rayons X pour la d\u00e9termination des structures prot\u00e9iques \u00e0 haute r\u00e9solution.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-crystallography-protein-structure-analysis-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n\n\n<div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":false,\"element\":\"other\",\"elementId\":\"sticky-item-2\",\"action\":\"inview\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"2560\" height=\"1707\" class=\"image-original \" alt=\"Laboratory setup with automated crystallization equipment used for high-throughput screening and optimization of protein crystalsLaboratory setup with automated crystallization equipment used for high-throughput screening and optimization of protein crystals\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-crystallization-automation-high-throughput-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n\n\n<div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":false,\"element\":\"other\",\"elementId\":\"sticky-item-3\",\"action\":\"inview\"})' styles=\";\">\n\t        \n    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640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTcwNyIgaGVpZ2h0PSIyNTYwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-data-collection-scaled.webp\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-data-collection-200x300.webp 200w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-data-collection-768x1152.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-data-collection-683x1024.webp 683w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-data-collection-1024x1536.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/x-ray-data-collection-720x1080.webp 720w, 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1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTYxIiBoZWlnaHQ9IjU4OCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-bottom:var(--wp--preset--spacing--90); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<h2 class=\"wp-block-heading has-text-align-center has-text-color has-link-color has-text-4-xl-font-size wp-elements-d8121ef306d2eba3e2088058443bb83b wp-container-content-1d651e7a\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--50)\">\u00c9coutez l\u2019un de nos experts<\/h2>\n\n\n\n<div class=\"TestimonialCard TestimonialCard--fifty_fifty has-border-radius has-padding-top has-padding-bottom has-padding-right has-padding-left\" style=\"color:var(--wp--preset--color--white);background-color:var(--wp--preset--color--dark-blue-700);border-radius:var(--wp--preset--spacing--30);padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--70);padding-right:clamp(3rem, 13vw, 15rem);padding-left:clamp(3rem, 13vw, 15rem);\">\n\n            <div class=\"TestimonialCard__fifty-fifty grid grid-cols-1 lg:grid-cols-12 gap-6 items-center\">\n            <div class=\"testimonial-content flex flex-col justify-between h-full lg:col-span-7 \">\n                                    <blockquote class=\"TestimonialCard__quote relative mb-8\">\n                        <div class=\"relative z-10 has-text-3-xl-font-size leading-tight\"><p><em>Our talented crystallography team brings decades of experience in solving X-ray crystal structures over a wide range of different protein classes. Our proven expertise ranges from de-novo protein structure determination of challenging targets to delivering rapid turnaround protein-ligand complexes as well as managing X-ray based FBLG projects.<\/em><\/p>\n<\/div>\n                    <\/blockquote>\n                                \n                <div class=\"testimonial-avatar\">\n                    <figure class=\"Avatar flex items-center text-left group md:min-w-64 -small \" style=\"\" itemscope itemtype=\"https:\/\/schema.org\/Person\">\n        <div class=\"Avatar__Image w-16 h-16 rounded-full overflow-hidden mr-6 flex-shrink-0\">\n        <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-150x150.webp 150w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"150\" height=\"150\" class=\"w-full object-cover\" alt=\"Profile picture of Derek Ogg\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" itemprop=\"image\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjUwIiBoZWlnaHQ9IjY1MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-150x150.webp 150w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n    <\/div>\n        <figcaption class=\"Avatar__Content\">\n        <h4 class=\"mb-1 font-medium\" itemprop=\"name\">Derek Ogg<\/h4>\n                    <p class=\"opacity-80 !mb-0\" itemprop=\"jobTitle\">Chief Scientific Officer and Protein Crystallographer<\/p>\n            <\/figcaption>\n<\/figure>\n\n                <\/div>\n            <\/div>\n            \n                            <div class=\"TestimonialCard__image lg:col-span-5 aspect-square rounded-lg overflow-hidden p-4 \">\n                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-300x300.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD.webp 650w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-360x360.webp 360w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-640x640.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"650\" height=\"650\" class=\"w-full h-full object-cover rounded-lg\" alt=\"Featured image for testimonial by Derek Ogg\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjUwIiBoZWlnaHQ9IjY1MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-300x300.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD.webp 650w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-360x360.webp 360w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Derek-Ogg-PhD-640x640.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n                <\/div>\n                    <\/div>\n    <\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   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ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-f4f353d6f3d0ad312919a94ff2812b8b wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data='postGrid({\"respondToFiltering\":true,\"singleFilterMode\":true,\"initialFilterSlug\":\"\"})' class=\"Post__Grid relative\" style=\"--post-grid-grid-cols: 3; --post-grid-row-gap: 1.5rem;\" data-single-filter-mode=\"false\" data-show-all-button=\"false\" data-initial-filter=\"\">\n                            \n\n                    <div class=\"featured-post-spacer min-h-32\">\n                <div x-show=\"!hasActiveFilters\" x-transition:enter=\"transition ease-out duration-300\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-300\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n                    <section class=\"w-full\" style=\"padding-top: var(--wp--preset--spacing--60); padding-bottom: var(--wp--preset--spacing--80);\">\n    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/generating-a-tl1a-crystal-structure\/\" class=\"block group \">\n        <div class=\"FeaturedPost flex flex-col-reverse md:flex-row items-stretch gap-6 rounded-3xl\">\n            <div class=\"flex-1 flex flex-col gap-4 justify-center md:pr-10 md:py-12\">\n                <h2 class=\"wp-block-heading has-text-4-xl-font-size