DMPK and Physical Sciences

Delivering tailored DMPK expertise through innovation, quality and commitment. The DMPK and Physical Sciences Department is dedicated to the understanding of the absorption, distribution, metabolism and excretion of drug candidates.

Our industry experienced scientists work in close partnership with the client and other departments within Sygnature.We deliver valuable and reproducible DMPK data using industry standard assay technologies and techniques that support an efficient design, make, test, analyse cycle during an integrated project.

Our scientists not only undertake the in vitro assays, but also have the expertise to interpret the data generated. They also have the know-how and experience to provide a comprehensive consultancy service to interpret in vitro DMPK and in vivo PK data generated elsewhere. In addition, throughout the course of a project our clients have direct access to our scientists to facilitate complete transparency and detailed discussions.

 

 

Flash Interview Series

 

Why Sygnature discovery?

 

 

 

Dr Ed Browne talks about why Sygnature Discovery is a great place to work for and how our scientists work together with our clients to efficiently deliver new drug candidates for a wide range of therapeutic areas.

 

DMPK and Physical Sciences capabilities

 

 

Physico-chemical profiling

 

Absorption

 

Distribution

 

Metabolism

 

Excretion

  • Bile, Faecal or Urine Metabolite Profiling in preclinical species

Preclinical Toxicology

  • Transport induction / inhibition
  • (BSEP inhibition, MRP2, OATP1B1, NTCP, MDR1, OCT2, and others on request)
  • Cell viability
  • Mitochondrial Toxicology
  • Phospholipidosis
  • UGT1A1/3 Inhibition

 

Pharmacokinetics and Bioanalysis

  • Formulation Assessment for DxPK studies
  • PK and PD Studies support (in-life phase outsourced)
  • Plasma/Blood/Tissue Bioanalysis
  • PK/PD relationships and dose predictions
  • PK or TK Parameters (WinNonLin)

 

In-house instrumentation

  • Waters Xevo G2-XS QTOF (UPLC-MS-TOF)
  • Waters Xevo TQS-micro (UPLC-MS-MS)
  • Waters Acquity QDa (UPLC-MS)
  • MD SpectraMax 384 (analyte detection)
  • Agilent HP1100/1200 (HPLC +/- MS Systems)
  • Waters Semi-Prep (HPLC)
  • Beckman Biomek NXP
  • Genevac EZ2-Plus evaporator

 

 

DMPK Posters available







 

 


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