{"id":13407,"date":"2025-03-18T11:54:00","date_gmt":"2025-03-18T11:54:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=journal-paper&p=13407"},"modified":"2026-01-29T12:04:30","modified_gmt":"2026-01-29T12:04:30","slug":"lysosomal-ion-channels-and-transporters-recent-findings-therapeutic-potential-and-technical-approaches","status":"publish","type":"journal-paper","link":"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/lysosomal-ion-channels-and-transporters-recent-findings-therapeutic-potential-and-technical-approaches\/","title":{"rendered":"Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches"},"content":{"rendered":"\n

Artem Kondratskyi\u00a0<\/sup>,\u00a0Andre Bazzone,\u00a0Markus Rapedius,\u00a0Rocco Zerlotti,\u00a0Bastien Masson,\u00a0Nidish Ponath Sadanandan,\u00a0Joanne L Parker,\u00a0Alexandre Santinho,\u00a0Marine Moutia,\u00a0Abdou Rachid Thiam,\u00a0Arlene Kemp<\/strong>,\u00a0Fitzwilliam Seibertz,\u00a0Nicoletta Murciano,\u00a0S\u00f8ren Friis,\u00a0Nadine Becker,\u00a0Alison Obergrussberger,\u00a0Maria Barthmes,\u00a0Cecilia George,\u00a0Michael George,\u00a0David Dalrymple<\/strong>,\u00a0Bruno Gasnier,\u00a0Simon Newstead,\u00a0Christian Grimm,\u00a0Niels Fertig<\/p>\n\n\n\n

Abstract<\/strong><\/p>\n\n\n\n

In recent years, there has been a growing interest in lysosomal ion channels and transporters due to their critical role in maintaining lysosomal function and their involvement in a variety of diseases, particularly lysosomal storage diseases, cancer, and neurodegenerative disorders. Recent advancements in research techniques, including manual and automated patch clamp (APC) electrophysiology, solid-supported membrane-based electrophysiology (SSME), and fluorescence-based ion imaging, have further enhanced our ability to investigate lysosomal ion channels and transporters in both physiological and pathological conditions, spurring drug discovery efforts. Several pharmaceutical companies are now developing therapies aimed at modulating these channels and transporters to improve lysosomal function in disease. Small molecules targeting channels like transient receptor potential mucolipin (TRPML) 1 and TMEM175, as well as drugs modulating lysosomal pH, are currently in preclinical and clinical development. This review provides an overview of the role of lysosomal ion channels and transporters in health and disease, highlights the cutting-edge techniques used to study them, and discusses the therapeutic potential of targeting these channels and transporters in the treatment of various diseases. Furthermore, in addition to summarizing recent discoveries, we contribute novel functional data on cystinosin, TRPML1, and two-pore channel 2 (TPC2), utilizing both SSME and APC approaches.<\/p>\n\n\n\n

Ref: Bioelectricity 2025<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[681,707,746],"resource_tag":[],"class_list":["post-13407","journal-paper","type-journal-paper","status-publish","hentry","category-bioscience","category-electrophysiology","category-ion-channels"],"acf":[],"yoast_head":"\nLysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/journal-paper\/lysosomal-ion-channels-and-transporters-recent-findings-therapeutic-potential-and-technical-approaches\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches - 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