{"id":3200,"date":"2018-02-07T10:16:54","date_gmt":"2018-02-07T10:16:54","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/case-study\/hit-identification-to-3-compounds-in-the-clinic-and-6-development-candidates\/"},"modified":"2025-11-26T16:18:45","modified_gmt":"2025-11-26T16:18:45","slug":"hit-identification-to-3-compounds-in-the-clinic-and-6-development-candidates","status":"publish","type":"case-study","link":"https:\/\/www.sygnaturediscovery.com\/fr\/case-study\/hit-identification-to-3-compounds-in-the-clinic-and-6-development-candidates\/","title":{"rendered":"Hit Identification to 3 Compounds in the Clinic and 6 Development Candidates"},"content":{"rendered":"<ul>\n<li>UK-based small molecule drug discovery company<\/li>\n<li>Focus on identifying novel treatments of inflammatory respiratory diseases, such as COPD<\/li>\n<li>No in-house medicinal chemistry capability \u2013 Sygnature has been the company\u2019s exclusive<br \/>\nmedicinal chemistry team since 2007, providing multiple FTEs of resource + intellectual input<\/li>\n<li>Considerable intellectual input from Sygnature\u2019s chemists \u2013 named on more than 20 patents and patent applications (so far)<\/li>\n<li>3 Compounds discovered at Sygnature have entered the clinic (Phases I and IIa) as potential \u2018first-in-class\u2019 treatments, and 6 more compounds have entered pre-clinical development<\/li>\n<li>The company was acquired by a major multi-national pharmaceutical company in 2010<\/li>\n<li>Since the acquisition, Sygnature has enjoyed a large FTE-based collaboration (medicinal<br \/>\nchemistry and <em>in vitro<\/em> bioscience) to discover additional small molecule-based drug candidates<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":3201,"template":"","category":[1],"resource_tag":[],"class_list":["post-3200","case-study","type-case-study","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hit Identification to 3 Compounds in the Clinic<\/title>\n<meta name=\"description\" content=\"Collaborating with Sygnature since 2007, leading to patents and clinical development. 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