{"id":4361,"date":"2025-11-10T16:40:17","date_gmt":"2025-11-10T16:40:17","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/conception-de-medicaments-basee-sur-la-structure\/"},"modified":"2026-02-06T15:28:53","modified_gmt":"2026-02-06T15:28:53","slug":"conception-de-medicaments-basee-sur-la-structure","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/conception-de-medicaments-basee-sur-la-structure\/","title":{"rendered":"Conception de m\u00e9dicaments bas\u00e9e sur la structure"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/bioinformatique\\\/\":\"Bioinformatique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/analyse-de-la-cible\\\/\":\"Analyse des cibles\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/depistage-virtuel\\\/\":\"d\\u00e9pistage virtuel\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/conception-de-medicaments-basee-sur-la-structure\\\/\":\"Conception de m\\u00e9dicaments bas\\u00e9e sur la structure  \",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/ia-generative-et-apprentissage-automatique\\\/\":\"Intelligence artificielle g\\u00e9n\\u00e9rative et apprentissage automatique\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/conception-de-medicaments-basee-sur-des-ligands\\\/\":\"Conception de m\\u00e9dicaments bas\\u00e9e sur les ligands\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/conception-de-la-bibliotheque\\\/\":\"Conception de biblioth\\u00e8que\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/solutions-scientifiques\\\/conception-de-medicaments-assistee-par-ordinateur\\\/predictions-admet\\\/\":\"Pr\\u00e9diction ADMET\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/informatique\\\/\":\"Informatique\"}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" false x-cloak style=\"\">\n    <div x-ref=\"fixedNav\" class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/\" class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Conception de m\u00e9dicaments assist\u00e9e par ordinateur<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/bioinformatique\/' === window.location.href ? 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'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Conception de biblioth\u00e8que\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/conception-de-medicaments-assistee-par-ordinateur\/predictions-admet\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Pr\u00e9diction ADMET\n                                    <\/a>\n                                <\/li>\n                                                            <li class=\"!m-0 !p-0 !list-none\">\n                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/\" class=\"block px-4 py-3 rounded-lg text-sm text-gray-700 hover:bg-ivory-300 transition-colors duration-150 focus:outline-none focus:bg-ivory-300 focus:ring-2 focus:ring-inset focus:ring-blue-500 \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/informatique\/' === window.location.href ? 'bg-blue-50 text-blue-700 font-medium' : ''\" false>\n                                        Informatique\n                                    <\/a>\n                                <\/li>\n                                                    <\/ul>\n\n                                                    <div class=\"mt-10 pb-5 \">\n                                \n        <div class=\"wp-block-button SubNav__ctaButton wp-block-button btn-primary dark mb-4 sm:mb-0 rounded-full inline-flex\">\n            <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/contact\/\">Entrer en contact<\/a>\n        <\/div>\n        \n                            <\/div>\n                                            <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative has-full-height-lg md:relative md:h-relative has-full-height-md relative h-fit  text-content-dark mobile-stacking-standard   banner-video -content-left -buttons is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 100%; --height-md-relative: 100%;  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7fc3d43a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-fe91d411 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-content-tertiary-color has-text-color has-link-color has-tag-style wp-elements-d5b0f3d68ff95b2254c06355018d5c2a\" style=\"padding-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:600;--paragraph-dot-color:#005de5\">solutions scientifiques | CAAD<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-content-primary-color has-text-color has-link-color has-text-4-xl-font-size wp-elements-03bbad5e0637cc869cd25e8ab0b82271\" style=\"margin-bottom:var(--wp--preset--spacing--30);font-style:normal;font-weight:400\">Conception de m\u00e9dicaments bas\u00e9e sur la structure<\/h1>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-c14adbd6ddb2e2aae76f199862151bc2\" style=\"margin-bottom:var(--wp--preset--spacing--45);line-height:1.4\">Nous vous aidons \u00e0 concevoir de meilleurs compos\u00e9s avec une plus grande confiance. Gr\u00e2ce \u00e0 des connaissances \u00e0 l\u2019\u00e9chelle quantique et \u00e0 des simulations dynamiques, nous pr\u00e9disons l\u2019affinit\u00e9, guidons l\u2019optimisation et vous aidons \u00e0 identifier plus rapidement les candidats les plus prometteurs. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-48d1dab7 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--1\" modaltype=\"side-inset\" data-pegasus-modal=\"Modal--side-inset\"><a class=\"wp-block-button__link has-white-color has-aqua-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\" style=\"padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-d6b9ab57 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width has-overlay w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Visualisation de la structure mol\u00e9culaire 3D utilis\u00e9e dans la conception de m\u00e9dicaments assist\u00e9e par ordinateur, repr\u00e9sentant les approches bas\u00e9es sur la structure et sur les ligands pour la mod\u00e9lisation pr\u00e9dictive dans la d\u00e9couverte de m\u00e9dicaments.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-300x144.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-768x369.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1024x492.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-1536x737.