{"id":2436,"date":"2021-03-31T08:42:28","date_gmt":"2021-03-31T08:42:28","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/journal-paper\/impact-of-mitochondrial-targeting-antibiotics-on-mitochondrial-function-and-proliferation-of-cancer-cells\/"},"modified":"2026-01-05T15:11:01","modified_gmt":"2026-01-05T15:11:01","slug":"impact-of-mitochondrial-targeting-antibiotics-on-mitochondrial-function-and-proliferation-of-cancer-cells","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/impact-of-mitochondrial-targeting-antibiotics-on-mitochondrial-function-and-proliferation-of-cancer-cells\/","title":{"rendered":"Impact of Mitochondrial Targeting Antibiotics on Mitochondrial Function and Proliferation of Cancer Cells"},"content":{"rendered":"

Edward J Cochrane,<\/strong> James Hulit, Franz P Lagasse,<\/strong> Tanguy Lechertier, Brett Stevenson,<\/strong> Corina Tudor, Diana Trebicka, Tim Sparey, and Andrew J Ratcliffe<\/p>\n

Abstract:<\/p>\n

Some marketed antibiotics can cause mitochondria dysfunction via inhibition of the mitochondrial translation process. There is great interest in exploiting such effects within a cancer setting. To enhance accumulation of antibiotics within the mitochondria of cancer cells, and therefore delivery of a greater potency payload, a mitochondrial targeting group in the form of a triphenylphosphonium (TPP) cation was appended via an alkyl chain length consisting of 7 to 11 carbons to the ribosomal antibiotics azithromycin and doxycycline. Using MDA-MB-231 cells, the effects of each subseries on mitochondrial translation, mitochondrial bioenergetics, and cell viability are described.<\/p>\n

Ref: ACS Med Chem Lett, 8 March 2021<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[682,691,713],"resource_tag":[],"class_list":["post-2436","journal-paper","type-journal-paper","status-publish","hentry","category-chemistry","category-hit-to-lead","category-medicinal-chemistry"],"acf":[],"yoast_head":"\nMitochondrial-Targeting Antibiotics' Impact on Cancer Cells<\/title>\n<meta name=\"description\" content=\"Mitochondrial-targeting antibiotics and cancer therapy: Cochrane, Hulit, Lagasse, et al. 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