{"id":4380,"date":"2025-11-11T12:21:44","date_gmt":"2025-11-11T12:21:44","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/sel-et-co-cristal\/"},"modified":"2026-02-13T12:59:21","modified_gmt":"2026-02-13T12:59:21","slug":"sel-et-co-cristal","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/","title":{"rendered":"D\u00e9pistage des sels et des cocristaux"},"content":{"rendered":"\n<div x-data='subNav({&quot;anchor_map&quot;:{&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/form-formulation\\\/early-clinical-formulation\\\/&quot;:&quot;Formulation clinique pr\\u00e9coce&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/analyse-de-la-forme-solide\\\/&quot;:&quot;Analyse de la forme solide&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/sel-et-co-cristal\\\/&quot;:&quot;D\\u00e9pistage des sels et des cocristaux&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/criblage-de-polymorphie\\\/&quot;:&quot;Criblage polymorphe&quot;,&quot;https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/formulation-preclinique\\\/&quot;:&quot;Formulation pr\\u00e9clinique&quot;}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" @click.away=\"mobileSubMenuOpen = false\" x-cloak style=\"\">\n    <div x-ref=\"fixedNav\"\n        class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/\" \n                                                                class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Forme et formulation<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/form-formulation\/early-clinical-formulation\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/form-formulation\/early-clinical-formulation\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/form-formulation\/early-clinical-formulation\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            Formulation clinique pr\u00e9coce\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/analyse-de-la-forme-solide\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/analyse-de-la-forme-solide\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/analyse-de-la-forme-solide\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            Analyse de la forme solide\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            D\u00e9pistage des sels et des cocristaux\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/criblage-de-polymorphie\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/criblage-de-polymorphie\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/criblage-de-polymorphie\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            Criblage polymorphe\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a\n                                            href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/formulation-preclinique\/\"\n                                            class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \"\n                                            :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/formulation-preclinique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/formulation-preclinique\/' === window.location.href ? '-active' : ''\"\n                                        >\n                                            Formulation pr\u00e9clinique\n                                        <\/a>\n                                    <\/div>\n                                <\/li>\n                                                    <\/ul>\n                        \n                        <div x-ref=\"scrollIndicator\" class=\"scroll-indicator\" \n                            x-show=\"showScrollIndicator\"\n                            x-transition:enter=\"transition ease-out duration-500\"\n                            x-transition:enter-start=\"opacity-0 transform translate-x-full\"\n                            x-transition:enter-end=\"opacity-100 transform translate-x-0\">\n                            <svg @click=\"scrollNavRight()\" class=\"chevron-icon w-4 h-4\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\">\n                                <path d=\"M5.65306 3.53025L10.6531 8.53025C10.7227 8.60018 10.7775 8.68297 10.8154 8.77414C10.8533 8.8653 10.8735 8.96304 10.8735 9.06175C10.8735 9.16046 10.8533 9.2582 10.8154 9.34936C10.7775 9.44053 10.7227 9.52332 10.6531 9.59325L5.65306 14.5932C5.51217 14.7341 5.32107 14.8133 5.12181 14.8133C4.92255 14.8133 4.73145 14.7341 4.59056 14.5932C4.44966 14.4523 4.37051 14.2612 4.37051 14.062C4.37051 13.8627 4.44966 13.6716 4.59056 13.5307L9.06294 9.06175L4.59056 4.59325C4.44966 4.45236 4.37051 4.26126 4.37051 4.062C4.37051 3.86274 4.44966 3.67164 4.59056 3.53075C4.73145 3.38985 4.92255 3.3107 5.12181 3.3107C5.32107 3.3107 5.51217 3.38985 5.65306 3.53075V3.53025Z\" fill=\"currentColor\"\/>\n                            <\/svg>\n                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n\n            <!-- Mobile menu button -->\n            <button\n                x-ref=\"navMenuButton\"\n                type=\"button\"\n                @click=\"mobileSubMenuOpen = !mobileSubMenuOpen;\"\n                class=\"flex justify-center items-center py-2 whitespace-nowrap pl-5 pr-2.5 ml-auto md:hidden\"\n                aria-label=\"Show more navigation items\"\n                :aria-expanded=\"mobileSubMenuOpen\"\n            >\n                <span class=\"sr-only pr-2 inline-block\">More<\/span>\n\n                <svg class=\"transition duration-500 ease-in-out\" :class=\"mobileSubMenuOpen ? 