{"id":4368,"date":"2025-11-18T13:56:20","date_gmt":"2025-11-18T13:56:20","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/conception-de-medicaments-basee-sur-des-ligands\/"},"modified":"2026-02-16T09:13:31","modified_gmt":"2026-02-16T09:13:31","slug":"conception-de-medicaments-basee-sur-des-ligands","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/conception-de-medicaments-basee-sur-des-ligands\/","title":{"rendered":"Conception de m\u00e9dicaments bas\u00e9e sur les ligands"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/bioinformatique\\\/\":\"Bioinformatique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/analyse-de-la-cible\\\/\":\"Analyse des cibles\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/depistage-virtuel\\\/\":\"d\\u00e9pistage virtuel\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/conception-de-medicaments-basee-sur-la-structure\\\/\":\"Conception de m\\u00e9dicaments bas\\u00e9e sur la structure  \",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/ia-generative-et-apprentissage-automatique\\\/\":\"Intelligence artificielle g\\u00e9n\\u00e9rative et apprentissage automatique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/conception-de-medicaments-basee-sur-des-ligands\\\/\":\"Conception de m\\u00e9dicaments bas\\u00e9e sur les ligands\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/conception-de-la-bibliotheque\\\/\":\"Conception de biblioth\\u00e8que\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/predictions-admet\\\/\":\"Pr\\u00e9diction ADMET\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/informatique\\\/\":\"Informatique\"}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" false x-cloak style=\"\">\n    <div x-ref=\"fixedNav\" class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/\" class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Conception de m\u00e9dicaments assist\u00e9e par ordinateur<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' === window.location.href ? 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'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Conception de biblioth\u00e8que\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Pr\u00e9diction ADMET\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Informatique\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-94a1c4cd32d981f6d2509bb7c853ff28\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">solutions scientifiques | CAAD<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-82ac316a20a682479246d2a2b75a6bc8\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Conception de m\u00e9dicaments bas\u00e9e sur les ligands<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-1a73a9d8b12b6d6d868606133771e74b\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">L\u2019exploitation des propri\u00e9t\u00e9s de mol\u00e9cules actives connues permet de g\u00e9n\u00e9rer et d\u2019optimiser rapidement de nouveaux compos\u00e9s. Lorsque les donn\u00e9es structurales sont limit\u00e9es, une conception plus intelligente des compos\u00e9s est possible gr\u00e2ce \u00e0 l\u2019analyse des ligands, aux outils d\u2019intelligence artificielle et \u00e0 l\u2019expertise collaborative. Cette approche ouvre de nouveaux horizons chimiques et acc\u00e9l\u00e8re la d\u00e9couverte, tandis qu\u2019une int\u00e9gration fluide avec les \u00e9quipes de chimie m\u00e9dicinale permet aux programmes de recherche de m\u00e9dicaments d\u2019\u00eatre men\u00e9s jusqu\u2019aux essais cliniques.  <\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" style=\"padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d6b9ab57 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Visualisation de la structure mol\u00e9culaire 3D utilis\u00e9e dans la conception de m\u00e9dicaments assist\u00e9e par ordinateur, repr\u00e9sentant les approches bas\u00e9es sur la structure et sur les ligands pour la mod\u00e9lisation pr\u00e9dictive dans la d\u00e9couverte de m\u00e9dicaments.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-aa44ba95d7be2dff44c637536503b178\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">soutenir vos recherches<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">Les capacit\u00e9s de conception de m\u00e9dicaments \u00e0 base de ligands (LBDD) de Sygnature Discovery offrent une alternative puissante lorsque les structures prot\u00e9iques ne sont pas disponibles.  <\/h2>\n\n\n\n<p style=\"padding-bottom:var(--wp--preset--spacing--20)\">Nos chimistes computationnels utilisent des informations d\u00e9riv\u00e9es des ligands, telles que les caract\u00e9ristiques du pharmacophore, la forme et l\u2019\u00e9lectrostatique, pour guider la conception et l\u2019optimisation des compos\u00e9s tout au long du processus de d\u00e9couverte.<\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">L\u2019expertise est combin\u00e9e \u00e0 des outils de pointe, tels que l\u2019IA g\u00e9n\u00e9rative, l\u2019analyse de paires mol\u00e9culaires appari\u00e9es et la mod\u00e9lisation pr\u00e9dictive, afin d\u2019explorer de nouvelles structures, d\u2019am\u00e9liorer les propri\u00e9t\u00e9s ADME et de prioriser les id\u00e9es les plus prometteuses. Une collaboration \u00e9troite avec les \u00e9quipes de chimie m\u00e9dicinale garantit que chaque d\u00e9cision de conception repose sur des donn\u00e9es probantes et est align\u00e9e sur les objectifs du programme. <\/p>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-300x181.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-768x464.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-1024x618.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-1536x928.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-596x360.webp 596w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-640x386.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1767\" height=\"1067\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"Mod\u00e8le mol\u00e9culaire color\u00e9 illustrant une approche de conception de m\u00e9dicaments bas\u00e9e sur les ligands, montrant les caract\u00e9ristiques du pharmacophore et les interactions \u00e9lectrostatiques utilis\u00e9es pour l'optimisation du compos\u00e9.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-300x181.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-768x464.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-1024x618.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-1536x928.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-596x360.webp 596w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ligand-based-drug-design-computation-chemistry-640x386.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Nos Solutions de conception de m\u00e9dicaments bas\u00e9e sur les ligands<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-f13030f3475bffc115301432641826d6\" style=\"color:#001024b3\">D\u00e9couvrez une conception de m\u00e9dicaments rationnelle gr\u00e2ce \u00e0 nos solutions bas\u00e9es sur les ligands et aliment\u00e9es par l\u2019IA pour g\u00e9n\u00e9rer de nouveaux compos\u00e9s, optimiser les profils ADME et acc\u00e9l\u00e9rer le cycle DMTA.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-000-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-300x140.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-768x358.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-1024x477.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-1536x715.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-640x298.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"illustration of scaffold hopping and fragment replacement strategies for generating novel compounds in ligand-based drug design.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-300x140.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-768x358.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-1024x477.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-1536x715.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/scaffold-hopping-fragment-replacement-tools-640x298.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-3f08e91c98a20baaa67bf0bd368cf42d\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Outils de remodelage de structure et remplacement de fragments<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-2a1cdae73e554d8ebb72a8556f0e79a0\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les techniques de remodelage de structure et de remplacement d\u2019isost\u00e8res permettent de g\u00e9n\u00e9rer de nouvelles propri\u00e9t\u00e9s intellectuelles, d\u2019explorer des s\u00e9ries secondaires ou de r\u00e9pondre aux exigences ADME. Gr\u00e2ce \u00e0 l\u2019acc\u00e8s \u00e0 l\u2019outil BROOD d\u2019OpenEye et \u00e0 ses bases de donn\u00e9es propri\u00e9taires, nous pouvons analyser rapidement plus de 50 millions de remplacements 3D afin d\u2019identifier des alternatives viables dans les meilleurs d\u00e9lais.