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/computer-aided-drug-design-molecular-model-640x307.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-12dd3699 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-266ccfb97f47b588d1144b0f03bbaa0e\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">SOUTENIR VOS RECHERCHES<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">Notre plateforme de conception de m\u00e9dicaments bas\u00e9e sur la structure combine l\u2019analyse au niveau quantique, les simulations dynamiques et les calculs avanc\u00e9s d\u2019\u00e9nergie libre pour vous aider \u00e0 comprendre avec pr\u00e9cision l\u2019\u00e9nerg\u00e9tique de liaison et les sch\u00e9mas d\u2019interaction.<\/h2>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">En int\u00e9grant des outils commerciaux et propri\u00e9taires, notamment les m\u00e9thodologies Fragment Molecular Orbital (FMO-SP), Molecular Dynamics et Non-Equilibrium Switching (NES), nous fournissons des informations plus approfondies qui guident l\u2019optimisation des compos\u00e9s et acc\u00e9l\u00e8rent la prise de d\u00e9cision en toute confiance.<\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">La plateforme SBDD de Sygnature Discovery int\u00e8gre la biologie structurale \u00e0 la chimie computationnelle avanc\u00e9e pour vous aider \u00e0 concevoir plus rapidement de meilleurs compos\u00e9s. En traduisant les structures prot\u00e9iques tridimensionnelles en informations exploitables, nous orientons les strat\u00e9gies d\u2019optimisation afin d\u2019am\u00e9liorer la puissance, la s\u00e9lectivit\u00e9 et la stabilit\u00e9. <\/p>\n\n\n\n<p class=\"has-text-base-font-size\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">Notre \u00e9quipe d\u2019experts utilise la m\u00e9canique quantique, les calculs d\u2019\u00e9nergie libre, la dynamique mol\u00e9culaire et l\u2019amarrage flexible pour approfondir la compr\u00e9hension des interactions prot\u00e9ine-ligand. Ces connaissances permettent de prendre des d\u00e9cisions \u00e9clair\u00e9es et bas\u00e9es sur les donn\u00e9es \u00e0 chaque \u00e9tape de votre programme de recherche. <\/p>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-300x179.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-768x459.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-1024x612.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design.webp 1214w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-602x360.webp 602w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-640x383.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1214\" height=\"726\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"Visualisation d'une plateforme de conception de m\u00e9dicaments bas\u00e9e sur la structure, montrant l'amarrage mol\u00e9culaire et l'analyse au niveau quantique pour comprendre les interactions prot\u00e9ine-ligand et optimiser la conception des compos\u00e9s.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-300x179.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-768x459.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-1024x612.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design.webp 1214w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-602x360.webp 602w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/orion-structure-based-drug-design-640x383.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full \" style=\"background-color:#f9f2e8;\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Nos solutions de conception bas\u00e9es sur la structure<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-dba583183441a4533dfcd38d04a1b202\" style=\"color:#001024b3\"><\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-300x154.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-768x395.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-1024x527.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-1536x791.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-640x330.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"graphs and molecular models illustrating RBFE calculations for precise compound ranking and optimization in structure-based drug design.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-300x154.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-768x395.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-1024x527.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-1536x791.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/relative-binding-free-energy-calculations-640x330.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-248eb12e22fe883613b50834856286e6\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Calculs de l\u2019\u00e9nergie libre de liaison relative (RBFE)<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-080f315b361c073fd4f5b9e2d57ec07a\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous utilisons des calculs RBFE de pointe via la m\u00e9thodologie de commutation hors \u00e9quilibre (NES) sur la plateforme Orion\u00ae d\u2019OpenEye pour pr\u00e9dire l\u2019affinit\u00e9 des compos\u00e9s avec une pr\u00e9cision exceptionnelle. Ceci permet un classement robuste des compos\u00e9s et aide \u00e0 prioriser les essais.<br> Les candidats les plus prometteurs. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/prediction-ternaire-des-proteines\/free-energy-methods\/\">Apprendre encore plus<\/a> <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis-300x198.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis.webp 744w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis-547x360.webp 547w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis-640x422.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"chart representing quantum-level calculations using fragment molecular orbital methodology for accurate interpretation of molecular interactions.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis-300x198.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis.webp 744w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis-547x360.webp 547w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/fragment-molecular-orbital-fmo-sp-analysis-640x422.