{"id":6692,"date":"2025-12-08T16:19:01","date_gmt":"2025-12-08T16:19:01","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=case-study&#038;p=6692"},"modified":"2026-02-02T18:06:15","modified_gmt":"2026-02-02T18:06:15","slug":"a-multi-platform-approach-to-tmem175-drug-discovery","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/a-multi-platform-approach-to-tmem175-drug-discovery\/","title":{"rendered":"A Multi-Platform Approach to TMEM175 Drug Discovery"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-0b472008391295a5eaeff3d29ad6cb07\">TMEM175 screening using a multi-platform approach \u2013 including electrophysiology and fluorescence-based assays \u2013 enables comprehensive profiling and characterization. Sygnature Discovery supports ion channel drug discovery through flexible, high-quality TMEM175 assay capabilities.<\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-25e4cdc2f8f9510344f929488ffd6d50\">Introduction<\/h3>\n\n\n\n<p>TMEM175 is a novel, constitutively active ion channel involved in the regulation of lysosomal pH, lysosomal \u0394\u03c8 and autophagy. TMEM175\u2019s significance lies not only in its physiological role but also in its therapeutic promise. \u00a0Dysfunction of TMEM175 has been associated with \u00a0lysosomal storage disorders and neurodegenerative diseases such as Parkinson\u2019s and Alzheimer\u2019s. As such, understanding TMEM175\u2019s role in health and disease may provide opportunities for therapeutic interventions \u00a0targeting these conditions. \u00a0Sygnature Discovery stands at the forefront of TMEM175 research, offering an array of specialized services and \u00a0cutting-edge capabilities to understand this target\u2019s \u00a0therapeutic potential.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-9521419d7dcff35ab2481483d5eacf2d\">Supporting Your Research<\/h3>\n\n\n\n<p>Despite TMEM175\u2019s emerging relevance in neurodegenerative disease biology, the lack of selective pharmacological tools has historically limited research into its functional mechanisms and therapeutic potential. At Sygnature Discovery, we address this challenge with a comprehensive, multi-platform approach designed to empower drug discovery teams to explore TMEM175 with precision and confidence.<\/p>\n\n\n\n<p>We offer a catalogue of validated cell lines and electrophysiology assays tailored for TMEM175, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Wild-type and disease-relevant TMEM175 variants<\/strong>, covering both\u00a0<strong>loss-of-function (LoF)<\/strong>\u00a0and\u00a0<strong>gain-of-function (GoF)<\/strong><\/li>\n\n\n\n<li><strong>Key species orthologs<\/strong><\/li>\n\n\n\n<li><strong>High-throughput screening cascades<\/strong>\u00a0that quantitatively assess compound effects across TMEM175 variants using EC\u2085\u2080\/IC\u2085\u2080 curves<\/li>\n\n\n\n<li><strong>Solid-supported membrane (SSM) electrophysiology<\/strong>, ideal for interrogating TMEM175 activity in lysosomal membranes<\/li>\n\n\n\n<li><strong>Orthogonal validation options<\/strong>, combining automated patch clamp and SSM electrophysiology to confirm modulator effects and mechanism of action<\/li>\n<\/ul>\n\n\n\n<p>By providing access to a spectrum of TMEM175 reagents and assay formats, Sygnature Discovery\u2019s platform enables you to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Profile variant-specific pharmacological responses<\/li>\n\n\n\n<li>Discover novel TMEM175 modulators with therapeutic potential<\/li>\n\n\n\n<li>Better understand the lysosomal pH regulation and its therapeutic disruption<\/li>\n<\/ul>\n\n\n\n<p>With over 20 years experience supporting ion channel drug discovery, we offer the scientific expertise and platform flexibility needed to support TMEM175 drug discovery programs.<\/p>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-ivory-000-color has-text-color has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"border-radius:1.5em;background:linear-gradient(90deg,rgb(0,60,97) 0%,rgb(4,30,46) 100%);margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--60)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\" style=\"line-height:.9\"><strong>CASE STUDY<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"schedule-a-visit\" style=\"font-size:clamp(20px, 1.25rem + ((1vw - 3.2px) * 0.938), 32px);line-height:1.15\"><strong>Download the PDF: A Multi-Platform Approach to TMEM175 Drug Discovery<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50\" modaltype=\"\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/A-multi-platform-approach-to-tmem175-drug-discovery.pdf.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[707,746,782],"resource_tag":[],"class_list":["post-6692","case-study","type-case-study","status-publish","hentry","category-electrophysiology","category-ion-channels","category-tmem175"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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