{"id":4360,"date":"2025-11-16T15:33:36","date_gmt":"2025-11-16T15:33:36","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/modalites\/conjugues-de-medicaments-anticorps-adc\/"},"modified":"2026-11-10T11:31:57","modified_gmt":"2026-11-10T11:31:57","slug":"conjugues-de-medicaments-anticorps-adc","status":"publish","type":"page","link":"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/conjugues-de-medicaments-anticorps-adc\/","title":{"rendered":"Conjugu\u00e9s anticorps-m\u00e9dicament (ADC)"},"content":{"rendered":"\n<div x-data='subNav({\"anchor_map\":{\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/modalites\\\/petites-molecules\\\/\":\"Petites mol\\u00e9cules\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/modalites\\\/peptides\\\/\":\"Peptides\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/modalities\\\/targeted-protein-degradation\":\"D\\u00e9gradation cibl\\u00e9e des prot\\u00e9ines\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/modalities\\\/antibody-drug-conjugates\\\/\":\"conjugu\\u00e9s anticorps-m\\u00e9dicament\",\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/modalites\\\/biologiques\\\/\":\"Produits biologiques\"}})' id=\"pegasus-subnav\" class=\"SubNav w-full text-content-tertiary \" x-on:click.away=\"mobileSubMenuOpen = false\" x-cloak style=\"\">\n    <div x-ref=\"fixedNav\" class=\"SubNav__bar w-full h-[var(--subnav-height)] z-page-header whitespace-nowrap border-t border-grey-200 container flex items-center justify-between shadow-sm\">\n\n                    <!-- Desktop Navigation (tablet and up) -->\n            <div class=\"flex items-center min-w-0 flex-1 mr-4\">\n                                    <div class=\"flex items-center gap-x-3 mr-4 sm:mr-8 pr-4 sm:pr-8 md:border-r md:border-grey-200 flex-shrink-0\">\n                        \n                                                    <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/\" class=\"wp-block-button wp-block-button is-style-back-chevron text-content-primary \">\n                                <span class=\"wp-block-button__link wp-element-button bg-ivory-300 text-content-primary rounded-full\">Modalit\u00e9s<\/span>\n                            <\/a>\n                                            <\/div>\n                \n                <div class=\"hidden md:block min-w-0 flex-1 overflow-hidden relative\">\n                    <div class=\"nav-container-wrapper\">\n                        <ul x-ref=\"navList\" class=\"flex flex-row items-center !m-0 !list-none gap-8 !py-4 overflow-x-auto scrollbar-hide pr-16\">\n                                                            <li class=\"!m-0 !p-0 !list-none flex-shrink-0\">\n                                    <div class=\"wp-block-button is-style-text-link\">\n                                        <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/petites-molecules\/\" class=\"wp-block-button__link wp-element-button has-text-sm-font-size px-2 whitespace-nowrap after:bg-transparent \" :class=\"currentLink === 'https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/petites-molecules\/' || 'https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/petites-molecules\/' === window.location.href ? 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\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-11f35101 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--90);padding-left:var(--wp--preset--spacing--90)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-align-center is-style-tag has-text-color has-link-color has-tag-style wp-elements-1 wp-block-paragraph\" style=\"color:#002b46;margin-top:0;margin-bottom:0;--paragraph-dot-color:#005DE5\">modalit\u00e9s<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center has-text-5-xl-font-size\" style=\"font-style:normal;font-weight:300\">Conjugu\u00e9s anticorps-m\u00e9dicament (ADC)<\/h1>\n\n\n\n<p class=\"has-text-align-center has-text-color has-link-color has-text-lg-font-size wp-elements-2 wp-block-paragraph\" style=\"color:#002b46;font-style:normal;font-weight:400\">Nous concevons et optimisons les connecteurs et les charges utiles qui d\u00e9finissent les performances des CAN.<br> vous aider \u00e0 cr\u00e9er des th\u00e9rapies plus s\u00fbres et plus s\u00e9lectives gr\u00e2ce \u00e0 une approche collaborative et scientifique.<br> innovation stimul\u00e9e.<\/p>\n\n\n\n<p class=\"has-text-align-center has-text-color has-link-color has-text-lg-font-size wp-elements-3 wp-block-paragraph\" style=\"color:#002b46;font-style:normal;font-weight:400\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-40dccddb wp-block-buttons-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-button\" modaltype=\"side\" data-pegasus-modal=\"Modal--side\"><a data-pegasus-modal=\"Modal--Side\" class=\"wp-block-button__link has-text-align-center wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/formulaire-de-discussion-de-projet-modal\/\">Entrer en contact<\/a><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n\n<div style=\"height:4vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<\/div>\n    <\/div>\n<\/section>\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--90); \" id=\"how-it-works\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8904fc3d wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23.8%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-1 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-b5580a65 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-text-color has-link-color has-tag-style wp-elements-4 wp-block-paragraph\" style=\"color:#00102480;padding-right:0;padding-left:0;--paragraph-dot-color:#005de5\">SOUTENIR VOS RECHERCHES<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--45)\">La plateforme ADC NewPath de Sygnature<\/h2>\n\n\n\n<p class=\"has-text-base-font-size wp-block-paragraph\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">D\u00e9couvrez une nouvelle approche ax\u00e9e sur les charges utiles (payloads) pour le d\u00e9veloppement de la prochaine g\u00e9n\u00e9ration de conjugu\u00e9s anticorps-m\u00e9dicament (ADC).<\/p>\n\n\n\n<p class=\"has-text-base-font-size wp-block-paragraph\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">La plateforme NewPath ADC de Sygnature Discovery propose des solutions enti\u00e8rement int\u00e9gr\u00e9es et centralis\u00e9es pour les conjugu\u00e9s anticorps-m\u00e9dicament (ADC). Nos \u00e9quipes multidisciplinaires associent chimie m\u00e9dicinale, sciences des prot\u00e9ines et \u00e9valuations <em>in vitro<\/em> et <em>in vivo<\/em> , notamment la DMPK, afin de cr\u00e9er des ADC performants.<\/p>\n\n\n\n<p class=\"has-text-base-font-size wp-block-paragraph\" style=\"padding-bottom:var(--wp--preset--spacing--20)\">La plupart des fournisseurs suivent un processus de d\u00e9veloppement ADC classique. Nous privil\u00e9gions une approche diff\u00e9rente. Sygnature Discovery mise sur l\u2019optimisation de la charge utile pour am\u00e9liorer l\u2019efficacit\u00e9 et la s\u00e9lectivit\u00e9, et ainsi maximiser les b\u00e9n\u00e9fices th\u00e9rapeutiques. R\u00e9sultat\u00a0? Des ADC plus performants qui contribuent \u00e0 votre r\u00e9ussite.    <\/p>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover has-aspect-ratio aspect-59x35 has-overlay absolute inset-0 w-full h-full\" style=\"\">\n            \n                                        <img decoding=\"async\" src=\"https:\/\/placehold.co\/1920x1080\/f3f4f6\/D2D5DA?text=Awaiting+Image\" width=\"100%\" height=\"auto\" class=\"absolute inset-0 w-full h-full object-cover\">\n        \n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-light mobile-stacking-standard   stacking-content -sticky-heading -two-columns is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--100); \" id=\"sticky-scroll-progress\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-dark-blue-700-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-b4425dac wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-global-padding is-layout-constrained wp-block-column-is-layout-constrained\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--80);margin-bottom:var(--wp--preset--spacing--80);padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Progress Progress--left Progress--scroll absolute z-[1000]\" style=\"--progress-thickness: 1px; --progress-color: var(--wp--preset--color--ivory-300); --progress-background: rgba(249, 242, 232, 0.2);\" x-data=\"progress()\" x-init='init({\"position\":\"left\",\"eventType\":\"scroll\",\"scrollOptions\":{\"scroll_target\":\"m\\u00e8re\",\"container_selector\":\"\"},\"tickerOptions\":[],\"formOptions\":[],\"anchorPoints\":{\"align_points\":true,\"points\":[{\"element_id\":\"\\u00e9l\\u00e9ment-collant-1\",\"label\":\"\"},{\"element_id\":\"\\u00e9l\\u00e9ment-collant-2\",\"label\":\"\"},{\"element_id\":\"\\u00e9l\\u00e9ment-collant-3\",\"label\":\"\"}]},\"showEndDot\":true,\"containerScrollOffset\":0.2,\"progressThreshold\":0.005})' x-cloak data-position=\"left\" data-event-type=\"scroll\">\n    <div class=\"Progress__track bg-[var(--progress-background,rgba(0,124,186,0.2))] relative overflow-visible\" x-ref=\"track\">\n        <div class=\"Progress__fill transition-all duration-100 ease-out bg-[var(--progress-color,#0053CC)]\" x-ref=\"fill\"><\/div>\n            <\/div>\n<\/div>\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-cfb3f328 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div id=\"sticky-item-1\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-bcfe1d36 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Comment pouvons-nous vous aider ?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nous pensons que notre sp\u00e9cialisation dans les petites mol\u00e9cules constitue un atout majeur pour les conjugu\u00e9s anticorps-m\u00e9dicament (ADC). En effet, la performance d\u2019un ADC repose avant tout sur le lieur et la charge utile, et c\u2019est l\u00e0 que nous excellons. <br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bien que nous puissions produire des anticorps, les conjuguer, les analyser et \u00e9valuer leur potentiel de d\u00e9veloppement, ce sont nos vastes comp\u00e9tences en mati\u00e8re de conception, de synth\u00e8se et d\u2019optimisation, tant du lieur que de la charge utile, qui nous distinguent r\u00e9ellement.