{"id":16939,"date":"2024-07-04T17:10:10","date_gmt":"2024-07-04T17:10:10","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets\/"},"modified":"2026-11-09T10:54:53","modified_gmt":"2026-11-09T10:54:53","slug":"intrinsically-disordered-proteins-as-drug-discovery-targets-01","status":"publish","type":"blog","link":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/","title":{"rendered":"Intrinsically Disordered Proteins as Drug Discovery Targets"},"content":{"rendered":"\n

The intriguing world of the Intrinsically disordered proteins and why they are important as targets for drug discovery<\/strong><\/h2>\n\n\n\n
\"\"<\/figure>\n\n\n\n

When we think about proteins, we usually picture them as having a well-defined, three-dimensional, globular shape; however, this doesn\u2019t apply to intrinsically disordered proteins or regions (IDPs\/IDRs), which lack a fixed structure. IDPs\/IDRs constitute at least 33% of the eukaryotic proteome.1,6<\/sup>\u00a0IDPs are of significant interest to biotech and pharmaceutical companies because they are involved in many pathologies. As a result, IDPs have emerged as promising candidates for drug design.<\/p>\n\n\n\n

In this blog we delve into the world of IDPs to understand their biophysics and their significance both to biology and drug design.<\/p>\n\n\n\n

What are Intrinsically Disordered Proteins (IDPs)?<\/h2>\n\n\n\n

By definition, an IDP is a polypeptide chain that lacks a stable structure and remains highly dynamic under physiological conditions, a characteristic crucial for their biological functions. These proteins can adopt transient, non-globular conformations, possessing secondary or tertiary structures.1,2,3<\/sup>\u00a0Short disorder regions are associated with flexible linker or loops, while long disordered regions are associated with recognition sites for protein \u2013 protein interactions due to their structural and functional independence from the rest of the protein core.1<\/sup><\/p>\n\n\n\n

\"\"
Figure 1.<\/strong> Representation of IDPs and IDRs<\/em><\/figcaption><\/figure>\n\n\n\n

Where do IDPs exist in nature?<\/h2>\n\n\n\n

IDPs are found in the proteomes of all kingdoms of life and play vital roles in various biological processes, often by participating in protein-protein interactions that govern key cellular functions such as transcription and cell-cycle regulation. While all proteins are made of amino acids linked by peptide bonds, disordered proteins have a different amino acid composition compared to globular proteins, resulting in a wider range of conformational and structural heterogeneity. IDPs generally favor hydrophilic amino acids over hydrophobic residues. As a result, they are typically rich in arginine, glutamine, glutamic acid, lysine, proline, and serine, while being deficient in cysteine, isoleucine, leucine, phenylalanine, tryptophan, tyrosine, and valine.<\/p>\n\n\n\n

The proportion of structural disorder increases with genome complexity, from bacteria to archaea to eukaryotes. Approximately 78% of eukaryotic proteins contain long intrinsically disordered regions (IDRs), compared to 12-14% in bacteria and 1% in archaea.<\/p>\n\n\n\n

\"\"
Figure 2. <\/strong>Statistics of the taxonomic classification of IDPs from DisProt database.<\/em><\/figcaption><\/figure>\n\n\n\n

What processes do IDPs and IDRs participate in?<\/h2>\n\n\n\n

The primary roles of IDPs and IDRs are in signaling and regulation within and between cells. They are involved in processes such as post-translational modification, alternative splicing, cell division, nucleic acid replication and repair, and response to external stimuli. Their lack of stable structure allows IDPs to interact with multiple partners, facilitating complex signaling networks. Phosphorylation and other post-translational modifications (PTMs), which are predominantly located in IDRs, significantly influence their conformation and interactions8,9<\/sup>. Additionally, alternative splicing often affects disordered regions, making it less disruptive compared to structured regions10<\/sup>.<\/p>\n\n\n\n

\"\"
Figure 3.<\/strong> Intrinsically disordered proteins roles in cell communication and signaling.<\/em><\/figcaption><\/figure>\n\n\n\n

Why IDPs Are Good Candidates for Drug Discovery?<\/h2>\n\n\n\n

IDPs play crucial roles in cellular functions, and their dysregulation can lead to diseases, particularly neurodegenerative disorders and cancer11<\/sup>. The tendency of IDPs to form aggregates is a hallmark of numerous neurodegenerative diseases12<\/sup>. For example, the IDP alpha-synuclein can form toxic aggregates that disrupt cellular functions, leading to Parkinson\u2019s disease.<\/p>\n\n\n\n

Targeting IDPs for therapeutics presents a series of challenges. Their natural dynamics make them difficult targets for traditional strategies, which typically involve small molecules binding to well-defined pockets.13<\/sup>\u00a0However, the ability of short amino acid sequences to bind diverse molecules suggests that rationally identifying small-molecule drugs targeting disordered proteins is feasible based on their sequence characteristics11<\/sup>. Recent advances in drug discovery and protein engineering suggest that stabilizing certain IDP conformations could prevent protein-protein interactions and mitigate toxic aggregation, making IDPs potential therapeutic targets.<\/p>\n\n\n\n

