{"id":16989,"date":"2023-08-25T14:46:22","date_gmt":"2023-08-25T14:46:22","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/blog\/bioavailability-can-we-improve-it\/"},"modified":"2023-08-25T14:46:22","modified_gmt":"2023-08-25T14:46:22","slug":"bioavailability-can-we-improve-it","status":"publish","type":"blog","link":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/bioavailability-can-we-improve-it\/","title":{"rendered":"Bioavailability &#8211; can we improve it?"},"content":{"rendered":"<h2>Bioavailability: What is it and what factors influence it?<span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Bioavailability (F) is a critical parameter in the developability of potential new drugs for unmet clinical needs. Where the bioavailability is a result of the structure of the molecule, there are technologies that might improve the performance, without changing the chemical structure.<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h3><span class=\"NormalTextRun CommentStart CommentHighlightClicked SCXW228596233 BCX0\">Can we improve the bioavailability? <\/span><\/h3>\n<p><span class=\"NormalTextRun CommentHighlightPipeClicked SCXW228596233 BCX0\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-15346 alignleft\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/bioanalysis.png\" alt=\"\" width=\"344\" height=\"195\">It\u2019s a question we often get asked here at <\/span><span class=\"SpellingError SCXW228596233 BCX0\">Sygnature<\/span><span class=\"NormalTextRun SCXW228596233 BCX0\"> Discovery. \u00a0In our integrated projects, we assess bioavailability within the design\u2013make\u2013test cycle during the late lead optimization stage. When chemical alteration isn\u2019t viable, our Form and Formulation Department\u2019s comprehensive toolbox is utilized to potentially enhance bioavailability.<\/span><\/p>\n<p><span data-contrast=\"auto\">Customers who do not have an integrated project with Sygnature can still access <a href=\"https:\/\/www.sygnaturediscovery.com\/drug-discovery\/preclinical-drug-safety\/form-and-drugs-formulation-services\/\">Form and Formulation<\/a> expertise through a fee-for-service model. <\/span>Typically engaged during late lead optimization or candidate nomination stages, the dialogue often begins after initial PK experiments, transitioning into efficacy studies. At this juncture, customers seek insights into the dose necessary to elicit an <em>in vivo<\/em> model effect, considering that only the free drug concentration is effective. Recognizing that a drug\u2019s bioavailability represents the fraction of orally administered drugs reaching systemic circulation, comprehending the interplay between dose, free concentration, and efficacy is pivotal for determining dosing strategies for subsequent toxicology studies and first-in-human trials.<\/p>\n<p><span data-contrast=\"auto\">The bioavailability of a compound is affected by both chemical and biological factors, which include:\u00a0<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\u2022\" data-font=\"Arial\" data-listid=\"1\" data-list-defn-props='{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Arial\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\u2022\",\"469777815\":\"hybridMultilevel\"}' aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">GI metabolism\/stability<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\u2022\" data-font=\"Arial\" data-listid=\"1\" data-list-defn-props='{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Arial\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\u2022\",\"469777815\":\"hybridMultilevel\"}' aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Transporter influence<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\u2022\" data-font=\"Arial\" data-listid=\"1\" data-list-defn-props='{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Arial\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\u2022\",\"469777815\":\"hybridMultilevel\"}' aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Liver clearance (metabolism and biliary)<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\u2022\" data-font=\"Arial\" data-listid=\"1\" data-list-defn-props='{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Arial\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\u2022\",\"469777815\":\"hybridMultilevel\"}' aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Solubility\/Dissolution<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<li data-leveltext=\"\u2022\" data-font=\"Arial\" data-listid=\"1\" data-list-defn-props='{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Arial\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\u2022\",\"469777815\":\"hybridMultilevel\"}' aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Permeability<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<p><span class=\"TextRun SCXW83142608 BCX0\" lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW83142608 BCX0\">Collaborating with an integrated service partner can significantly conserve time, resources, materials, and finances. Any solution offered needs to address the ultimate question: <\/span><\/span><span class=\"TextRun SCXW83142608 BCX0\" lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW83142608 BCX0\">Why<\/span><\/span><span class=\"TextRun SCXW83142608 BCX0\" lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW83142608 BCX0\"> is the bioavailability low? Initially, verification from the DMPK team is essential to rule out any inherent drawbacks in the compound. This involves confirming that the clearance rate is not excessively high, leading to consistently low free concentrations unable to induce an effective response. Once it has been established that bioavailability is not a function of liver clearance, the next step is to determine where the compound sits in the Developability Classification <\/span><span class=\"NormalTextRun SCXW83142608 BCX0\">System (<\/span><span class=\"NormalTextRun SCXW83142608 BCX0\">DCS).\u00a0\u00a0<\/span><\/span><\/p>\n<div id=\"attachment_15345\" style=\"width: 383px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-15345\" class=\"wp-image-15345\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/FormFormulation-Graphic-1.png\" alt=\"\" width=\"373\" height=\"298\"><p id=\"caption-attachment-15345\" class=\"wp-caption-text\">The integration of formulation, DMPK, and Pharmacology into delivery at Sygnature Discovery.<\/p><\/div>\n<h2><b><span data-contrast=\"auto\">The Developability Classification System<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The DCS system is used to rank compounds in terms of ease of development. Solubility and permeability are the two key parameters that limit bioavailability. Compounds in DCS Class I, marked by high permeability and solubility, are the most straightforward to develop, while those in Class IV, characterized by low solubility and permeability, pose the greatest challenges. For compounds placed in Classes IIa-IV, formulation strategies can be employed to enhance their bioavailability.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-15483 aligncenter\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/permeability-graph-NEW-01.png\" alt=\"\" width=\"437\" height=\"309\"><\/p>\n<p><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Formulation Strategies for Class IIa<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p>Dissolution limitation affects Class IIa compounds. Enhancing dissolution primarily involves reducing particle size, thereby increasing the particle\u2019s surface area-to-volume ratio and improving its dissolution capacity. Techniques such as micronization and nano-milling achieve particle size reduction.<\/p>\n<p><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Formulation Strategies for Class IIb<\/span><\/b><\/h2>\n<p>In contrast to Class IIa compounds, Class IIb compounds exhibit genuinely low solubility. Many of these compounds are crystalline. Modifying the solubility of a Class IIb compound involves altering its form, often through the creation of a new salt form or by developing a lyophilized or spray-dried amorphous solid dispersion.<\/p>\n<p><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Formulation Strategies for Class III<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">For Class III compounds, solubility is not an issue, but permeability is. Permeation enhancers and\/or inhibitors of efflux substrates can be used to help maximise exposure.<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Formulation Strategies for Class IV<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Class IV compounds are the most challenging. When a client chooses to pursue the development of a Class IV compound, various strategies can be applied. These encompass formulations like micro\/nanoemulsion suspension or solid dispersions.<\/span><\/p>\n<div id=\"attachment_15334\" style=\"width: 369px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-15334\" class=\"wp-image-15334\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/3970-08-01_fAssgf-t30.jpg\" alt=\"\" width=\"359\" height=\"281\"><p id=\"caption-attachment-15334\" class=\"wp-caption-text\">Lipidic formulation demonstrating emulsion formation.<\/p><\/div>\n<p><span data-contrast=\"auto\">At Sygnature Discovery, we possess the expertise, experience, and dedication to drive your molecule towards clinical success. We have the instrumentation onsite to generate everything from lipidic SMEDDS\/SNEDDS, spray-dried and lyophilised smorphous solid dispersions, simple solvent\u2013cosolvent systems to nano milling, adding permeation enhancers, PGP inhibitors or combinations thereof to give your material the best chance of success.<\/span><\/p>\n<p><span class=\"TextRun SCXW50592004 BCX0\" lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW50592004 BCX0\">The team uses state-of-the-art instrumentation to <\/span><span class=\"NormalTextRun SCXW50592004 BCX0\">rapidly <\/span><span class=\"NormalTextRun SCXW50592004 BCX0\">test the formulations, such as the <\/span><span class=\"NormalTextRun SCXW50592004 BCX0\" data-ccp-charstyle=\"ui-provider\" data-ccp-charstyle-defn='{\"ObjectId\":\"3a0eea41-6acc-4548-b999-17d9c3f15dce|29\",\"ClassId\":1073872969,\"Properties\":[469775450,\"ui-provider\",201340122,\"1\",134233614,\"true\",469778129,\"ui-provider\",335572020,\"1\",469778324,\"Default Paragraph Font\"]}'>Pion \u00b5Diss system, which enables simultaneous dissolution and flux measurements.