{"id":6660,"date":"2025-12-08T15:48:03","date_gmt":"2025-12-08T15:48:03","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=case-study&#038;p=6660"},"modified":"2026-02-02T18:10:39","modified_gmt":"2026-02-02T18:10:39","slug":"clc-k-electrophysiology","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/","title":{"rendered":"CLC-K Electrophysiology"},"content":{"rendered":"\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-25e4cdc2f8f9510344f929488ffd6d50\">Introduction<\/h3>\n\n\n\n<p>CLC-Ka and CLC-Kb are members of the CLC family of chloride channels and transporters, crucial for maintaining chloride ion homeostasis across cell membranes. CLC-Ka is predominantly found in the thin ascending limb of Henle\u2019s loop, while CLC-Kb is expressed in both the thick ascending limb of Henle\u2019s loop and the distal convoluted tubule. These channels facilitate the reabsorption of chloride ions from the filtrate back into the bloodstream, essential for maintaining the body\u2019s fluid and electrolyte balance. Additionally, these channels are expressed in the inner ear, where they are vital for normal hearing and balance.<\/p>\n\n\n\n<figure data-wp-context='{\"imageId\":\"69f5ce9f0b3a6\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f5ce9f0b3a6\" class=\"wp-block-image size-large has-custom-border wp-lightbox-container\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"508\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-1024x508.webp\" alt=\"\" class=\"wp-image-6661\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-1024x508.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-300x149.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-768x381.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-1536x762.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-640x317.webp 640w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb.webp 1716w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><strong><em>Figure 1. Schematic representation of CLC-Ka and CLC-Kb structure together with their auxillary subunit \u03b2-barrtin.<\/em><\/strong><\/figcaption><\/figure>\n\n\n\n<p>Given their vital role in renal function, CLC-Ka and CLC-Kb present promising targets for therapeutic intervention in various kidney-related disorders. Modulation of these channels can potentially treat conditions characterized by improper chloride handling and disrupted electrolyte balance, such as hypertension, edema, congestive heart failure, Bartter syndrome, and chronic kidney disease.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-9521419d7dcff35ab2481483d5eacf2d\">Supporting Your Research<\/h3>\n\n\n\n<p>Our specialized electrophysiology screening services offer cutting-edge solutions for drug discovery targeting CLC-Ka and CLC-Kb channels. Utilizing state-of-the-art technology, we provide comprehensive and high-throughput assays to evaluate the efficacy of potential drug candidates.\u00a0<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-7779c1399acea8586fb46e84f809e600\">Methods<\/h3>\n\n\n\n<p>HEK cells stably expressing CLC-Ka and CLC-Kb were produced by Sygnature Discovery. Whole cell patch-clamp experiments were carried out at room temperature using multi-hole chips on the SynchroPatch 384i automated electrophysiology platform. Currents were elicited by using repeated ramps, steadily increasing from -140 mV to + 60 mV over 500 ms, from a holding potential of \u2013 30 mV.<br>Data analysis was performed using Data Control 384 V2.3 (Nanion) and GraphPad Prism V10.1.<\/p>\n\n\n\n<figure data-wp-context='{\"imageId\":\"69f5ce9f0bff8\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f5ce9f0bff8\" class=\"wp-block-image alignwide size-full has-custom-border wp-lightbox-container\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\"><img loading=\"lazy\" decoding=\"async\" width=\"602\" height=\"181\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/voltage-protocol.webp\" alt=\"\" class=\"wp-image-6663\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/voltage-protocol.webp 602w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/voltage-protocol-300x90.webp 300w\" sizes=\"(max-width: 602px) 100vw, 602px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em><strong>Figure 2. Voltage Protocol.\u00a0\u00a0<\/strong>CLC-Ka and CLC-Kb currents were elicited by using repeated ramps, steadily increasing from -140 mV to + 60 mV over 500ms, from a holding potential of -30 mV. The red cursors indicate the area of analysis at \u2013 140 mV, which is used to measure inward chloride currents<\/em><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-e275a50be7a72cb07bcd79d90cc33902\">CLC-Ka Electrophysiology\u00a0<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-65e523f9 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f5ce9f0c937\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f5ce9f0c937\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"369\" height=\"246\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/2.-current-trace.webp\" alt=\"\" class=\"wp-image-6665\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/2.-current-trace.webp 369w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/2.-current-trace-300x200.webp 300w\" sizes=\"(max-width: 369px) 100vw, 369px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f5ce9f0df51\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f5ce9f0df51\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"369\" height=\"246\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/2.