{"id":17107,"date":"2021-10-08T10:56:41","date_gmt":"2021-10-08T10:56:41","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/blog\/hitting-the-drug-target-takes-teamwork\/"},"modified":"2021-10-08T10:56:41","modified_gmt":"2021-10-08T10:56:41","slug":"hitting-the-drug-target-takes-teamwork","status":"publish","type":"blog","link":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/hitting-the-drug-target-takes-teamwork\/","title":{"rendered":"Hitting the drug target takes teamwork"},"content":{"rendered":"<p><span data-contrast=\"none\">Drug discovery programmes can be made or broken by the approaches organisations take in the early stages. <\/span><\/p>\n<p><span data-contrast=\"none\">As project viability and investment decisions are often made at drug target identification and validation, it\u2019s imperative to implement robust strategies to make sure well-informed conclusions are drawn and the programme has the best chance of success.<br>\n<\/span><\/p>\n<p><span data-contrast=\"none\">A key part\u00a0of this process is to have systems that allow integration and\u00a0the\u00a0sharing of expertise across different teams, ensuring every\u00a0team member\u2019s\u00a0unique abilities can contribute to the success of a project.\u00a0<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h4><a href=\"https:\/\/info.sygnaturediscovery.com\/ebook-accelerating-drug-discovery-with-integrated-strategies\"><strong><span class=\"TextRun SCXW256011834 BCX0\" lang=\"EN-GB\" xml_lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW256011834 BCX0\" data-ccp-parastyle=\"Normal (Web)\">Discover how truly integrated drug discovery approaches can revolutionise your programme with<\/span><span class=\"NormalTextRun SCXW256011834 BCX0\" data-ccp-parastyle=\"Normal (Web)\">\u00a0<\/span><span class=\"NormalTextRun SCXW256011834 BCX0\" data-ccp-parastyle=\"Normal (Web)\">our eBook.<\/span><\/span><span class=\"EOP SCXW256011834 BCX0\" data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/strong><\/a><\/h4>\n<p><span class=\"TextRun SCXW42292965 BCX0\" lang=\"EN-GB\" xml_lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW42292965 BCX0\" data-ccp-parastyle=\"Normal (Web)\">In this blog, we\u2019ll <\/span><span class=\"NormalTextRun SCXW42292965 BCX0\" data-ccp-parastyle=\"Normal (Web)\">explore\u00a0<\/span><span class=\"NormalTextRun SCXW42292965 BCX0\" data-ccp-parastyle=\"Normal (Web)\">drug <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/integrated-drug-discovery\/target-validation\/\">target validation<\/a>, and<\/span><span class=\"NormalTextRun SCXW42292965 BCX0\" data-ccp-parastyle=\"Normal (Web)\">\u00a0how\u00a0<\/span><span class=\"NormalTextRun SCXW42292965 BCX0\" data-ccp-parastyle=\"Normal (Web)\">adopting an integrated approach enables you to implement robust strategies that ultimately provide strong foundations for your entire drug discovery project.\u00a0<\/span><\/span><span class=\"EOP SCXW42292965 BCX0\" data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'> <span class=\"TextRun SCXW188116820 BCX0\" lang=\"EN-GB\" xml_lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW188116820 BCX0\" data-ccp-parastyle=\"Normal (Web)\">What makes <\/span><span class=\"NormalTextRun SCXW188116820 BCX0\" data-ccp-parastyle=\"Normal (Web)\">a good\u00a0<\/span><span class=\"NormalTextRun SCXW188116820 BCX0\" data-ccp-parastyle=\"Normal (Web)\">drug\u00a0<\/span><span class=\"NormalTextRun SCXW188116820 BCX0\" data-ccp-parastyle=\"Normal (Web)\">target<\/span><span class=\"NormalTextRun SCXW188116820 BCX0\" data-ccp-parastyle=\"Normal (Web)\">?<\/span><\/span><span class=\"EOP SCXW188116820 BCX0\" data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/span><\/h2>\n<p aria-level=\"2\"><span data-contrast=\"none\">The types of molecules considered as potential drug targets have broadened in recent years, but there remains a common range of desirable characteristics. To be a real prospect for further study, a biological target must be susceptible to modulation through the binding to a potential therapeutic agent and have a good pharmacological profile. Widely sought-after properties include:<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">A proven function in the pathophysiology of a disease, or in modifying the disease<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Expression and activity in disease-relevant cells and signalling pathways<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">A known and available 3D structure for the assessment of druggability<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">A level of \u2018assayability\u2019 that enables <a href=\"https:\/\/www.sygnaturediscovery.com\/news-and-events\/webinars\/how-we-created-a-world-leading-hts-system\/\">high-throughput screening (HTS)<\/a>, a robust (but not exclusive) method for measuring changes of activity to enable hit-finding and compound evaluation\u202f<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">A promising toxicity profile and the ability to predict potential adverse effects using phenotypic data<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">The existence of target\/disease-specific biomarkers to monitor target engagement and therapeutic efficacy<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">A favourable intellectual property (IP) status<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">The likelihood of leading to an improvement over the current standard of care<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<h2><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'> <span class=\"TextRun SCXW134388991 BCX0\" lang=\"EN-GB\" xml_lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW134388991 BCX0\" data-ccp-parastyle=\"heading 2\">A systematic method of d<\/span><span class=\"NormalTextRun SCXW134388991 BCX0\" data-ccp-parastyle=\"heading 2\">rug t<\/span><span class=\"NormalTextRun SCXW134388991 BCX0\" data-ccp-parastyle=\"heading 2\">arget validation<\/span><\/span><span class=\"EOP SCXW134388991 BCX0\" data-ccp-props='{\"201341983\":0,\"335559738\":200,\"335559739\":120,\"335559740\":276}'>\u00a0<\/span><\/span><\/h2>\n<p><span data-contrast=\"none\">Once a drug target is acquired, the drug\u2019s effect on a target\u00a0must be shown to\u00a0provide a therapeutic benefit within an acceptable safety window.