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery.webp 1344w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-640x427.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Illustration num\u00e9rique de deux mains formant une connexion \u00e0 travers un r\u00e9seau de n\u0153uds lumineux, symbolisant l'intelligence artificielle dans les flux de travail informatiques de d\u00e9couverte de m\u00e9dicaments.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery.webp\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery.webp 1344w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/ai-tools-utilization-drug-discovery-640x427.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-b95e2952f108c2af13caf113be5367b3\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">LBDD propuls\u00e9 par l\u2019IA<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-50fdafa4454933a1bfbd476ddf610523\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">La plateforme d\u2019IA g\u00e9n\u00e9rative d\u2019Iktos Makya permet d\u2019explorer l\u2019espace chimique afin de g\u00e9n\u00e9rer de nouvelles id\u00e9es de structures 2D et 3D \u00e0 partir de petites mol\u00e9cules. Associ\u00e9e \u00e0 des mod\u00e8les QSAR, cette approche favorise l\u2019am\u00e9lioration de la liason, le d\u00e9veloppement de nouvelles propri\u00e9t\u00e9s intellectuelles et l\u2019optimisation ADMET. Les outils d\u2019analyse de paires mol\u00e9culaires appari\u00e9es (MMPA) de MedChemica contribuent \u00e0 affiner les concepts de conception et \u00e0 prioriser les compos\u00e9s au sein du cycle DMTA.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-300x160.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-768x411.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-1024x548.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-1536x821.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-640x342.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"screenshot of QSAR models and matched molecular pair analysis tools used for predictive compound optimization.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU1NiIgaGVpZ2h0PSIxMzY3IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-300x160.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-768x411.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-1024x548.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-1536x821.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/qsar-models-molecular-pair-analysis-640x342.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-7dfc98bd3271db707467ab6bbc50e2d3\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Mod\u00e8les QSAR locaux, mod\u00e8les de Free-Wilson, analyse de paires mol\u00e9culaires appari\u00e9es<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-2a58cbb920c163248401293c30185df0\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les mod\u00e8les QSAR 2D et 3D, les analyses de Free-Wilson et les protocoles d\u2019apprentissage automatique sont utilis\u00e9s pour pr\u00e9dire la puissance et les propri\u00e9t\u00e9s ADMET de nouveaux compos\u00e9s. Ces outils facilitent l\u2019optimisation multi-objectifs et orientent la s\u00e9lection des compos\u00e9s. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-300x145.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-768x371.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-1024x495.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-1536x742.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-640x309.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"graph and molecular visualization showing confirmational analysis and quantum mechanics geometry optimization for compound design.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTY4MyIgaGVpZ2h0PSI4MTMiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-300x145.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-768x371.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-1024x495.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-1536x742.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/conformation-analysis-qm-geometry-optimization-640x309.