-time-course.webp\" alt=\"\" class=\"wp-image-6666\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/2.-time-course.webp 369w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/2.-time-course-300x200.webp 300w\" sizes=\"(max-width: 369px) 100vw, 369px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f5ce9f0e5bb\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f5ce9f0e5bb\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1843\" height=\"1407\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004.webp\" alt=\"\" class=\"wp-image-6667\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004.webp 1843w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-300x229.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-1024x782.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-768x586.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-1536x1173.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-1415x1080.webp 1415w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-472x360.webp 472w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKb-Barttin-Flufenamic-IC50-Day-to-Day-NMDP-004-640x489.webp 640w\" sizes=\"(max-width: 1843px) 100vw, 1843px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><em><strong>Figure 4. Representative current trace, time course and concentration response curve showing the effect of inhibitor against CLC-Kb and\u00a0<\/strong><\/em><strong><em>reproducibility across 3 plates.\u00a0<\/em><\/strong><em>An example of superimosed CLC-Kb current traces under control conditions (grey line), in the presence of 30 \u03bcM Flufenamic acid (blue line) and a saturating concentration of 300 \u03bcM Flufenamic acid (black line).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[781,707,746,687],"resource_tag":[],"class_list":["post-6660","case-study","type-case-study","status-publish","hentry","category-chloride-channels","category-electrophysiology","category-ion-channels","category-target-classes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CLC-K Electrophysiology - Sygnature<\/title>\n<meta name=\"description\" content=\"Discover Sygnature Discovery&#039;s advanced CLC-K electrophysiology assays for drug discovery. Custom, precise, and high-throughput solutions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CLC-K Electrophysiology - Sygnature\" \/>\n<meta property=\"og:description\" content=\"Discover Sygnature Discovery&#039;s advanced CLC-K electrophysiology assays for drug discovery. Custom, precise, and high-throughput solutions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-02T18:10:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1716\" \/>\n\t<meta property=\"og:image:height\" content=\"851\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/\",\"name\":\"CLC-K Electrophysiology - Sygnature\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/CLCKa-CLCKb-1024x508.webp\",\"datePublished\":\"2025-12-08T15:48:03+00:00\",\"dateModified\":\"2026-02-02T18:10:39+00:00\",\"description\":\"Discover Sygnature Discovery's advanced CLC-K electrophysiology assays for drug discovery. Custom, precise, and high-throughput solutions.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/CLCKa-CLCKb-1024x508.webp\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/CLCKa-CLCKb-1024x508.webp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/clc-k-electrophysiology\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"CLC-K Electrophysiology\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CLC-K Electrophysiology - Sygnature","description":"Discover Sygnature Discovery's advanced CLC-K electrophysiology assays for drug discovery. Custom, precise, and high-throughput solutions.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/","og_locale":"fr_CA","og_type":"article","og_title":"CLC-K Electrophysiology - Sygnature","og_description":"Discover Sygnature Discovery's advanced CLC-K electrophysiology assays for drug discovery. Custom, precise, and high-throughput solutions.","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/","og_site_name":"Sygnature","article_modified_time":"2026-02-02T18:10:39+00:00","og_image":[{"width":1716,"height":851,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/","name":"CLC-K Electrophysiology - Sygnature","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-1024x508.webp","datePublished":"2025-12-08T15:48:03+00:00","dateModified":"2026-02-02T18:10:39+00:00","description":"Discover Sygnature Discovery's advanced CLC-K electrophysiology assays for drug discovery. Custom, precise, and high-throughput solutions.","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-1024x508.webp","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/CLCKa-CLCKb-1024x508.webp"},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/clc-k-electrophysiology\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"CLC-K Electrophysiology"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/case-study\/6660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/case-study"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/case-study"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/case-study\/6660\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=6660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=6660"},{"taxonomy":"resource_tag","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/resource_tag?post=6660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}