<br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le d\u00e9veloppement des charges utiles des ADC est encore en \u00e9volution, mais nos partenaires utilisent d\u00e9j\u00e0 notre plateforme pour faire progresser des ADC plus s\u00fbrs et plus s\u00e9lectifs vers la clinique.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br><\/p>\n<\/div>\n\n\n\n<div id=\"sticky-item-1\" class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-bcfe1d36 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--site-gutter);padding-bottom:var(--wp--preset--spacing--100)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-3-xl-font-size\" style=\"font-style:normal;font-weight:300\">Nos solutions<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Notre cadre complet de d\u00e9veloppement des ADC permet de relever les d\u00e9fis, de la conception initiale jusqu\u2019aux \u00e9tudes habilitantes \u00e0 la pr\u00e9sentation d\u2019une demande d\u2019IND. Nous mettons l\u2019accent sur l\u2019optimisation avanc\u00e9e des charges utiles (payloads) et sur une compr\u00e9hension approfondie des m\u00e9canismes d\u2019action afin de faciliter le d\u00e9veloppement futur et la progression clinique. En int\u00e9grant des analyses in vitro et in vivo, nous optimisons la puissance, l\u2019efficacit\u00e9 et l\u2019innocuit\u00e9 des ADC pour favoriser de meilleurs r\u00e9sultats pour les patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><section class=\"Pegasus__Container w-full hidden sm:block  sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-2 is-position-sticky\" style=\"  padding-top:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><div class=\"Reveal \" x-data='reveal({\"initiallyVisible\":true,\"element\":\"autre\",\"elementId\":\"\\u00e9l\\u00e9ment-collant-1\",\"action\":\"vue\"})' styles=\";\">\n\t        \n    \t\t<div x-show=\"show\" x-transition:enter=\"transition ease-out duration-500\" x-transition:enter-start=\"opacity-0\" x-transition:enter-end=\"opacity-100\" x-transition:leave=\"transition ease-in duration-500 absolute inset-0\" x-transition:leave-start=\"opacity-100\" x-transition:leave-end=\"opacity-0\" x-cloak>\n\n\t\t\t<div class=\"acf-innerblocks-container\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-768x433.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-1024x577.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics.webp 1065w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-640x360.webp 640w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-640x361.webp 640w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1065\" height=\"600\" class=\"image-original \" alt=\"3D molecular visualization representing diverse therapeutic modalities in drug discovery, including PROTACs, molecular glues, peptides, and RNA-targeting therapies.\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-768x433.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-1024x577.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics.webp 1065w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-640x360.webp 640w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/multimodal-drug-discovery-protacs-molecular-glues-biologics-640x361.webp 640w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\t\n\t\t<\/div>\n    \n\t\t\t<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full block sm:hidden md:hidden  sticky top-0 lg:relative lg:h-fixed md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-3 is-position-sticky\" style=\" --height-lg-fixed: 630px;  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media original has-aspect-ratio aspect-1x1 shrink-0\" style=\"\">\n            \n                                    <picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"561\" height=\"588\" class=\"image-original \" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.jpg\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-286x300.webp 286w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1.webp 561w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Scientist-Administering-607x589-1-343x360.webp 343w\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-light mobile-stacking-standard   carousel-gap-1xs is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-dark-blue-700-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section x-data='newcarousel({\"transition\":\"slide\",\"overflow\":false,\"autoplay\":0,\"infinite\":true,\"preview\":false,\"slidesInView\":3,\"slidesInViewTablet\":2,\"slidesInViewMobile\":1.15,\"slideGap\":0,\"align\":\"left\",\"swipeScroll\":false,\"snapToSlides\":false})' x-intersect.once=\"initAutoplay()\" class=\"Content__Carousel carousel-gap-1xs wp-elements-5 relative h-full\" style=\"--slides-to-show-desktop: 3; --slides-to-show-tablet: 2; --slides-to-show-mobile: 1.15; --slide-gap: 0px; --carousel-arrow-spacing: 1%; --carousel-arrow-inset: 0rem;\">\n            \n    <div class=\"Carousel__WrapperOuter relative z-10\" data-carousel-anchor style=\"--carousel-arrow-spacing: 1%; --carousel-arrow-inset: 0rem\">\n\n                    <div class=\"pb-10 intro-text-wrapper\">\n                <div class=\"flex flex-col md:flex-row relative\">\n                    <div class=\"Carousel__introText mb-16 md:mb-0 w-full md:w-[45%] text-left md:max-w-[708px]\">\n                        <p class=\"has-text-4-xl-font-size has-text-3-xl-font-size\">Un gros probl\u00e8me de convertisseur analogique-num\u00e9rique ? Des solutions \u00e0 base de petites mol\u00e9cules <\/p>\n<p>Notre approche holistique du d\u00e9veloppement des ADC s\u2019appuie sur une expertise dans quatre domaines cl\u00e9s\u00a0:<\/p>\n\n                    <\/div>\n                                            <div class=\"Navigation__Arrows container md:absolute alignment vertical-bottom horizontal-right \" style=\"--carousel-arrow-spacing: 1%; --carousel-arrow-inset: 0rem\">\n                                                    <button x-on:click=\"previousSlide()\" class=\"Navigation__Arrows--prev flex items-center justify-center w-10 h-10 rounded-full p-2 transition-opacity duration-500\" :class=\"firstSlide ? 'opacity-50 pointer-events-none' : 'opacity-100'\" style=\"background-color:var(--wp--preset--color--blue-300);\">\n                                <span class=\"sr-only\">Previous Slide<\/span>\n                                <svg width=\"29\" height=\"29\" viewbox=\"0 0 29 29\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path d=\"M22.8047 14.6992L6.60438 14.6992\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                    <path d=\"M14.7031 22.8008L6.60297 14.7006L14.7031 6.60048\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                <\/svg>\n                            <\/button>\n                        \n                                                    <button x-on:click=\"nextSlide()\" class=\"Navigation__Arrows--next flex items-center justify-center w-10 h-10 rounded-full p-2 transition-opacity duration-500\" :class=\"lastSlide ? 'opacity-50 pointer-events-none' : 'opacity-100'\" style=\"background-color:var(--wp--preset--color--blue-300);\">\n                                <span class=\"sr-only\">Next Slide<\/span>\n                                <svg width=\"28\" height=\"28\" viewbox=\"0 0 28 28\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path d=\"M5.92188 14.0264H22.1222\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                    <path d=\"M14.0234 5.92871L22.1236 14.0289L14.0234 22.129\" stroke=\"currentColor\" stroke-width=\"1.73575\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n                                <\/svg>\n                            <\/button>\n                        \n                        <\/div>\n                                    <\/div>\n            <\/div>\n            \n        <div x-ref=\"sliderContainer\" class=\"Carousel__Container h-full \">\n        <div class=\"Carousel__Wrapper overflow-hidden  Carousel--snap-scroll Carousel--snap-left  Carousel--infinite-scroll \" style=\"\">\n            <div class=\"Carousel\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-223614e0 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-79ec1831 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-6\" style=\"font-style:normal;font-weight:400\">Optimisation des ADC ax\u00e9e sur la chimie m\u00e9dicinale<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a5dcd082 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-7 wp-block-paragraph\">M\u00eame une petite modification chimique ou st\u00e9rique de la charge utile peut avoir un impact consid\u00e9rable sur la s\u00e9lectivit\u00e9, le d\u00e9veloppement et la tol\u00e9rance.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-ab59a944 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-79ec1831 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-8\" style=\"font-style:normal;font-weight:400\">Profilage DMPK pour les charges utiles<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a5dcd082 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-9 wp-block-paragraph\">La compr\u00e9hension des profils m\u00e9taboliques et pharmacocin\u00e9tiques garantit une s\u00e9curit\u00e9 optimale, car l\u2019\u00e9limination de la charge utile est essentielle pour limiter la toxicit\u00e9 syst\u00e9mique.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-ab59a944 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-79ec1831 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-10\" style=\"font-style:normal;font-weight:400\">Optimisation synergique<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a5dcd082 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-11 wp-block-paragraph\">Les conjugu\u00e9s anticorps-m\u00e9dicament (ADC) de nouvelle g\u00e9n\u00e9ration ne sont pas con\u00e7us par composants (anticorps, linker, charge utile)\u00a0; ils sont optimis\u00e9s dans leur ensemble. Comprendre ce fonctionnement global est essentiel pour d\u00e9velopper les ADC de nouvelle g\u00e9n\u00e9ration. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-ab59a944 wp-block-group-is-layout-flex\" style=\"border-radius:24px;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-79ec1831 wp-block-group-is-layout-flex\" style=\"margin-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h4 class=\"wp-block-heading has-dark-blue-700-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-12\" style=\"font-style:normal;font-weight:400\">R\u00e9utilisation des actifs \u00e0 base de petites mol\u00e9cules<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-a5dcd082 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-base-font-size wp-elements-13 wp-block-paragraph\">La transformation de petites mol\u00e9cules cliniques en charges utiles d\u2019ADC cr\u00e9e des opportunit\u00e9s de double sp\u00e9cificit\u00e9 et peut relancer des compos\u00e9s qui avaient auparavant \u00e9chou\u00e9 en raison de probl\u00e8mes de DMPK ou de toxicit\u00e9.