{"id":13421,"date":"2024-01-29T15:30:00","date_gmt":"2024-01-29T15:30:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=journal-paper&p=13421"},"modified":"2026-01-29T15:36:56","modified_gmt":"2026-01-29T15:36:56","slug":"key-aspects-of-modern-gpcr-drug-discovery","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/key-aspects-of-modern-gpcr-drug-discovery\/","title":{"rendered":"Key aspects of modern GPCR drug discovery"},"content":{"rendered":"\n

Phil Addis,\u00a0Utsav Bali,\u00a0Frank Baron,\u00a0Adrian Campbell,\u00a0Steven Harborne,\u00a0Liz Jagger,\u00a0Gavin Milne,\u00a0Martin Pearce,\u00a0Elizabeth M Rosethorne,\u00a0Rupert Satchell,\u00a0Denise Swift,\u00a0Barbara Young,\u00a0John F Unitt<\/strong><\/p>\n\n\n\n

Abstract<\/strong><\/p>\n\n\n\n

G-protein-coupled receptors (GPCRs) are the largest and most versatile cell surface receptor family with a broad repertoire of ligands and functions. We’ve learned an enormous amount about discovering drugs of this receptor class since the first GPCR was cloned and expressed in 1986, such that it’s now well-recognized that GPCRs are the most successful target class for approved drugs. Here we take the reader through a GPCR drug discovery journey from target to the clinic, highlighting the key learnings, best practices, challenges, trends and insights on discovering drugs that ultimately modulate GPCR function therapeutically in patients. The future of GPCR drug discovery is inspiring, with more desirable drug mechanisms and new technologies enabling the delivery of better and more successful drugs.<\/p>\n\n\n\n

Ref: SLAS Discov 2024<\/a><\/p>\n\n\n\n

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