The structural plasticity of IDPs makes them difficult to study with traditional drug discovery biophysics approaches. However,\u00a0Nuclear Magnetic Resonance (NMR) spectroscopy\u00a0in solution is valuable for exploring protein-ligand interactions in IDPs for therapeutic purposes. These techniques are available within the Protein & Structure department at Sygnature Discovery.<\/p>\n\n\n\n

Our experience in working with IDPs<\/h2>\n\n\n\n

\u00a0<\/em><\/strong>Understanding the structural and dynamic properties of proteins is crucial for drug discovery. Historically, most attention has been given to well-structured proteins. However, this subset of disordered proteins is now at the forefront of research.<\/p>\n\n\n\n

Here at Sygnature Discovery, we pride ourselves on our extensive experience of working with these fascinating molecules. Our team possesses extensive expertise in protein biochemistry, cell science, structural biology, and biophysics, all dedicated to unraveling the complexities of IDPs and IDRs. We have led challenging projects related to IDPs, successfully expressing, purifying, and structurally characterizing these targets. Our successes include:<\/p>\n\n\n\n

    \n
  • Improvements in expression<\/li>\n\n\n\n
  • Improvements in solubility<\/li>\n\n\n\n
  • Degradation mitigation<\/li>\n\n\n\n
  • Improvements in yield<\/li>\n\n\n\n
  • Improvements in protein sample quality.<\/li>\n\n\n\n
  • Establishing SPR assays to measure compound binding<\/li>\n\n\n\n
  • NMR studies of the dynamics of IDPs<\/li>\n<\/ul>\n\n\n\n
    \"\"
    Figure 4.<\/strong> Example of expression and purification of a challenge, disorder transcription factor protein at Sygnature Discovery. Left is the clients prior experience. Right is after we redesigned the strategy to produce mgs of biotinylated protein for SPR.<\/em><\/figcaption><\/figure>\n\n\n\n

    References<\/h2>\n\n\n\n
      \n
    1. 1.- Trivedi R, Nagarajaram HA. Intrinsically Disordered Proteins: An Overview. Int J Mol Sci. 2022 Nov .<\/li>\n\n\n\n
    2. 2.- Uversky, Vladimir N. \u201cIntroduction to intrinsically disordered proteins (IDPs).\u201d\u00a0Chemical reviews<\/em><\/li>\n\n\n\n
    3. 3.- Arai, Munehito et al. \u201cDynamics and interactions of intrinsically disordered proteins.\u201d\u00a0Current opinion in structural biology<\/em>\u00a0vol. 84 (2024)<\/li>\n\n\n\n
    4. 4.- Uversky Vladimir N.Intrinsically Disordered Proteins and Their \u201cMysterious\u201d (Meta)Physics.Frontiers in Physics, 7, 2019<\/li>\n\n\n\n
    5. 5.- Dunker AK, Babu MM, Barbar E, Blackledge M, Bondos SE, Doszt\u00e1nyi Z, Dyson HJ, Forman-Kay J, Fuxreiter M, Gsponer J, Han KH, Jones DT, Longhi S, Metallo SJ, Nishikawa K, Nussinov R, Obradovic Z, Pappu RV, Rost B, Selenko P, Subramaniam V, Sussman JL, Tompa P, Uversky VN. What\u2019s in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered. Intrinsically Disord Proteins. 2013 Apr.<\/li>\n\n\n\n
    6. 6.- Basile W, Salvatore M, Bassot C, Elofsson A. Why do eukaryotic proteins contain more intrinsically disordered regions? PLoS Comput Biol. 2019 Jul 22.<\/li>\n\n\n\n
    7. 7.- Dunker, A.K., Cortese, M.S., Romero, P., Iakoucheva, L.M. and Uversky, V.N. (2005), Flexible nets. The FEBS Journal.<\/li>\n\n\n\n
    8. 8.- Wright, Peter E, and H Jane Dyson. \u201cIntrinsically disordered proteins in cellular signalling and regulation.\u201d Nature reviews. Molecular cell biology vol. 16,1 (2015).<\/li>\n\n\n\n
    9. 9.- Bondos, Sarah E et al. \u201cIntrinsically disordered proteins play diverse roles in cell signaling.\u201d Cell communication and signaling : CCS vol. 20,1 20. 17 Feb. 2022.<\/li>\n\n\n\n
    10. 10.- Buljan, Marija et al. \u201cAlternative splicing of intrinsically disordered regions and rewiring of protein interactions.\u201d Current opinion in structural biology vol. 23,3 (2013).<\/li>\n\n\n\n
    11. 11.- Metallo SJ. Intrinsically disordered proteins are potential drug targets. Curr Opin Chem Biol. 2010 Aug;14(4):481-8. doi: 10.1016\/j.cbpa.2010.06.169. Epub 2010 Jul 2.<\/li>\n\n\n\n
    12. 12.- Saurabh S, Nadendla K, Purohit SS, Sivakumar PM, Cetinel S. Fuzzy Drug Targets: Disordered Proteins in the Drug-Discovery Realm. ACS Omega. 2023 Mar 8.<\/li>\n\n\n\n
    13. 13.- Chen J, Kriwacki RW. Intrinsically Disordered Proteins: Structure, Function and Therapeutics. J Mol Biol. 2018 Aug 3.<\/li>\n<\/ol>\n\n\n\n