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'bg-blue-50 text-blue-700 font-medium' : ''\"\n                                        @click=\"mobileSubMenuOpen = false\"\n                                                                            >\n                                        Formulation clinique pr\u00e9coce\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a\n                                        href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/analyse-de-la-forme-solide\/\"\n                                        class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \"\n                                        :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/analyse-de-la-forme-solide\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/analyse-de-la-forme-solide\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\"\n                                        @click=\"mobileSubMenuOpen = false\"\n                                                                            >\n                                        Analyse de la forme solide\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a\n                                        href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/\"\n                                        class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \"\n                                        :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\"\n                                        @click=\"mobileSubMenuOpen = false\"\n                                                                            >\n                                        D\u00e9pistage des sels et des cocristaux\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a\n                                        href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/criblage-de-polymorphie\/\"\n                                        class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \"\n                                        :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/criblage-de-polymorphie\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/criblage-de-polymorphie\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\"\n                                        @click=\"mobileSubMenuOpen = false\"\n                                                                            >\n                                        Criblage polymorphe\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a\n                                        href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/formulation-preclinique\/\"\n                                        class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \"\n                                        :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/formulation-preclinique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/formulation-preclinique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\"\n                                        @click=\"mobileSubMenuOpen = false\"\n                                                                            >\n                                        Formulation pr\u00e9clinique\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\" >Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-8001f5d0dd205dfb337bcf8f975703a1\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">Solutions scientifiques | Forme et formulation<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-1af9c4357bc90a48f98478683c07825c\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Criblage de sels et de co-cristaux<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-c4aab227d4d7110ec6b25caa432b8121\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">De la d\u00e9couverte pr\u00e9coce \u00e0 la pr\u00e9paration clinique, nous vous accompagnons dans le choix de la forme solide qui optimise les performances, cr\u00e9e de la propri\u00e9t\u00e9 intellectuelle et facilite un d\u00e9veloppement sans faille.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" 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alt=\"Laboratory workstation displaying formulation development data on a computer screen, illustrating scalable design for successful clinical development.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-scaled.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-300x214.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-768x547.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-1024x729.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-1536x1094.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-1516x1080.webp 1516w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-505x360.webp 505w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/formulation-development-solid-state-analysis-drug-design-640x456.webp 640w\"><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-084c6aec43f61d19de55fe083338bbac\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">SOUTENIR VOS RECHERCHES<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">Nous adaptons chaque criblage aux besoins sp\u00e9cifiques de votre mol\u00e9cule, en tenant compte de la voie d&rsquo;administration, de la dose et du profil physico-chimique, puis nous appliquons des techniques et analyses avanc\u00e9es pour confirmer la g\u00e9n\u00e9ration de la forme et les performances.<\/h2>\n\n\n\n<p style=\"padding-bottom:var(--wp--preset--spacing--20)\">La s\u00e9lection du sel et du co-cristal appropri\u00e9s am\u00e9liore les propri\u00e9t\u00e9s du principe actif, notamment sa solubilit\u00e9, sa stabilit\u00e9 et sa cristallinit\u00e9, tout en renfor\u00e7ant la valeur strat\u00e9gique de votre propri\u00e9t\u00e9 intellectuelle.<\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">Nos services de criblage de sels et de co-cristaux sont con\u00e7us pour optimiser des propri\u00e9t\u00e9s physico-chimiques cl\u00e9s telles que la dissolution, la stabilit\u00e9 thermique et la cristallinit\u00e9. Ces modifications am\u00e9liorent non seulement les performances, mais constituent \u00e9galement un moyen efficace de consolider votre propri\u00e9t\u00e9 intellectuelle.