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Bioanalytical Method Development Specialist – Nottingham

This growing department is looking for an experienced method development bioanalytical scientist to join a method development team to provided LC-MS support for the DMPK Department.

You will join a dynamic department actively discovering new drugs for a broad range of projects, molecular targets and therapeutic indications.


  • Ensure efficient operation of Departmental LC-MS/MS systems, including preventative maintenance and system performance checks.
  • Develop chromatographic methodologies and mass spectrometer/uv detection methods to cover a wide range of chemical matter from multiple Discovery Programmes.
  • Experience in developing sample preparation approaches for plasma, blood, urine and tissues. Also apply these strategies to trouble-shoot both DMPK and Bioscience assay development.
  • Ability to trouble-shoot bioanalytical measurements supporting in vitro and in vivo DMPK assays.
  • Support the expansion of LC-MS support to other Departments, help champion the application of mass spectrometry to provide solutions to project team challenges.
  • Build strong, effective working relationships with the internal team and clients where applicable.


Key requirements;

  • MSc. and/or PhD. in Pharmaceutical Sciences, Chemistry, Biochemistry or related disciplines with 4+ years laboratory-based experience of quantitative LC-MS assay support is essential.
  • Significant experience of LC-MS/MS techniques (triple quadrupoles, orbitraps, UPLC chromatography).
  • Significant experience of LC-MS operating software packages from one or more of Thermo Scientific, Waters and Sciex.
  • Significant experience of preventative maintenance of autosampler, UPLC pumps and mass spectrometers to maximise system up-time.
  • Significant expertise in bioanalytical method development supporting analysis of compounds from biological matrices.
  • Flexible approach to work, able to deal with changing priorities and deadlines.
  • Outstanding written and verbal communication skills.


In return you will receive an excellent training and benefits package, including a highly competitive salary which is reviewed annually, a bonus scheme, a well-regarded pension scheme, and private medical insurance. All our benefits are tailored to enhancing your experience at Sygnature as it is important to us that you share in our success.

We also recognise that the environment you work in is a priority, so we have built a collaborative and supportive culture with plenty of opportunities to grow and succeed, tailored to individual and business needs. This includes an excellent set of bespoke training and development courses to accelerate both your scientific and personal career growth.

Since 2011, 34 compounds discovered by Sygnature for customers have entered pre-clinical development. So far, 17 of these have progressed to clinical trials (Phases I, II and III). In 2017, Sygnature Discovery received the prestigious Queen’s Award for Enterprise for International Trade, in 2020 the Medilink Outstanding Achievement Award, and in 2021 the Bionow Company of the Year Award.

If you’re interested in joining a company that places people at the heart of its business, please apply through the link and include:

Apply here

  • Your CV
  • A covering letter that briefly outlines your suitability for the role and your current notice period (if applicable)
  • Confirmation of your status of eligibility to work in the UK (we can consider sponsoring potential employees with relevant levels of qualifications and experience under a Skilled Worker visa).


Your application will be submitted through our trusted partners, LogicMelon, but only employees of Sygnature Discovery will review your application and personal data.

We will be interviewing on an ongoing basis, so please submit your application as soon as possible. We look forward to hearing from you.

If you have any questions or need further information, please contact the Careers team at Please do not submit your application to this email address.


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