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-222fb7a0abe60233f478ebcc12099639\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Analyse conformationnelle et optimisation g\u00e9om\u00e9trique QM<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-3dd7fc5be6f360a5e14f042caeb58333\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">L\u2019analyse et la restriction de la conformation des ligands, y compris l\u2019analyse FreeForm et les capacit\u00e9s QM, sont utilis\u00e9es pour \u00e9valuer la flexibilit\u00e9 du compos\u00e9 et sa pr\u00e9disposition \u00e0 des conformations bioactives optimales, soutenant une conception de compos\u00e9 affin\u00e9e et un potentiel de liaison am\u00e9lior\u00e9.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening-300x202.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening.webp 766w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening-534x360.webp 534w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening-640x431.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"colourful molecular diagram illustration pharmacophore alignment and shape-based screening for ligand-based drug design.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNzY2IiBoZWlnaHQ9IjUxNiIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening-300x202.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening.webp 766w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening-534x360.webp 534w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/pharmacophore-alignment-shape-based-screening-640x431.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-782662c940402e7b938209013ddb7aa9\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Alignement de pharmacophores et criblage bas\u00e9 sur la forme<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-5b02cc523b5a783b449599087115d9aa\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les techniques pharmacophoriques et les m\u00e9thodes d\u2019alignement bas\u00e9es sur la forme du ligand et la similarit\u00e9 \u00e9lectrostatique sont utilis\u00e9es pour comparer diff\u00e9rentes s\u00e9ries de compos\u00e9s, analyser les donn\u00e9es de relation structure-activit\u00e9 (RSA) et identifier de nouveaux compos\u00e9s actifs par criblage virtuel.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow has-background pegasus-responsive-bg-961\" style=\"  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); ;background-position:5% 100%;background-size:cover;background-image: url('https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/slim-gradient-bg-768x432.webp');\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-a082ea85 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--60)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">Principaux avantages<\/h2>\n\n\n\n<p class=\"has-text-align-center has-content-secondary-color has-text-color has-link-color wp-elements-98df353e7c6d49997e8eb52355d49d87\">Nos \u00e9quipes exp\u00e9riment\u00e9es ont fait leurs preuves dans la g\u00e9n\u00e9ration de plusieurs nouveaux prospects<br> s\u00e9rie gr\u00e2ce \u00e0 des strat\u00e9gies ax\u00e9es sur les ligands. Nous mettons \u00e0 profit notre exp\u00e9rience accrue<br> \u00e0 chaque projet auquel nous participons. <\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-5e6b6c71 wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-cb358442 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media original shrink-0\" style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 10.1451 6.2975L7.75508 12.75L1.30258 15.125C0.920493 15.2656 0.59074 15.5201 0.357814 15.854C0.124888 16.188 0 16.5853 0 16.9925C0 17.3997 0.124888 17.797 0.357814 18.131C0.59074 18.4649 0.920493 18.7194 1.30258 18.86L7.75508 21.25L10.1301 27.7025C10.2707 28.0846 10.5252 28.4143 10.8591 28.6473C11.1931 28.8802 11.5904 29.0051 11.9976 29.0051C12.4047 29.0051 12.8021 28.8802 13.136 28.6473C13.47 28.4143 13.7244 28.0846 13.8651 27.7025L16.2551 21.25L22.7076 18.875C23.0897 18.7344 23.4194 18.4799 23.6523 18.146C23.8853 17.812 24.0102 17.4147 24.0102 17.0075C24.0102 16.6003 23.8853 16.203 23.6523 15.869C23.4194 15.5351 23.0897 15.2806 22.7076 15.14L22.7026 15.1325ZM15.1301 19.5275C14.9943 19.5775 14.8711 19.6564 14.7688 19.7587C14.6665 19.861 14.5876 19.9843 14.5376 20.12L12.0051 26.9813L9.47758 20.125C9.42764 19.9878 9.34826 19.8633 9.24504 19.76C9.14182 19.6568 9.01725 19.5774 8.88008 19.5275L2.02383 17L8.88008 14.4725C9.01725 14.4226 9.14182 14.3432 9.24504 14.24C9.34826 14.1367 9.42764 14.0122 9.47758 13.875L12.0051 7.01875L14.5326 13.875C14.5826 14.0107 14.6615 14.134 14.7638 14.2363C14.8661 14.3386 14.9893 