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-94450c992d9245e7a6d421e76f8a0814\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Plateforme de synth\u00e8se par orbitales mol\u00e9culaires de fragments (FMO-SP)<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-0879c65f4045cbc3ffac3b704c0a9177\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les champs de force classiques passent souvent \u00e0 c\u00f4t\u00e9 d\u2019interactions cruciales. Notre plateforme FMO applique la m\u00e9canique quantique pour quantifier l\u2019\u00e9nerg\u00e9tique au niveau des r\u00e9sidus, permettant une interpr\u00e9tation pr\u00e9cise des effets \u00e9lectrostatiques, de transfert de charge et de dispersion dans les syst\u00e8mes complexes. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-300x192.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-768x492.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-1024x656.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design.webp 1197w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-562x360.webp 562w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-640x410.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTE5NyIgaGVpZ2h0PSI3NjciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-300x192.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-768x492.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-1024x656.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design.webp 1197w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-562x360.webp 562w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/molecular-dynamics-simulations-drug-design-640x410.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-bea5ddfcbfbd0ce5fcdd32c98bfdf998\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Simulations de dynamique mol\u00e9culaire (DM)<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-2dc67289f57bd01d7ee1e73d4928c437\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">D\u00e9couvrez des structures plus complexes que les structures statiques. Nos m\u00e9thodes de dynamique mol\u00e9culaire r\u00e9v\u00e8lent le comportement des cibles et des ligands en mouvement afin d\u2019\u00e9valuer leur stabilit\u00e9, de mettre en \u00e9vidence des sites d\u2019interaction cach\u00e9s et d\u2019identifier les sch\u00e9mas d\u2019interaction. Nous combinons des outils commerciaux \u00e0 des syst\u00e8mes propri\u00e9taires de solvants mixtes et de membranes pour fournir rapidement des informations exploitables et guider une conception mol\u00e9culaire plus intelligente.  <\/p>\n\n\n\n<p><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/molecular-dynamic-simulations\/\">Apprendre encore plus<\/a> <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-300x204.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-768x522.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-1024x696.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-1536x1044.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-530x360.webp 530w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-640x435.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNzQwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-scaled.webp\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-300x204.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-768x522.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-1024x696.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-1536x1044.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-530x360.webp 530w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/protein-structure-prediction-ai-homology-modeling-640x435.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-2804844615a08a28ce42bbb2bb395ca5\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Pr\u00e9diction de la structure des prot\u00e9ines<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-101849de4371cf61f5c749ec43f61808\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous appliquons la mod\u00e9lisation par homologie et des approches bas\u00e9es sur l\u2019IA pour pr\u00e9dire les structures prot\u00e9iques lorsque les donn\u00e9es exp\u00e9rimentales sont indisponibles, ce qui permet une conception bas\u00e9e sur la structure m\u00eame pour des cibles difficiles.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\">Apprendre encore plus  <\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-768x476.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-1024x634.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity.webp 1035w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-581x360.webp 581w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-640x396.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Illustration showing water network analysis in protein-ligand interactions, comparing conserved water molecules and reoriented water effects on binding affinity and ligand design.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAzNSIgaGVpZ2h0PSI2NDEiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-768x476.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-1024x634.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity.webp 1035w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-581x360.webp 581w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/water-network-analysis-protein-ligand-binding-affinity-640x396.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-dab7c13cc31adf6c5ed4429733a200a2\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Thermodynamique des solvants<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-d0519e4613fc19a19858a407ebe7617e\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Gr\u00e2ce \u00e0 la technologie de cartographie de l\u2019eau, nous identifions les r\u00e9gions de solvant favorables et d\u00e9favorables au niveau du site de liaison. Ceci permet d\u2019orienter le positionnement des groupes fonctionnels dans un compos\u00e9 principal afin d\u2019en am\u00e9liorer la puissance et la s\u00e9lectivit\u00e9. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Mod\u00e8les structuraux D de biomol\u00e9cules, repr\u00e9sentant les techniques de biologie structurale pour la conception de m\u00e9dicaments, la cartographie des \u00e9pitopes et le criblage de fragments\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNzA3IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-scaled.webp\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-cad0625ac2eb6ff58f8c7e6908dd2fe3\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Biologie structurale<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-454357002222987dea96174047aefea4\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous g\u00e9n\u00e9rons des constructions prot\u00e9iques et obtenons des donn\u00e9es de cristallographie aux rayons X pour les cibles d\u00e9pourvues d\u2019informations structurales. Ceci permet d\u2019\u00e9lucider le mode de liaison et oriente l\u2019optimisation bas\u00e9e sur la structure. <\/p>\n\n\n\n<p>Apprendre encore plus  <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Illustration of a protein-ligand docking model showing colorful 3D molecular structures, representing flexible docking and real-time optimization within the binding site.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjA0OCIgaGVpZ2h0PSIxMTUyIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-768x432.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-1024x576.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-1536x864.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/flexible-protein-ligand-docking-3d-visualization-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-c9de5427a9dcf78e8ea48efcf528ae97\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">Amarrage flexible prot\u00e9ine-ligand<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-703eb45f4ef19f7e7c12886095c90c46\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nous pouvons prioriser les id\u00e9es de conception et prendre en compte la flexibilit\u00e9 du ligand et\/ou de la prot\u00e9ine, tandis que l\u2019utilisation d\u2019un \u00e9diteur de ligands 3D enti\u00e8rement interactif permet une optimisation en temps r\u00e9el au sein du site de liaison.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow has-background pegasus-responsive-bg-961\" style=\"  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); ;background-position:5% 100%;background-size:cover;background-image: url('https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/slim-gradient-bg-768x432.webp');\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-a082ea85 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--60)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">Principaux avantages<\/h2>\n\n\n\n<p class=\"has-text-align-center has-content-secondary-color has-text-color has-link-color wp-elements-597e44aa6bd2140e3a7f410f82b23b1f\">Notre plateforme informatique compl\u00e8te exploite la puissance des technologies avanc\u00e9es<br> chimie computationnelle combinant des connaissances \u00e0 l\u2019\u00e9chelle quantique avec des technologies de pointe<br> des calculs pour vous aider \u00e0 classer les compos\u00e9s avec assurance, \u00e0 optimiser les interactions et<br> Acc\u00e9l\u00e9rez votre processus de d\u00e9couverte de m\u00e9dicaments.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-5e6b6c71 wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-cb358442 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media original shrink-0\" style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 10.1451 6.2975L7.75508 12.75L1.30258 15.125C0.920493 15.2656 0.59074 15.5201 0.357814 15.854C0.124888 16.188 0 16.5853 0 16.9925C0 17.3997 0.124888 17.797 0.357814 18.131C0.59074 18.4649 0.920493 18.7194 1.30258 18.86L7.75508 21.25L10.1301 27.7025C10.2707 28.0846 10.5252 28.4143 10.8591 28.6473C11.1931 28.8802 11.5904 29.0051 11.9976 29.0051C12.4047 29.0051 12.8021 28.8802 13.136 28.6473C13.47 28.4143 13.7244 28.0846 13.8651 27.7025L16.2551 21.25L22.7076 18.875C23.0897 18.7344 23.4194 18.4799 23.6523 18.146C23.8853 17.812 24.0102 17.4147 24.0102 17.0075C24.0102 16.6003 23.8853 16.203 23.6523 15.869C23.4194 15.5351 23.0897 15.2806 22.7076 15.14L22.7026 15.1325ZM15.1301 19.5275C14.9943 19.5775 14.8711 19.6564 14.7688 19.7587C14.6665 19.861 14.5876 19.9843 14.5376 20.12L12.0051 26.9813L9.47758 20.125C9.42764 19.9878 9.34826 19.8633 9.24504 19.76C9.14182 19.6568 9.01725 19.5774 8.88008 19.5275L2.02383 17L8.88008 14.4725C9.01725 14.4226 9.14182 14.3432 9.24504 14.24C9.34826 14.1367 9.42764 14.0122 9.47758 13.875L12.0051 7.01875L14.5326 13.875C14.5826 14.0107 14.6615 14.134 14.7638 14.2363C14.8661 14.3386 14.9893 14.4175 15.1251 14.4675L21.9863 17L15.1301 19.5275ZM16.0051 4C16.0051 3.73478 16.1104 3.48043 16.298 3.29289C16.4855 3.10536 16.7399 3 17.0051 3H19.0051V1C19.0051 0.734784 19.1104 0.48043 19.298 0.292893C19.4855 0.105357 19.7399 0 20.0051 0C20.2703 0 20.5247 0.105357 20.7122 0.292893C20.8997 0.48043 21.0051 0.734784 21.0051 1V3H23.0051C23.2703 3 23.5247 3.10536 23.7122 3.29289C23.8997 3.48043 24.0051 3.73478 24.0051 4C24.0051 4.26522 23.8997 4.51957 23.7122 4.70711C23.5247 4.89464 23.2703 5 23.0051 5H21.0051V7C21.0051 7.26522 20.8997 7.51957 20.7122 7.70711C20.5247 7.89464 20.2703 8 20.0051 8C19.7399 8 19.4855 7.89464 19.298 7.70711C19.1104 7.51957 19.0051 7.26522 19.0051 7V5H17.0051C16.7399 5 16.4855 4.89464 16.298 4.70711C16.1104 4.51957 16.0051 4.26522 16.0051 4ZM29.0051 10C29.0051 10.2652 28.8997 10.5196 28.7122 10.7071C28.5247 10.8946 28.2703 11 28.0051 11H27.0051V12C27.0051 12.2652 26.8997 12.5196 26.7122 12.7071C26.5247 12.8946 26.2703 13 26.0051 13C25.7399 13 25.4855 12.8946 25.298 12.7071C25.1104 12.5196 25.0051 12.2652 25.0051 12V11H24.0051C23.7399 11 23.4855 10.8946 23.298 10.7071C23.1104 10.5196 23.0051 10.2652 23.0051 10C23.0051 9.73478 23.1104 9.48043 23.298 9.29289C23.4855 9.10536 23.7399 9 24.0051 9H25.0051V8C25.0051 7.73478 25.1104 7.48043 25.298 7.29289C25.4855 7.10536 25.7399 7 26.0051 7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"><\/path>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Bo\u00eete \u00e0 outils de calcul compl\u00e8te<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-7b175b61a8f671fb669997c6dbb3476c\">Notre plateforme int\u00e8gre des outils commerciaux et propri\u00e9taires, notamment des calculs d\u2019\u00e9nergie libre de commutation hors \u00e9quilibre, l\u2019analyse des orbitales mol\u00e9culaires de fragments, la dynamique mol\u00e9culaire et l\u2019amarrage flexible, afin de fournir une compr\u00e9hension approfondie de l\u2019\u00e9nerg\u00e9tique de liaison et des mod\u00e8les d\u2019interaction.