{"id":7084,"date":"2025-12-09T16:04:11","date_gmt":"2025-12-09T16:04:11","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=case-study&#038;p=7084"},"modified":"2026-02-02T18:01:23","modified_gmt":"2026-02-02T18:01:23","slug":"gdf15-gfral-screening-assay-development","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/gdf15-gfral-screening-assay-development\/","title":{"rendered":"GDF15-GFRAL Screening &amp; Assay Development"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-dede66a985f5cdfed03f66aceaefebe3\">GDF15-GFRAL screening tools developed by Sygnature Discovery support the creation of multimodal assay systems for comprehensive target characterization. These custom assays enable functional readouts across key signalling pathways, facilitating drug discovery efforts focused on GDF15-GFRAL interactions within metabolic and apetite regulation research.<\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-25e4cdc2f8f9510344f929488ffd6d50\">Introduction<\/h3>\n\n\n\n<p>As a distant member of the transforming growth factor-beta (TGF-\u03b2) superfamily, Growth Differentiation Factor 15 (GDF15) functions through its receptor, Glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL). Recently, the GDF15-GFRAL-RET signalling complex has emerged as a focal point for research, with RET acting as a co-receptor for GFRAL and facilitating downstream signalling pathways.<\/p>\n\n\n\n<figure data-wp-context='{\"imageId\":\"69f3b6ac8811b\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3b6ac8811b\" class=\"wp-block-image size-full is-style-rounded is-style-rounded--1 wp-lightbox-container\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\"><div class=\"gif_wrap 1083\" data-wpmf-gif-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system.gif\" data-wpmf-still-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system-150x150.gif\" data-wpmf-attachment-id=\"7089\"><a href=\"javascript:void(0);\" class=\"gif_link_wrap 1083\" title=\"Click to play\" rel=\"nofollow\" data-wpmf-gif-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system.gif\"><\/a><span class=\"play_gif 1083\">GIF<\/span><img src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system-150x150.gif\" class=\"_showing frame no-lazy wp-image-7089\" alt=\"\" data-wpmf-gif-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system.gif\" data-lazy-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system.gif\" data-wpmf-still-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system-150x150.gif\"><\/div><img src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system-150x150.gif\" class=\"_hidden no-lazy\" alt=\"\" style=\"display:none;\" data-wpmf-gif-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system.gif\" data-lazy-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system.gif\" data-wpmf-still-src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system-150x150.gif\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em><strong>Figure 1.<\/strong>\u00a0Schematic representation of GDF15-GFRAL-RET complex signalling pathway.<\/em><\/figcaption><\/figure>\n\n\n\n<p>This collaboration underscores the multifunctional nature of GDF15-GFRAL-RET, impacting pathways critical for cellular stress response and energy balance. Given its regulatory influence across broad physiological systems, this pathway presents new therapeutic opportunities, particularly in areas such as metabolic disorders and cancer.<\/p>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-ivory-000-color has-text-color has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"border-radius:1.5em;background:linear-gradient(90deg,rgb(0,60,97) 0%,rgb(4,30,46) 100%);margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--60)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\" style=\"line-height:.9\"><strong>CASE STUDY<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"schedule-a-visit\" style=\"font-size:clamp(20px, 1.25rem + ((1vw - 3.2px) * 0.938), 32px);line-height:1.15\">Download the PDF: GDF15-GFRAL Screening &amp; Assay Development<\/h2>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/Development-of-a-multimodal-assay-system-for-GDF15-GFRAL-drug-discovery.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[705],"resource_tag":[],"class_list":["post-7084","case-study","type-case-study","status-publish","hentry","category-cell-line-generation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GDF15-GFRAL Screening &amp; 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