<\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">Bien que la formation de sels soit souvent privil\u00e9gi\u00e9e pour la protection de la propri\u00e9t\u00e9 intellectuelle, la nature cristalline des sels n&rsquo;est pas toujours garantie. L&rsquo;identification et la confirmation de sels cristallins peuvent accro\u00eetre significativement la valeur de votre programme en alliant performance et brevetabilit\u00e9.<\/p>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\"\n         style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property.webp 800w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-640x480.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"600\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"Structures cristallines allong\u00e9es et color\u00e9es sous lumi\u00e8re polaris\u00e9e, repr\u00e9sentant le criblage de sels et de co-cristaux pour am\u00e9liorer la solubilit\u00e9, la puret\u00e9 et la stabilit\u00e9.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property.webp 800w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property-640x480.webp 640w\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-light mobile-stacking-standard   stacking-content -sticky-heading -two-columns is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100); \" id=\"sticky-scroll-progress\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-dark-blue-700-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-cbe57604 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-global-padding is-layout-constrained wp-block-column-is-layout-constrained\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--80);margin-bottom:var(--wp--preset--spacing--80);padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div\n    class=\"Progress Progress--left Progress--scroll absolute z-[1000]\"\n    style=\"--progress-thickness: 1px; --progress-color: var(--wp--preset--color--ivory-300); --progress-background: rgba(249, 242, 232, 0.2);\"            x-data=\"progress()\"\n        x-init=\"init({&quot;position&quot;:&quot;left&quot;,&quot;eventType&quot;:&quot;scroll&quot;,&quot;scrollOptions&quot;:{&quot;scroll_target&quot;:&quot;m\\u00e8re&quot;,&quot;container_selector&quot;:&quot;&quot;},&quot;tickerOptions&quot;:[],&quot;formOptions&quot;:[],&quot;anchorPoints&quot;:{&quot;align_points&quot;:true,&quot;points&quot;:[{&quot;element_id&quot;:&quot;\\u00e9l\\u00e9ment-collant-1&quot;,&quot;label&quot;:&quot;&quot;},{&quot;element_id&quot;:&quot;\\u00e9l\\u00e9ment-collant-2&quot;,&quot;label&quot;:&quot;&quot;},{&quot;element_id&quot;:&quot;\\u00e9l\\u00e9ment-collant-3&quot;,&quot;label&quot;:&quot;&quot;}]},&quot;showEndDot&quot;:true,&quot;containerScrollOffset&quot;:0.2,&quot;progressThreshold&quot;:0.005})\"\n        x-cloak\n        data-position=\"left\"\n    data-event-type=\"scroll\"\n>\n    <div\n        class=\"Progress__track bg-[var(--progress-background,rgba(0,124,186,0.2))] relative overflow-visible\" x-ref=\"track\">\n        <div\n            class=\"Progress__fill transition-all duration-100 ease-out bg-[var(--progress-color,#0053CC)]\"  x-ref=\"fill\"        ><\/div>\n            <\/div>\n<\/div>\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-57067efd wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div id=\"sticky-item-1\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-6752e3ba wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Conception d&rsquo;un criblage<\/h2>\n\n\n\n<p>Nous adaptons chaque criblage aux caract\u00e9ristiques, \u00e0 la voie d&rsquo;administration et \u00e0 la dose de votre mol\u00e9cule. Nous validons ensuite les performances \u00e0 l&rsquo;aide d&rsquo;analyses appropri\u00e9es afin de vous permettre de prendre des d\u00e9cisions \u00e9clair\u00e9es.<\/p>\n\n\n\n<p><br><strong>Donn\u00e9es d&rsquo;entr\u00e9e<\/strong><\/p>\n\n\n\n<p>Nous commen\u00e7ons par une compr\u00e9hension approfondie de votre mol\u00e9cule&nbsp;:<\/p>\n\n\n\n<p>\u2022 pKa et comportement d&rsquo;ionisation<\/p>\n\n\n\n<p>\u2022 Voie d&rsquo;administration pr\u00e9vue<\/p>\n\n\n\n<p>\u2022 Dose attendue\/exposition cible<\/p>\n\n\n\n<p>\u2022 Contraintes de solubilit\u00e9 et de stabilit\u00e9<\/p>\n\n\n\n<p>\u2022 Exigences quant \u00e0 la facilit\u00e9 de fabrication.<\/p>\n\n\n\n<p><br><strong>Criblage<\/strong><\/p>\n\n\n\n<p>Notre processus de criblage comprend&nbsp;:<\/p>\n\n\n\n<p>\u2022 S\u00e9lection des contre-ions et co-formateurs adapt\u00e9s \u00e0 la phase<\/p>\n\n\n\n<p>\u2022 Essais de cristallisation et isolement<\/p>\n\n\n\n<p>\u2022 Confirmation orthogonale par XRPD, DSC, TGA, DVS et PLM<\/p>\n\n\n\n<p>\u2022 V\u00e9rification de la formation de sels et de la st\u0153chiom\u00e9trie par RMN multi-noyaux et FT-IR<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><br><strong>R\u00e9sultats et livrables<\/strong><\/p>\n\n\n\n<p>Vous recevrez :<\/p>\n\n\n\n<p>\u2022 Solubilit\u00e9 dans les milieux pertinents<\/p>\n\n\n\n<p>\u2022 Profils de dissolution obtenus avec Pion \u03bcDISS ou \u03bcFLUX, le cas \u00e9ch\u00e9ant<\/p>\n\n\n\n<p>\u2022 Donn\u00e9es de stabilit\u00e9 dans les conditions ICH (25\u00b0C\/60% HR et 40\u00b0C\/75% HR)<\/p>\n\n\n\n<p>\u2022 Recommandations hi\u00e9rarchis\u00e9es avec des pistes claires pour la formulation et la strat\u00e9gie de propri\u00e9t\u00e9 intellectuelle<\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-2\" class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-ecffb728 wp-block-group-is-layout-constrained\" style=\"padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Propri\u00e9t\u00e9s modifiables<\/h2>\n\n\n\n<p>Le criblage de sels et de co-cristaux peut vous aider \u00e0&nbsp;:<\/p>\n\n\n\n<p>\u2022 Convertir une substance m\u00e9dicamenteuse amorphe en un sel cristallin<\/p>\n\n\n\n<p>\u2022 Am\u00e9liorer la stabilit\u00e9 thermique par la formation de sels ioniques<\/p>\n\n\n\n<p>\u2022 Modifier l\u2019hygroscopicit\u00e9 pour contr\u00f4ler l\u2019absorption d\u2019humidit\u00e9<\/p>\n\n\n\n<p>\u2022 Am\u00e9liorer la solubilit\u00e9, souvent un crit\u00e8re d\u00e9terminant dans le choix du sel<\/p>\n\n\n\n<p>\u2022 Ajuster la taille et la morphologie des cristaux pour faciliter leur isolement et leur s\u00e9chage.