{"id":7156,"date":"2025-12-09T17:14:49","date_gmt":"2025-12-09T17:14:49","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=case-study&#038;p=7156"},"modified":"2026-03-02T11:50:52","modified_gmt":"2026-03-02T11:50:52","slug":"pept1-transporter-assays","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/pept1-transporter-assays\/","title":{"rendered":"PepT1 Transporter Assays"},"content":{"rendered":"\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-35a2008107cd0bd88be28cbdc752ecf5\">High-throughput, label-free functional profiling with SSME technology<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The human peptide transporter 1 (hPepT1 \/ SLC15A1) plays a critical role in intestinal absorption of di- and tri-peptides, peptide-based drugs and prodrugs such as cephalosporins, ACE inhibitors and valacyclovir. With broad substrate specificity and high expression in the gut, PepT1 is increasingly explored as a target for drug delivery, absorption and therapeutic intervention across antiviral, anticancer and metabolic disease applications.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-8da8c4c878722b6d3746e2684da31a50\">PepT1 Assay Platform<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Sygnature Discovery\u2019s robust PepT1 transporter assays utilizing solid-supported membrane electrophysiology 9SSME) on the SURFE<sup>2<\/sup>R 96SE platform delivers precise, reproducible, label-free functional data to support:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hit identification and screening<\/li>\n\n\n\n<li>Kinetic profiling<\/li>\n\n\n\n<li>pH-dependent transporter characterisation<\/li>\n\n\n\n<li>Mechanistic analysis of inhibitors and substrates<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Our PepT1 assays couples high-throughput performance with sensitive detection of low-turnover transporter activity, providing the resolution and reliability needed to accelerate early drug discovery.<\/p>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-ivory-000-color has-text-color has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"border-radius:1.5em;background:linear-gradient(90deg,rgb(0,60,97) 0%,rgb(4,30,46) 100%);margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-small-font-size wp-block-paragraph\" style=\"line-height:.9\"><strong>CASE STUDY<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"schedule-a-visit\" style=\"font-size:clamp(20px, 1.25rem + ((1vw - 3.2px) * 0.938), 32px);line-height:1.15\">Download the PDF: PepT1 Transporter Assays<\/h2>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-dd0a6548 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-High-Throughput-Electrophysiological-Assays-for-PepT1-Drug-Discovery.pdf.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":13523,"template":"","category":[707,687,748],"resource_tag":[],"class_list":["post-7156","case-study","type-case-study","status-publish","has-post-thumbnail","hentry","category-electrophysiology","category-target-classes","category-transporters"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PepT1 Transporter Assays - Sygnature<\/title>\n<meta name=\"description\" content=\"PepT1 transporter assays with SSME technology. 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