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-cb358442 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media original shrink-0\" style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 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16.0051 4ZM29.0051 10C29.0051 10.2652 28.8997 10.5196 28.7122 10.7071C28.5247 10.8946 28.2703 11 28.0051 11H27.0051V12C27.0051 12.2652 26.8997 12.5196 26.7122 12.7071C26.5247 12.8946 26.2703 13 26.0051 13C25.7399 13 25.4855 12.8946 25.298 12.7071C25.1104 12.5196 25.0051 12.2652 25.0051 12V11H24.0051C23.7399 11 23.4855 10.8946 23.298 10.7071C23.1104 10.5196 23.0051 10.2652 23.0051 10C23.0051 9.73478 23.1104 9.48043 23.298 9.29289C23.4855 9.10536 23.7399 9 24.0051 9H25.0051V8C25.0051 7.73478 25.1104 7.48043 25.298 7.29289C25.4855 7.10536 25.7399 7 26.0051 7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"><\/path>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Analyse des interactions au niveau quantique<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-5119bb68a3759d05b32ba1693c1ab31c\">Notre approche Fragment Molecular Orbital (FMO-SP) applique la m\u00e9canique quantique pour diss\u00e9quer l\u2019\u00e9nerg\u00e9tique au niveau des r\u00e9sidus ; capturant les effets \u00e9lectrostatiques, de transfert de charge et de dispersion que les m\u00e9thodes classiques de champ de force manquent souvent.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-cb358442 wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media original shrink-0\" style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 10.1451 6.2975L7.75508 12.75L1.30258 15.125C0.920493 15.2656 0.59074 15.5201 0.357814 15.854C0.124888 16.188 0 16.5853 0 16.9925C0 17.3997 0.124888 17.797 0.357814 18.131C0.59074 18.4649 0.920493 18.7194 1.30258 18.86L7.75508 21.25L10.1301 27.7025C10.2707 28.0846 10.5252 28.4143 10.8591 28.6473C11.1931 28.8802 11.5904 29.0051 11.9976 29.0051C12.4047 29.0051 12.8021 28.8802 13.136 28.6473C13.47 28.4143 13.7244 28.0846 13.8651 27.7025L16.2551 21.25L22.7076 18.875C23.0897 18.7344 23.4194 18.4799 23.6523 18.146C23.8853 17.812 24.0102 17.4147 24.0102 17.0075C24.0102 16.6003 23.8853 16.203 23.6523 15.869C23.4194 15.5351 23.0897 15.2806 22.7076 15.14L22.7026 15.1325ZM15.1301 19.5275C14.9943 19.5775 14.8711 19.6564 14.7688 19.7587C14.6665 19.861 14.5876 19.9843 14.5376 20.12L12.0051 26.9813L9.47758 20.125C9.42764 19.9878 9.34826 19.8633 9.24504 19.76C9.14182 19.6568 9.01725 19.5774 8.88008 19.5275L2.02383 17L8.88008 14.4725C9.01725 14.4226 9.14182 14.3432 9.24504 14.24C9.34826 14.1367 9.42764 14.0122 9.47758 13.875L12.0051 7.01875L14.5326 13.875C14.5826 14.0107 14.6615 14.134 14.7638 14.2363C14.8661 14.3386 14.9893 14.4175 15.1251 14.4675L21.9863 17L15.1301 19.5275ZM16.0051 4C16.0051 3.73478 16.1104 3.48043 16.298 3.29289C16.4855 3.10536 16.7399 3 17.0051 3H19.0051V1C19.0051 0.734784 19.1104 0.48043 19.298 0.292893C19.4855 0.105357 19.7399 0 20.0051 0C20.2703 0 20.5247 0.105357 20.7122 0.292893C20.8997 0.48043 21.0051 0.734784 21.0051 1V3H23.0051C23.2703 3 23.5247 3.10536 23.7122 3.29289C23.8997 3.48043 24.0051 3.73478 24.0051 4C24.0051 4.26522 23.8997 4.51957 23.7122 4.70711C23.5247 4.89464 23.2703 5 23.0051 5H21.0051V7C21.0051 7.26522 20.8997 7.51957 20.7122 7.70711C20.5247 7.89464 20.2703 8 20.0051 8C19.7399 8 19.4855 7.89464 19.298 7.70711C19.1104 7.51957 19.0051 7.26522 19.0051 7V5H17.0051C16.7399 5 16.4855 4.89464 16.298 4.70711C16.1104 4.51957 16.0051 4.26522 16.0051 4ZM29.0051 10C29.0051 10.2652 28.8997 10.5196 28.7122 10.7071C28.5247 10.8946 28.2703 11 28.0051 11H27.0051V12C27.0051 12.2652 26.8997 12.5196 26.7122 12.7071C26.5247 12.8946 26.2703 13 26.0051 13C25.7399 13 25.4855 12.8946 25.298 12.7071C25.1104 12.5196 25.0051 12.2652 25.0051 12V11H24.0051C23.7399 11 23.4855 10.8946 23.298 10.7071C23.1104 10.5196 23.0051 10.2652 23.0051 10C23.0051 9.73478 23.1104 9.48043 23.298 9.29289C23.4855 9.10536 23.7399 9 24.0051 9H25.0051V8C25.0051 7.73478 25.1104 7.48043 25.298 7.29289C25.4855 7.10536 25.7399 7 26.0051 7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"><\/path>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Pr\u00e9cision dans la pr\u00e9diction d\u2019affinit\u00e9<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-710d38d3c97acf90bc393bb11ec5093a\">Les calculs avanc\u00e9s d\u2019\u00e9nergie libre de liaison relative (RBFE) utilisant la m\u00e9thodologie NES sur la plateforme Orion\u00ae permettent un classement rapide et pr\u00e9cis des compos\u00e9s, vous aidant \u00e0 prioriser en toute confiance les candidats les plus prometteurs.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-e84fdc4b wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2c75125d wp-block-group-is-layout-constrained\" style=\"margin-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-left is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style wp-elements-74f2bbf7c2f1dbcb134229150002b271\" style=\"color:#001024b3;padding-right:0;padding-left:0;font-style:normal;font-weight:600;letter-spacing:0.96px;--paragraph-dot-color:#005de5\">Ressources<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-b8085af24bff4b40b0d89dbacd6ac6a2 wp-container-content-d25f37ba\" style=\"color:#002b46;margin-top:0;margin-bottom:var(--wp--preset--spacing--30)\">Ressources connexes<\/h2>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n\n<section x-data='postGrid({\"respondToFiltering\":true,\"singleFilterMode\":true,\"initialFilterSlug\":\"\"})' class=\"Post__Grid relative\" style=\"--post-grid-grid-cols: 3; --post-grid-row-gap: 1.5rem;\" data-single-filter-mode=\"false\" data-show-all-button=\"false\" data-initial-filter=\"\">\n                            \n\n        \n        \n            <div class=\"Post__Grid-grid   flex-col relative\" 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begin=\"0s\" repeatcount=\"indefinite\"><\/animate>\n                            <\/path>\n                        <\/g>\n                    <\/svg>\n                <\/div>\n\n                                                \n                                                                                        <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-a-choisi-elsevier-comme-nouveau-partenaire-privilegie-pour-renforcer-son-equipe-mondiale-de-chimistes\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Sygnature Discovery a choisi Elsevier comme nouveau partenaire privil\u00e9gi\u00e9 pour renforcer son \u00e9quipe mondiale de chimistes.