<\/p>\n\n\n\n<p>\u2022 Explorez de nouveaux paysages polymorphes distincts de l&rsquo;API libre<\/p>\n\n\n\n<p>\u2022 Am\u00e9liorer les propri\u00e9t\u00e9s m\u00e9caniques pour le broyage, l&rsquo;\u00e9coulement, la compressibilit\u00e9 et la densit\u00e9<\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-3\" class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-2004cc39 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Pourquoi choisir Sygnature Discovery pour votre accompagnement en criblage de sels et de co-cristaux&nbsp;?<\/h2>\n\n\n\n<p>Le choix de la forme solide est une \u00e9tape cruciale du d\u00e9veloppement de m\u00e9dicaments. Notre approche allie rigueur scientifique, flexibilit\u00e9 et collaboration pour garantir l\u2019optimisation de votre mol\u00e9cule en termes de performance, de facilit\u00e9 de fabrication et de conformit\u00e9 r\u00e9glementaire.<br><\/p>\n\n\n\n<p>Voici ce qui nous distingue :<\/p>\n\n\n\n<p>\u2022 <strong>Expertise int\u00e9gr\u00e9e :<\/strong> Notre \u00e9quipe multidisciplinaire r\u00e9unit une expertise approfondie en chimie de l\u2019\u00e9tat solide, en analyse thermique et en formulation.<\/p>\n\n\n\n<p>\u2022 <strong>Strat\u00e9gies de criblage personnalis\u00e9es&nbsp;:<\/strong> Nous concevons des protocoles sur mesure \u00e0 partir d\u2019une vaste biblioth\u00e8que de contre-ions et de co-formateurs pharmaceutiquement acceptables, adapt\u00e9s au profil physico-chimique, \u00e0 la voie d\u2019administration et \u00e0 la dose de votre mol\u00e9cule.<\/p>\n\n\n\n<p>\u2022 <strong>Capacit\u00e9s de caract\u00e9risation avanc\u00e9es&nbsp;:<\/strong> Nous utilisons la diffraction des rayons X sur poudre (XRPD), l\u2019analyse thermique, la microscopie et la spectroscopie pour g\u00e9n\u00e9rer des donn\u00e9es compl\u00e8tes permettant une prise de d\u00e9cision \u00e9clair\u00e9e.<\/p>\n\n\n\n<p>\u2022 <strong>Accompagnement de bout en bout&nbsp;:<\/strong> Que vous soyez en phase de d\u00e9couverte pr\u00e9coce ou en pr\u00e9paration du d\u00e9veloppement clinique, nos services s\u2019int\u00e8grent parfaitement \u00e0 votre strat\u00e9gie de d\u00e9veloppement globale.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><section class=\"Pegasus__Container w-full hidden sm:block  sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"  padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20); \" >\n\t        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x-data=\"PegasusMediaBlock\" \n         class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\"\n         style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening.webp 800w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-640x480.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"800\" height=\"600\" class=\"image-original \" alt=\"Laboratory instruments including an orange and gray analytical system on a benchtop, representing solid form screening and crystallization analysis using XRPD, DSC, and related techniques.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening.webp 800w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-dsc-screening-640x480.webp 640w\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n\n\n<div class=\"Reveal \" x-data=\"reveal({&quot;initiallyVisible&quot;:false,&quot;element&quot;:&quot;autre&quot;,&quot;elementId&quot;:&quot;\\u00e9l\\u00e9ment-collant-2&quot;,&quot;action&quot;:&quot;vue&quot;})\" styles=\";\">\n\t        \n    \t\t<div x-show=\"show\"\n\t\t\tx-transition:enter=\"transition ease-out duration-500\"\n\t\t\tx-transition:enter-start=\"opacity-0\"\n\t\t\tx-transition:enter-end=\"opacity-100\"\n\t\t\tx-transition:leave=\"transition ease-in duration-500 absolute inset-0\"\n\t\t\tx-transition:leave-start=\"opacity-100\"\n\t\t\tx-transition:leave-end=\"opacity-0\"\n\t\t\tx-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\"\n         style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-1024x768.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures.webp 1280w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-640x480.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"1280\" height=\"960\" class=\"image-original \" alt=\"Colorful elongated crystal structures viewed under polarized light, illustrating salt and co-crystal screening to enhance solubility, stability, and intellectual property strategy.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-1024x768.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures.webp 1280w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-crystal-structures-640x480.webp 640w\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full block sm:hidden md:hidden  sticky top-0 lg:relative lg:h-fixed md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-4 is-position-sticky\" style=\" --height-lg-fixed: 630px;  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"561\" height=\"588\" class=\"image-original \" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTYxIiBoZWlnaHQ9IjU4OCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100); \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        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class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-f18c0ecd912fb133fad7f43b5a9b568b wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Actualit\u00e9s r\u00e9centes et ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data=\"postGrid({&quot;respondToFiltering&quot;:true,&quot;singleFilterMode&quot;:true,&quot;initialFilterSlug&quot;:&quot;post&quot;})\"  