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    \n\t\t\t\t\t            \t\n\t\t\t\t\n                <\/div>\n    <\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\">Concevoir, fabriquer, tester, analyser<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nous appliquons la pens\u00e9e des petites mol\u00e9cules \u00e0 la d\u00e9couverte des grandes mol\u00e9cules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Notre expertise en chimie permet d\u2019optimiser les anticorps, les techniques de conjugaison, les agents de liaison et les charges utiles, tandis que nos \u00e9quipes de prot\u00e9omique et de biologie garantissent un processus simplifi\u00e9, de la conception de votre conjugu\u00e9 anticorps-m\u00e9dicament \u00e0 son test.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-bottom:var(--wp--preset--spacing--100);padding-top:var(--wp--preset--spacing--70); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-f9bc3583 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"font-style:normal;font-weight:400\">Nos capacit\u00e9s <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-300-color\">de conception et de fabrication<\/mark> de CAN<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-aef0a2cf wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Expression et purification des anticorps<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Synth\u00e8se de la charge utile du linker  <\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group wp-container-content-2155ee95 has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-top-style:none;border-top-width:0px;border-right-style:none;border-right-width:0px;border-bottom-style:none;border-bottom-width:0px;border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Conjugaison<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-top-style:none;border-top-width:0px;border-right-style:none;border-right-width:0px;border-bottom-style:none;border-bottom-width:0px;border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Contr\u00f4le qualit\u00e9\/caract\u00e9risation  <\/h3>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-bottom:var(--wp--preset--spacing--50)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-4-xl-font-size\" style=\"font-style:normal;font-weight:400\">Nos capacit\u00e9s <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-300-color\">de test et d\u2019analyse<\/mark> des CAN<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-aef0a2cf wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Criblage biophysique<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">analyse PD <em>in vitro<\/em><\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Analyse DMPK <em>in vitro<\/em><\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Analyse <em>in vivo<\/em><\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-group wp-container-content-2155ee95 has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-7ab26050 wp-block-group-is-layout-constrained\" style=\"border-left-color:var(--wp--preset--color--grey-200);border-left-width:2px;padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--10)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:1.5rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-sm-font-size\" style=\"margin-top:0;margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">d\u00e9veloppabilit\u00e9<\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-5bfd8226 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--90)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"is-style-tag has-tag-style wp-block-paragraph\" style=\"margin-bottom:var(--wp--preset--spacing--30);padding-top:0;padding-right:0;padding-bottom:0;padding-left:0;--paragraph-dot-color:#005de5\">Our team<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left has-text-color has-link-color has-text-4-xl-font-size wp-elements-14 wp-container-content-1d651e7a\" style=\"color:#002b46\">Nos experts en ADC<\/h2>\n<\/div>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard   vacancies-post-list -sticky-heading -dynamic is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-white-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-95eae3bd wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-4 is-position-sticky\" style=\"  padding-top:var(--wp--preset--spacing--30); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-68a16a07 wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-display-lg-font-size has-text-color has-link-color has-text-4-xl-font-size wp-elements-15\" style=\"color:#101828;font-style:normal;font-weight:400\">Rencontrez notre \u00e9quipe<\/h2>\n\n\n\n<p class=\"has-text-color has-link-color has-text-lg-font-size wp-elements-16 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--45)\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/a-propos-de-nous\/notre-equipe\/\">D\u00e9couvrez toute 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md:w-1\/3 overflow-hidden aspect-video md:aspect-[4\/3] \">\n\t\t\t\t\t<span class=\"sr-only\">Joshua Greally, Doctorat<\/span>\n\t\t\t\t\t<div class=\"absolute inset-0 w-full h-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Joshua-Greally_Scientific-BD-Manager_ADC-Lead_UK-285x300.webp 285w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Joshua-Greally_Scientific-BD-Manager_ADC-Lead_UK.webp 342w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"342\" height=\"360\" class=\"h-full w-full object-cover transition-transform duration-500 ease-in-out absolute top-1\/2 left-1\/2 -translate-x-1\/2 -translate-y-1\/2 !h-full group-hover:scale-105\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Joshua-Greally_Scientific-BD-Manager_ADC-Lead_UK.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Joshua-Greally_Scientific-BD-Manager_ADC-Lead_UK-285x300.webp 285w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Joshua-Greally_Scientific-BD-Manager_ADC-Lead_UK.webp 342w\"><\/source><\/picture>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t\t\n                    <div class=\"post-content flex flex-col p-6 w-full md:w-2\/3\">\n                <div class=\"flex-1 flex flex-col gap-2\">\n                                                                <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/people\/joshua-greally-doctorat\/\" data-pegasus-modal=\"Modal--team\" class=\"wp-block-heading has-text-2-xl-font-size !mb-0 text-dark-blue-700 \">Joshua Greally, Doctorat<\/a>  \n                                        \n                                            <div class=\"has-blue-500-color font-medium has-text-color has-link-color text-base\">\n                            Consultant en d\u00e9couverte chez ADC\n                        <\/div>\n                    \n                                            <div class=\"mt-3 text-sm transition-colors duration-300\">\n                            <p class=\"wp-block-paragraph\">Fort d\u2019une expertise en chimie m\u00e9dicinale, en bioconjugaison et en d\u00e9couverte d\u2019ADC, Joshua supervise\u2026\n                        <\/p><\/div>\n                    \n                <\/div>\n            \n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"Post__Grid-post flex overflow-hidden rounded-lg bg-ivory-300 mb-6 w-full min-h-56\" data-pegasus-single-card=\"\">\n    <div class=\"group flex flex-col md:flex-row w-full\">\n    \n        \t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/people\/allan-jordan-docteur-es-sciences\/\" data-pegasus-modal=\"Modal--team\" class=\"block relative w-full md:w-1\/3 overflow-hidden aspect-video md:aspect-[4\/3] \">\n\t\t\t\t\t<span class=\"sr-only\">Allan Jordan, Doctorat<\/span>\n\t\t\t\t\t<div class=\"absolute inset-0 w-full h-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<picture><source srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Allan-Jordan_VP_Oncology_UK-1-285x300.webp 285w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Allan-Jordan_VP_Oncology_UK-1.webp 342w\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" width=\"342\" height=\"360\" class=\"h-full w-full object-cover transition-transform duration-500 ease-in-out absolute top-1\/2 left-1\/2 -translate-x-1\/2 -translate-y-1\/2 !h-full group-hover:scale-105\" loading=\"eager\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Allan-Jordan_VP_Oncology_UK-1.png\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Allan-Jordan_VP_Oncology_UK-1-285x300.webp 285w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Allan-Jordan_VP_Oncology_UK-1.webp 342w\"><\/source><\/picture>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t\t\n                    <div class=\"post-content flex flex-col p-6 w-full md:w-2\/3\">\n                <div class=\"flex-1 flex flex-col gap-2\">\n                                                                <a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/people\/allan-jordan-docteur-es-sciences\/\" data-pegasus-modal=\"Modal--team\" class=\"wp-block-heading has-text-2-xl-font-size !mb-0 text-dark-blue-700 \">Allan Jordan, Doctorat<\/a>  \n                                        \n                                            <div class=\"has-blue-500-color font-medium has-text-color has-link-color text-base\">\n                            Vice-pr\u00e9sident senior, Recherche et d\u00e9veloppement de m\u00e9dicaments oncologiques\n                        <\/div>\n                    \n                                            <div class=\"mt-3 text-sm transition-colors duration-300\">\n                            <p class=\"wp-block-paragraph\">Allan assure la supervision scientifique globale et le mentorat de l\u2019ensemble des projets oncologiques\u2026\n                        <\/p><\/div>\n                    \n                <\/div>\n            \n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n\t\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\n\t<\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--80); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t<div