{"id":7152,"date":"2025-12-09T16:52:25","date_gmt":"2025-12-09T16:52:25","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=case-study&#038;p=7152"},"modified":"2026-02-02T17:59:06","modified_gmt":"2026-02-02T17:59:06","slug":"functional-and-pharmacological-profiling-of-kv1-x-ion-channels","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/functional-and-pharmacological-profiling-of-kv1-x-ion-channels\/","title":{"rendered":"Functional and Pharmacological Profiling of Kv1.x Ion Channels"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-5-xl-font-size wp-elements-e1562f16165807e37d87a88db37fcc3d\">Sygnature Discovery offers a fully validated panel of electrophysiology assays spanning the K<sub>V<\/sub>1.x subfamily. Using automated electrophysiology platforms, each isoform was profiled to define its unique activation and inactivation kinetics, alongside pharmacological assessment using both broad-spectrum and subtype-selective inhibitors. The K<sub>V<\/sub>1.x panel enables detailed analysis of potency, selectivity and mechanism of action, providing a robust platform for compound screening and mechanistic studies.<\/h2>\n\n\n\n<p>Kv1 channels play essential roles in regulating neuronal excitability, immune cell function ad cardiac repolarisation. K<sub>V<\/sub>1.3, in particular, has emerged as a target of interest in oncology, autoimmune and metabolic diseases, while other K<sub>V<\/sub>1.x family members have been implicated in neurological and cardiovascular disorders. These findings highlight the value of isoform-resolved assays in supporting ion channel drug discovery across diverse therapeutic areas.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Electrophysiology and pharmacological profiling revealed distinct kinetic signatures and selective compound responses across the K<sub>V<\/sub>1.x subfamily. The full dataset, including current traces, I-V curves, and compound response profiles is available in the downloadable case study.<\/strong><\/h5>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-ivory-000-color has-text-color has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"border-radius:1.5em;background:linear-gradient(90deg,rgb(0,60,97) 0%,rgb(4,30,46) 100%);margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--60)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\" style=\"line-height:.9\"><strong>CASE STUDY<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"schedule-a-visit\" style=\"font-size:clamp(20px, 1.25rem + ((1vw - 3.2px) * 0.938), 32px);line-height:1.15\">Download the PDF: Functional and Pharmacological Profiling of Kv1.x Ion Channels<\/h2>\n\n\n\n<p class=\"has-text-align-center has-text-xl-font-size\">To read the full eBook please click the button below to download<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/functional-and-pharmacological-profiling-kv1x-ion-channel-assays.pdf.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[707,746,780,687],"resource_tag":[],"class_list":["post-7152","case-study","type-case-study","status-publish","hentry","category-electrophysiology","category-ion-channels","category-potassium-channels","category-target-classes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pharmacological Profiling of Kv1.x ion channels<\/title>\n<meta name=\"description\" content=\"Sygnature Discovery&#039;s Kv1.x assays offer kinetic and pharmacological profiling using automated electrophysiology.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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