<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-300x225.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Untitled-6-480x360.png 480w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/png\"><img decoding=\"async\" loading=\"lazy\" width=\"480\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxOTIwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" 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mondiale de chimistes.<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSygnature Discovery a le plaisir d\u2019annoncer son nouveau partenariat avec Elsevier, soci\u00e9t\u00e9 mondiale d\u2019information et\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/a-comparison-of-the-structural-techniques-used-at-sygnature-discovery-x-ray-crystallography-nmr-and-cryo-em\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1-300x173.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1.webp 600w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"600\" height=\"345\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" alt=\"A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjAwIiBoZWlnaHQ9IjM0NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1-300x173.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Peptide_in_pocket_2-600x345-1.webp 600w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/a-comparison-of-the-structural-techniques-used-at-sygnature-discovery-x-ray-crystallography-nmr-and-cryo-em\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tIn this article we discuss the three techniques used for determining protein and nucleic acid\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/synnature-discovery-et-daewoong-pharma-annoncent-une-collaboration-de-recherche\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Synnature Discovery et Daewoong Pharma annoncent une collaboration de recherche<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-300x183.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-592x360.jpg 592w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"592\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjAwIiBoZWlnaHQ9IjM2NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-300x183.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/HTS-web-592x360.jpg 592w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/synnature-discovery-et-daewoong-pharma-annoncent-une-collaboration-de-recherche\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Synnature Discovery et Daewoong Pharma annoncent une collaboration de recherche<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSygnature Discovery est heureuse d\u2019avoir conclu un accord de collaboration de recherche avec le groupe\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-deploie-la-technologie-dia-diktos-makya\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Sygnature Discovery d\u00e9ploie la technologie d\u2019IA d\u2019Iktos, \u00ab Makya\u2122 \u00bb.<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"540\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTAwMCIgaGVpZ2h0PSI2NjciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-discovery-deploie-la-technologie-dia-diktos-makya\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Sygnature Discovery d\u00e9ploie la technologie d\u2019IA d\u2019Iktos, \u00ab Makya\u2122 \u00bb.<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tNous sommes ravis d\u2019annoncer que nous avons entam\u00e9 un accord de collaboration de 3 ans\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-se-renforce-grace-a-la-solution-logicielle-de-medchemica\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Sygnature se renforce gr\u00e2ce \u00e0 la solution logicielle de MedChemica.<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/jpeg\"><img decoding=\"async\" loading=\"lazy\" width=\"540\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTIwMCIgaGVpZ2h0PSI4MDAiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-300x200.jpg 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/computational-cover-1-540x360.jpg 540w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/sygnature-se-renforce-grace-a-la-solution-logicielle-de-medchemica\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Sygnature se renforce gr\u00e2ce \u00e0 la solution logicielle de MedChemica.<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tNous avons encore renforc\u00e9 notre offre en mati\u00e8re de d\u00e9couverte de m\u00e9dicaments \u2013 en acqu\u00e9rant\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/amelioration-des-services-de-conception-moleculaire-sygnature-discovery-adopte-la-plateforme-orion-dopeneye\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Am\u00e9lioration des services de conception mol\u00e9culaire\u00a0: Sygnature Discovery adopte la plateforme Orion\u2122 d\u2019OpenEye<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-300x167.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-640x356.png 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/png\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"356\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNDIzIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-scaled.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-300x167.png 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Orion-Example-HighRes-3a_-640x356.png 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/amelioration-des-services-de-conception-moleculaire-sygnature-discovery-adopte-la-plateforme-orion-dopeneye\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Am\u00e9lioration des services de conception mol\u00e9culaire\u00a0: Sygnature Discovery adopte la plateforme Orion\u2122 d\u2019OpenEye<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tSygnature acc\u00e9l\u00e8re le processus de d\u00e9couverte de m\u00e9dicaments de ses clients gr\u00e2ce \u00e0 une meilleure\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tNews\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group is-vertical is-content-justification-stretch is-layout-flex wp-container-core-group-is-layout-353c4f5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-eb5039d6 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-c9ee0c5a wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">FAQ<\/h2>\n\n\n\n<p class=\"has-text-align-center has-text-color has-link-color has-text-base-font-size wp-elements-b3178ea9452aecb4c2ff0bfb9e98ea35\" style=\"color:#001024b3\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a7849e3a wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Accordion relative w-full mx-auto \" style=\"\">\n            \n        <div>\n        <div class=\"acf-innerblocks-container\">\n<div x-data=\"accordionPanel(1, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-c11c479b94fb43e07d15bf7acb675871\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Avec quels types de cibles pourriez-vous travailler pour le SBDD chez Sygnature\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-b640847ca1f6781d7302b040911ecd1e\" style=\"color:#475467\">Nous travaillons sur diverses classes de cibles, notamment les kinases, les RCPG, les canaux ioniques et les syst\u00e8mes pour lesquels nous manquons de donn\u00e9es structurelles.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-f4f44fce58d7b09f9ebd53bc9ad2ff96\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Quels types de r\u00e9sultats les clients peuvent-ils attendre des flux de travail SBDD de Sygnature Discovery\u00a0?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-b1bd91f8373a293a7a3c0f03bbfcf033\" style=\"color:#475467\">Cartes d\u2019interaction d\u00e9taill\u00e9es, profils d\u2019\u00e9nergie libre, analyses de trajectoires MD et \u00e9nerg\u00e9tiques des r\u00e9sidus au niveau quantique, plus<br> Rapports personnalis\u00e9s et fichiers de donn\u00e9es brutes sur demande<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-43ecc55a02e1daee7bfe8fd448d3ca56\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <p class=\"has-text-2-xl-font-size\">Qu\u2019est-ce qui rend l\u2019approche SBDD de Sygnature unique ?<\/p>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-74039e5667095900e8160acf96f11406\" style=\"color:#475467\">Nous combinons des outils de pointe tels que la dynamique mol\u00e9culaire \u00e0 trajectoire courte (STMD) et la commutation hors \u00e9quilibre (NES) avec<br> des innovations exclusives comme Fragment Molecular Orbital (FMO) et MD \u00e0 solvant mixte pour fournir des informations plus approfondies et<br> mener \u00e0 bien des programmes de conception de m\u00e9dicaments bas\u00e9s sur la structure.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n    \n            <\/section><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-87beb0d0 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-4 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2a411371 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-7c4158aaf8a22a35edef55f5030853b1\" style=\"color:#001024b3\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d\u2019experts chevronn\u00e9s de l\u2019industrie pharmaceutique du monde entier, garantissant l\u2019excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-e74d460a wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Free Energy Methods\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/free-energy-methods.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-b74d5a24506c4be2f04af56c52f5cb95\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/free-energy-methods\/\" type=\"page\" id=\"4911\">M\u00e9thodes d\u2019\u00e9nergie libre<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-dd529cd9743ac96f6c685c129f30b65e\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Calcul de l\u2019\u00e9nergie libre de liaison relative par commutation hors \u00e9quilibre (NES) gr\u00e2ce \u00e0 la plateforme Orion\u00ae d\u2019OpenEye. Fournit des pr\u00e9dictions pr\u00e9cises d\u2019affinit\u00e9 de liaison pour vous aider \u00e0 classer les compos\u00e9s avec confiance et \u00e0 prioriser les d\u00e9cisions de synth\u00e8se pour les candidats les plus prometteurs d\u00e8s les premi\u00e8res \u00e9tapes de la d\u00e9couverte. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/free-energy-methods\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory.webp 1336w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Laboratory setting with scientific equipment and colorful containers in the foreground, illustrating drug discovery workflows including assay development, high-throughput screening, and integrated pharmacology solutions.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTMzNiIgaGVpZ2h0PSI4OTEiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory.webp 1336w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/drug-discovery-assay-development-high-throughput-screening-laboratory-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-d0afa7ade39bbf5f1d29363f5a74ba36\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/molecular-dynamic-simulations\/\" type=\"page\" id=\"4926\">Simulations de dynamique mol\u00e9culaire<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-ae4b5fadc8d28e2dd0088af562ca2579\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Identifier les interactions cl\u00e9s n\u2019est pas toujours simple. Les mod\u00e8les statiques peuvent passer \u00e0 c\u00f4t\u00e9 de dynamiques essentielles influen\u00e7ant la liaison et la stabilit\u00e9. Les simulations de dynamique mol\u00e9culaire permettent d\u2019observer les cibles en mouvement, de r\u00e9v\u00e9ler des interactions cach\u00e9es et d\u2019am\u00e9liorer les strat\u00e9gies de conception mol\u00e9culaire.  <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/molecular-dynamic-simulations\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein Structure Prediction\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-Structure-Prediction.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-a8d3376898730941dacee6d3174ef9ff\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\" type=\"page\" id=\"4821\">Pr\u00e9diction de la structure des prot\u00e9ines<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-65a8460d368c8c8bb6d0cf5c14469527\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">L\u2019utilisation d\u2019une IA avanc\u00e9e et de techniques de mod\u00e9lisation \u00e9prouv\u00e9es permet de pr\u00e9dire avec pr\u00e9cision les structures prot\u00e9iques, acc\u00e9l\u00e9rant ainsi la conception de m\u00e9dicaments bas\u00e9e sur la structure et la d\u00e9couverte de nouvelles th\u00e9rapies.