class=\"Post__Grid relative\" style=\"--post-grid-grid-cols: 3; --post-grid-row-gap: 1.5rem;\" data-single-filter-mode=\"false\" data-show-all-button=\"false\" data-initial-filter=\"post\">\n                                <div class=\"Post__Grid-filters-wrapper relative flex flex-col-reverse overflow-auto filter-between pt-4 pb-8 has-body-font-family gap-8 sm:gap-4 md:gap-0\">\n\t<div class=\"Post__Grid-filters relative inline-flex \">\n\t\t<div class=\"p-1 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'bg-white text-black pointer-events-none' : 'bg-transparent text-black'\">\n\t\t\t\t\t\t<span>Nouvelles<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t\t\t\t\t<button type=\"button\" \n\t\t\t\t\t\t\t@click=\"toggleFilters('blog,webinar-and-podcast,technical-note,protocol,journal-paper,e-book,poster,case-study', 'post_type', 'post_type'); isLoading = true;\" \n\t\t\t\t\t\t\tclass=\"w-auto px-6 h-9 font-normal font-body leading-none rounded-full whitespace-nowrap transition-colors ease-in-out\"\n\t\t\t\t\t\t\t:class=\"filterIsActive('blog,webinar-and-podcast,technical-note,protocol,journal-paper,e-book,poster,case-study', 'post_type', 'post_type') ? 'bg-white text-black pointer-events-none' : 'bg-transparent text-black'\">\n\t\t\t\t\t\t<span>Ressources<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n                \n\n        \n        \n            <div class=\"Post__Grid-grid   flex-col relative\" data-pegasus-filterable=\"block_c5706f562f87e1456d99f54b3b658900\">\n                <div x-cloak x-show=\"isLoading\" class=\"absolute -top-3 -left-3 -right-3 -bottom-3 flex items-start justify-center pt-8 md:items-center md:pt-0 z-10 rounded-2xl overflow-visible transition duration-200 pointer-events-none bg-white\/80 backdrop-blur-sm\" style=\"background-color: rgb(255 255 255 \/ 80%);\">\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n                         width=\"50\" height=\"50\" viewBox=\"0 0 40 48\"\n                         role=\"img\" aria-label=\"Loading\" style=\"color:#005DE5\">\n                        <title>Loading\u2026<\/title>\n                        <g 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                                             from=\"0 19.6318 23.7783\"\n                                              to=\"360 19.6318 23.7783\"\n                                              dur=\"1s\"\n                                              repeatCount=\"indefinite\"\/>\n                        <\/g>\n                        <g fill=\"currentColor\" opacity=\"1\">\n                            <path>\n                                <animate attributeName=\"opacity\" values=\"1;0.4;1\" dur=\"1.2s\" begin=\"0s\" repeatCount=\"indefinite\"\/>\n                            <\/path>\n                        <\/g>\n                    <\/svg>\n                <\/div>\n\n                                                \n                                                                                        <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/hit-synergy-direct-to-biology-drug-discovery\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Integrating Hit Finding and Direct-to-Biology to Shorten Time to Development Candidate<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Through-Hit-Synergy-and-Beyond-Integrating-Hit-Finding-and-Direct-to-Biology-300x212.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Through-Hit-Synergy-and-Beyond-Integrating-Hit-Finding-and-Direct-to-Biology-509x360.webp 509w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"509\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"Feature image showing a scientific poster on integrating hit finding and direct\u2011to\u2011biology approaches to accelerate drug discovery, with screening workflows, assay data and structural validation.\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAyNCIgaGVpZ2h0PSI3MjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Through-Hit-Synergy-and-Beyond-Integrating-Hit-Finding-and-Direct-to-Biology.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Through-Hit-Synergy-and-Beyond-Integrating-Hit-Finding-and-Direct-to-Biology-300x212.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Through-Hit-Synergy-and-Beyond-Integrating-Hit-Finding-and-Direct-to-Biology-509x360.webp 509w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/hit-synergy-direct-to-biology-drug-discovery\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Integrating Hit Finding and Direct-to-Biology to Shorten Time to Development Candidate<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tHelicases have been implicated in the progression of microsatellite instability-high (MSI-H) tumours and therefore represent&hellip;\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tPosters\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/why-early-process-chemistry-matters\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Why Early Process Chemistry Matters?<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Why-early-process-chemistry-matters-300x212.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Why-early-process-chemistry-matters-509x360.webp 509w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"509\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"Feature image showing a scientific poster explaining why early process chemistry matters, highlighting route optimisation, scale\u2011up strategies and flow chemistry examples.\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAyNCIgaGVpZ2h0PSI3MjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Why-early-process-chemistry-matters.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Why-early-process-chemistry-matters-300x212.