Show results for
  • Sygnature
  • News
  • Drug Discovery
  • Therapeutic Areas
  • Events
  • Vacancies

PK/PD Senior Scientist (Alderley Park or Nottingham)

Scientists within the DMPK department at Sygnature Discovery play an essential role in supporting client projects. We are looking for an experience PK/PD scientist to further support our capabilities in this area.


  • You will design and execute discovery studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates.
  • You will aid in the analysis, interpretation, integration and reporting of discovery DMPK data generated.
  • Provide PK/PD modelling input to support drug discovery projects.
  • You will independently apply basic DMPK scientific principles, attend scientific meetings, and keep abreast of DMPK literature.
  • Where appropriate, you will represent DMPK as the subject matter expert on Sygnature Discovery’s client project teams.
  • Where appropriate, you will assist junior level scientists with experimental design and troubleshooting.
  • Where appropriate, you will support business development activities.

Experience / Requirements;

  • You will have a B.Sc., M.Sc. and/or Ph.D. in pharmaceutical sciences, Chemistry, Biochemistry or related disciplines with knowledge of absorption, distribution and drug metabolism
  • You will have a good understanding of pharmacokinetics and PK/PD.
  • You will have experience of using modelling packages (e.g. Phoenix WinNonlin) or other relevant software for non-compartmental and compartmental analysis of PK data would be beneficial
  • You will have some awareness of predicting human pharmacokinetics and dose.
  • You will have some experience in working with cross functional project teams to support drug discovery and/or pre-clinical development.
  • You will have some biotech and/or pharmaceutical industry experience in discovery DMPK.
  • You will have outstanding written and verbal communication skills.

In return you will receive an excellent training and benefits package, including a highly competitive salary and pension scheme. All our benefits are tailored to enhancing your experience at Sygnature as it is important to us that you share our success. We also recognise that our environment is paramount, so we foster a collaborative and supportive culture with plenty of opportunities to grow and develop, tailored to individual and business needs.

We are an award-winning provider of fully integrated drug discovery research programmes to the global pharmaceutical industry. Our clients place great value on our highly flexible, transparent and collaborative business model.

If you are interested in joining a successful, engaged and award-winning company that places its people at the heart of its business, please apply through the link below including the following;

Apply here

  • CV
  • Covering letter (briefly outlining your suitability for the role)
  • Confirmation of your status of eligibility to work in the UK (we have the ability to sponsor employees under a Tier 2 visa)

You will submit your application through our trusted partners, LogicMelon. Please be assured that only employees of Sygnature Discovery will review your application and personal data.

If you have any questions, please contact the Careers team at Please do not submit your application to this email address.

More Vacancies

Senior Informatics Scientist

As a Senior Informatics Scientist, you will work within a small, established team in...


Senior Computational Chemist

Computational Chemists at Sygnature Discovery are at the forefront of our scientific research, driving projects...


Get in Touch

For more details on how we can provide innovative support to your project please use this contact form.

CTA Form

The information you supply will be processed in accordance with the General Data Protection Regulation (EU) 2016/679. For further details about how Sygnature Discovery collects, uses and stores personal data, please refer to our Website Privacy Notice available here.