{"id":2429,"date":"2018-11-19T11:24:14","date_gmt":"2018-11-19T11:24:14","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/journal-paper\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\/"},"modified":"2018-11-19T11:24:14","modified_gmt":"2018-11-19T11:24:14","slug":"synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\/","title":{"rendered":"Synthesis of 4-\u200baminotetrahydropyran scaffolds for drug discovery"},"content":{"rendered":"

Andrew Nortcliffe, Gavin D.S. Milne, Daniel Hamza, Christopher J. Moody<\/p>\n

Abstract<\/strong><\/p>\n

Functionalised tetrahydropyran scaffolds were prepared using a tethered enol-ether Prins cyclisation and elaborated to show their potential use in library synthesis. The key 4-hydroxytetrahydropyran scaffold could be readily manipulated to the 4-azidotetrahydropyran that could be elaborated via copper catalysed azide-alkyne cycloaddition or by reduction to the amine, to provide sp3-rich scaffolds useful for drug discovery.<\/p>\n

Ref:\u00a0<\/strong>Bioorganic & Medicinal Chemistry\u00a0(2017),\u00a025(7),\u00a02218-2225.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-2429","journal-paper","type-journal-paper","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nSynthesis of 4-\u200baminotetrahydropyran scaffolds for drug discovery - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis of 4-\u200baminotetrahydropyran scaffolds for drug discovery - Sygnature\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/sygnature-hit-to-lead-team-collaboration-scaled.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/journal-paper\\\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/journal-paper\\\/synthesis-of-4-aminotetrahydropyran-scaffolds-for-drug-discovery\\\/\",\"name\":\"Synthesis of 4-\u200baminotetrahydropyran scaffolds for drug discovery - 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