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Why-early-process-chemistry-matters-509x360.webp 509w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/why-early-process-chemistry-matters\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Why Early Process Chemistry Matters?<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tBuild Scalable Chemistry from Day One With Early Process Chemistry Early-stage medicinal chemistry is designed&hellip;\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tPosters\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">LRRK2 Degrader Discovery: A High-Throughput Direct-to-Biology Screening Platform<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform-300x212.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform-509x360.webp 509w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"509\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"Feature image showing a scientific poster on a direct\u2011to\u2011biology screening platform for LRRK2 degrader discovery, including workflow diagrams, assay data and degradation results.\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAyNCIgaGVpZ2h0PSI3MjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform-300x212.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/High-Throughput-Direct-to-Biology-LRRK2-Degrader-Platform-509x360.webp 509w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/lrrk2-degrader-discovery-a-high-throughput-direct-to-biology-screening-platform\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">LRRK2 Degrader Discovery: A High-Throughput Direct-to-Biology Screening Platform<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tAccelerating CNS Drug Discovery with a Direct-to-Biology Platform Parkinson\u2019s Disease&hellip;\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tPosters\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/crbn-fragment-screening-protac-discovery\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">A Structural Platform for Molecular Glues and PROTAC Discovery<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/04\/A-Structural-Platform-for-Molecular-Glues-PROTACs-Discovery-212x300.webp 212w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/04\/A-Structural-Platform-for-Molecular-Glues-PROTACs-Discovery-255x360.webp 255w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"255\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"Poster titled \u2018A Structural Platform for Molecular Glues &#038; PROTACs Discovery\u2019 showing CRBN midi\u2013based SPR fragment screening data and crystallographic validation of ligand binding.\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNzI0IiBoZWlnaHQ9IjEwMjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/04\/A-Structural-Platform-for-Molecular-Glues-PROTACs-Discovery.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/04\/A-Structural-Platform-for-Molecular-Glues-PROTACs-Discovery-212x300.webp 212w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/04\/A-Structural-Platform-for-Molecular-Glues-PROTACs-Discovery-255x360.webp 255w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/poster\/crbn-fragment-screening-protac-discovery\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">A Structural Platform for Molecular Glues and PROTAC Discovery<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSPR Fragment Screening &#038; Crystallography Hit Validation with CRBNmidi\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tPosters\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/more-papain-more-problems\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">More Papain, More Problems<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/case-study-thumbnail-1-300x178.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/case-study-thumbnail-1-608x360.webp 608w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"608\" height=\"360\" class=\"w-full object-cover absolute-center !h-full\" alt=\"Sygnature Drug Discovery - Case Study\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjQzMiIgaGVpZ2h0PSIxNDQwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/case-study-thumbnail-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/case-study-thumbnail-1-300x178.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/case-study-thumbnail-1-608x360.webp 608w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/more-papain-more-problems\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">More Papain, More Problems<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tThe Challenge Clients sometimes as us to generate Fab and Fc pools from a full-length&hellip;\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tCase Studies\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/recombinant-%ce%b2-catenin-ctnnb1-expression-and-purification-provides-an-early-handle-for-therapeutic-targeting-of-the-wnt-signalling-pathway\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Recombinant \u03b2-catenin (CTNNB1) expression and purification provides an early handle for therapeutic targeting of the Wnt signalling pathway<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/2z6h-300x203.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/2z6h-531x360.webp 531w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"531\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAwMCIgaGVpZ2h0PSI2NzgiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/2z6h.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/2z6h-300x203.