\u00a0This\u00a0validation step is\u00a0critical\u00a0for drug development.\u00a0When therapeutics in development fail in the clinic, it\u2019s typically due to inadequate target validation.\u00a0<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">To overcome this, the validation phase must\u00a0include\u00a0systematic\u00a0evidence\u00a0from multiple sources. This approach includes clinical human disease and gene manipulation data, the use of tool compounds biomarkers, biological assays in patient-derived cells, and many other techniques.\u00a0<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Understanding the biology of the disease is also\u00a0crucial for <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/integrated-drug-discovery\/target-validation\/\">target validation<\/a>. Here, genetic association data and proteomics data, alongside\u00a0methods to manipulate the genome and proteome (such as CRISPR or genetically modified animal models),\u00a0are widely used\u00a0to validate the disease-modifying abilities of drug targets and their targeting compounds.\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">All of these facets feed into a scaffold of evidence that supports the confidence in how well the target is linked to the disease and whether modulating it is likely to be efficacious. <\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><img decoding=\"async\" class=\"alignnone size-medium wp-image-11740\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/shutterstock_794460844.jpg\" alt=\"\"><\/h2>\n<h2 aria-level=\"2\">How taking an integrated approach can boost\u00a0your\u00a0chances of success\u00a0in drug discovery<\/h2>\n<p><span data-contrast=\"none\">Drug target validation is a significant phase that underpins a project\u2019s viability and investment decisions. It therefore pays to have as wide an input as possible across a range of competencies and to boost the potential of drug discovery projects by creating multidisciplinary team environments and collaborating with external organisations like contract research organisations (CROs). <\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">As such,\u00a0creating an environment that enables the true\u00a0<\/span><b><span data-contrast=\"none\">integration of expertise\u00a0increases\u00a0the chances of success in drug discovery<\/span><\/b><span data-contrast=\"none\">.\u00a0Sharing the\u00a0expertise and experience of\u00a0different\u00a0teams, both internal and in <a href=\"https:\/\/www.sygnaturediscovery.com\/news-and-events\/blog\/5-key-things-to-look-for-in-a-drug-discovery-cro-partnership\/\">partnerships with CROs<\/a>\u00a0boosts teamwork efficiency and\u00a0ensures\u00a0the\u00a0most robust experimental designs\u00a0for further\u00a0validation.\u00a0<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">This also\u00a0<\/span><b><span data-contrast=\"none\">strengthens confidence in\u00a0making crucial decisions about\u00a0a\u00a0project<\/span><\/b><span data-contrast=\"none\">.\u00a0There will be times when the evidence indicates that early project termination is the best course of action, or that there is a need to take a different direction to avoid financial wastage down the line.\u00a0<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The scientific integrity and openness fostered in a\u00a0truly integrated, multidisciplinary environment also\u00a0ensures\u00a0that\u00a0everyone stays up to date throughout the drug discovery\u00a0process, keeping abreast of competitor intelligence and operating collaboratively with academic groups in the target space.<\/span><span data-ccp-props='{\"134233117\":true,\"134233118\":true,\"201341983\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ultimately, the most powerful approaches to drug\u00a0target\u00a0validation harness the shared expertise, deep experience, and practical leanings of a diverse range of professionals.\u00a0<\/span><span data-contrast=\"auto\">Channelling the\u00a0experience and expertise of interdisciplinary teams delivers the firepower needed to bring new drugs through the discovery lifecycle quickly and with\u00a0a\u00a0greater chance of success.<\/span><\/p>\n<h4><strong><a href=\"https:\/\/info.sygnaturediscovery.com\/ebook-accelerating-drug-discovery-with-integrated-strategies\"><span class=\"TextRun SCXW99437078 BCX0\" lang=\"EN-GB\" xml_lang=\"EN-GB\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW99437078 BCX0\" data-ccp-parastyle=\"Normal (Web)\">[eBook] Accelerating Drug Discovery: How To Increase Productivity with Integrated Strategies<\/span><\/span><\/a><\/strong><\/h4>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":17108,"template":"","category":[29],"class_list":["post-17107","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-non-categorise"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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