class=\"row-background absolute w-full bottom-0 left-0 z-0 h-full has-ivory-300-background-color\" style=\"\">\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">    <section class=\"FeaturedPostGrid\">\n        <div class=\"FeaturedPostGrid__container\">\n                            <div class=\"FeaturedPost bg-white flex flex-col md:flex-row items-stretch gap-8 rounded-3xl\">\n                    <div class=\"flex-1 flex flex-col justify-between gap-6 p-[clamp(2rem,3vw,4rem)]\">\n        <div class=\"flex flex-col\">\n            <h2 class=\"wp-block-heading has-text-4-xl-font-size text-dark-blue-700 !mb-0\">Next-Generation Antibody Drug Conjugates<\/h2>\n            <p class=\"has-text-4-xl-font-size text-content-tertiary mb-10\">Ebook<\/p>\n    \n                            <div class=\"text-content-secondary has-text-base-font-size has-heading-font-family max-w-[560px]\">\n                    Expert insights into the scientific strategies shaping the future of ADC development Developing successful antibody drug conjugates (ADCs) is becoming increasingly complex. Advances in payload design, linker chemistry, target selection and conjugation technologies are creating new opportunities, while introducing new scientific and development challenges. To help navigate this evolving landscape, we\u2019ve developed this eBook, bringing together insights from 14 ADC experts at\u2026\n                <\/div>\n                    <\/div>\n\n        <div class=\"wp-block-buttons is-layout-flex items-center gap-6 pt-2\">\n                        <div class=\"wp-block-button btn-primary\">\n                    <a class=\"wp-block-button__link wp-element-button \" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/e-book\/next-generation-antibody-drug-conjugates\/\">Download<\/a>\n                <\/div>\n                                        <div class=\"wp-block-button is-style-text-link\">\n                    <a class=\"wp-block-button__link wp-element-button \" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/centre-de-ressources\/livres-electroniques\/\" target=\"_self\">View all eBooks<\/a>\n                <\/div>\n                    <\/div>\n    <\/div>\n\n    <div class=\"md:w-1\/2 w-full relative p-6\">\n                                        <div class=\"w-full h-0 pb-[73%] relative overflow-hidden rounded-2xl\">\n                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-300x211.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-768x539.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-1024x719.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-1536x1079.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-1538x1080.webp 1538w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-513x360.webp 513w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-640x450.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"1538\" height=\"1080\" class=\"absolute inset-0 w-full h-full object-cover rounded-2xl\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNzk4IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-300x211.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-768x539.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-1024x719.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-1536x1079.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-1538x1080.webp 1538w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-513x360.webp 513w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/eBook_2560x1798px_no-logo-640x450.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n                <\/div>\n                <\/div>\n<\/div>\n\n\n\n                    <\/div>\n    <\/section>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit overflow-hidden text-content-dark mobile-stacking-standard   left-aligned-multi-slide-carousel is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--50); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section x-data='newcarousel({\"transition\":\"slide\",\"overflow\":false,\"autoplay\":0,\"infinite\":false,\"preview\":false,\"slidesInView\":1.75,\"slidesInViewTablet\":1,\"slidesInViewMobile\":1.15,\"slideGap\":0,\"align\":\"left\",\"swipeScroll\":false,\"snapToSlides\":false})' x-intersect.once=\"initAutoplay()\" class=\"Content__Carousel wp-elements-21 relative h-full\" style=\"--slides-to-show-desktop: 1.75; --slides-to-show-tablet: 1; --slides-to-show-mobile: 1.15; --slide-gap: 0px; --carousel-arrow-spacing: 50%; --carousel-arrow-inset: 0rem; padding-top:0;padding-bottom:var(--wp--preset--spacing--60);;\">\n            \n    <div class=\"Carousel__WrapperOuter relative z-10\" data-carousel-anchor style=\"--carousel-arrow-spacing: %; --carousel-arrow-inset: rem\">\n\n                    <div class=\"pb-10 intro-text-wrapper\">\n                <div class=\"flex flex-col md:flex-row relative\">\n                    <div class=\"Carousel__introText mb-16 md:mb-0 w-full md:w-[45%] text-left md:max-w-[708px]\">\n                        <p class=\"has-text-align-center is-style-tag has-text-color has-link-color has-text-xs-font-size has-tag-style\" style=\"padding-bottom: var(--wp--preset--spacing--30); color: rgba(0, 16, 36, 0.7); padding-right: 0px; padding-left: 0px; font-style: normal; font-weight: 600; letter-spacing: 0.96px; --paragraph-dot-color: #005de5; text-align: left;\">\u00c9tudes de cas<\/p>\n<h2 class=\"heading-two wp-block-heading has-text-4-xl-font-size\">Approuv\u00e9 par des clients du monde entier<\/h2>\n<p>\u00a0<\/p>\n<p>Nos clients nous disent que nous agissons comme un prolongement de leur \u00e9quipe et que nous leur apportons une expertise de haut niveau \u00e0 chaque \u00e9tape du processus de d\u00e9couverte de m\u00e9dicaments. Que nous vous accompagnions tout au long du processus ou seulement sur une partie, notre objectif n\u2019est pas simplement de vous faire passer \u00e0 l\u2019\u00e9tape suivante, mais de jeter les bases d\u2019un m\u00e9dicament commercialis\u00e9 avec succ\u00e8s. <\/p>\n\n                    <\/div>\n                                    <\/div>\n            <\/div>\n            \n        <div x-ref=\"sliderContainer\" class=\"Carousel__Container h-full \">\n        <div class=\"Carousel__Wrapper overflow-hidden  Carousel--snap-scroll Carousel--snap-left \" style=\"padding-top:0;padding-bottom:var(--wp--preset--spacing--60);;\">\n            <div class=\"Carousel\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-22\" style=\"font-style:normal;font-weight:500\">De la prise de contact \u00e0 la pr\u00e9-nomination des candidats en 18 mois  <\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-23 wp-block-paragraph\">En passant de la phase de s\u00e9lection \u00e0 la nomination de pr\u00e9-candidat en moins de la moiti\u00e9 du d\u00e9lai standard du secteur, ce programme d\u00e9montre comment des \u00e9quipes scientifiques connect\u00e9es et des informations en temps r\u00e9el peuvent acc\u00e9l\u00e9rer les d\u00e9couvertes complexes.<\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--8\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/storm-therapeutics-from-lead-to-pre-candidate-nomination-in-18-months\/\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature.webp 600w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature-469x360.webp 469w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"600\" height=\"461\" class=\"absolute inset-0 w-full h-full object-cover\" alt=\"STORM Therapeutics logo featuring a stylized DNA helix and gradient background\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNjAwIiBoZWlnaHQ9IjQ2MSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature.webp 600w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/storm-therapeutics-logo-feature-469x360.webp 469w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-24\" style=\"font-style:normal;font-weight:500\">Sitryx : Donner vie aux nouvelles id\u00e9es<\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-25 wp-block-paragraph\">De nombreux programmes de recherche de m\u00e9dicaments prometteurs voient le jour au sein de jeunes entreprises de biotechnologie. Pourtant, \u00e0 leurs d\u00e9buts, ces nouvelles organisations disposent rarement des ressources ou des infrastructures de laboratoire n\u00e9cessaires pour transformer imm\u00e9diatement leurs id\u00e9es novatrices en un nouveau m\u00e9dicament. <\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--9\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/sitryx-empowering-new-ideas-2\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"598\" height=\"460\" class=\"absolute inset-0 w-full h-full object-cover\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTk4IiBoZWlnaHQ9IjQ2MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/10\/Frame-1597884672-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-26\" style=\"font-style:normal;font-weight:500\">Cr\u00e9ation rapide d\u2019id\u00e9es gr\u00e2ce \u00e0 l\u2019IA g\u00e9n\u00e9rative (GenAI) avec Iktos Makya<\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-27 wp-block-paragraph\">Les principaux algorithmes <a href=\"\/drug-discovery\/computer-aided-drug-design\/artificial-intelligence-ai\/\"><strong>d\u2019intelligence artificielle<\/strong><\/a> g\u00e9n\u00e9rative (GenAI) pour la conception <em>de novo<\/em> sont utilis\u00e9s de mani\u00e8re routini\u00e8re dans nos programmes de chimie m\u00e9dicinale pour permettre une g\u00e9n\u00e9ration rapide d\u2019id\u00e9es afin d\u2019atteindre les objectifs du projet.<\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--10\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/rapid-creation-of-ideas-using-generative-ai-genai-with-iktos-makya\/\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"598\" height=\"460\" class=\"absolute inset-0 w-full h-full object-cover\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTk4IiBoZWlnaHQ9IjQ2MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/AI_case_study_banner_final_mock_up-scaled-e1762789851208-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-28\" style=\"font-style:normal;font-weight:500\">Corcept Therapeutics : Collaboration int\u00e9gr\u00e9e en mati\u00e8re de d\u00e9couverte de m\u00e9dicaments<\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-29 wp-block-paragraph\">Corcept Therapeutics, situ\u00e9e \u00e0 Menlo Park, en Californie, est un chef de file dans la d\u00e9couverte et le d\u00e9veloppement de m\u00e9dicaments qui r\u00e9gulent les effets du cortisol.  <\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--11\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/corcept-therapeutics-integrated-drug-discovery-collaboration\/\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"598\" height=\"460\" class=\"absolute inset-0 w-full h-full object-cover\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTk4IiBoZWlnaHQ9IjQ2MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Posters-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-30\" style=\"font-style:normal;font-weight:500\">Campagne d\u2019optimisation des leads CellCentric \u2013 CCS1477<\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-31 wp-block-paragraph\">CellCentric d\u00e9veloppe de nouveaux traitements contre le cancer en s\u2019appuyant sur sa compr\u00e9hension de l\u2019\u00e9pig\u00e9n\u00e9tique.  <\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--12\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/cellcentric-lead-optimisation-campaign\/\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"598\" height=\"460\" class=\"absolute inset-0 w-full h-full object-cover\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTk4IiBoZWlnaHQ9IjQ2MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1293-scaled-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-32\" style=\"font-style:normal;font-weight:500\">D\u00e9couverte de cibles \u00e9pig\u00e9n\u00e9tiques par criblage de fragments, ciblant BRD3.<\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-33 wp-block-paragraph\">La d\u00e9couverte de m\u00e9dicaments bas\u00e9e sur des fragments permet d\u2019explorer un large \u00e9ventail de l\u2019espace chimique gr\u00e2ce \u00e0 une biblioth\u00e8que relativement restreinte mais diversifi\u00e9e de petites mol\u00e9cules.<\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--13\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/fragment-based-hit-discovery-for-the-epigenetic-target-brd3\/\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"598\" height=\"460\" class=\"absolute inset-0 w-full h-full object-cover\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTk4IiBoZWlnaHQ9IjQ2MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/TechnicalNotes-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-7bf36063 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group h-full has-border-color has-gray-200-border-color has-background overflow-hidden has-global-padding is-layout-constrained wp-container-core-group-is-layout-c846c3aa wp-block-group-is-layout-constrained\" style=\"border-width:1px;border-radius:1.5rem;background-color:#f9f2e8;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\">\n<div class=\"wp-block-columns h-full is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group h-full is-vertical is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-2b0208da wp-block-group-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--45);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--45);padding-left:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-relative md:relative md:h-relative relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-relative: 90%; --height-md-relative: 90%;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-grey-blue-1000-color has-text-color has-link-color has-text-lg-font-size wp-elements-34\" style=\"font-style:normal;font-weight:500\">Identification de 3 compos\u00e9s actifs en phase clinique et de 6 candidats au d\u00e9veloppement<\/h3>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-35 wp-block-paragraph\">Soci\u00e9t\u00e9 britannique de d\u00e9couverte de m\u00e9dicaments \u00e0 petites mol\u00e9cules<\/p>\n\n\n\n<p class=\"has-placeholder-grey-color has-text-color has-link-color has-text-lg-font-size wp-elements-36 wp-block-paragraph\">Il convient de se concentrer sur l\u2019identification de nouveaux traitements pour les maladies respiratoires inflammatoires, telles que la BPCO.<\/p>\n\n\n\n<div style=\"height:1.5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   lg:relative lg:h-fit md:relative md:h-fit relative  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill is-style-fill--14\" modaltype=\"\"><a class=\"wp-block-button__link has-ivory-000-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/case-study\/hit-identification-to-3-compounds-in-the-clinic-and-6-development-candidates\/\" style=\"background-color:#005de5\">Lisez l\u2019\u00e9tude de cas<\/a><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center h-full is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0;flex-basis:50%\"><section class=\"Pegasus__Container w-full   lg:relative lg:h-fixed md:relative md:h-relative has-full-height-md relative h-fixed overflow-hidden text-content-dark mobile-stacking-standard   h-full is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\" --height-lg-fixed: 460px; --height-md-relative: 100%; --height-fixed: 320px;   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-center  w-full\">\n<section x-data=\"PegasusMediaBlock\" class=\"Media object-cover absolute inset-0 w-full h-full\" style=\"aspect-ratio:1;\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"598\" height=\"460\" class=\"absolute inset-0 w-full h-full object-cover\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTk4IiBoZWlnaHQ9IjQ2MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1-300x231.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1.webp 598w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/PRP1262-scaled-1-468x360.webp 468w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    \n\t\t\t\t\n\t\t\t\t\n                <\/div>\n    <\/section>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-group is-vertical is-content-justification-stretch is-layout-flex wp-container-core-group-is-layout-10dd94be wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-global-padding is-content-justification-center is-layout-constrained wp-container-core-group-is-layout-9b336992 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--45)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-c9eb356c wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-4-xl-font-size\">FAQs<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-ddcd2f8d wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section class=\"Accordion relative w-full mx-auto \" style=\"\">\n            \n        <div>\n        <div class=\"acf-innerblocks-container\">\n<div x-data=\"accordionPanel(1, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-37\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Comment l\u2019exp\u00e9rience de Sygnature Discovery en d\u00e9veloppement d\u2019ADC profite-t-elle aux clients ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-38 wp-block-paragraph\" style=\"color:#475467\">Notre plateforme ADC r\u00e9unit des \u00e9quipes exp\u00e9riment\u00e9es issues de multiples disciplines pour lancer et faire progresser des programmes de d\u00e9couverte d\u2019ADC. Nous sommes sp\u00e9cialis\u00e9s dans le d\u00e9veloppement centr\u00e9 sur les charges utiles (payloads) et disposons de solides capacit\u00e9s pour optimiser les fen\u00eatres th\u00e9rapeutiques et les propri\u00e9t\u00e9s biophysiques.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-39 wp-block-paragraph\" style=\"color:#475467\">Nous poss\u00e9dons une expertise couvrant de nombreux m\u00e9canismes d\u2019action (MOA) et pouvons optimiser vos charges utiles existantes afin d\u2019am\u00e9liorer \u00e0 la fois la fen\u00eatre th\u00e9rapeutique et les propri\u00e9t\u00e9s biophysiques de l\u2019ADC. Notre \u00e9quipe exp\u00e9riment\u00e9e d\u00e9veloppe des essais sur mesure adapt\u00e9s aux projets ADC, qu\u2019il s\u2019agisse d\u2019\u00e9valuations biophysiques, in vitro ou in vivo des propri\u00e9t\u00e9s pharmacodynamiques (PD) et pharmacocin\u00e9tiques (PK).<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-40\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Que faire si mon m\u00e9dicament pr\u00e9sente une mauvaise pharmacocin\u00e9tique (PK) et ne permet pas d\u2019atteindre une exposition th\u00e9rapeutique suffisante ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-41 wp-block-paragraph\" style=\"color:#475467\">La conjugaison \u00e0 un ADC am\u00e9liore l\u2019acheminement du m\u00e9dicament vers la tumeur par rapport \u00e0 son exposition syst\u00e9mique, augmentant ainsi sa concentration locale. Gr\u00e2ce \u00e0 diff\u00e9rents ratios m\u00e9dicament-anticorps (DAR), nous pouvons vous aider \u00e0 mieux contr\u00f4ler l\u2019exposition et \u00e0 optimiser les propri\u00e9t\u00e9s pharmacocin\u00e9tiques. <\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-42 wp-block-paragraph\" style=\"color:#475467\">Notre exp\u00e9rience nous permet \u00e9galement d\u2019\u00e9valuer comment de l\u00e9g\u00e8res modifications de la chimie du linker, de la charge utile, du DAR ou d\u2019autres param\u00e8tres peuvent avoir un impact majeur sur la pharmacocin\u00e9tique et l\u2019efficacit\u00e9.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-43\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Que faire si ma th\u00e9rapie cibl\u00e9e pr\u00e9sente une toxicit\u00e9 syst\u00e9mique li\u00e9e \u00e0 la cible ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-44 wp-block-paragraph\" style=\"color:#475467\">Nous concevons des ADC capables d\u2019acheminer les compos\u00e9s directement vers leur site d\u2019action, r\u00e9duisant ainsi la toxicit\u00e9 hors cible. Notre expertise en chimie m\u00e9dicinale permet d\u2019assurer la stabilit\u00e9 des compos\u00e9s tout en pr\u00e9servant leur puissance, afin que tout compos\u00e9 passant dans la circulation syst\u00e9mique apr\u00e8s d\u00e9gradation lysosomale ou mort cellulaire soit rapidement \u00e9limin\u00e9.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-45\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Comment Sygnature Discovery peut-elle m\u2019aider \u00e0 relever mes d\u00e9fis de d\u00e9veloppement d\u2019ADC ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-46 wp-block-paragraph\" style=\"color:#475467\">Bien que notre expertise historique repose sur les petites mol\u00e9cules, nous disposons \u00e9galement d\u2019une solide exp\u00e9rience dans d\u2019autres modalit\u00e9s th\u00e9rapeutiques, notamment les produits biologiques, les ADC et les peptides. Notre important d\u00e9partement de sciences des prot\u00e9ines poss\u00e8de une vaste exp\u00e9rience de l\u2019expression, de la purification, du contr\u00f4le qualit\u00e9 et de l\u2019\u00e9valuation de la d\u00e9veloppabilit\u00e9 des anticorps et autres produits biologiques.