14.4175 15.1251 14.4675L21.9863 17L15.1301 19.5275ZM16.0051 4C16.0051 3.73478 16.1104 3.48043 16.298 3.29289C16.4855 3.10536 16.7399 3 17.0051 3H19.0051V1C19.0051 0.734784 19.1104 0.48043 19.298 0.292893C19.4855 0.105357 19.7399 0 20.0051 0C20.2703 0 20.5247 0.105357 20.7122 0.292893C20.8997 0.48043 21.0051 0.734784 21.0051 1V3H23.0051C23.2703 3 23.5247 3.10536 23.7122 3.29289C23.8997 3.48043 24.0051 3.73478 24.0051 4C24.0051 4.26522 23.8997 4.51957 23.7122 4.70711C23.5247 4.89464 23.2703 5 23.0051 5H21.0051V7C21.0051 7.26522 20.8997 7.51957 20.7122 7.70711C20.5247 7.89464 20.2703 8 20.0051 8C19.7399 8 19.4855 7.89464 19.298 7.70711C19.1104 7.51957 19.0051 7.26522 19.0051 7V5H17.0051C16.7399 5 16.4855 4.89464 16.298 4.70711C16.1104 4.51957 16.0051 4.26522 16.0051 4ZM29.0051 10C29.0051 10.2652 28.8997 10.5196 28.7122 10.7071C28.5247 10.8946 28.2703 11 28.0051 11H27.0051V12C27.0051 12.2652 26.8997 12.5196 26.7122 12.7071C26.5247 12.8946 26.2703 13 26.0051 13C25.7399 13 25.4855 12.8946 25.298 12.7071C25.1104 12.5196 25.0051 12.2652 25.0051 12V11H24.0051C23.7399 11 23.4855 10.8946 23.298 10.7071C23.1104 10.5196 23.0051 10.2652 23.0051 10C23.0051 9.73478 23.1104 9.48043 23.298 9.29289C23.4855 9.10536 23.7399 9 24.0051 9H25.0051V8C25.0051 7.73478 25.1104 7.48043 25.298 7.29289C25.4855 7.10536 25.7399 7 26.0051 7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"><\/path>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Une approche du leadership fond\u00e9e sur les connaissances<br> identification<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-3e4f2987518dcf36edd90ec2b37bfa05\">Cela permet la conception de nouvelles structures et de nouveaux fragments, constituant ainsi un moyen efficace de d\u00e9velopper de nouvelles substances chimiques gr\u00e2ce \u00e0 l\u2019utilisation d\u2019outils informatiques bas\u00e9s sur les ligands pour concevoir de nouvelles structures.<br> ou des fragments mol\u00e9culaires.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-cb358442 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media original shrink-0\" style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 10.1451 6.2975L7.75508 12.75L1.30258 15.125C0.920493 15.2656 0.59074 15.5201 0.357814 15.854C0.124888 16.188 0 16.5853 0 16.9925C0 17.3997 0.124888 17.797 0.357814 18.131C0.59074 18.4649 0.920493 18.7194 1.30258 18.86L7.75508 21.25L10.1301 27.7025C10.2707 28.0846 10.5252 28.4143 10.8591 28.6473C11.1931 28.8802 11.5904 29.0051 11.9976 29.0051C12.4047 29.0051 12.8021 28.8802 13.136 28.6473C13.47 28.4143 13.7244 28.0846 13.8651 27.7025L16.2551 21.25L22.7076 18.875C23.0897 18.7344 23.4194 18.4799 23.6523 18.146C23.8853 17.812 24.0102 17.4147 24.0102 17.0075C24.0102 16.6003 23.8853 16.203 23.6523 15.869C23.4194 15.5351 23.0897 15.2806 22.7076 15.14L22.7026 15.1325ZM15.1301 19.5275C14.9943 19.5775 14.8711 19.6564 14.7688 19.7587C14.6665 19.861 14.5876 19.9843 14.5376 20.12L12.0051 26.9813L9.47758 20.125C9.42764 19.9878 9.34826 19.8633 9.24504 19.76C9.14182 19.6568 9.01725 19.5774 8.88008 19.5275L2.02383 17L8.88008 14.4725C9.01725 14.4226 9.14182 14.3432 9.24504 14.24C9.34826 14.1367 9.42764 14.0122 9.47758 13.875L12.0051 7.01875L14.5326 13.875C14.5826 14.0107 14.6615 14.134 14.7638 14.2363C14.8661 14.3386 14.9893 14.4175 15.1251 14.4675L21.9863 17L15.1301 19.5275ZM16.0051 4C16.0051 3.73478 16.1104 3.48043 16.298 3.29289C16.4855 3.10536 16.7399 3 17.0051 3H19.0051V1C19.0051 0.734784 19.1104 0.48043 19.298 0.292893C19.4855 0.105357 19.7399 0 20.0051 0C20.2703 0 20.5247 0.105357 20.7122 0.292893C20.8997 0.48043 21.0051 0.734784 21.0051 1V3H23.0051C23.2703 3 23.5247 3.10536 23.7122 3.29289C23.8997 3.48043 24.0051 3.73478 24.0051 4C24.0051 4.26522 23.8997 4.51957 23.7122 4.70711C23.5247 4.89464 23.2703 5 23.0051 5H21.0051V7C21.0051 7.26522 20.8997 7.51957 20.7122 7.70711C20.5247 7.89464 20.2703 8 20.0051 8C19.7399 8 19.4855 7.89464 19.298 7.70711C19.1104 7.51957 19.0051 7.26522 19.0051 7V5H17.0051C16.7399 5 16.4855 4.89464 16.298 4.70711C16.1104 4.51957 16.0051 4.26522 16.0051 4ZM29.0051 10C29.0051 10.2652 28.8997 10.5196 28.7122 10.7071C28.5247 10.8946 28.2703 11 28.0051 11H27.0051V12C27.0051 12.2652 26.8997 12.5196 26.7122 12.7071C26.5247 12.8946 26.2703 13 26.0051 13C25.7399 13 25.4855 12.8946 25.298 12.7071C25.1104 12.5196 25.0051 12.2652 25.0051 12V11H24.0051C23.7399 11 23.4855 10.8946 23.298 10.7071C23.1104 10.5196 23.0051 10.2652 23.0051 10C23.0051 9.73478 23.1104 9.48043 23.298 9.29289C23.4855 9.10536 23.7399 9 24.0051 9H25.0051V8C25.0051 7.73478 25.1104 7.48043 25.298 7.29289C25.4855 7.10536 25.7399 7 26.0051 7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"><\/path>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Collaboration sans faille avec le secteur m\u00e9dical<br> \u00e9quipes de chimie<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-3d32fdfed853de40fcb562438b6f664f\">Nous ne travaillons pas en vase clos, notre approche collaborative facilite la g\u00e9n\u00e9ration d\u2019id\u00e9es et leur priorisation pr\u00e9coce.