{"id":2439,"date":"2024-12-16T16:15:18","date_gmt":"2024-12-16T16:15:18","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/journal-paper\/5-ht1b-receptor-activation-produces-rapid-antidepressant-like-effects-in-rodents\/"},"modified":"2026-01-19T14:19:18","modified_gmt":"2026-01-19T14:19:18","slug":"5-ht1b-receptor-activation-produces-rapid-antidepressant-like-effects-in-rodents","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/5-ht1b-receptor-activation-produces-rapid-antidepressant-like-effects-in-rodents\/","title":{"rendered":"5-HT1B receptor activation produces rapid antidepressant-like effects in rodents"},"content":{"rendered":"

Erin A. Clark, Lien Wang, Taleen Hanania, Karla Kretschmannova, Massimiliano Bianchi, Elizabeth Jagger,<\/strong> Tingting Hu, Fugang Li, Yasir Gallero-Salas, Kenneth S. Koblan, Nina Dedic, Linda J. Bristow<\/h4>\n

Abstract<\/strong><\/span>:<\/p>\n

Ketamine is noted for its rapid onset antidepressant response and effectiveness in patients with treatment resistant depression. While most research has focused on glutamatergic mechanisms, recent studies show that antidepressant-like effects in rodents are dependent upon the serotonergic (5-HT) system and suggest a potential contribution of the 5-HT1B receptor. In this study we utilized CP-94253 to examine whether 5-HT1B receptor agonism produces rapid and sustained antidepressant-like effects, focusing on rodent models and treatment approaches commonly used to demonstrate the differentiated response to ketamine. We first confirmed that CP-94253 is a potent 5-HT1B agonist in vitro and that CP-94253 occupies brain 5-HT1B receptors at the doses tested. CP-94253 reduced immobility in the mouse forced swim test (FST) and exhibited a prominent antidepressant signature in the mouse-behaviour phenotyping platform SmartCube\u00ae. When examined 24 h after acute treatment, CP-94253 reduced FST immobility in both na\u00efve rats and in rats receiving chronic interferon alpha treatment. Ex vivo hippocampal long-term potentiation was also enhanced in na\u00efve rats receiving acute CP-94253 treatment, 24 h prior to the recordings. In mice exposed to chronic social defeat stress, antidepressant-like effects in the tail suspension and sucrose preference tests were seen 1 h and 24 h after acute treatment, respectively. Finally, whole brain c-fos imaging in mice showed that CP-94253 modulates neuronal activity in discrete brain regions including the lateral habenula circuit implicated in depression and the ketamine treatment response. Collectively these results support the further investigation of 5-HT1B agonism as a novel treatment approach for major depressive disorder.<\/p>\n

Ref: Pharmacology Biochemistry and Behavior,<\/span><\/span>\u00a0February 2025<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Ketamine is noted for its rapid onset antidepressant response and effectiveness in patients with treatment resistant depression. While most research has focused on glutamatergic mechanisms, recent studies show that antidepressant-like effects in rodents are dependent upon the serotonergic (5-HT) system and suggest a potential contribution of the 5-HT1B receptor.<\/p>\n","protected":false},"featured_media":0,"template":"","category":[747,685,753,687,688],"resource_tag":[],"class_list":["post-2439","journal-paper","type-journal-paper","status-publish","hentry","category-gpcrs","category-in-vivo-pharmacology","category-neuroscience","category-target-classes","category-therapeutic-areas"],"acf":[],"yoast_head":"\n5-HT1B receptor activation linked to anti depressant-like behaviour<\/title>\n<meta name=\"description\" content=\"Discover how 5-HT1B receptor activation showed anti-depressant-like behaviour in rodents. 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