The proton-coupled amino acid transporter PAT-1 (SLC36A1) is a critical component of neurotransmitter precursor transport and nutrient absorption. Functioning via a 1:1 proton-to-substrate exchange mechanism, PAT-1 facilitates the uptake of small neutral amino acids such as glycine and proline\u2014essential for neurological, gastrointestinal, and metabolic health. Its involvement in diseases such as Hartnup disorder and its role in maintaining neurotransmitter balance position PAT-1 as a highly promising neurological disease drug target.<\/p>\n\n\n\n
At Sygnature Discovery, we support PAT-1 drug discovery and broader transporter drug discovery through custom assay development and SSM-based electrophysiology, enabling deeper investigation into PAT-1 and other proton-coupled transporters. Our platforms deliver the flexibility and throughput you need to accelerate screening and optimize PAT-1-targeted therapies.<\/p>\n\n\n\n
In this case study, our team demonstrates the development and optimization of PAT-1 functional assays using our SURFE2<\/sup>R N1 and SURFE2<\/sup>R 96SE platforms.<\/p>\n\n\n\n Our dual-platform approach combines flexibility of SURFE2<\/sup>R N1 for early assays development with the high-throughput power of the SURFE2<\/sup>R 96SE system- delivering scalable solutions for PAT-1 drug discovery and high-throughput transporter screening.<\/p>\n\n\n\n At Sygnature Discovery, we deliver custom cell-based transporter assays tailored to your target biology and discovery goals.<\/p>\n\n\n\n Our capabilities include:<\/p>\n\n\n\n CASE STUDY<\/strong><\/p>\n\n\n\n To read the full eBook please click the button below to download<\/p>\n\n\n\nSupporting Your Research<\/h4>\n\n\n\n
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Download the PDF: Advanced Electrophysiology Solutions for PAT-1 Drug Discovery<\/strong><\/h2>\n\n\n\n