      <\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":11945,"template":"","category":[815],"class_list":["post-16939","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-proteines-et-structure"],"acf":[],"yoast_head":"\nIntrinsically Disordered Proteins (IDPs) in Drug Discovery<\/title>\n<meta name=\"description\" content=\"IDPs make up at least a third of the eukaryotic proteome. Learn why their structural plasticity makes them hard but promising drug targets. Read more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intrinsically Disordered Proteins (IDPs) in Drug Discovery\" \/>\n<meta property=\"og:description\" content=\"IDPs make up at least a third of the eukaryotic proteome. Learn why their structural plasticity makes them hard but promising drug targets. Read more.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/\" \/>\n<meta property=\"og:site_name\" content=\"Sygnature\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-09T10:54:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2024\/07\/intrinsically-disordered-protein-drug-discovery.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"318\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/\",\"name\":\"Intrinsically Disordered Proteins (IDPs) in Drug Discovery\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/intrinsically-disordered-protein-drug-discovery.webp\",\"datePublished\":\"2024-07-04T17:10:10+00:00\",\"dateModified\":\"2026-11-09T10:54:53+00:00\",\"description\":\"IDPs make up at least a third of the eukaryotic proteome. Learn why their structural plasticity makes them hard but promising drug targets. Read more.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/intrinsically-disordered-protein-drug-discovery.webp\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/intrinsically-disordered-protein-drug-discovery.webp\",\"width\":400,\"height\":318,\"caption\":\"Structural representation of an intrinsically disordered protein with folded regions highlighted, illustrating its role as a challenging drug discovery target.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/blog\\\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Intrinsically Disordered Proteins as Drug Discovery Targets\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"name\":\"Sygnature Discovery\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\"},\"alternateName\":\"Sygnature\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#organization\",\"name\":\"Sygnature Discovery\",\"alternateName\":\"Sygnature\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Sygnature Discovery\"},\"image\":{\"@id\":\"https:\\\/\\\/www.sygnaturediscovery.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.youtube.com\\\/@sygnature.discovery\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/sygnature-discovery\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intrinsically Disordered Proteins (IDPs) in Drug Discovery","description":"IDPs make up at least a third of the eukaryotic proteome. Learn why their structural plasticity makes them hard but promising drug targets. Read more.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/","og_locale":"fr_CA","og_type":"article","og_title":"Intrinsically Disordered Proteins (IDPs) in Drug Discovery","og_description":"IDPs make up at least a third of the eukaryotic proteome. Learn why their structural plasticity makes them hard but promising drug targets. Read more.","og_url":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/","og_site_name":"Sygnature","article_modified_time":"2026-11-09T10:54:53+00:00","og_image":[{"width":400,"height":318,"url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2024\/07\/intrinsically-disordered-protein-drug-discovery.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimation du temps de lecture":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/","url":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/","name":"Intrinsically Disordered Proteins (IDPs) in Drug Discovery","isPartOf":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/#primaryimage"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2024\/07\/intrinsically-disordered-protein-drug-discovery.webp","datePublished":"2024-07-04T17:10:10+00:00","dateModified":"2026-11-09T10:54:53+00:00","description":"IDPs make up at least a third of the eukaryotic proteome. Learn why their structural plasticity makes them hard but promising drug targets. Read more.","breadcrumb":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/#primaryimage","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2024\/07\/intrinsically-disordered-protein-drug-discovery.webp","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2024\/07\/intrinsically-disordered-protein-drug-discovery.webp","width":400,"height":318,"caption":"Structural representation of an intrinsically disordered protein with folded regions highlighted, illustrating its role as a challenging drug discovery target."},{"@type":"BreadcrumbList","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/blog\/intrinsically-disordered-proteins-as-drug-discovery-targets-01\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sygnaturediscovery.com\/fr\/"},{"@type":"ListItem","position":2,"name":"Intrinsically Disordered Proteins as Drug Discovery Targets"}]},{"@type":"WebSite","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#website","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","name":"Sygnature Discovery","description":"","publisher":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization"},"alternateName":"Sygnature","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sygnaturediscovery.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"},{"@type":"Organization","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#organization","name":"Sygnature Discovery","alternateName":"Sygnature","url":"https:\/\/www.sygnaturediscovery.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","contentUrl":"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2025\/11\/Logo.svg","width":1,"height":1,"caption":"Sygnature Discovery"},"image":{"@id":"https:\/\/www.sygnaturediscovery.com\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.youtube.com\/@sygnature.discovery","https:\/\/www.linkedin.com\/company\/sygnature-discovery\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog\/16939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/types\/blog"}],"version-history":[{"count":1,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog\/16939\/revisions"}],"predecessor-version":[{"id":20486,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/blog\/16939\/revisions\/20486"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media\/11945"}],"wp:attachment":[{"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/media?parent=16939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sygnaturediscovery.com\/fr\/wp-json\/wp\/v2\/category?post=16939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}