text-dark-blue-700\">\n                    Generating a TL1A Crystal Structure\n                <\/h2>\n                \n                <div class=\"text-[#001024B2] has-text-base-font-size max-w-prose\">\n                                                                \nAt Sygnature Discovery, we thrive on solving complex protein challenges\u2014and our recent success in solving\u2026                                    <\/div>\n                \n                <div class=\"wp-block-buttons is-layout-flex items-center pt-4 md:pt-16\">\n                    <div class=\"wp-block-button btn-primary\">\n                        <span class=\"wp-block-button__link wp-element-button pointer-events-none\">Read more<\/span>\n                    <\/div>\n                <\/div>\n            <\/div>\n            \n            <div class=\"md:w-1\/2 xl:w-2\/3 w-full rounded-2xl overflow-hidden relative\">\n                                                        <div class=\"w-full h-0 pb-[56%] rounded-3xl relative overflow-hidden\">\n                        <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Sygnature-TL1A-Structure-400x359-1-300x269.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Sygnature-TL1A-Structure-400x359-1.webp 400w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"400\" height=\"359\" class=\"absolute inset-0 w-full h-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out\" alt=\"Sygnature TL1A [C95S\/C135S] Structure\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNDAwIiBoZWlnaHQ9IjM1OSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" 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                                                                                       <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/a-comparison-of-the-structural-techniques-used-at-sygnature-discovery-x-ray-crystallography-nmr-and-cryo-em\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1-300x173.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1.webp 600w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"600\" height=\"345\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjAwIiBoZWlnaHQ9IjM0NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1-300x173.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1.webp 600w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/a-comparison-of-the-structural-techniques-used-at-sygnature-discovery-x-ray-crystallography-nmr-and-cryo-em\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tIn this article we discuss the three techniques used for determining protein and nucleic acid\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-5 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e17f75369917380307a8227af22f62bc\" style=\"color:#001024b3\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d\u2019experts chevronn\u00e9s de l\u2019industrie pharmaceutique du monde entier, garantissant l\u2019excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein &amp; Structure\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-5191219c2e3f32f7b49742142e92c0b0\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\">Prot\u00e9ines et structure<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-6d0ad0b56328052437b8544c1326311a\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Page d\u2019accueil du d\u00e9partement de prot\u00e9omique et de biologie structurale. Nous prenons le temps de comprendre votre objectif et les finalit\u00e9s de votre projet afin d\u2019adapter notre approche en cons\u00e9quence. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/fragment-based-drug-discovery-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/fragment-based-drug-discovery.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Fragment Based Drug Discovery\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/fragment-based-drug-discovery.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/fragment-based-drug-discovery-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/fragment-based-drug-discovery.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-99b6f80a5f7af2ab139dc1172af467a3\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/decouverte-integree-de-medicaments\/decouverte-de-medicaments-basee-sur-des-fragments\/\">D\u00e9couverte de m\u00e9dicaments bas\u00e9e sur les fragments<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-d8149800839fd3c27860718e32ef77e1\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Des points de d\u00e9part de haute qualit\u00e9 aux pistes optimis\u00e9es, nous combinons le criblage de fragments, la biologie structurale, la chimie computationnelle et la chimie m\u00e9dicinale pour faire progresser votre programme.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/decouverte-integree-de-medicaments\/decouverte-de-medicaments-basee-sur-des-fragments\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Cryo-EM-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Cryo-EM.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Cryo-EM\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Cryo-EM.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Cryo-EM-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Cryo-EM.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-fd5b7790148b0a1865a9991891eca4d1\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/\">Cryo-EM<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-695b8cfcf3b09b449c61ba13ab72431b\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous proposons non seulement un service complet allant du g\u00e8ne \u00e0 la structure cryo-EM, mais nous accompagnons \u00e9galement votre projet gr\u00e2ce \u00e0 notre expertise et \u00e0 nos connaissances, selon une approche par \u00e9tapes cl\u00e9s.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/cryo-em-a-particule-unique\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-NMR-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-NMR.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein NMR\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-NMR.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-NMR-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-NMR.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-1595e0e0eebc2cf7f39b2d88cda53508\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/protein-science-and-structural-biology\/protein-nmr\/\">RMN des prot\u00e9ines<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-7a7f64cbe6b5f767502c22ffd34d03a6\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous proposons divers services de RMN, notamment la caract\u00e9risation des prot\u00e9ines et la liaison des ligands en solution, la d\u00e9couverte de m\u00e9dicaments bas\u00e9e sur des fragments et la d\u00e9termination de la structure des g\u00e8nes par RMN.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/protein-science-and-structural-biology\/protein-nmr\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":8003,"parent":4386,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-5187","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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