{"id":6145,"date":"2025-12-05T13:40:06","date_gmt":"2025-12-05T13:40:06","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=case-study&#038;p=6145"},"modified":"2026-02-05T16:45:26","modified_gmt":"2026-02-05T16:45:26","slug":"sygnature-discoverys-mia-joint-pain-model","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/","title":{"rendered":"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-3-xl-font-size wp-elements-6c238e565d7d1d2dc1f52c92540e3321\">The MIA joint pain model, as orchestrated at Sygnature Discovery, serves as a robust and highly translational representation of human osteoarthritis (OA) pain. <\/h2>\n\n\n\n<p>Central to its pathophysiology is the introduction of monoiodoacetate (MIA) into the articular space, which instigates chondrocyte death and consequential cartilage damage, replicating the degenerative processes witnessed in osteoarthritis. Given this foundational pathology, the model becomes an exemplary tool for the evaluation of prospective OA joint pain targets.<\/p>\n\n\n\n<p>Induction in the MIA model involves a precise intra-articular injection of MIA into the knee joint of rat. To accurately quantify the resultant pain, a dynamic weight-bearing (DWB) methodology is employed. The temporal evolution of pain in this model is noteworthy. The initial period, spanning up to 7 days post-induction, is largely characterized by an inflammatory phase, rendering it sensitive to NSAID intervention. As the model progresses, the late phase, typically between 14 to 28 days, sees a transition to a predominantly NSAID-insensitive pain profile.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7d11ce30 wp-block-columns-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f3a6fda7773\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3a6fda7773\" class=\"wp-block-image size-large has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-1024x768.webp\" alt=\"\" class=\"wp-image-6146\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-1024x768.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-300x225.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-768x576.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-480x360.webp 480w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-640x480.webp 640w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2.webp 1420w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f3a6fda876c\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3a6fda876c\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"421\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-4.webp\" alt=\"\" class=\"wp-image-6147\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-4.webp 620w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-4-300x204.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-4-530x360.webp 530w\" sizes=\"(max-width: 620px) 100vw, 620px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n<\/div>\n\n\n\n<figure data-wp-context='{\"imageId\":\"69f3a6fda8dc6\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3a6fda8dc6\" class=\"wp-block-image size-full is-resized has-custom-border wp-lightbox-container\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\"><img loading=\"lazy\" decoding=\"async\" width=\"1136\" height=\"1145\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3.webp\" alt=\"\" class=\"wp-image-6152\" style=\"border-radius:1.5em;width:500px\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3.webp 1136w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-298x300.webp 298w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-1016x1024.webp 1016w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-150x150.webp 150w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-768x774.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-1072x1080.webp 1072w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-357x360.webp 357w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-1-3-635x640.webp 635w\" sizes=\"(max-width: 1136px) 100vw, 1136px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<p>Our foundational study design for the MIA joint pain model invariably encompasses 4-6 groups, with each group being populated by 10 subjects, ensuring a rich tapestry of data points and a robust statistical framework. As a testament to the model\u2019s sensitivity and reliability, Naproxen and Dexamethasone have been incorporated and tested as positive controls.<\/p>\n\n\n\n<p>Through rigorous evaluations within the framework of the MIA joint pain model, Sygnature Discovery has identified and operationalized distinct dosing paradigms to elicit the \u201cjoint pain\u201d phenotype. Predominantly, doses ranging from 2-3 mg of MIA have emerged as the optimal concentration to drive this phenotype. For the sake of precision and reproducibility, our validation endeavors have consistently employed a dose of 3 mg MIA, optimizing the model\u2019s sensitivity and relevance.<\/p>\n\n\n\n<p>Post-induction, a salient observation is the weight-bearing deficit manifesting in the ipsilateral right hind limb\u2014a physiological reaction that persisted up to four weeks. This persistent alteration in weight distribution underscores the model\u2019s ability to reliably mirror the chronic pain dynamics typically associated with osteoarthritis.<\/p>\n\n\n\n<figure data-wp-context='{\"imageId\":\"69f3a6fda94c5\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3a6fda94c5\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\"><img loading=\"lazy\" decoding=\"async\" width=\"1801\" height=\"1036\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2.webp\" alt=\"\" class=\"wp-image-6150\" style=\"border-radius:1.5em;object-fit:cover\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2.webp 1801w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2-300x173.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2-1024x589.webp 1024w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2-768x442.