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/2z6h-531x360.webp 531w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/recombinant-%ce%b2-catenin-ctnnb1-expression-and-purification-provides-an-early-handle-for-therapeutic-targeting-of-the-wnt-signalling-pathway\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Recombinant \u03b2-catenin (CTNNB1) expression and purification provides an early handle for therapeutic targeting of the Wnt signalling pathway<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\t\u03b2-catenin (CTNNB1) is a multifunctional protein that plays a pivotal role in the canonical Wnt&hellip;\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tCase Studies\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group is-vertical is-content-justification-stretch is-layout-flex wp-container-core-group-is-layout-353c4f5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-eb5039d6 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-c9ee0c5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">FAQ<\/h2>\n\n\n\n<p class=\"has-text-align-center has-text-color has-link-color has-text-base-font-size wp-elements-b3178ea9452aecb4c2ff0bfb9e98ea35\" style=\"color:#001024b3\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a7849e3a wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Accordion relative w-full mx-auto \"\n         style=\"\">\n            \n        <div>\n        <div class=\"acf-innerblocks-container\">\n<div x-data=\"accordionPanel(1, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-0381cc730dbf6466117722525e57b38d\"\n     :class=\"panelOpen ? 'Accordion__Panel--open' : ''\"\n     style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" \n                class=\"w-full flex justify-start group relative items-center\" \n                style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"\/>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"\/>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\"\n                    :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Pourquoi envisager les sels ou les co-cristaux lors du d\u00e9veloppement d&rsquo;un m\u00e9dicament\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-8734e3f7522bcb7c7104d0ca61e95284\" style=\"color:#475467\">Les sels et les co-cristaux peuvent am\u00e9liorer significativement la solubilit\u00e9, la stabilit\u00e9, la biodisponibilit\u00e9 et la facilit\u00e9 de fabrication d&rsquo;un compos\u00e9; des facteurs cl\u00e9s pour une formulation r\u00e9ussie et le d\u00e9veloppement clinique.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-a700a917dd883feb96c9627c1f016b2f\"\n     :class=\"panelOpen ? 'Accordion__Panel--open' : ''\"\n     style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" \n                class=\"w-full flex justify-start group relative items-center\" \n                style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"\/>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"\/>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\"\n                    :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">\u00c0 quel stade faut-il r\u00e9aliser un criblage de sels ou de co-cristaux\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-983f2ac9b3215d6106f5c329add12ded\" style=\"color:#475467\">Id\u00e9alement lors de l&rsquo;optimisation de la mol\u00e9cule t\u00eate de s\u00e9rie ou au d\u00e9but du d\u00e9veloppement pr\u00e9clinique, mais cela peut \u00e9galement s&rsquo;av\u00e9rer utile ult\u00e9rieurement en cas de probl\u00e8mes de solubilit\u00e9 ou de stabilit\u00e9.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-f5493ec5a2dac04a818f7404e2c9d18e\"\n     :class=\"panelOpen ? 'Accordion__Panel--open' : ''\"\n     style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" \n                class=\"w-full flex justify-start group relative items-center\" \n                style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"\/>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"\/>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\"\n                    :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quelles informations dois-je fournir pour initier un projet de criblage\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-1aee30d1d65e55cb18e5606337893324\" style=\"color:#475467\">Nous avons g\u00e9n\u00e9ralement besoin de la structure chimique, des donn\u00e9es physico-chimiques (par exemple, la solubilit\u00e9, le pKa) et de toute difficult\u00e9 connue de formulation ou de stabilit\u00e9. Nous vous accompagnerons pour le reste.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-dd8ddc475d2e9ca3d123786caa3b54ae\"\n     :class=\"panelOpen ? 'Accordion__Panel--open' : ''\"\n     style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" \n                class=\"w-full flex justify-start group relative items-center\" \n                style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"\/>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"\/>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\"\n                    :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Comment s\u00e9lectionner les contre-ions ou les co-formateurs pour le criblage ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-0dac386f0e07c402cb0104a237113cf1\" style=\"color:#475467\">Nous utilisons un processus de s\u00e9lection rationnel bas\u00e9 sur l&rsquo;acceptabilit\u00e9 r\u00e9glementaire, la compl\u00e9mentarit\u00e9 mol\u00e9culaire, la voie d&rsquo;administration et les propri\u00e9t\u00e9s physico-chimiques.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-27aafe81bd9655d7f17add57180146e1\"\n     :class=\"panelOpen ? 'Accordion__Panel--open' : ''\"\n     style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" \n                class=\"w-full flex justify-start group relative items-center\" \n                style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"\/>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"\/>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\"\n                    :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quelles techniques analytiques sont utilis\u00e9es pour caract\u00e9riser les sels et les co-cristaux ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-ef1ad5783824889499b53fe0df5b5a17\" style=\"color:#475467\">Nous utilisons notamment la diffraction des rayons X sur poudre (XRPD), la calorim\u00e9trie diff\u00e9rentielle \u00e0 balayage (DSC), l&rsquo;analyse thermogravim\u00e9trique (TGA), la microscopie, la spectroscopie infrarouge (FTIR) et la r\u00e9sonance magn\u00e9tique nucl\u00e9aire (NMR), ainsi que la chromatographie liquide \u00e0 haute performance (HPLC), pour confirmer l&rsquo;identit\u00e9, la puret\u00e9 et les propri\u00e9t\u00e9s \u00e0 l&rsquo;\u00e9tat solide.