\u00a0\u00a0<\/span><\/span><span class=\"EOP SCXW50592004 BCX0\" data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<div id=\"attachment_15335\" style=\"width: 307px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-15335\" class=\"wp-image-15335\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/20230112_163640-scaled.jpg\" alt=\"\" width=\"297\" height=\"396\"><p id=\"caption-attachment-15335\" class=\"wp-caption-text\">Pion \u00b5Diss system.<\/p><\/div>\n<h2><\/h2>\n<h2><b><span data-contrast=\"auto\">Choosing the right formulation for your molecule<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">With a range of formulation technologies available, choosing the right formulation for your compound is a decision you will need to face. The Form and Formulation team collaborates with customers to select the most suitable formulation solution that ensures the required drug exposure for efficacy and clinical translation. The team will not only advise on the cost of developing a formulation but also the impact on the cost of goods as you proceed to the clinic. Formulations might undergo redevelopment as clients move from Phase I to Phase III. For instance, what works for a Phase I safety study, like a capsule, might not be suitable for a larger Phase III efficacy study where a tablet could be more cost-effective.<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Enabling Formulations for Toxicology Studies<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The Form and Formulation team can also support customers who require an enabling formulation for toxicology studies. In cases where a customer has chosen a candidate compound with adequate bioavailability to drive efficacy in an <em>in vivo<\/em> model but experiences non-linear PK, our team can step in.<\/span><\/p>\n<p><span data-contrast=\"auto\">When a drug exhibits non-linear PK, the increase (or decrease) of dose results in a disproportionate response in free drug concentration at a steady state. For example, doubling the dose won\u2019t lead to a doubling of plasma drug concentration. Non-linear PK can be a factor of absorption, first-pass metabolism, binding, excretion and biotransformation. Where the non-linear PK arises as a factor of absorption or permeation, i.e., an increased dose does not result in a proportional increase in drug plasma concentration, Sygnature Discovery can assist in developing an enabling formulation to enhance the compound\u2019s bioavailability at higher doses.<\/span><\/p>\n<p><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">About the author \u2013 David Pearson, Director of the Form and Formulation Department<\/span><\/b><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Dr David Pearson, the Director of Sygnature Discovery\u2019s Form and Formulation Department, is a highly experienced solid form expert with extensive experience at the interface with medicinal chemistry, process chemistry, DMPK and pharmacology. David has spent 20+ years working to support customers to take their molecules from the lab to the clinic. He has achieved this by understanding, controlling and improving the solid-state properties, such as crystallinity, stability and dissolution profiles, of their compounds. David oversees a team at Sygnature whose aim is to deliver a formulation process in a rapid and nimble R&amp;D environment which can then be transferred to cGMP production. David has helped 15+ compounds move to the clinic and beyond.<\/span><span data-ccp-props='{\"201341983\":0,\"335559739\":0,\"335559740\":240}'>\u00a0<\/span><\/p>\n<div class=\"flex justify-between lg:block\">\n<div class=\"flex justify-between items-center p-4 rounded-md bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-sm\">\n<div class=\"mr-4\"><\/div>\n<\/div>\n<\/div>\n<p><span style=\"font-size: 18pt; color: #00ccff;\"><b>Meet David at:<\/b><\/span><\/p>\n<p><span style=\"font-size: 18pt; color: #00ccff;\"><b><a style=\"color: #00ccff;\" href=\"http:\/\/www.formulationsbioavailability.com\/\" target=\"_blank\" rel=\"noopener\">Life Science Sweden \u2013 New Updates in drug formulation and bioavailability. <\/a><\/b><\/span><\/p>\n<p><span style=\"font-size: 18pt; color: #00ccff;\"><b>Copenhagen 6<\/b><b>th<\/b><b> September<\/b>\u00a0<\/span><\/p>\n<p><span style=\"font-size: 18pt; color: #00ccff;\">To arrange a meeting with David in person or remotely, please contact info@sygnaturedsicovery.com\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":16991,"template":"","category":[819,992,1073,850],"class_list":["post-16989","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-decouverte-integree-de-medicaments","category-dmpk","category-forme-et-formulation","category-optimisation-des-leads"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bioavailability - can we improve it? 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