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2-1536x884.webp 1536w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2-626x360.webp 626w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-3-2-640x368.webp 640w\" sizes=\"(max-width: 1801px) 100vw, 1801px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<p>In terms of pharmacological interventions, our findings with the NSAID Naproxen and the steroid Dexamethasone are particularly illuminating. Naproxen demonstrates efficacy primarily within the early phase, aligning with the model\u2019s inflammatory and NSAID-sensitive period. Conversely, Dexamethasone showcases a broader spectrum of activity, exerting therapeutic effects during both the initial inflammatory stage and the subsequent NSAID-insensitive phase. This nuanced differential response further attests to the model\u2019s discriminating power and its capacity to discern between varied pharmacological mechanisms of action.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7d11ce30 wp-block-columns-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f3a6fda9ac7\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3a6fda9ac7\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"576\" height=\"441\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-6.webp\" alt=\"\" class=\"wp-image-6159\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-6.webp 576w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-6-300x230.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-6-470x360.webp 470w\" sizes=\"(max-width: 576px) 100vw, 576px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure data-wp-context='{\"imageId\":\"69f3a6fdaa025\"}' data-wp-interactive=\"core\/image\" data-wp-key=\"69f3a6fdaa025\" class=\"wp-block-image size-full has-custom-border wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"574\" height=\"441\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-5.webp\" alt=\"\" class=\"wp-image-6160\" style=\"border-radius:1.5em\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-5.webp 574w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-5-300x230.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-5-469x360.webp 469w\" sizes=\"(max-width: 574px) 100vw, 574px\"><button class=\"lightbox-trigger\" type=\"button\" aria-haspopup=\"dialog\" aria-label=\"Agrandir\" data-wp-init=\"callbacks.initTriggerButton\" data-wp-on--click=\"actions.showLightbox\" data-wp-style--right=\"state.imageButtonRight\" data-wp-style--top=\"state.imageButtonTop\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewbox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\"><\/path>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading has-dark-blue-500-color has-text-color has-link-color has-text-2-xl-font-size wp-elements-da3673c02ebeda7daa61b47db347de09\">Conclusion<\/h3>\n\n\n\n<p>In summation, the parameters and outcomes observed in the MIA joint pain model at Sygnature Discovery are a testament to the model\u2019s sophistication, reliability, and paramount relevance in the realm of osteoarthritis pain research.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","category":[735,685],"resource_tag":[],"class_list":["post-6145","case-study","type-case-study","status-publish","hentry","category-cns-pain-models","category-in-vivo-pharmacology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0 - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0 - Sygnature\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-05T16:45:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1420\" \/>\n\t<meta property=\"og:image:height\" content=\"1065\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/\",\"name\":\"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0 - Sygnature\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/MIA-joint-pain-model-2-1024x768.webp\",\"datePublished\":\"2025-12-05T13:40:06+00:00\",\"dateModified\":\"2026-02-05T16:45:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/MIA-joint-pain-model-2-1024x768.webp\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/MIA-joint-pain-model-2-1024x768.webp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/case-study\\\/sygnature-discoverys-mia-joint-pain-model\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0 - Sygnature","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/","og_locale":"fr_CA","og_type":"article","og_title":"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0 - Sygnature","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/","og_site_name":"Sygnature","article_modified_time":"2026-02-05T16:45:26+00:00","og_image":[{"width":1420,"height":1065,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/","name":"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0 - Sygnature","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-1024x768.webp","datePublished":"2025-12-05T13:40:06+00:00","dateModified":"2026-02-05T16:45:26+00:00","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-1024x768.webp","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/12\/MIA-joint-pain-model-2-1024x768.webp"},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/sygnature-discoverys-mia-joint-pain-model\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"Sygnature Discovery\u2019s\u00a0MIA joint pain model\u00a0"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/case-study\/6145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/case-study"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/case-study"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/case-study\/6145\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=6145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=6145"},{"taxonomy":"resource_tag","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/resource_tag?post=6145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}