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-d7ef4bb088c819cd2a22ab191664cf2d\"\n     :class=\"panelOpen ? 'Accordion__Panel--open' : ''\"\n     style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" \n                class=\"w-full flex justify-start group relative items-center\" \n                style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"\/>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"\/>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\"\n                    :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Pouvez-vous nous aider \u00e0 \u00e9valuer les performances <em>in vivo<\/em> de certaines formes ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-6f885056d6c3cc79e14f5e35f628f048\" style=\"color:#475467\">Oui. Nous proposons des \u00e9tudes pharmacocin\u00e9tiques in vivo et des \u00e9valuations de biodisponibilit\u00e9 pour faciliter la s\u00e9lection des candidats et les d\u00e9cisions relatives \u00e0 la formulation.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\"\n     class=\"Accordion__Panel mb-2 wp-elements-12e2367da9423458026d4f9df9d66efa\"\n     :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Si je remplace la base libre par un sel pour les essais cliniques, une \u00e9tude de transition est-elle n\u00e9cessaire\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-0c2266202a5a490c7564d88a42d91a7e\" style=\"color:#475467\">C&rsquo;est possible. Une \u00e9tude de transition peut \u00eatre requise si la forme saline modifie la pharmacocin\u00e9tique ou le profil de s\u00e9curit\u00e9. Nous pouvons vous accompagner dans l&rsquo;\u00e9valuation de ces aspects gr\u00e2ce \u00e0 des analyses DMPK et une mod\u00e9lisation PBPK.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n    \n            <\/section><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-13 is-position-sticky\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e17f75369917380307a8227af22f62bc\" style=\"color:#001024b3\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d&rsquo;experts chevronn\u00e9s de l&rsquo;industrie pharmaceutique du monde entier, garantissant l&rsquo;excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"DMPK\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-20a9d1f97dec8154f34e9ef075da94b8\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">DMPK<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-580ddb750647abb5e91988335168eaf9\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Des solutions DMPK int\u00e9gr\u00e9es combinant des analyses avanc\u00e9es, la mod\u00e9lisation et la bioanalyse, fournissant des informations pr\u00e9dictives qui r\u00e9duisent les risques et guident la s\u00e9lection des candidats.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media full-width w-full\"\n         style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"in vivo Pharmacology\" loading=\"lazy\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/in-vivo-Pharmacology.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-95cb6840b5cc45da381f55b6b4c9fa98\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/pharmacologie-in-vivo\/\">Pharmacologie <em>in vivo<\/em><\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e7ea388b7a5e7a088a42b5217fefa086\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les mod\u00e8les <em>in vivo<\/em> valid\u00e9s fournissent des donn\u00e9es cliniquement pertinentes dans tous les domaines th\u00e9rapeutiques, acc\u00e9l\u00e9rant la prise de d\u00e9cisions \u00e9clair\u00e9es et r\u00e9duisant les risques li\u00e9s au d\u00e9veloppement de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/pharmacologie-in-vivo\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":9527,"parent":4389,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-4380","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Criblage de sels et de cocristaux chez Sygnature Discovery<\/title>\n<meta name=\"description\" content=\"Explorez le criblage de sels et de cocristaux dans les produits pharmaceutiques pour am\u00e9liorer la valeur de la propri\u00e9t\u00e9 intellectuelle et modifier les propri\u00e9t\u00e9s des m\u00e9dicaments \u00e0 l&#039;aide de techniques \u00e9prouv\u00e9es \u00e0 l&#039;\u00e9tat solide.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Criblage de sels et de cocristaux chez Sygnature Discovery\" \/>\n<meta property=\"og:description\" content=\"Explorez le criblage de sels et de cocristaux dans les produits pharmaceutiques pour am\u00e9liorer la valeur de la propri\u00e9t\u00e9 intellectuelle et modifier les propri\u00e9t\u00e9s des m\u00e9dicaments \u00e0 l&#039;aide de techniques \u00e9prouv\u00e9es \u00e0 l&#039;\u00e9tat solide.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/forme-et-formulation\/sel-et-co-cristal\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T12:59:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/salt-co-crystal-screening-solubility-stability-intellectual-property.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"13 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/sel-et-co-cristal\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/forme-et-formulation\\\/sel-et-co-cristal\\\/\",\"name\":\"Criblage de sels et de cocristaux chez Sygnature 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