Sarah J. Cully, Thomas E. Storr, Michael J. Rawling, Induka R. Abeysena, Daniel Hamza, Geraint Jones, Christopher A. Pearce, Abdul Quddus, William Lewis, Robert A. Stockman<\/p>\n
Abstract<\/strong><\/p>\n In order to address the current downturn in the drug discovery pipeline, initiatives are being undertaken to synthesise screening libraries of sp3-rich, low molecular weight compounds. As part of the European Lead Factory initiative, the synthesis and derivatisation of a simple hexahydrooxazolo[5,4-c]pyridin-2(1H)-one bicyclic carbamate has been achieved. The synthetic route employed involved a telescoped hetero-Diels\u2013Alder\/[2,3]-sigmatropic rearrangement\/cyclisation sequence to deliver the desired core scaffold containing two points for further diversification. When applied, this synthesis was found to be robust and scalable which allowed the production of a 155 compound library.<\/p>\n Ref:<\/strong>\u00a0Bioorgan. Med. Chem.\u00a0(2016),\u00a024(21),\u00a05249-5257<\/p>\n","protected":false},"excerpt":{"rendered":" Experience the expedient synthesis of an atypical oxazolidinone compound library. Uncover an efficient approach for generating diverse compounds, offering potential for drug development and research.<\/p>\n","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-2427","journal-paper","type-journal-paper","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"\n