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-47\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Qu\u2019est-ce que la d\u00e9couverte d\u2019anticorps conjugu\u00e9s \u00e0 un m\u00e9dicament (ADC) ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-48 wp-block-paragraph\" style=\"color:#475467\">La d\u00e9couverte d\u2019ADC consiste \u00e0 concevoir, produire et \u00e9valuer des conjugu\u00e9s anticorps-m\u00e9dicament afin d\u2019identifier des candidats pr\u00e9sentant le bon \u00e9quilibre entre puissance, s\u00e9lectivit\u00e9 et stabilit\u00e9 pour progresser vers le d\u00e9veloppement clinique. Les ADC associent un anticorps ciblant une cellule sp\u00e9cifique, une charge th\u00e9rapeutique (payload) et un linker chimique.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-49 wp-block-paragraph\" style=\"color:#475467\">Autrefois utilis\u00e9s principalement pour d\u00e9livrer des charges cytotoxiques puissantes, les ADC \u00e9voluent aujourd\u2019hui vers l\u2019utilisation d\u2019approches th\u00e9rapeutiques plus cibl\u00e9es, permettant de d\u00e9velopper des traitements plus s\u00fbrs, mieux tol\u00e9r\u00e9s et potentiellement plus efficaces.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-50\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Qu\u2019est-ce que le DAR (Drug-to-Antibody Ratio) et pourquoi est-il important ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-51 wp-block-paragraph\" style=\"color:#475467\">Le DAR repr\u00e9sente le nombre moyen de mol\u00e9cules de charge utile conjugu\u00e9es \u00e0 chaque anticorps. Sa compr\u00e9hension et sa ma\u00eetrise sont essentielles pour la d\u00e9veloppabilit\u00e9 des ADC ainsi que pour leur efficacit\u00e9 in vivo. Les technologies modernes de conjugaison permettent d\u00e9sormais un contr\u00f4le plus pr\u00e9cis du DAR et r\u00e9duisent l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 des ADC, am\u00e9liorant ainsi leurs propri\u00e9t\u00e9s globales.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-52\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Qu\u2019est-ce que l\u2019effet bystander dans la conception des ADC et est-il important pour ma cible ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-53 wp-block-paragraph\" style=\"color:#475467\">L\u2019effet bystander se produit lorsqu\u2019une charge utile lib\u00e9r\u00e9e diffuse vers des cellules tumorales voisines ne pr\u00e9sentant pas l\u2019antig\u00e8ne cibl\u00e9. L\u2019activit\u00e9 th\u00e9rapeutique s\u2019\u00e9tend alors aux cellules adjacentes, et pas seulement \u00e0 celles directement reconnues par l\u2019anticorps.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-54 wp-block-paragraph\" style=\"color:#475467\">Cet effet peut am\u00e9liorer l\u2019efficacit\u00e9 dans des tumeurs h\u00e9t\u00e9rog\u00e8nes pr\u00e9sentant diff\u00e9rents niveaux d\u2019expression antig\u00e9nique. Toutefois, il peut \u00e9galement entra\u00eener une lib\u00e9ration accrue de la charge utile dans la circulation syst\u00e9mique et r\u00e9duire la tol\u00e9rabilit\u00e9 du traitement. Il doit donc \u00eatre soigneusement \u00e9valu\u00e9 et \u00e9quilibr\u00e9.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-55\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Pouvez-vous r\u00e9aliser une \u00e9tude cibl\u00e9e d\u2019optimisation de charge utile ou de linker, ou devons-nous nous engager dans un programme ADC complet ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-56 wp-block-paragraph\" style=\"color:#475467\">Oui. Les projets d\u2019optimisation de charges utiles ou de linkers peuvent \u00eatre r\u00e9alis\u00e9s de mani\u00e8re autonome. Il n\u2019est pas n\u00e9cessaire de s\u2019engager dans un programme ADC complet pour b\u00e9n\u00e9ficier de cette expertise.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-57\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Une seule \u00e9quipe peut-elle g\u00e9rer \u00e0 la fois les aspects anticorps et chimie des petites mol\u00e9cules de notre ADC, ou devons-nous faire appel \u00e0 plusieurs fournisseurs ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-58 wp-block-paragraph\" style=\"color:#475467\">Oui. C\u2019est pr\u00e9cis\u00e9ment le besoin auquel notre plateforme r\u00e9pond. Le d\u00e9veloppement d\u2019ADC se situe \u00e0 l\u2019interface entre les produits biologiques et la chimie des petites mol\u00e9cules, et peu de prestataires ma\u00eetrisent pleinement ces deux domaines.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-59 wp-block-paragraph\" style=\"color:#475467\">Nous disposons de plusieurs d\u00e9cennies d\u2019exp\u00e9rience dans l\u2019optimisation de th\u00e9rapies pour diverses applications et travaillons aussi bien avec les grandes que les petites mol\u00e9cules, ainsi qu\u2019avec un large \u00e9ventail de modalit\u00e9s th\u00e9rapeutiques.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-60\" :class=\"panelOpen ? 'Accordion__Panel--open' : ''\" style=\"border-top-color:#f2e8d9;border-top-width:1px;border-bottom-color:#f2e8d9;border-bottom-width:1px;   \">\n        <div class=\"Accordion__Title\">\n        <button type=\"button\" x-on:click=\"togglePanel()\" class=\"w-full flex justify-start group relative items-center\" style=\"color:#101828;\">\n           \n            <span class=\"mr-6\">\n                <svg x-show=\"panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16ZM29 16C29 18.5712 28.2376 21.0846 26.8091 23.2224C25.3807 25.3603 23.3503 27.0265 20.9749 28.0104C18.5995 28.9944 15.9856 29.2518 13.4638 28.7502C10.9421 28.2486 8.6257 27.0105 6.80762 25.1924C4.98953 23.3743 3.75141 21.0579 3.2498 18.5362C2.74819 16.0144 3.00563 13.4006 3.98957 11.0251C4.97351 8.64968 6.63975 6.61935 8.77759 5.1909C10.9154 3.76244 13.4288 3 16 3C19.4467 3.00364 22.7512 4.37445 25.1884 6.81163C27.6256 9.24882 28.9964 12.5533 29 16ZM27 16C27 13.8244 26.3549 11.6977 25.1462 9.88873C23.9375 8.07979 22.2195 6.66989 20.2095 5.83733C18.1995 5.00476 15.9878 4.78692 13.854 5.21136C11.7202 5.6358 9.76021 6.68345 8.22183 8.22183C6.68345 9.7602 5.63581 11.7202 5.21137 13.854C4.78693 15.9878 5.00477 18.1995 5.83733 20.2095C6.66989 22.2195 8.07979 23.9375 9.88873 25.1462C11.6977 26.3549 13.8244 27 16 27C18.9164 26.9967 21.7123 25.8367 23.7745 23.7745C25.8367 21.7123 26.9967 18.9164 27 16Z\" fill=\"#005DE5\"><\/path>\n                <\/svg>\n                <svg x-show=\"!panelOpen\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\">\n                    <path d=\"M16 3C13.4288 3 10.9154 3.76244 8.77759 5.1909C6.63975 6.61935 4.97351 8.64968 3.98957 11.0251C3.00563 13.4006 2.74819 16.0144 3.2498 18.5362C3.75141 21.0579 4.98953 23.3743 6.80762 25.1924C8.6257 27.0105 10.9421 28.2486 13.4638 28.7502C15.9856 29.2518 18.5995 28.9944 20.9749 28.0104C23.3503 27.0265 25.3807 25.3603 26.8091 23.2224C28.2376 21.0846 29 18.5712 29 16C28.9964 12.5533 27.6256 9.24882 25.1884 6.81163C22.7512 4.37445 19.4467 3.00364 16 3ZM16 27C13.8244 27 11.6977 26.3549 9.88873 25.1462C8.07979 23.9375 6.66989 22.2195 5.83733 20.2095C5.00477 18.1995 4.78693 15.9878 5.21137 13.854C5.63581 11.7202 6.68345 9.7602 8.22183 8.22183C9.76021 6.68345 11.7202 5.6358 13.854 5.21136C15.9878 4.78692 18.1995 5.00476 20.2095 5.83733C22.2195 6.66989 23.9375 8.07979 25.1462 9.88873C26.3549 11.6977 27 13.8244 27 16C26.9967 18.9164 25.8367 21.7123 23.7745 23.7745C21.7123 25.8367 18.9164 26.9967 16 27ZM22 16C22 16.2652 21.8946 16.5196 21.7071 16.7071C21.5196 16.8946 21.2652 17 21 17H17V21C17 21.2652 16.8946 21.5196 16.7071 21.7071C16.5196 21.8946 16.2652 22 16 22C15.7348 22 15.4804 21.8946 15.2929 21.7071C15.1054 21.5196 15 21.2652 15 21V17H11C10.7348 17 10.4804 16.8946 10.2929 16.7071C10.1054 16.5196 10 16.2652 10 16C10 15.7348 10.1054 15.4804 10.2929 15.2929C10.4804 15.1054 10.7348 15 11 15H15V11C15 10.7348 15.1054 10.4804 15.2929 10.2929C15.4804 10.1054 15.7348 10 16 10C16.2652 10 16.5196 10.1054 16.7071 10.2929C16.8946 10.4804 17 10.7348 17 11V15H21C21.2652 15 21.5196 15.1054 21.7071 15.2929C21.8946 15.4804 22 15.7348 22 16Z\" fill=\"#001024\" fill-opacity=\"0.5\"><\/path>\n                <\/svg>\n            <\/span>\n           \n            <span class=\"panel-title text-left\" :class=\"panelOpen ? 'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Comment sont g\u00e9r\u00e9es la confidentialit\u00e9 et la propri\u00e9t\u00e9 intellectuelle dans le cadre d\u2019un programme ADC ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-61 wp-block-paragraph\" style=\"color:#475467\">Nous accordons une importance majeure \u00e0 la confidentialit\u00e9 et \u00e0 la propri\u00e9t\u00e9 intellectuelle tout au long des programmes de d\u00e9couverte d\u2019ADC. Les donn\u00e9es des clients sont g\u00e9r\u00e9es au moyen de syst\u00e8mes s\u00e9curis\u00e9s \u00e0 acc\u00e8s contr\u00f4l\u00e9 et de plateformes s\u00e9curis\u00e9es de partage de fichiers, soutenus par des processus de s\u00e9curit\u00e9 de l\u2019information certifi\u00e9s ISO 27001, une surveillance continue ainsi que des m\u00e9canismes robustes de sauvegarde et de reprise.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-62 wp-block-paragraph\" style=\"color:#475467\">Toute la propri\u00e9t\u00e9 intellectuelle g\u00e9n\u00e9r\u00e9e dans le cadre du projet appartient \u00e0 nos clients. Nous ne percevons ni redevances, ni paiements d\u2019\u00e9tape, ni frais de licence pour l\u2019acc\u00e8s \u00e0 notre expertise ou \u00e0 nos technologies.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-63\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Que se passe-t-il si notre ADC pr\u00e9sente une faible stabilit\u00e9 ou une lib\u00e9ration pr\u00e9matur\u00e9e de la charge utile dans la circulation ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-64 wp-block-paragraph\" style=\"color:#475467\">La compr\u00e9hension de la stabilit\u00e9 d\u2019un ADC est essentielle pour garantir une d\u00e9livrance efficace de la charge utile tout en limitant la toxicit\u00e9 syst\u00e9mique. En fonction des besoins sp\u00e9cifiques de votre projet, nous pouvons concevoir et \u00e9valuer des linkers et des strat\u00e9gies de conjugaison sur mesure afin d\u2019obtenir le bon \u00e9quilibre entre stabilit\u00e9 syst\u00e9mique et lib\u00e9ration de la charge utile au site cible.