{"id":2429,"date":"2018-11-19T11:24:14","date_gmt":"2018-11-19T11:24:14","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/journal-paper\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\/"},"modified":"2018-11-19T11:24:14","modified_gmt":"2018-11-19T11:24:14","slug":"synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\/","title":{"rendered":"Synthesis of 4-\u200baminotetrahydropyran scaffolds for drug discovery"},"content":{"rendered":"<p>Andrew Nortcliffe, Gavin D.S. Milne, Daniel Hamza, Christopher J. Moody<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Functionalised tetrahydropyran scaffolds were prepared using a tethered enol-ether Prins cyclisation and elaborated to show their potential use in library synthesis. The key 4-hydroxytetrahydropyran scaffold could be readily manipulated to the 4-azidotetrahydropyran that could be elaborated via copper catalysed azide-alkyne cycloaddition or by reduction to the amine, to provide sp3-rich scaffolds useful for drug discovery.<\/p>\n<p><strong>Ref:\u00a0<\/strong>Bioorganic &amp; Medicinal Chemistry\u00a0(2017),\u00a025(7),\u00a02218-2225.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-2429","journal-paper","type-journal-paper","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>4-Aminotetrahydropyran Scaffolds for Drug Discovery | Paper<\/title>\n<meta name=\"description\" content=\"This journal paper describes the synthesis and elaboration of sp3-rich 4-aminotetrahydropyran scaffolds for compound-library development. 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