{"id":17056,"date":"2022-04-06T15:13:58","date_gmt":"2022-04-06T15:13:58","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/"},"modified":"2022-04-06T15:13:58","modified_gmt":"2022-04-06T15:13:58","slug":"thoughts-on-the-challenges-of-treating-ovarian-cancer","status":"publish","type":"blog","link":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/","title":{"rendered":"Thoughts on the challenges of treating ovarian cancer"},"content":{"rendered":"

At the American Association for Cancer Research<\/a> meeting in New Orleans this week, Sygnature are sponsoring a PhD student, Rita A Avelar<\/a>, to present their work, as part of the AACR\u2019s \u201cScholar in Training\u201d award. Rita this year will be presenting a poster on potential new approaches to certain types of ovarian cancer.<\/p>\n

Despite significant research, ovarian cancer remains at the \u201cproblematic to treat\u201d end of the cancer spectrum, especially when diagnosed late or later in life, with limited options and significant risk of relapse after therapy.\u00a0 Early diagnosis has helped improve survival in younger women, but for those diagnosed in later years the prognosis is less encouraging.\u00a0 Only about a fifth of cancers have an identifiable and \u201cactionable\u201d genetic mutation (such as loss of the BRCA gene which can sensitise to PARP inhibitors) and whilst often considered a single disease, ovarian cancer consists of perhaps half a dozen different subtypes.<\/p>\n

Whilst the newer therapies such as bevacizumab and the PARP inhibitors have helped for some, for the 60% or so of patients with the high grade Serous Ovarian Cancer (HGSOC) subtype, relapses are frequent with few further therapeutic options.<\/p>\n

Having had close friends and colleagues who have battled this particular disease, I\u2019ve seen some of these challenges play out in real time, and seen the hope and benefits that new therapies, accessed through early clinical trials, can bring to women with ovarian cancer.\u00a0 This new work is still in the early stages, but suggests that activation of the phosphatase PP2A, a potential tumour suppressor, may offer a new way of targeting these tumours. Interestingly, PP2A is thought to help repress oncogenic signalling through AKT, Raf and MEK, so activators of this enzyme have been often sought, but seldom reported.<\/p>\n

This is an unfolding story I\u2019ll watch with interest.\u00a0 In a disease where new therapeutics are scarce and responses are often short-lived, potential paths forward such as this one are urgently needed.<\/p>\n

If you will be attending AACR this year, be sure to visit Rita\u2019s poster, located at A3340, set to be unveiled at 13:00pm on Tuesday 12th April.<\/p>\n

\"\"<\/p>\n

\n

Author: Allan Jordan<\/a>, Vice President, Oncology Drug Discovery, Sygnature Discovery<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":17058,"template":"","category":[29],"class_list":["post-17056","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-non-categorise"],"acf":[],"yoast_head":"\nThoughts on the challenges of treating ovarian cancer - Sygnature<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thoughts on the challenges of treating ovarian cancer - Sygnature\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/sygnature-hit-to-lead-team-collaboration-scaled.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/\",\"name\":\"Thoughts on the challenges of treating ovarian cancer - Sygnature\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/ovarian-cancer.jpg\",\"datePublished\":\"2022-04-06T15:13:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/ovarian-cancer.jpg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/ovarian-cancer.jpg\",\"width\":1000,\"height\":667},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/thoughts-on-the-challenges-of-treating-ovarian-cancer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/page-daccueil\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Thoughts on the challenges of treating ovarian cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Thoughts on the challenges of treating ovarian cancer - Sygnature","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/","og_locale":"fr_CA","og_type":"article","og_title":"Thoughts on the challenges of treating ovarian cancer - Sygnature","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/","og_site_name":"Sygnature","og_image":[{"width":2560,"height":1707,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/02\/sygnature-hit-to-lead-team-collaboration-scaled.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/","name":"Thoughts on the challenges of treating ovarian cancer - Sygnature","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/ovarian-cancer.jpg","datePublished":"2022-04-06T15:13:58+00:00","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/ovarian-cancer.jpg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/ovarian-cancer.jpg","width":1000,"height":667},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/thoughts-on-the-challenges-of-treating-ovarian-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/page-daccueil\/"},{"@type":"ListItem","position":2,"name":"Thoughts on the challenges of treating ovarian cancer"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog\/17056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/blog"}],"version-history":[{"count":0,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog\/17056\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/17058"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=17056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=17056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}