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-cb358442 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media original shrink-0\" style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 10.1451 6.2975L7.75508 12.75L1.30258 15.125C0.920493 15.2656 0.59074 15.5201 0.357814 15.854C0.124888 16.188 0 16.5853 0 16.9925C0 17.3997 0.124888 17.797 0.357814 18.131C0.59074 18.4649 0.920493 18.7194 1.30258 18.86L7.75508 21.25L10.1301 27.7025C10.2707 28.0846 10.5252 28.4143 10.8591 28.6473C11.1931 28.8802 11.5904 29.0051 11.9976 29.0051C12.4047 29.0051 12.8021 28.8802 13.136 28.6473C13.47 28.4143 13.7244 28.0846 13.8651 27.7025L16.2551 21.25L22.7076 18.875C23.0897 18.7344 23.4194 18.4799 23.6523 18.146C23.8853 17.812 24.0102 17.4147 24.0102 17.0075C24.0102 16.6003 23.8853 16.203 23.6523 15.869C23.4194 15.5351 23.0897 15.2806 22.7076 15.14L22.7026 15.1325ZM15.1301 19.5275C14.9943 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       \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Acc\u00e8s aux leaders du secteur<br> outils d\u2019exploration de la litt\u00e9rature et des brevets<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-fc3910b1ea7009be44f14063fed2c40f\">Cela inclut les outils Reaxys et LBDD de MedChemica et les outils de bureau OpenEye + plateforme Orion pour permettre nos approches bas\u00e9es sur les ligands.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-e84fdc4b wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2c75125d wp-block-group-is-layout-constrained\" style=\"margin-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style wp-elements-db8ae020b0d7ab6b85a31c1d595ff20f\" style=\"color:#001024b3;padding-right:0;padding-left:0;font-style:normal;font-weight:600;letter-spacing:0.96px;--paragraph-dot-color:#005de5\">Centre de ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-f4f353d6f3d0ad312919a94ff2812b8b wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data='postGrid({\"respondToFiltering\":true,\"singleFilterMode\":true,\"initialFilterSlug\":\"\"})' 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Qu\u2019est-ce que la conception de m\u00e9dicaments bas\u00e9e sur les ligands (LBDD) et quand est-elle utilis\u00e9e\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-f20fef22c30272ce81c240658195be73\" style=\"color:#475467\">La conception de m\u00e9dicaments bas\u00e9e sur les ligands (LBDD) est une approche computationnelle qui s\u2019appuie sur les informations concernant les ligands connus plut\u00f4t que sur les donn\u00e9es structurales des prot\u00e9ines. Elle est particuli\u00e8rement pr\u00e9cieuse lorsque les structures prot\u00e9iques sont indisponibles, permettant une conception par mod\u00e9lisation de pharmacophores, similarit\u00e9 de forme et similarit\u00e9 \u00e9lectrostatique.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-81e20d6fb0524b3d0f2391ad66968429\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quels outils et techniques sont utilis\u00e9s ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-81c01f8cb784c67d49265b9a670b6083\" style=\"color:#475467\">Nous utilisons le remodelage de structures, le remplacement de fragments, l\u2019alignement pharmacophorique, la mod\u00e9lisation QSAR (2D\/3D), l\u2019analyse de Free-Wilson et l\u2019apprentissage automatique. Des outils d\u2019IA g\u00e9n\u00e9rative, tels qu\u2019Iktos Makya et MedChemica, nous permettent d\u2019explorer l\u2019espace chimique virtuel et d\u2019optimiser les profils de compos\u00e9s. <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-1ba136726216ae793167b83ae93a4926\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quels sont les principaux avantages de l\u2019approche de d\u00e9couverte de m\u00e9dicaments bas\u00e9e sur les ligands de