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Target Analysis

Discerning the best route to a new drug candidate can often be illuminated by building a comprehensive knowledge of a target in order to choose the best approach for a drug discovery project, to decide a hit finding strategy and ultimately to design better, selective compounds.

Sygnature scientists are able to apply a range of computational techniques to help you gain a deep understanding of your target and to complement any biological validation.

  • Binding site identification and druggability assessment of new biological targets.
  • Protein sequence analysis, multiple sequences alignments and selectivity analysis.
  • Analysis of available structural data and protein structure visualisation shared with medicinal chemists to empower them to design improved compounds.
  • Homology modelling for targets lacking specific structural information.
  • Water assessment to understand the role of water in molecular interactions and its impact on binding affinity.

Get in Touch

For more details on how we can provide innovative support to your project please use this contact form.

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