{"id":2415,"date":"2018-03-27T14:11:54","date_gmt":"2018-03-27T14:11:54","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/journal-paper\/surface-plasmon-resonance-identifying-characterising-small-molecule-ligands\/"},"modified":"2018-03-27T14:11:54","modified_gmt":"2018-03-27T14:11:54","slug":"surface-plasmon-resonance-identifying-characterising-small-molecule-ligands","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/surface-plasmon-resonance-identifying-characterising-small-molecule-ligands\/","title":{"rendered":"Surface Plasmon Resonance for Small Molecule Ligand Analysis"},"content":{"rendered":"

From the book \u00ab\u00a0Biophysical Techniques in Drug Discovery\u00a0\u00bb, Chapter 7,\u00a0Pages\u00a0170 – 207<\/p>\n

Editor: Angeles Canales<\/span><\/p>\n

S. J. Pollack<\/p>\n

Abstract<\/strong><\/h2>\n

Surface plasmon resonance (SPR) is a powerful technology that allows an information-rich assessment of the interactions of tethered protein molecular targets with their interacting ligands in real time. As such, SPR has proven useful at all stages of drug discovery, from initial hit finding (particularly the screening of fragment<\/a> libraries) to mechanistic kinetic and thermodynamic profiling during hit validation and lead optimisation phases. Each of these stages of drug discovery involves somewhat different considerations in the optimal design and interpretation of SPR experiments. These factors will be discussed along with other relevant applications of SPR technology for drug discovery, such as in DMPK and toxicology assessments. Finally, the future developments in SPR for drug discovery will be considered.<\/p>\n

If you would like a copy feel free to get in touch via: BusDev@sygnaturediscovery.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[1],"resource_tag":[],"class_list":["post-2415","journal-paper","type-journal-paper","status-publish","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nSurface Plasmon Resonance (SPR) for Small-Molecule Ligands<\/title>\n<meta name=\"description\" content=\"Book chapter on how SPR supports fragment library screening, hit validation and lead optimization, plus DMPK and toxicology applications. 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