Sygnature\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-957ffcf5db19d8625017143ade99f016\" style=\"color:#475467\">Notre approche de conception bas\u00e9e sur les connaissances acc\u00e9l\u00e8re l\u2019identification des compos\u00e9s candidats, favorise l\u2019optimisation multi-objectifs et encourage une collaboration \u00e9troite avec les \u00e9quipes de chimie m\u00e9dicinale. Il en r\u00e9sulte de nouvelles structures, des propri\u00e9t\u00e9s ADME am\u00e9lior\u00e9es et une priorisation efficace des id\u00e9es pour les projets int\u00e9gr\u00e9s de d\u00e9couverte de m\u00e9dicaments. <\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n    \n            <\/section><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-4 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e17f75369917380307a8227af22f62bc\" style=\"color:#001024b3\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d\u2019experts chevronn\u00e9s de l\u2019industrie pharmaceutique du monde entier, garantissant l\u2019excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling.webp 1000w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"illustration of a digital brain network representing machine learning and AI tools applied to predictive modeling for ADMET property optimization.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAwMCIgaGVpZ2h0PSI2NjciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling.webp 1000w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/machine-learning-ai-modeling-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-246d4853a3d7c89ab6af716b7f6dede1\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Intelligence artificielle g\u00e9n\u00e9rative et apprentissage automatique<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-10070ff87203f556660e679f92b9b807\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Int\u00e9grer l\u2019IA g\u00e9n\u00e9rative, l\u2019apprentissage automatique et la mod\u00e9lisation pr\u00e9dictive pour concevoir des compos\u00e9s plus intelligents, optimiser les d\u00e9cisions et acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/generative-ai-and-machine-learning\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Laboratory setting showing scientists working with glassware and reagents, representing medicinal chemistry for optimizing drug profiles and advancing compounds toward clinical development.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNzA3IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-scaled.webp\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/medicinal-chemistry-drug-design-laboratory-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-547c36689459f8f482759aeefee7bb02\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Chimie m\u00e9dicinale  <\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-e5255814495daa73e2192f087e50bc3e\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Une chimie m\u00e9dicinale \u00e0 vocation clinique, alliant excellence en conception, connaissances issues de l\u2019IA et expertise collaborative pour fournir des mol\u00e9cules align\u00e9es sur vos objectifs.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/chimie-medicinale\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Visualisation de la structure mol\u00e9culaire 3D utilis\u00e9e dans la conception de m\u00e9dicaments assist\u00e9e par ordinateur, repr\u00e9sentant les approches bas\u00e9es sur la structure et sur les ligands pour la mod\u00e9lisation pr\u00e9dictive dans la d\u00e9couverte de m\u00e9dicaments.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjAwMCIgaGVpZ2h0PSI5NjAiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-70215282a62489a7b9ef2c8058964953\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Conception de m\u00e9dicaments assist\u00e9e par ordinateur<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-af1896a3b929fc16de70579b02362163\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Concevoir des compos\u00e9s plus intelligents gr\u00e2ce \u00e0 la mod\u00e9lisation pilot\u00e9e par l\u2019IA, \u00e0 l\u2019informatique avanc\u00e9e et \u00e0 l\u2019expertise collaborative pour acc\u00e9l\u00e9rer les d\u00e9cisions et r\u00e9duire les risques.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":7210,"parent":16400,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4368","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the 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