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-65 wp-block-paragraph\" style=\"color:#475467\">Cette approche s\u2019appuie sur notre vaste expertise en d\u00e9couverte de m\u00e9dicaments ainsi que sur notre connaissance approfondie des propri\u00e9t\u00e9s DMPK de diff\u00e9rentes modalit\u00e9s th\u00e9rapeutiques.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n\n<div x-data=\"accordionPanel(0, '', false)\" class=\"Accordion__Panel mb-2 wp-elements-66\" :class=\"panelOpen ? 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'panel-title-open' : 'text-[#101828]'\">\n                    <h3 class=\"has-text-2-xl-font-size\">Une \u00e9tude pr\u00e9coce de faisabilit\u00e9 ADC peut-elle \u00e9voluer vers un programme complet jusqu\u2019aux \u00e9tudes habilitantes \u00e0 l\u2019IND avec la m\u00eame \u00e9quipe ?<\/h3>\n\n                <\/span>\n        <\/button>\n    <\/div>\n    \n        <div class=\"Accordion__Content\" x-show=\"panelOpen\" x-collapse>\n        <div style=\"\">\n            <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<p class=\"has-text-color has-link-color wp-elements-67 wp-block-paragraph\" style=\"color:#475467\">Oui. Notre plateforme ADC couvre l\u2019ensemble du parcours, depuis la conception initiale jusqu\u2019aux premi\u00e8res \u00e9tudes habilitantes \u00e0 l\u2019IND. Une \u00e9tude de faisabilit\u00e9 ou d\u2019optimisation men\u00e9e au d\u00e9part peut donc progresser directement vers les \u00e9tapes suivantes avec la m\u00eame \u00e9quipe.<\/p>\n<\/div>\n\n<\/div>\n        <\/div>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n    \n            <\/section><\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--100);padding-bottom:var(--wp--preset--spacing--60); \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \">\n\t        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21.7023 8.48145 22.7182 8.48145 23.7783C8.48145 24.8386 8.63235 25.8591 8.90332 26.8262C8.9061 26.8402 8.90929 26.8541 8.91211 26.8682C10.2498 31.5309 14.539 34.9395 19.623 34.9395C25.7751 34.9393 30.7674 29.9399 30.7676 23.7783C30.7676 17.6166 25.7797 12.6164 19.623 12.6162Z\"><\/path>\n                            <animatetransform attributename=\"transform\" type=\"rotate\" from=\"0 19.6318 23.7783\" to=\"360 19.6318 23.7783\" dur=\"1s\" repeatcount=\"indefinite\"><\/animatetransform>\n                        <\/g>\n                        <g fill=\"currentColor\" opacity=\"1\">\n                            <path>\n                                <animate attributename=\"opacity\" values=\"1;0.4;1\" dur=\"1.2s\" begin=\"0s\" repeatcount=\"indefinite\"><\/animate>\n                            <\/path>\n                        <\/g>\n                    <\/svg>\n                <\/div>\n\n                                                \n                                                                                        <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/event\/pegs-europe\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">PEGS Europe<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/PEGS-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/PEGS-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iOTYwIiBoZWlnaHQ9IjU0MCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/PEGS.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/PEGS-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/10\/PEGS-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/event\/pegs-europe\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">PEGS Europe<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tRetrouvez-nous au stand n\u00b0223\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tEvents\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/toxicity-efficacy-in-adcs\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Toxicity &amp; Efficacy in ADCs: How to Get it Right<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTA2MiIgaGVpZ2h0PSI1OTciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/toxicity-efficacy-in-adcs\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Toxicity &amp; Efficacy in ADCs: How to Get it Right<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tCatch up on our ADC development series on YouTube to\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/exploring-new-paths-in-adc-development\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Exploring New Paths in ADC Development<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTA2MiIgaGVpZ2h0PSI1OTciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/exploring-new-paths-in-adc-development\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Exploring New Paths in ADC Development<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tCatch up on our ADC development series on YouTube to\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/evolving-role-of-med-chem-in-adc-development\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">What\u2019s the Evolving Role of Medicinal Chemistry in ADC Development?<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTA2MiIgaGVpZ2h0PSI1OTciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/evolving-role-of-med-chem-in-adc-development\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">What\u2019s the Evolving Role of Medicinal Chemistry in ADC Development?<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tCatch up on our ADC development series on YouTube to\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/linker-technologies-in-adcs\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">Linker Technologies in ADCs: How They Impact Efficacy &amp; Stability<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTA2MiIgaGVpZ2h0PSI1OTciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/linker-technologies-in-adcs\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">Linker Technologies in ADCs: How They Impact Efficacy &amp; Stability<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tCatch up on our ADC development series on YouTube to\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t                                                                            <div class=\"Post__Grid-post \" data-pegasus-single-card>\n\t<div class=\"group\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/transformative-changes-in-adc-development-over-the-next-decade\/\" class=\"block rounded-2xl overflow-hidden \">\n\t\t\t\t\t<span class=\"sr-only\">3 Transformative Changes in ADC Development Over the Next Decade<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full relative overflow-hidden h-0 pb-[64%]\">\n\t\t\t\t\t\t\t<picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"w-full object-cover group-hover:scale-105 transition-transform duration-500 ease-in-out absolute-center !h-full group-hover:-translate-y-1\/2 group-hover:-translate-x-1\/2\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTA2MiIgaGVpZ2h0PSI1OTciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgZmlsbD0iI2YzZjRmNiIvPjwvc3ZnPg==\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image.png\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-300x169.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/06\/ADC_Feature-image-640x360.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"pt-6\">\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/transformative-changes-in-adc-development-over-the-next-decade\/\" class=\"font-medium has-text-2-xl-font-size has-body-font-family \">3 Transformative Changes in ADC Development Over the Next Decade<\/a>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mt-3 has-text-sm-font-size text-black has-body-font-family\">\n\t\t\t\t\t\t\tCatch up on our ADC development series on YouTube to\u2026\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap items-center gap-3 mt-4 has-body-font-family\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"flex flex-wrap -mx-px gap-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"tag inline-block mx-px my-px py-1 text-base font-regular text-blue-500 tracking-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBlog\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n                                                                \t\t\t    \n                            <\/div>\n\n        \n    \n<\/section>\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8904fc3d wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-15 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-dce8ee25 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-3-xl-font-size\">Autres modalit\u00e9s th\u00e9rapeutiques<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les conjugu\u00e9s anticorps-m\u00e9dicament (ADC) s\u2019inscrivent dans l\u2019expertise plus large de Sygnature en mati\u00e8re de modalit\u00e9s th\u00e9rapeutiques. D\u00e9couvrez l\u2019ensemble de nos capacit\u00e9s :<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-832e19e4 wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-393eae96 wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-300x229.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-768x585.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-1024x780.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-1536x1170.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-1418x1080.webp 1418w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-473x360.webp 473w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-640x488.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Repr\u00e9sentation structurelle 3D de mol\u00e9cules peptidiques illustrant des approches avanc\u00e9es de d\u00e9couverte de m\u00e9dicaments int\u00e9grant la chimie, les biosciences et la pharmacologie in vivo.\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxOTUwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-scaled.webp\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-300x229.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-768x585.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-1024x780.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-1536x1170.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-1418x1080.webp 1418w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-473x360.webp 473w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/peptide-drug-discovery-structural-biology-complex-molecule-640x488.