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Sygnature Discovery, Mironid®, and Peak Proteins to collaborate to discover new therapies for life-threatening and currently incurable kidney disease, ADPKD

Sygnature Discovery, Mironid® Limited, a leader in cell signalling-directed drug discovery and Peak Proteins, have announced they will work closely together to discover new therapies against diseases driven by elevated cyclic AMP (cAMP), such as Autosomal Dominant Polycystic Kidney Disease (ADPKD). ADPKD is a devastating, life-threatening and currently incurable genetic disorder in which kidney cysts […]

Pelago Bioscience and Sygnature Discovery collaborate to Provide CETSA® based Target Engagement Assays

Sygnature Discovery today announced that it will collaborate with Pelago Bioscience, a Swedish biotech company to provide target engagement assays with Pelago’s patented Cellular Thermal Shift Assay (CETSA®) method. While target engagement has long been recognised as pivotal to targeted drug efficacy. Pelago’s CETSA method adds a new dimension to this valuable assay, as it […]

Sygnature further enhances capabilities and services within the translational sciences.

Sygnature Discovery has released a biology publication focusing on our collaboration with Corcept Therapeutics. This work highlights our biomarker validation work and reports the outcome of phase I QBR116598 study that was also recently presented at Sygnature by Quotient clinical. The publication, sets the scene to support further phase II studies where FKBP5 might be […]

Sygnature Discovery expands DMPK team with appointment of Dr. Edward Browne

Sygnature announces the expansion of its DMPK team with the appointment of Dr Ed Browne as Associate Director of DMPK. Ed is an experienced drug discovery scientist who brings a thorough understanding of developing and prosecuting a lead optimisation strategy, having worked at GSK, Singapore for the last ten years as head of the Drug […]

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