<br> possibilit\u00e9s.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/computer-aided-drug-design\/protein-structure-prediction\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Mod\u00e8les structuraux D de biomol\u00e9cules, repr\u00e9sentant les techniques de biologie structurale pour la conception de m\u00e9dicaments, la cartographie des \u00e9pitopes et le criblage de fragments\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNzA3IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-scaled.webp\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-300x200.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-768x512.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1024x683.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-1536x1024.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-540x360.webp 540w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/structural-biology-640x427.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-f627666a78aed81cdd1fc17dd1f1faed\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/biologie-structurale\/\" type=\"page\" id=\"1689\">Biologie structurale<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-c2783252ac1dedc188e9309366fc8e87\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Obtenez des informations structurelles qui guident une conception de m\u00e9dicaments plus intelligente gr\u00e2ce \u00e0 la cryo-microscopie \u00e9lectronique, la RMN et la cristallographie aux rayons X, appuy\u00e9es par une analyse et une collaboration d\u2019experts.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/biologie-structurale\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/target-classes-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/target-classes.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Target Classes\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/target-classes.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/target-classes-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/target-classes.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-15ad26224fe7287ee6ba9bb35573043b\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/classes-cibles\/\">Classes cibles<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-17a9d2503c0e12a2a65ab9cd15e44719\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Les solutions compl\u00e8tes par classe cible int\u00e8grent des analyses avanc\u00e9es, la biologie structurale et la chimie m\u00e9dicinale pour acc\u00e9l\u00e9rer la s\u00e9lection des compos\u00e9s candidats et l\u2019identification des mol\u00e9cules actives.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/classes-cibles\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-f7b5deab wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein &amp; Structure\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-5191219c2e3f32f7b49742142e92c0b0\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\">Prot\u00e9ines et structure<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-6d0ad0b56328052437b8544c1326311a\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Page d\u2019accueil du d\u00e9partement de prot\u00e9omique et de biologie structurale. Nous prenons le temps de comprendre votre objectif et les finalit\u00e9s de votre projet afin d\u2019adapter notre approche en cons\u00e9quence. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Hit-ID-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Hit-ID.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Hit Identification\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Hit-ID.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Hit-ID-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Hit-ID.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-5e663fe54823aeda0207b0b1b6ee8797\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/decouverte-integree-de-medicaments\/identification-des-impacts\/\" type=\"page\" id=\"941\">Identification des impacts<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-a0a4485cf1595d92057798bebf30c0e2\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Fournir des r\u00e9sultats valid\u00e9s et de haute qualit\u00e9 gr\u00e2ce \u00e0 des technologies int\u00e9gr\u00e9es, une vision strat\u00e9gique et une collaboration d\u2019experts pour faire progresser votre programme en toute confiance.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/decouverte-integree-de-medicaments\/identification-des-impacts\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-ed8e509d wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/App-Shot-Wrapper-1-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/App-Shot-Wrapper-1.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/App-Shot-Wrapper-1.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/App-Shot-Wrapper-1-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/App-Shot-Wrapper-1.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-fe9cc265 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-3682337da7cb9cff5f89a91a0e4c58fe\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/\" type=\"page\" id=\"1086\">Conception de m\u00e9dicaments assist\u00e9e par ordinateur<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-a2605c409f88fc4401b911c63a689394\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Nos capacit\u00e9s de conception de m\u00e9dicaments assist\u00e9e par ordinateur (CADD) combinent une expertise scientifique approfondie avec une infrastructure avanc\u00e9e d\u2019IA, d\u2019apprentissage automatique et d\u2019informatique pour soutenir une prise de d\u00e9cision plus intelligente et plus rapide tout au long du processus de d\u00e9couverte de m\u00e9dicaments.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/computer-aided-drug-design\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":7636,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4361","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Conception de m\u00e9dicaments bas\u00e9e sur la structure<\/title>\n<meta name=\"description\" content=\"La conception de m\u00e9dicaments bas\u00e9e sur la structure r\u00e9volutionne le domaine de la d\u00e9couverte de m\u00e9dicaments. 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