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-130\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/peptides\/\">Peptides<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-131 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Transformer des concepts peptidiques complexes en th\u00e9rapies de nouvelle g\u00e9n\u00e9ration gr\u00e2ce \u00e0 une conception int\u00e9gr\u00e9e, des analyses de pointe et une expertise collaborative en mati\u00e8re de recherche de bout en bout.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/peptides\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-393eae96 wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Targeted-Protein-Degradation-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Targeted-Protein-Degradation.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Targeted Protein Degradation\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Targeted-Protein-Degradation.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Targeted-Protein-Degradation-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/Targeted-Protein-Degradation.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-132\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/degradation-ciblee-des-proteines\/\" type=\"page\" id=\"7231\">D\u00e9gradation cibl\u00e9e des prot\u00e9ines<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-133 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">La d\u00e9gradation cibl\u00e9e des prot\u00e9ines (DCP) est une approche novatrice de d\u00e9couverte de m\u00e9dicaments qui s\u2019int\u00e9resse aux prot\u00e9ines auparavant consid\u00e9r\u00e9es comme \u00ab\u00a0non ciblables\u00a0\u00bb. La DCP exploite le syst\u00e8me ubiquitine-prot\u00e9asome de la cellule pour marquer ces prot\u00e9ines en vue de leur d\u00e9gradation. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/degradation-ciblee-des-proteines\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-9285342f wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/biologics-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/biologics.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"biologics\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/biologics.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/biologics-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/biologics.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-134\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/biologiques\/\">Produits biologiques<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-135 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Stimuler l\u2019innovation en produits biologiques gr\u00e2ce \u00e0 une conception int\u00e9gr\u00e9e, \u00e0 la biologie structurale et \u00e0 une expertise multidisciplinaire afin d\u2019acc\u00e9l\u00e9rer le d\u00e9veloppement des th\u00e9rapies de nouvelle g\u00e9n\u00e9ration, du concept \u00e0 la clinique.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/modalites\/biologiques\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"  padding-top:var(--wp--preset--spacing--90);padding-bottom:var(--wp--preset--spacing--90); \" id=\"identification-techniques\">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8904fc3d wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:342px\"><section class=\"Pegasus__Container w-full   sticky top-0 relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow wp-container-16 is-position-sticky\" style=\"   \">\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-dce8ee25 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-3-xl-font-size\">Solutions connexes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Nous r\u00e9unissons un m\u00e9lange dynamique de nouveaux talents et d\u2019experts chevronn\u00e9s de l\u2019industrie pharmaceutique du monde entier, garantissant l\u2019excellence \u00e0 chaque \u00e9tape de la d\u00e9couverte.<\/p>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:74.58%\">\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-832e19e4 wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-393eae96 wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Protein &amp; Structure\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Protein-and-Structure.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-136\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\">Science des Prot\u00e9ines et Biologie Structurale<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-137 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Page d\u2019accueil du d\u00e9partement de prot\u00e9omique et de biologie structurale. Nous prenons le temps de comprendre votre objectif et les finalit\u00e9s de votre projet afin d\u2019adapter notre approche en cons\u00e9quence. <\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/science-des-proteines-et-biologie-structurale\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-393eae96 wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/chemistry-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/chemistry.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"Chemistry\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/chemistry.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/chemistry-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/chemistry.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-138\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/fr\/chimie\/\" type=\"page\" id=\"1500\">Chimie<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-139 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Une expertise mondiale en chimie et des strat\u00e9gies sur mesure combinant des comp\u00e9tences m\u00e9dicinales, de synth\u00e8se et de proc\u00e9d\u00e9s pour faire progresser les mol\u00e9cules candidates de qualit\u00e9 gr\u00e2ce \u00e0 une collaboration transparente.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/chimie\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-393eae96 wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-300x210.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-768x538.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-1024x717.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery.webp 1500w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-514x360.webp 514w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-640x448.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMTUwMCIgaGVpZ2h0PSIxMDUwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiIGZpbGw9IiNmM2Y0ZjYiLz48L3N2Zz4=\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-300x210.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-768x538.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-1024x717.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery.webp 1500w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-514x360.webp 514w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/09\/oncology-drug-discovery-640x448.webp 640w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-140\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\"><a href=\"https:\/\/www.sygnaturediscovery.com\/therapeutic-areas\/oncology\/\">Oncologie<\/a><\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-141 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments en oncologie gr\u00e2ce \u00e0 une expertise int\u00e9gr\u00e9e, des modalit\u00e9s innovantes et une vision translationnelle pour proposer des candidats ayant un r\u00e9el impact clinique.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"side\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/therapeutic-areas\/oncology\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-9285342f wp-block-group-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group overflow-hidden has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-radius:24px\" allowchildrentofillwidth=\"\" overflow=\"hidden\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" class=\"Media full-width w-full\" style=\"\">\n            \n                                    <picture class=\"pegasus-lazy-wrapper\"><source data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" type=\"image\/webp\"><img decoding=\"async\" loading=\"lazy\" width=\"100%\" height=\"auto\" class=\"image-original \" alt=\"DMPK\" sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTE3IiBoZWlnaHQ9IjMyMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48cmVjdCB3aWR0aD0iMTAwJSIgaGVpZ2h0PSIxMDAlIiBmaWxsPSIjZjNmNGY2Ii8+PC9zdmc+\" data-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1.jpg\" data-srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1-300x186.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/DMPK-1.webp 517w\" data-sizes=\"(min-width: 1536px) 1536px, (min-width: 1280px) 1280px, (min-width: 1024px) 1024px, (min-width: 768px) 768px, (min-width: 640px) 640px, 100vw\"><\/source><\/picture>\n\n                \n            <\/section><\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-1bbac977 wp-block-group-is-layout-flex\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-color has-link-color has-text-2-xl-font-size wp-elements-142\" style=\"color:#002b46;margin-bottom:var(--wp--preset--spacing--20)\">DMPK<\/h3>\n\n\n\n<p class=\"has-text-color has-link-color has-text-base-font-size wp-elements-143 wp-block-paragraph\" style=\"color:#001024b3;margin-bottom:var(--wp--preset--spacing--20)\">Des solutions DMPK int\u00e9gr\u00e9es combinant des analyses avanc\u00e9es, la mod\u00e9lisation et la bioanalyse, fournissant des informations pr\u00e9dictives qui r\u00e9duisent les risques et guident la s\u00e9lection des candidats.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-text-link\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/solutions-scientifiques\/metabolisme-des-medicaments-et-pharmacocinetique-dmpk\/\">Apprendre encore plus<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":17446,"parent":4347,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4360","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sygnature<\/title>\n<meta name=\"description\" content=\"La solution de conjugu\u00e9s anticorps-m\u00e9dicament de Sygnature privil\u00e9gie l&#039;optimisation de la charge utile afin d&#039;am\u00e9liorer l&#039;efficacit\u00e9 et la s\u00e9lectivit\u00e9 du m\u00e9dicament. 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